+F Repair protein KO
#
DNA Repair and Recombination Proteins - Photinus pyralis (common eastern firefly)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 116176920 DNA oxidative demethylase ALKBH2-like isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 116167822 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 116167470 uncharacterized protein LOC116167470 isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 116173967 uncharacterized protein LOC116173967 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 116160348 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 116175004 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 116179423 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 116179164 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 116165619 DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 116168508 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 116179289 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 116173828 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 116158617 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 116158713 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 116173098 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 116177189 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 116159642 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 116160300 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 116180988 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 116161862 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 116168726 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 116166984 DNA ligase 3-like K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
E 116176881 DNA ligase 3-like K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 116170000 probable tyrosyl-DNA phosphodiesterase isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 116180344 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 116159835 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 116160257 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 116177501 uncharacterized protein F21D5.5-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 116182767 uncharacterized protein F21D5.5-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 116168560 high mobility group protein DSP1-like isoform X1 K10802 HMGB1; high mobility group protein B1
E 116161645 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 116158664 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 116161782 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 116168719 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 116165530 cullin-4A K10609 CUL4; cullin 4
F 116158663 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 116171312 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 116175621 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 116171474 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 116171475 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 116180392 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 116172438 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 116170346 DNA-directed RNA polymerase II subunit RPB7-like K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 116172634 DNA-directed RNA polymerase II subunit RPB7-like K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 116177532 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 116162231 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 116176446 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 116168719 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 116165530 cullin-4A K10609 CUL4; cullin 4
F 116158663 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 116158597 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
D TFIIH complex
E 116173180 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 116180933 general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 116169472 general transcription factor IIH subunit 1 isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 116175834 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 116176391 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 116169339 general transcription factor IIH subunit 4-like K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 116169349 general transcription factor IIH subunit 4-like K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 116175106 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 116159842 cyclin-H-like K06634 CCNH; cyclin H
E 116172202 cyclin-H-like K06634 CCNH; cyclin H
E 116158773 CDK-activating kinase assembly factor MAT1-like K10842 MNAT1; CDK-activating kinase assembly factor MAT1
E 116160351 CDK-activating kinase assembly factor MAT1-like K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 116173011 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 116160279 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116175564 replication protein A 14 kDa subunit-like isoform X1 K10740 RPA3; replication factor A3
D Other NER factors
E 116176858 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 116162772 DNA excision repair protein ERCC-1-like K10849 ERCC1; DNA excision repair protein ERCC-1
E 116162773 DNA excision repair protein ERCC-1-like K10849 ERCC1; DNA excision repair protein ERCC-1
E 116171868 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 116171906 DNA repair protein UVH3 K10846 ERCC5; DNA excision repair protein ERCC-5
E 116180988 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 116164344 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 116170417 cullin-3-A isoform X1 K03869 CUL3; cullin 3
E 116163583 cullin-5 K10612 CUL5; cullin 5
E 116158798 elongin-C isoform X1 K03872 ELOC; elongin-C
E 116167984 elongin-B-like K03873 ELOB; elongin-B
E 116162784 elongin-B-like isoform X1 K03873 ELOB; elongin-B
E 116163140 elongin-B-like K03873 ELOB; elongin-B
E 116178133 transcription elongation factor B polypeptide 3-like isoform X1 K15076 ELOA; elongin-A
E 116166789 transcription elongation factor B polypeptide 3-like isoform X1 K15076 ELOA; elongin-A
E 116160319 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 116164748 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 116161368 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 116161172 DNA mismatch repair protein Mlh1-like K08734 MLH1; DNA mismatch repair protein MLH1
E 116181591 DNA mismatch repair protein Mlh1-like K08734 MLH1; DNA mismatch repair protein MLH1
E 116181050 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 116164304 DNA mismatch repair protein Mlh3-like isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 116168508 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 116179289 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 116173828 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 116173011 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 116160279 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116175564 replication protein A 14 kDa subunit-like isoform X1 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 116171361 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 116161020 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 116171446 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 116161508 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 116177991 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 116164108 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 116159642 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 116180482 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 116168560 high mobility group protein DSP1-like isoform X1 K10802 HMGB1; high mobility group protein B1
E 116180988 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 116179353 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116173700 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 116173767 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 116158738 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
E 116170142 uncharacterized protein LOC116170142 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 116183003 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 116167440 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 116176424 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 116162820 DNA topoisomerase 2-binding protein 1-like isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 116179353 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116173700 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 116173767 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 116159228 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 116159228 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 116178459 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 116175877 DNA repair protein RAD51 homolog 4-like K10871 RAD51L3; RAD51-like protein 3
E 116161666 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 116159813 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 116162243 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 116177187 LOW QUALITY PROTEIN: uncharacterized protein LOC116177187 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 116170311 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 116161412 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 116175946 Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 116174259 ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 116161576 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 116168098 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116168746 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116166192 uncharacterized protein LOC116166192 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 116173011 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 116160279 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116175564 replication protein A 14 kDa subunit-like isoform X1 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 116161138 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 116169371 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 116169737 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 116181817 serine/threonine-protein phosphatase 4 regulatory subunit 3-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 116162242 serine/threonine-protein phosphatase 4 regulatory subunit 3-like isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 116168662 serine/threonine-protein phosphatase 4 regulatory subunit 4-like K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 116159524 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 116159469 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 116168637 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 116178802 uncharacterized protein LOC116178802 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 116177711 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 116167395 EP300-interacting inhibitor of differentiation 3-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 116160281 EP300-interacting inhibitor of differentiation 3-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 116167698 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 116175013 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 116162425 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 116174638 structure-specific endonuclease subunit slx1-like K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 116181739 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 116170696 spatacsin K19026 SPG11; spatacsin
E 116171882 zinc finger FYVE domain-containing protein 26 homolog K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 116163201 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 116163378 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 116178143 uncharacterized protein LOC116178143 K23112 BRAT1; BRCA1-associated ATM activator 1
E 116168411 acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 116169904 uncharacterized protein LOC116169904 K23456 CFAP410; cilla- and flagella-associated protein
E 116161058 uncharacterized protein LOC116161058 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 116171785 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 116181276 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 116174492 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 116176029 biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 116161723 uncharacterized protein C17orf53-like K27803 HROB; homologous recombination OB-fold protein
E 116177732 DNA helicase MCM8-like K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 116168482 DNA helicase MCM9-like isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
E 116165403 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 116170343 uncharacterized protein LOC116170343 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 116172630 uncharacterized protein LOC116172630 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 116181277 uncharacterized protein LOC116181277 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 116166624 DNA-dependent protein kinase catalytic subunit-like isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 116179353 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116173700 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 116173673 DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 116176754 uncharacterized protein LOC116176754 K10886 XRCC4; DNA-repair protein XRCC4
D X-family DNA polymerases
E 116161862 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 116180344 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 116159835 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 116160257 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 116177810 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 116163018 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 116181175 Fanconi anemia group M protein homolog isoform X1 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 116172309 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 116176991 centromere protein S-like K11511 APITD1; centromere protein S
E 116159279 centromere protein X-like K15360 STRA13; centromere protein X
E 116158843 ubiquitin-conjugating enzyme E2 T-like isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 116168098 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116168746 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116166192 uncharacterized protein LOC116166192 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 116163667 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 116163475 Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 116158629 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 116159228 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 116178459 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 116165878 ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 116166929 ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 116164196 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 116164527 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 116175093 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 116161170 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 116181590 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 116161805 RING finger protein 141-like K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 116171888 E3 ubiquitin-protein ligase RNF168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 116162655 E3 ubiquitin-protein ligase HERC2-like isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 116178457 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
E 116181275 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 116180448 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 116177079 DNA polymerase iota-like K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 116174290 DNA polymerase iota-like K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 116161848 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 116163396 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 116163769 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 116173540 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 116171256 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 116165654 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 116159642 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 116179945 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 116171453 acidic repeat-containing protein-like K26957 GCNA; germ cell nuclear acidic protein
D 116172430 acidic repeat-containing protein-like K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 116161617 cell cycle checkpoint control protein RAD9A-like K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 116159618 checkpoint protein HUS1-like isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 116159708 checkpoint protein HUS1-like isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 116163784 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 116178267 cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 116161020 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 116171446 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 116161508 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 116177991 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 116164108 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 116163784 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 116162890 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 116177910 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 116167917 claspin-like K25773 CLSPN; claspin
C Triple T complex
D 116163685 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 116163686 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 116173334 large proline-rich protein bag6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 116164634 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 116177689 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
D 116178476 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 116178062 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 116179287 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 116177601 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 116177430 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 116177683 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 116182569 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 116166777 M-phase inducer phosphatase-like isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 116164584 M-phase inducer phosphatase-like K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 116173184 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 116161534 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 116163074 protein sickie-like K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 116167425 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 116172526 period circadian protein-like K02633 PER2; period circadian protein 2
D 116159991 uncharacterized protein LOC116159991 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 116159992 uncharacterized protein LOC116159992 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 116166628 plastin-1 isoform X1 K17336 PLS3; plastin-3
D 116164261 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 116165069 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 116165077 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 116165366 KN motif and ankyrin repeat domain-containing protein 2-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 116159227 suppressor protein of bem1/bed5 double mutants-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 116181052 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 116163553 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 116166566 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 116163484 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 116161127 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 116173518 three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 116159305 ankyrin repeat and LEM domain-containing protein 1-like isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 116162815 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 116175563 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 116163486 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 116171167 pre-mRNA-splicing factor SPF27-like K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 116171363 pre-mRNA-splicing factor SPF27-like K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 116163175 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 116177664 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 116178722 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 116163100 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 116176451 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 116158953 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 116169634 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 116172349 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E 116160348 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 116175004 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 116173967 uncharacterized protein LOC116173967 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 116179164 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 116169227 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
E 116169251 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 116169227 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
D 116169251 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 116158953 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024