+F Repair protein KO
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DNA Repair and Recombination Proteins - Paenibacillus riograndensis
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PRIO_0380 methylated-DNA-protein-cysteinemethyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E PRIO_4781 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PRIO_0106 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E PRIO_0718 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PRIO_4412 nth; putative endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E PRIO_2906 type III restriction protein res subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E PRIO_6406 helicase K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D PRIO_0893 CTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_1090 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_1101 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_3918 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_3299 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_3392 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_3404 MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_2858 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_4020 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PRIO_0380 methylated-DNA-protein-cysteinemethyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D PRIO_0379 protein AdaA K13530 adaA; AraC family transcriptional regulator, regulatory protein of adaptative response / methylphosphotriester-DNA alkyltransferase methyltransferase [EC:2.1.1.-]
C BER (base exicision repair)
D DNA glycosylases
E PRIO_4781 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PRIO_1149 Uracil-DNA glycosylase superfamily K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E PRIO_0381 alkA; DNA-3-methyladenine glycosylase K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E PRIO_0106 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E PRIO_0718 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PRIO_5210 tag; DNA-3-methyladenine glycosylase 1 K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E PRIO_2363 mutM; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E PRIO_3832 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E PRIO_4412 nth; putative endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E PRIO_3081 exoA; Exodeoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E PRIO_1472 nfo1; putative endonuclease 4 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E PRIO_3831 nfo3; putative endonuclease 4 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E PRIO_5298 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E PRIO_6182 ligA2; DNA ligase 2 K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E PRIO_2362 polA; DNA-directed DNA polymerase K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E PRIO_6212 uvrA3; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
E PRIO_1745 Excinuclease ATPase subunit K03701 uvrA; excinuclease ABC subunit A
E PRIO_2388 uvrA1; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
E PRIO_6213 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
E PRIO_6569 GIY-YIG catalytic domain protein K03703 uvrC; excinuclease ABC subunit C
E PRIO_5631 uvrC; UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
E PRIO_5287 uvrd/rep helicase family protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_1269 UvrD/Rep family helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_2999 helD; Helicase IV K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_0441 putative ATP-dependent helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_6183 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_2409 hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_2362 polA; DNA-directed DNA polymerase K02335 polA; DNA polymerase I [EC:2.7.7.7]
E PRIO_6182 ligA2; DNA ligase 2 K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F PRIO_6145 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F PRIO_6144 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F PRIO_6107 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F PRIO_0116 DNA-directed RNA polymerase, delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta
F PRIO_2933 hypothetical protein K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F PRIO_0043 mfd; Transcription-repair-coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E PRIO_3861 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E PRIO_2060 mutS2; MutS2 protein K07456 mutS2; DNA mismatch repair protein MutS2
E PRIO_6798 DNA mismatch repair protein MutS domain-containing protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E PRIO_3860 DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E PRIO_4673 xseA; Exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E PRIO_4672 hypothetical protein K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E PRIO_2334 DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E PRIO_4034 polC; DNA polymerase III PolC-type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E PRIO_0002 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E PRIO_5235 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E PRIO_0021 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E PRIO_2564 hypothetical protein K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E PRIO_1643 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E PRIO_0125 dnaX; DNA polymerase III subunits gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E PRIO_6182 ligA2; DNA ligase 2 K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E PRIO_5287 uvrd/rep helicase family protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_1269 UvrD/Rep family helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_2999 helD; Helicase IV K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_0441 putative ATP-dependent helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_6183 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_2409 hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PRIO_6800 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E PRIO_4000 recA; Protein RecA K03553 recA; recombination protein RecA
E PRIO_5317 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E PRIO_5316 ruvB; Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E PRIO_5318 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E PRIO_2935 primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E PRIO_5196 hypothetical protein K03546 sbcC; DNA repair protein SbcC/Rad50
E PRIO_5197 sbcD; Nuclease SbcCD subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E PRIO_4000 recA; Protein RecA K03553 recA; recombination protein RecA
E PRIO_6166 radA; DNA repair protein RadA homolog K04485 radA; DNA repair protein RadA/Sms
E PRIO_0004 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E PRIO_2947 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E PRIO_5298 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E PRIO_5179 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E PRIO_0127 recR; Recombination protein RecR K06187 recR; recombination protein RecR
E PRIO_4666 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E PRIO_5317 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E PRIO_5316 ruvB; Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E PRIO_5318 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E PRIO_5198 recombination helicase AddA K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E PRIO_5199 addB; ATP-dependent helicase/deoxyribonuclease subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
E PRIO_1411 cas1-1; CRISPR-associated endonuclease Cas1 1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E PRIO_5196 hypothetical protein K03546 sbcC; DNA repair protein SbcC/Rad50
E PRIO_5197 sbcD; Nuclease SbcCD subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E PRIO_1238 ykoV; putative DNA repair protein YkoV K10979 ku; DNA end-binding protein Ku
E PRIO_1233 DNA polymerase LigD, polymerase domain protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E PRIO_1237 ATP dependent DNA ligase K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F PRIO_0008 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F PRIO_0006 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F PRIO_4084 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F PRIO_0049 DNA-binding protein HU (DNA-binding protein II) K03530 hupB; DNA-binding protein HU-beta
F PRIO_4485 DNA-binding protein HU 1 K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F PRIO_5298 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F PRIO_5179 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F PRIO_0127 recR; Recombination protein RecR K06187 recR; recombination protein RecR
F PRIO_6182 ligA2; DNA ligase 2 K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F PRIO_1564 recQ; putative ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F PRIO_6212 uvrA3; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
F PRIO_1745 Excinuclease ATPase subunit K03701 uvrA; excinuclease ABC subunit A
F PRIO_2388 uvrA1; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
F PRIO_6213 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D PRIO_2568 dinB1; DNA polymerase IV 1 K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D PRIO_4000 recA; Protein RecA K03553 recA; recombination protein RecA
D PRIO_3841 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D PRIO_4666 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D PRIO_6800 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D PRIO_3999 regulatory protein recx K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D PRIO_4435 DnaQ family exonuclease/DinG family helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D PRIO_3681 DEAD/DEAH box helicase domain-containing protein K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D PRIO_0893 CTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_1090 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_1101 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_3918 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_3299 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_3392 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_3404 MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_2858 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D PRIO_4020 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D PRIO_0590 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D PRIO_2619 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D PRIO_0589 nrdB; Ribonucleoside-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D PRIO_4027 phosphoesterase recj domain protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024