+F Repair protein KO
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DNA Repair and Recombination Proteins - Polyodon spathula (Mississippi paddlefish)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 121322210 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 121299989 alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 121330137 alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 121316281 ascc3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 121323167 CPD photolyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 121296847 uracil-DNA glycosylase-like isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 121299574 uracil-DNA glycosylase-like isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 121315098 cyclin-O-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 121304009 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 121318478 G/T mismatch-specific thymine DNA glycosylase-like isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 121319620 G/T mismatch-specific thymine DNA glycosylase-like K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 121300630 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 121301476 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 121308810 smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 121326474 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 121328486 methyl-CpG-binding domain protein 4-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 121328274 ogg1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 121294645 neil1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 121299160 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 121320684 neil3; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 121330466 nthl1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 121320140 apex1; DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 121307881 probable endonuclease 4 isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 121317943 DNA-(apurinic or apyrimidinic site) endonuclease-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 121328264 apex2; DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 121306001 pold1; LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 121302420 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
F 121303073 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
F 121302593 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
F 121302280 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 121307687 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 121330357 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 121309634 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 121300540 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
F 121301617 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 121302355 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 121303097 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 121312994 zgc:110269; probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 121305206 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 121307359 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 121302391 DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 121303203 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 121298651 DNA repair protein XRCC1-like K10803 XRCC1; DNA-repair protein XRCC1
E 121302810 zgc:110224; putative short transient receptor potential channel 2-like protein K10803 XRCC1; DNA-repair protein XRCC1
E 121304431 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 121305081 lig3; DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 121329588 tyrosyl-DNA phosphodiesterase 1-like K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 121324825 tyrosyl-DNA phosphodiesterase 1-like K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 121296574 aptx; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 121317235 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 121305886 bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 121302871 hmgb1a; high mobility group protein B1a K10802 HMGB1; high mobility group protein B1
E 121321627 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 121317135 parp1; poly [ADP-ribose] polymerase 1 isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 121298493 protein mono-ADP-ribosyltransferase PARP3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 121328826 protein mono-ADP-ribosyltransferase PARP3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 121305084 protein mono-ADP-ribosyltransferase PARP4-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 121305222 poly [ADP-ribose] polymerase 1-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 121305292 parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 121298412 xpc; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 121314630 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
F 121301557 UV excision repair protein RAD23 homolog A-like K10839 RAD23; UV excision repair protein RAD23
F 121301619 rad23ab; RAD23 homolog A, nucleotide excision repair protein b isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 121303479 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
F 121295179 centrin-1 K10840 CETN2; centrin-2
F 121318723 cetn2; centrin-1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 121306188 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 121295690 cullin-4B-like K10609 CUL4; cullin 4
F 121320873 cullin-4A-like K10609 CUL4; cullin 4
F 121327867 cullin-4A-like K10609 CUL4; cullin 4
F 121318828 cul4b; cullin-4B K10609 CUL4; cullin 4
F 121307614 ddb1; DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 121294299 ddb2; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 121306456 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 121306479 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 121305686 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 121294893 DNA-directed RNA polymerase II subunit RPB2-like K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 121323251 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 121308014 polr2c; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 121327202 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 121323301 DNA-directed RNA polymerase II subunit RPB4-like isoform X1 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 121309267 DNA-directed RNA polymerases I, II, and III subunit RPABC1-like K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 121309567 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 121306187 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 121306377 polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 121326345 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 121322598 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 121300450 polr2i; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 121330255 polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 121305075 polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 121308470 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 121313876 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 121306188 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 121295690 cullin-4B-like K10609 CUL4; cullin 4
F 121320873 cullin-4A-like K10609 CUL4; cullin 4
F 121327867 cullin-4A-like K10609 CUL4; cullin 4
F 121318828 cul4b; cullin-4B K10609 CUL4; cullin 4
F 121307614 ddb1; DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 121316847 ercc8; DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
F 121328338 DNA excision repair protein ERCC-8-like K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 121321822 ercc6; DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 121325620 uvssa; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
D TFIIH complex
E 121323354 ercc3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 121303737 general transcription and DNA repair factor IIH helicase subunit XPD-like K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 121303911 general transcription and DNA repair factor IIH helicase subunit XPD-like K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 121304842 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 121294849 gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 121312703 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 121297045 gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 121298676 gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 121316520 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 121305006 cyclin-dependent kinase 7-like isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 121313800 cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 121306205 cyclin-H-like isoform X1 K06634 CCNH; cyclin H
E 121329584 CDK-activating kinase assembly factor MAT1-like K10842 MNAT1; CDK-activating kinase assembly factor MAT1
E 121324104 mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 121308725 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 121303297 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 121313571 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 121325150 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 121320788 ercc1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 121300560 ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 121321022 ercc5; DNA repair protein complementing XP-G cells homolog isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 121307359 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 121326040 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 121321794 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 121326760 cullin-3 K03869 CUL3; cullin 3
E 121323285 cullin-3 K03869 CUL3; cullin 3
E 121302792 cullin-5 K10612 CUL5; cullin 5
E 121313410 elongin-C K03872 ELOC; elongin-C
E 121314358 elongin-C K03872 ELOC; elongin-C
E 121305213 elob; elongin-B K03873 ELOB; elongin-B
E 121316385 elongin-A-like K15076 ELOA; elongin-A
E 121316644 eloal; elongin A, like K15076 ELOA; elongin-A
E 121303427 eloa; elongin-A K15076 ELOA; elongin-A
E 121305284 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 121306933 ubap2l; ubiquitin-associated protein 2-like K26545 UBAP2; ubiquitin-associated protein 2
E 121307063 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 121316326 msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 121306412 msh3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 121303907 DNA mismatch repair protein Msh3-like K08736 MSH3; DNA mismatch repair protein MSH3
E 121316323 DNA mismatch repair protein Msh6-like isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
E 121316697 DNA mismatch repair protein Msh6-like K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 121322153 PMS1 protein homolog 1-like isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 121323047 pms1; LOW QUALITY PROTEIN: PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 121314709 mlh1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 121300609 pms2; mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 121329948 DNA mismatch repair protein Mlh3-like K08739 MLH3; DNA mismatch repair protein MLH3
E 121324746 DNA mismatch repair protein Mlh3-like K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 121306001 pold1; LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 121302420 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
E 121303073 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
E 121302593 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E 121302280 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 121308725 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 121303297 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 121313571 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 121326398 LOW QUALITY PROTEIN: replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
E 121329277 rfc1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 121326548 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
E 121308536 rfc2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 121323042 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
E 121296878 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
E 121299605 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 121320334 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 121302355 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 121303097 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 121315255 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 121316747 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 121302871 hmgb1a; high mobility group protein B1a K10802 HMGB1; high mobility group protein B1
E 121307359 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 121302846 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 121324775 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 121313194 nibrin-like K10867 NBN; nibrin
E 121313991 LOW QUALITY PROTEIN: nibrin-like K10867 NBN; nibrin
D BRCA1-core complex
E 121302017 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 121322656 bard1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 121302017 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 121303690 abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 121296922 BRCA1-A complex subunit RAP80-like isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 121324971 BRCA1-A complex subunit RAP80-like isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 121301013 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 121301538 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 121316216 babam2; BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 121295820 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 121318642 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 121302017 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 121308803 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 121313075 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 121313940 DNA topoisomerase 2-binding protein 1-A-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 121302017 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 121313509 DNA endonuclease RBBP8-like K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 121314446 DNA endonuclease RBBP8-like K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 121302846 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 121324775 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 121313194 nibrin-like K10867 NBN; nibrin
E 121313991 LOW QUALITY PROTEIN: nibrin-like K10867 NBN; nibrin
D BRCA complex
E 121302017 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 121302850 brca2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 121300776 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 121309356 meiotic recombination protein DMC1/LIM15 homolog K04482 RAD51; DNA repair protein RAD51
E 121323939 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 121329753 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 121309356 meiotic recombination protein DMC1/LIM15 homolog K04482 RAD51; DNA repair protein RAD51
E 121323939 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 121329753 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 121330381 rad51b; DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 121308498 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 121305099 rad51d; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 121314055 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 121329545 xrcc3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
E 121324306 DNA repair protein XRCC3-like K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 121318598 rad52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 121323984 rdm1; RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 121326564 rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 121297838 helicase ARIP4-like isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 121329007 helicase ARIP4-like isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 121314977 rad54b; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 121320109 ATP-dependent DNA helicase Q1-like isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 121320110 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 121318002 ATP-dependent DNA helicase Q1-like isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 121301087 wrn; Werner syndrome ATP-dependent helicase homolog isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 121298792 blm; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 121315160 recql4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 121295919 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
E 121296431 recql5; ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 121298792 blm; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 121299983 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 121301599 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 121296233 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 121331019 rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 121308725 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 121303297 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 121313571 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 121306776 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 121305216 serine/threonine-protein phosphatase 4 catalytic subunit-like K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 121297741 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 121313528 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 121319444 serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 121314467 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 121298125 serine/threonine-protein phosphatase 4 regulatory subunit 2-like isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 121328809 serine/threonine-protein phosphatase 4 regulatory subunit 2-like isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 121316148 serine/threonine-protein phosphatase 4 regulatory subunit 3-like isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 121317279 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 121329808 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 121324206 serine/threonine-protein phosphatase 4 regulatory subunit 3A-like isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 121324242 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
E 121330363 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 121328280 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 121328842 AP-5 complex subunit beta-1-like K19022 AP5B1; AP-5 complex subunit beta-1
E 121330189 ap5m1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 121294340 AP-5 complex subunit sigma-1-like K19024 AP5S1; AP-5 complex subunit sigma-1
E 121312878 AP-5 complex subunit sigma-1-like K19024 AP5S1; AP-5 complex subunit sigma-1
E 121301213 ap5z1; AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 121299097 smc5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 121315530 smc6; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 121315595 si:dkey-119f1.1; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 121315523 lratd1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 121317513 protein LRATD1-like K22805 FAM84A; protein FAM84A
E 121301089 nsmce1; non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 121313128 nsmce2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 121305403 ndnl2; necdin-like 2 isoform X1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 121325610 nsmce4a; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 121305970 slf1; SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 121321712 SMC5-SMC6 complex localization factor protein 2-like K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
E 121325735 SMC5-SMC6 complex localization factor protein 2-like isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 121295696 eme1; crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 121323757 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 121329975 exd2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 121310117 mus81; crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 121315039 26S proteasome complex subunit SEM1-like K10881 SHFM1; 26 proteasome complex subunit DSS1
E 121313558 sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 121303560 swi5; DNA repair protein SWI5 homolog isoform X1 K10991 SWI5; DNA repair protein Swi5/Sae3
E 121321724 sfr1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 121306569 slx1b; structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 121301586 slx4; structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 121315596 flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 121294641 spatacsin-like isoform X1 K19026 SPG11; spatacsin
E 121299197 spatacsin-like isoform X1 K19026 SPG11; spatacsin
E 121329660 LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 26-like K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 121324238 zfyve26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 121320019 rad51ap1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 121299301 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 121295006 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 121298479 samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 121320222 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 121307874 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 121312947 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 121314414 spidr; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 121307877 protein LRATD2-like K22810 FAM84B; protein FAM84B
E 121313844 protein LRATD2-like K22810 FAM84B; protein FAM84B
E 121300585 brat1; BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 121322248 cilia- and flagella-associated protein 410-like K23456 CFAP410; cilla- and flagella-associated protein
E 121323177 cfap410; cilia and flagella associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 121300749 hepatoma-derived growth factor-related protein 2-like isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 121301279 hepatoma-derived growth factor-related protein 2-like K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 121305110 zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 121310194 swsap1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 121302621 emsy; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 121321046 heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 121317369 mms22l; protein MMS22-like K26125 MMS22L; protein MMS22-like
E 121312992 tonsl; tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 121329957 bod1l1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 121319667 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
E 121302034 hrob; homologous recombination OB-fold protein isoform X1 K27803 HROB; homologous recombination OB-fold protein
E 121315935 mcm8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 121317304 mcm9; DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 121309347 xrcc6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 121323608 xrcc5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 121314412 prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 121302846 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 121324775 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 121328013 lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 121306287 DNA repair protein XRCC4-like isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 121312874 xrcc4; DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 121323132 nhej1; non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 121321627 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 121303011 polm; DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 121325345 dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 121302391 DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 121303203 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 121296574 aptx; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 121317235 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 121318201 dclre1c; protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 121313024 tdp2b; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 121313157 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 121300726 PWWP domain-containing DNA repair factor 3A-like isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 121301452 PWWP domain-containing DNA repair factor 3A-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 121306706 paxx; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 121319646 uncharacterized protein LOC121319646 isoform X1 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 121330516 jmjd8; jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 121315939 shieldin complex subunit 1-like K26128 SHLD1; shieldin complex subunit 1
E 121324156 BEN domain-containing protein 4 K27845 BEND4; BEN domain-containing protein 4
E 121327469 BEN domain-containing protein 4-like isoform X1 K27845 BEND4; BEN domain-containing protein 4
C FA (Fanconi anemia) pathway
D FA core complex
E 121325595 Fanconi anemia group A protein-like isoform X1 K10888 FANCA; fanconi anemia group A protein
E 121321297 Fanconi anemia group B protein-like K10889 FANCB; fanconi anemia group B protein
E 121303063 fancc; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 121299796 fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 121330377 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 121323610 Fanconi anemia group G protein homolog K10894 FANCG; fanconi anemia group G protein
E 121316144 fancl; E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 121324113 fancm; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 121325114 faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 121295376 faap100; Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 121327435 transcription factor HES-1-like isoform X1 K06054 HES1; hairy and enhancer of split 1
E 121322569 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 121328254 transcription factor HES-4-B-like K06054 HES1; hairy and enhancer of split 1
E 121328271 transcription factor HES-4-B-like K06054 HES1; hairy and enhancer of split 1
E 121328587 centromere protein S-like K11511 APITD1; centromere protein S
E 121328635 cenps; centromere protein S K11511 APITD1; centromere protein S
E 121296215 cenpx; centromere protein X isoform X1 K15360 STRA13; centromere protein X
E 121299641 ubiquitin-conjugating enzyme E2 T-like isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 121298792 blm; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 121299983 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 121301599 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 121296233 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 121331019 rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 121298299 fancd2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 121298871 Fanconi anemia group I protein-like K10895 FANCI; fanconi anemia group I protein
E 121304144 Fanconi anemia group I protein-like K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 121302017 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 121302850 brca2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 121308803 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 121300776 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 121295118 fan1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 121309356 meiotic recombination protein DMC1/LIM15 homolog K04482 RAD51; DNA repair protein RAD51
E 121323939 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 121329753 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 121308498 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 121294128 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 121327106 ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 121331204 ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 121309969 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
E 121314039 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 121307075 serine/threonine-protein phosphatase 6 catalytic subunit-like isoform X1 K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 121303553 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 121305940 serine/threonine-protein phosphatase 6 regulatory subunit 1-like K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 121318166 serine/threonine-protein phosphatase 6 regulatory subunit 2-like isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 121319940 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 2-like K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 121294587 serine/threonine-protein phosphatase 6 regulatory subunit 3-like isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 121329780 serine/threonine-protein phosphatase 6 regulatory subunit 3-like isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 121315126 ankrd28b; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 121313649 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 121322392 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 121323186 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 121308836 ankrd52a; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 121315984 E3 ubiquitin-protein ligase rnf8-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 121317115 E3 ubiquitin-protein ligase rnf8-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 121326457 E3 ubiquitin-protein ligase rnf168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 121323246 E3 ubiquitin-protein ligase rnf168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 121302779 rnf169; E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 121321014 E3 ubiquitin-protein ligase HERC2-like isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
E 121327935 E3 ubiquitin-protein ligase HERC2-like isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 121305611 wrap53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 121310838 tprn; taperin isoform X1 K24164 TPRN; taperin
E 121304282 taperin-like K24164 TPRN; taperin
E 121304292 proton channel OtopLc-like K24164 TPRN; taperin
E 121318428 WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 121304909 WD repeat-containing protein 70-like K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 121316811 polh; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 121317903 poli; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 121313503 DNA polymerase kappa-like isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 121320487 DNA repair protein REV1-like isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
D 121327899 DNA repair protein REV1-like isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 121315480 DNA polymerase zeta catalytic subunit-like K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 121317571 DNA polymerase zeta catalytic subunit-like K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 121330813 DNA polymerase nu-like K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 121318839 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 121297254 ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 121324253 ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 121298399 rad18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 121326680 hltf; helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 121297923 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 121313427 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 121319193 ube2v1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 121314369 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 121318397 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 121319700 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 121302355 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 121303097 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 121319667 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 121315909 sprtn; DNA-dependent metalloprotease SPRTN isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 121318724 gcna; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 121302270 rad9a; cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 121300245 cell cycle checkpoint control protein RAD9B-like K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 121312759 hus1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 121318235 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 121306499 rad17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 121312763 cell cycle checkpoint protein RAD17-like K06662 HRAD17; cell cycle checkpoint protein
D 121326548 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 121308536 rfc2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 121323042 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 121296878 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 121299605 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 121320334 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 121318235 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 121309059 timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 121298858 TIMELESS-interacting protein-like isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 121304419 TIMELESS-interacting protein-like K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 121303311 claspin K25773 CLSPN; claspin
C Triple T complex
D 121294128 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 121319381 tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 121302468 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
D 121303128 TELO2-interacting protein 2-like isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 121298633 large proline-rich protein BAG6-like isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 121304344 large proline-rich protein BAG6-like isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 121297799 ubiquitin-like protein 4A-A K23388 UBL4; ubiquitin-like protein 4
D 121303779 ubiquitin-like protein 4A-B K23388 UBL4; ubiquitin-like protein 4
D 121304475 ubiquitin-like protein 4A isoform X1 K23388 UBL4; ubiquitin-like protein 4
D 121304534 ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 121318976 ubiquitin-like protein 4A-A K23388 UBL4; ubiquitin-like protein 4
D 121305874 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 121300939 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
D 121331064 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 121326592 LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 121323613 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 121328705 ATR-interacting protein-like isoform X1 K10905 ATRIP; ATR interacting protein
D 121302935 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 121306517 cellular tumor antigen p53-like K04451 TP53; tumor protein p53
D 121305685 cellular tumor antigen p53-like K04451 TP53; tumor protein p53
D 121309546 serine/threonine-protein kinase Chk1-like isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 121299476 chek2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 121294349 M-phase inducer phosphatase 2-like isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 121312996 M-phase inducer phosphatase 1-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 121323933 M-phase inducer phosphatase 1-B-like K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 121297946 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 121314939 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 121315401 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 121317537 ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 121313242 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 121319475 ywhaba; 14-3-3 protein beta/alpha-A isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 121297394 14-3-3 protein eta isoform X1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 121300130 14-3-3 protein eta isoform X1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 121308007 14-3-3 protein gamma-B K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 121308632 ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 121294475 neuron navigator 2-like isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 121329543 nav2a; neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 121294975 wee1; wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 121329937 wee1-like protein kinase 1-A isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 121318612 wee2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 121305670 LOW QUALITY PROTEIN: period circadian protein homolog 1-like K21944 PER1; period circadian protein 1
D 121326350 period circadian protein homolog 2-like isoform X1 K02633 PER2; period circadian protein 2
D 121322552 period circadian protein homolog 2-like isoform X1 K02633 PER2; period circadian protein 2
D 121298628 mdc1; mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 121295490 plastin-3 isoform X1 K17336 PLS3; plastin-3
D 121318630 plastin-3-like isoform X1 K17336 PLS3; plastin-3
D 121294634 isg20; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 121299025 apoptosis-enhancing nuclease-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 121327258 serine/threonine-protein kinase PLK3-like K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 121331080 serine/threonine-protein kinase PLK3-like K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 121297711 serine/threonine-protein kinase Nek4-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 121320556 serine/threonine-protein kinase Nek5-like K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 121329049 serine/threonine-protein kinase Nek4-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 121323530 nek1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 121313963 nek10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 121314639 serine/threonine-protein kinase Nek11-like K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 121325244 serine/threonine-protein kinase Nek11-like isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 121321111 LOW QUALITY PROTEIN: protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 121327617 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 121300624 KN motif and ankyrin repeat domain-containing protein 3-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 121300289 KN motif and ankyrin repeat domain-containing protein 1-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 121301602 KN motif and ankyrin repeat domain-containing protein 3-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 121327114 kank4; KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 121317246 KN motif and ankyrin repeat domain-containing protein 1-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 121304532 kank2; KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 121323362 schlafen family member 13-like isoform X1 K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 121312714 charged multivesicular body protein 4c-like K24782 CHMP4C; charged multivesicular body protein 4C
D 121314175 charged multivesicular body protein 4c-like K24782 CHMP4C; charged multivesicular body protein 4C
D 121296392 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 121314581 vacuolar protein sorting-associated protein 4B-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 121313101 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 121325468 vacuolar protein sorting-associated protein 4A-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 121324488 zfyve19; abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 121316793 sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 121321260 DNA polymerase theta-like K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 121302587 polq; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 121308526 mybbp1a; myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 121297508 primpol; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 121328782 three prime repair exonuclease 2-like K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 121326152 dclre1a; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 121299724 5' exonuclease Apollo-like isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 121299912 5' exonuclease Apollo-like K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 121308688 exo5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 121296119 endonuclease V-like isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 121322339 zranb3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 121301537 ankle1; ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
D 121310455 uncharacterized protein LOC121310455 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 121303659 helq; helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 121316341 DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
D 121303025 ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 121307227 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 121302283 LOW QUALITY PROTEIN: pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 121315620 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 121317433 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 121300369 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 121300376 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 121322998 plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 121320554 nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 121300508 nudt1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 121302419 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 121303219 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 121294840 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 121298773 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 121320378 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 121302884 rrm1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 121314935 rrm2b; ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 121315396 ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 121308376 ribonucleoside-diphosphate reductase subunit M2 isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 121317530 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 121322210 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 121323167 CPD photolyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 121296847 uracil-DNA glycosylase-like isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 121299574 uracil-DNA glycosylase-like isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 121308810 smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 121300630 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 121301476 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 121326474 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 121330466 nthl1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 121318519 single-stranded DNA-binding protein, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
E 121319579 single-stranded DNA-binding protein, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 121318519 single-stranded DNA-binding protein, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
D 121319579 single-stranded DNA-binding protein, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 121320554 nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 121294840 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 121298773 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 121320378 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024