+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Piliocolobus tephrosceles (Ugandan red Colobus)</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
D      111523757 ORC1; origin recognition complex subunit 1	K02603 ORC1; origin recognition complex subunit 1 
D      111547017 ORC2; origin recognition complex subunit 2 isoform X1	K02604 ORC2; origin recognition complex subunit 2 
D      111538062 ORC3; origin recognition complex subunit 3 isoform X1	K02605 ORC3; origin recognition complex subunit 3 
D      111546135 ORC4; origin recognition complex subunit 4 isoform X1	K02606 ORC4; origin recognition complex subunit 4 
D      111526692 ORC5; origin recognition complex subunit 5	K02607 ORC5; origin recognition complex subunit 5 
D      111524399 ORC6; origin recognition complex subunit 6	K02608 ORC6; origin recognition complex subunit 6 
D      111553840 CDT1; DNA replication factor Cdt1 isoform X1	K10727 CDT1; chromatin licensing and DNA replication factor 1 
D      111537452 CDC6; cell division control protein 6 homolog	K02213 CDC6; cell division control protein 6 
D      111544756 MCM2; DNA replication licensing factor MCM2	K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3] 
D      111543133 MCM3; DNA replication licensing factor MCM3 isoform X1	K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3] 
D      113225143 DNA replication licensing factor MCM4	K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3] 
D      111525256 MCM4; DNA replication licensing factor MCM4	K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3] 
D      111548862 MCM5; DNA replication licensing factor MCM5	K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3] 
D      111527476 MCM6; DNA replication licensing factor MCM6	K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3] 
D      111530194 MCM7; DNA replication licensing factor MCM7 isoform X1	K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3] 
C    CDK (cyclin dependent kinase)
D      111546231 CCNA2; cyclin-A2	K06627 CCNA; cyclin-A 
D      111540405 CCNA1; cyclin-A1 isoform X1	K06627 CCNA; cyclin-A 
D      111553938 CCNE1; G1/S-specific cyclin-E1 isoform X1	K06626 CCNE; G1/S-specific cyclin-E1 
D      111549709 CCNE2; G1/S-specific cyclin-E2 isoform X1	K06626 CCNE; G1/S-specific cyclin-E1 
D      111541872 CDK2; cyclin-dependent kinase 2	K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22] 
C    DDK (Dbf-4 dependent kinase)
D      111555155 CDC7; cell division cycle 7-related protein kinase isoform X1	K02214 CDC7; cell division control protein 7 [EC:2.7.11.1] 
D      111552408 DBF4; protein DBF4 homolog A isoform X1	K06629 DBF4; protein DBF4 
D      111525800 DBF4B; protein DBF4 homolog B isoform X1	K06629 DBF4; protein DBF4 
C    GINS complex
D      113219570 GINS1; DNA replication complex GINS protein PSF1	K10732 GINS1; GINS complex subunit 1 
D      111553883 GINS2; DNA replication complex GINS protein PSF2	K10733 GINS2; GINS complex subunit 2 
D      111541303 GINS3; DNA replication complex GINS protein PSF3	K10734 GINS3; GINS complex subunit 3 
D      111544101 GINS4; DNA replication complex GINS protein SLD5 isoform X1	K10735 GINS4; GINS complex subunit 4 
C    Other initiation factors
D      111539535 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1	K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 
D      111523583 RECQL4; ATP-dependent DNA helicase Q4	K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] 
D      111526722 CDC45; cell division control protein 45 homolog	K06628 CDC45; cell division control protein 45 
D      111546456 MCM8; DNA helicase MCM8	K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4] 
D      111547286 MCM9; DNA helicase MCM9	K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4] 
D      111550051 MCM10; protein MCM10 homolog isoform X1	K10736 MCM10; minichromosome maintenance protein 10 
D      111551217 HELB; DNA helicase B	K15254 HELB; DNA helicase B [EC:5.6.2.3] 
D      111544849 FAM111A; protein FAM111A	K24274 FAM111A; protein FAM111A 
D      111538316 CINP; cyclin-dependent kinase 2-interacting protein isoform X1	K26052 CINP; cyclin-dependent kinase 2-interacting protein 
D      111550918 MTBP; mdm2-binding protein isoform X1	K26116 MTBP; Mdm2-binding protein 
D      111522877 TICRR; treslin	K26117 TICRR; Treslin 
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
D      111536281 POLA1; DNA polymerase alpha catalytic subunit isoform X1	K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7] 
D      111522350 POLA2; DNA polymerase alpha subunit B	K02321 POLA2; DNA polymerase alpha subunit B 
D      111541832 PRIM1; DNA primase small subunit	K02684 PRI1; DNA primase small subunit [EC:2.7.7.102] 
D      111549758 PRIM2; DNA primase large subunit isoform X1	K02685 PRI2; DNA primase large subunit 
C    DNA polymerase epsilon complex
D      111529820 POLE; DNA polymerase epsilon catalytic subunit A	K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] 
D      111549517 POLE2; DNA polymerase epsilon subunit 2 isoform X1	K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] 
D      111550372 POLE3; DNA polymerase epsilon subunit 3	K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] 
D      111523424 POLE4; DNA polymerase epsilon subunit 4 isoform X1	K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] 
C    DNA polymerase delta complex
D      111519964 DNA polymerase delta catalytic subunit isoform X5	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
D      111552255 POLD2; DNA polymerase delta subunit 2	K02328 POLD2; DNA polymerase delta subunit 2 
D      111540842 POLD3; DNA polymerase delta subunit 3 isoform X1	K03504 POLD3; DNA polymerase delta subunit 3 
D      111522258 POLD4; DNA polymerase delta subunit 4 isoform X1	K03505 POLD4; DNA polymerase delta subunit 4 
C    DNA polymerase gamma complex (mitochondrial)
D      111522853 POLG; DNA polymerase subunit gamma-1	K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7] 
D      111542525 POLG2; DNA polymerase subunit gamma-2, mitochondrial	K02333 POLG2; DNA polymerase gamma 2 
C    RPA (replication protein A)
D      111521304 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
D      111547615 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit	K10739 RFA2; replication factor A2 
D      111551087 RPA3; replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
D      111519976 replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
D      111536486 RPA4; replication protein A 30 kDa subunit	K10741 RPA4; replication factor A4 
C    RFC (replication factor C)
D      111550866 RFC1; replication factor C subunit 1 isoform X1	K10754 RFC1; replication factor C subunit 1 
D      111533287 RFC2; replication factor C subunit 2	K10755 RFC2_4; replication factor C subunit 2/4 
D      111544261 RFC4; replication factor C subunit 4	K10755 RFC2_4; replication factor C subunit 2/4 
D      111537532 RFC5; replication factor C subunit 5	K10756 RFC3_5; replication factor C subunit 3/5 
D      111540486 RFC3; replication factor C subunit 3	K10756 RFC3_5; replication factor C subunit 3/5 
C    RNase H
D      111531535 RNASEH1; ribonuclease H1	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
D      111523887 RNASEH2A; ribonuclease H2 subunit A	K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4] 
D      111523055 RNASEH2B; ribonuclease H2 subunit B isoform X1	K10744 RNASEH2B; ribonuclease H2 subunit B 
D      111522270 RNASEH2C; ribonuclease H2 subunit C isoform X1	K10745 RNASEH2C; ribonuclease H2 subunit C 
C    Other elongation factors
D      111546471 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
D      111537926 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1	K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-] 
D      111524320 FEN1; flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
D      111545219 EXO1; exonuclease 1	K10746 EXO1; exonuclease 1 [EC:3.1.-.-] 
D      111527480 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1	K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-] 
D      111520166 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
D      111520267 ATAD5; ATPase family AAA domain-containing protein 5	K26118 ATAD5; ATPase family AAA domain-containing protein 5 
B  DNA Replication Termination Factors
C    DNA methylation enzymes
D      111527762 DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1	K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 
D      111554400 DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1	K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37] 
D      111548206 DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1	K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37] 
C    Prevention of re-replication factors
D      111541096 GMNN; geminin	K10749 GMNN; geminin 
D      111541551 MCIDAS; multicilin	K26119 MCIDAS; multicilin 
D      111539895 CCNB1; G2/mitotic-specific cyclin-B1	K05868 CCNB1; G2/mitotic-specific cyclin-B1 
D      111553698 CCNB2; G2/mitotic-specific cyclin-B2	K21770 CCNB2; G2/mitotic-specific cyclin-B2 
D      111547435 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like	K21770 CCNB2; G2/mitotic-specific cyclin-B2 
D      111531432 CCNB3; G2/mitotic-specific cyclin-B3 isoform X1	K21771 CCNB3; G2/mitotic-specific cyclin-B3 
D      111521941 CDK1; cyclin-dependent kinase 1	K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] 
C    Telomere proteins
D      Shelterin complex
E        111550187 POT1; protection of telomeres protein 1 isoform X1	K11109 POT1; protection of telomeres protein 1 
E        111520935 TERF1; telomeric repeat-binding factor 1	K11110 TERF1; telomeric repeat-binding factor 1 
E        111541407 TERF2; telomeric repeat-binding factor 2 isoform X1	K11111 TERF2; telomeric repeat-binding factor 2 
E        111536081 LOW QUALITY PROTEIN: telomeric repeat-binding factor 2-like	K11111 TERF2; telomeric repeat-binding factor 2 
E        111552866 TINF2; TERF1-interacting nuclear factor 2	K11112 TINF2; TERF1-interacting nuclear factor 2 
E        113222491 LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2-like	K11112 TINF2; TERF1-interacting nuclear factor 2 
E        111541356 ACD; adrenocortical dysplasia protein homolog	K11114 ACD; adrenocortical dysplasia protein 
D      TERB1-TERB2-MAJIN complex
E        111541320 TERB1; telomere repeats-binding bouquet formation protein 1	K25749 TERB1; telomere repeats-binding bouquet formation protein 1 
E        111552816 TERB2; telomere repeats-binding bouquet formation protein 2	K25750 TERB2; telomere repeats-binding bouquet formation protein 2 
E        111522313 MAJIN; membrane-anchored junction protein isoform X1	K25751 MAJIN; membrane-anchored junction protein 
D      CST complex (animals)
E        111527018 CTC1; CST complex subunit CTC1 isoform X1	K23311 CTC1; CST complex subunit CTC1 
E        111538874 STN1; CST complex subunit STN1 isoform X1	K23312 STN1; CST complex subunit STN1 
E        111542401 TEN1; CST complex subunit TEN1	K23313 TEN1; CST complex subunit TEN1 
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      111521378 SMG6; telomerase-binding protein EST1A isoform X1	K11124 SMG6; protein SMG6 [EC:3.1.-.-] 
D      111543783 SMG5; protein SMG5	K11125 SMG5; protein SMG5 
D      111528337 TERT; telomerase reverse transcriptase isoform X1	K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49] 
D      111522554 TEP1; telomerase protein component 1	K11127 TEP1; telomerase protein component 1 
D      Dyskerin complex
E        111547890 GAR1; H/ACA ribonucleoprotein complex subunit 1	K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1 
E        111527420 NHP2; H/ACA ribonucleoprotein complex subunit 2	K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2 
E        111542455 H/ACA ribonucleoprotein complex subunit 3	K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3 
E        111534775 NOP10; H/ACA ribonucleoprotein complex subunit 3	K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3 
E        111527396 DKC1; H/ACA ribonucleoprotein complex subunit DKC1	K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-] 
C    Telomerase complex (fungi)
D      111528337 TERT; telomerase reverse transcriptase isoform X1	K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49] 
D      Sm core complex
E        111548091 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1	K11086 SNRPB; small nuclear ribonucleoprotein B and B' 
E        111539779 SNRPD1; small nuclear ribonucleoprotein Sm D1	K11087 SNRPD1; small nuclear ribonucleoprotein D1 
E        111520134 SNRPD2; small nuclear ribonucleoprotein Sm D2	K11096 SNRPD2; small nuclear ribonucleoprotein D2 
E        111544265 small nuclear ribonucleoprotein Sm D3	K11088 SNRPD3; small nuclear ribonucleoprotein D3 
E        111530559 SNRPD3; small nuclear ribonucleoprotein Sm D3	K11088 SNRPD3; small nuclear ribonucleoprotein D3 
E        111522775 SNRPE; small nuclear ribonucleoprotein E isoform X1	K11097 SNRPE; small nuclear ribonucleoprotein E 
E        111554833 SNRPF; small nuclear ribonucleoprotein F	K11098 SNRPF; small nuclear ribonucleoprotein F 
E        111550485 SNRPG; small nuclear ribonucleoprotein G isoform X1	K11099 SNRPG; small nuclear ribonucleoprotein G 
E        111523196 small nuclear ribonucleoprotein G	K11099 SNRPG; small nuclear ribonucleoprotein G 
E        111524325 small nuclear ribonucleoprotein G	K11099 SNRPG; small nuclear ribonucleoprotein G 
C    ELG1-RFC complex
D      111533287 RFC2; replication factor C subunit 2	K10755 RFC2_4; replication factor C subunit 2/4 
D      111544261 RFC4; replication factor C subunit 4	K10755 RFC2_4; replication factor C subunit 2/4 
D      111537532 RFC5; replication factor C subunit 5	K10756 RFC3_5; replication factor C subunit 3/5 
D      111540486 RFC3; replication factor C subunit 3	K10756 RFC3_5; replication factor C subunit 3/5 
C    MRN complex
D      111551618 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
D      111529467 RAD50; DNA repair protein RAD50 isoform X1	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      111549662 NBN; nibrin	K10867 NBN; nibrin 
C    Other termination factors
D      111540104 ATM; serine-protein kinase ATM isoform X1	K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] 
D      111544151 WRN; Werner syndrome ATP-dependent helicase isoform X1	K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4] 
D      111528644 BLM; Bloom syndrome protein isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
D      111525260 DNA-dependent protein kinase catalytic subunit	K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1] 
D      111525257 PRKDC; DNA-dependent protein kinase catalytic subunit	K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1] 
D      111555228 ERCC4; DNA repair endonuclease XPF isoform X1	K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] 
D      111537070 PARP1; poly [ADP-ribose] polymerase 1	K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] 
D      111528785 PARP3; protein mono-ADP-ribosyltransferase PARP3 isoform X1	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
D      111522561 PARP2; poly [ADP-ribose] polymerase 2	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
D      111525018 PARP4; protein mono-ADP-ribosyltransferase PARP4 isoform X1	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
D      111551362 TNKS; poly [ADP-ribose] polymerase tankyrase-1 isoform X1	K10799 TNKS; tankyrase [EC:2.4.2.30] 
D      111552179 TNKS2; poly [ADP-ribose] polymerase tankyrase-2	K10799 TNKS; tankyrase [EC:2.4.2.30] 
D      111551377 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1	K11135 PINX1; Pin2-interacting protein X1 
D      111520506 RTEL1; regulator of telomere elongation helicase 1 isoform X2	K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3] 
D      111524166 TELO2; telomere length regulation protein TEL2 homolog isoform X1	K11137 TELO2; telomere length regulation protein 
D      111523883 TRIR; telomerase RNA component interacting RNase isoform X1	K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-] 
D      111546119 RIF1; telomere-associated protein RIF1 isoform X1	K11138 RIF1; telomere-associated protein RIF1 
D      111548402 PIF1; ATP-dependent DNA helicase PIF1 isoform X1	K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3] 
D      111528309 transcriptional activator protein Pur-alpha	K21772 PURA; transcriptional activator protein Pur-alpha 
D      113224860 transcriptional activator protein Pur-alpha	K21772 PURA; transcriptional activator protein Pur-alpha 
D      111544196 PURG; purine-rich element-binding protein gamma isoform X1	K21800 PURG; purine-rich element-binding protein gamma 
D      111527066 WRAP53; telomerase Cajal body protein 1 isoform X1	K23314 WRAP53; telomerase Cajal body protein 1 
D      111537076 SDE2; replication stress response regulator SDE2 isoform X1	K25059 SDE2; replication stress response regulator SDE2 
D      111555635 RTF2; replication termination factor 2 isoform X1	K25186 RTF2; replication termination factor 2 
B  DNA Topoisomerases
C    111553206 TOP1; DNA topoisomerase 1 isoform X1	K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1] 
C    111553347 TOP1MT; DNA topoisomerase I, mitochondrial isoform X1	K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1] 
C    111537448 TOP2A; DNA topoisomerase 2-alpha	K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2] 
C    111539462 TOP2B; DNA topoisomerase 2-beta isoform X1	K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2] 
C    111530658 TOP3B; DNA topoisomerase 3-beta-1 isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
C    111526180 TOP3A; DNA topoisomerase 3-alpha	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      111521520 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1	K03111 ssb; single-strand DNA-binding protein 
C    Initiation factors (archaeal)
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
D      RNase H
E        111531535 RNASEH1; ribonuclease H1	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
D      Other elongation factors
C    Elongation factors (archaeal)
D      B-family DNA polymerases
D      D-family DNA polymerases
D      RNase H
E        111531535 RNASEH1; ribonuclease H1	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
D      RFC (replication factor C)
D      Other elongation factors
E        111537926 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1	K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-] 
E        111524320 FEN1; flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        111520166 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DNA Replication Termination Factors
C    Terminus site-binding protein
C    DNA methylation enzymes
C    Prevention of re-replication factors
B  DNA Topoisomerases
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#Last updated: November 2, 2022