+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Picrophilus oshimae</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
C    CDK (cyclin dependent kinase)
C    DDK (Dbf-4 dependent kinase)
C    GINS complex
C    Other initiation factors
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
C    DNA polymerase epsilon complex
C    DNA polymerase delta complex
C    DNA polymerase gamma complex (mitochondrial)
C    RPA (replication protein A)
C    RFC (replication factor C)
C    RNase H
C    Other elongation factors
D      PTO1316 DNA polymerase sliding clamp	K04802 PCNA; proliferating cell nuclear antigen 
D      PTO0228 RAD-2/FEN-1 exonuclease	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
D      PTO0672 DNA ligase	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DNA Replication Termination Factors
C    DNA methylation enzymes
C    Prevention of re-replication factors
C    Telomere proteins
D      Shelterin complex
D      TERB1-TERB2-MAJIN complex
D      CST complex (animals)
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      Dyskerin complex
C    Telomerase complex (fungi)
D      Sm core complex
C    ELG1-RFC complex
C    MRN complex
C    Other termination factors
B  DNA Topoisomerases
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      PTO0375 DNA-binding protein	K03530 hupB; DNA-binding protein HU-beta 
D      PTO0617 DNA primase	K02316 dnaG; DNA primase [EC:2.7.7.101] 
C    Initiation factors (archaeal)
D      PTO1257 origin recognition complex subunit	K10725 cdc6A; archaeal cell division control protein 6 
D      PTO1217 cell division control protein (mcm family)	K10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3] 
D      PTO0802 DNA primase small subunit	K02683 priS; DNA primase small subunit [EC:2.7.7.102] 
D      PTO0982 DNA primase 58 kDa subunit	K18882 priL; DNA primase large subunit 
D      PTO0266 hypothetical protein	K09723 ginS; DNA replication factor GINS 
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
D      RNase H
E        PTO1263 ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      Other elongation factors
C    Elongation factors (archaeal)
D      B-family DNA polymerases
E        PTO0128 DNA polymerase delta catalytic subunit	K02319 pol; DNA polymerase, archaea type [EC:2.7.7.7] 
D      D-family DNA polymerases
E        PTO0558 DNA polymerase II large subunit	K02322 polC; DNA polymerase II large subunit [EC:2.7.7.7] 
E        PTO0469 DNA polymerase II small subunit	K02323 polB; DNA polymerase II small subunit [EC:2.7.7.7] 
D      RNase H
E        PTO1263 ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      RFC (replication factor C)
E        PTO0873 replication factor C, large subunit	K04800 rfcL; replication factor C large subunit 
E        PTO0587 replication factor C, small subunit	K04801 rfcS; replication factor C small subunit 
D      Other elongation factors
E        PTO0228 RAD-2/FEN-1 exonuclease	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        PTO0672 DNA ligase	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DNA Replication Termination Factors
C    Terminus site-binding protein
C    DNA methylation enzymes
D      PTO1076 DNA adenine methylase	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
C    Prevention of re-replication factors
B  DNA Topoisomerases
C    PTO1415 DNA gyrase subunit A	K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 
C    PTO1414 DNA gyrase subunit B	K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 
C    PTO0747 DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
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#Last updated: August 27, 2025