+F Repair protein KO
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DNA Repair and Recombination Proteins - Pan troglodytes (chimpanzee)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 737624 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X4 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 107967636 ALKBH2; DNA oxidative demethylase ALKBH2 isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 741336 ALKBH3; alpha-ketoglutarate-dependent dioxygenase AlkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
C BER (base exicision repair)
D DNA glycosylases
E 452217 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 461871 CCNO; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 452188 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X2 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 112205005 LOW QUALITY PROTEIN: G/T mismatch-specific thymine DNA glycosylase-like K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 749794 MPG; DNA-3-methyladenine glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 451953 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 456539 MUTYH; adenine DNA glycosylase isoform X7 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 738526 MBD4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 460152 OGG1; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 467829 NEIL1; endonuclease 8-like 1 isoform X2 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 463992 NEIL2; endonuclease 8-like 2 isoform X1 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 471359 NEIL3; endonuclease 8-like 3 isoform X2 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 468087 NTHL1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 465200 APEX1; DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 473625 APEX2; DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 456228 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 472654 POLD2; DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 451422 POLD3; DNA polymerase delta subunit 3 isoform X2 K03504 POLD3; DNA polymerase delta subunit 3
F 451366 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 467165 POLE; DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 452888 POLE2; DNA polymerase epsilon subunit 2 isoform X4 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 741748 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 459343 POLE4; DNA polymerase epsilon subunit 4 isoform X2 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 458081 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 129137336 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 451242 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 468936 LIG1; DNA ligase 1 isoform X4 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 737210 POLB; DNA polymerase beta isoform X4 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 456094 XRCC1; DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 454581 LIG3; DNA ligase 3 isoform X2 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 453096 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 465037 APTX; aprataxin isoform X8 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 459293 APLF; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 747683 PNKP; bifunctional polynucleotide phosphatase/kinase isoform X2 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 749557 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 452518 HMGB1; high mobility group protein B1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 749521 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 107970066 LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1 K10802 HMGB1; high mobility group protein B1
E 736904 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 129143312 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 450687 POLL; DNA polymerase lambda isoform X9 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 457785 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 465197 PARP2; poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 460409 PARP3; protein mono-ADP-ribosyltransferase PARP3 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 452486 PARP4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 460195 XPC; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 473012 RAD23B; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 100608041 RAD23A; UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 107971232 CETN2; centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 458860 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X2 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 465835 CUL4B; cullin-4B isoform X2 K10609 CUL4; cullin 4
F 107968010 CUL4A; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 451234 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 451165 DDB2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 454463 POLR2A; DNA-directed RNA polymerase II subunit RPB1 isoform X1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 461305 POLR2B; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 454119 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 100612569 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 456359 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 129135271 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 740537 POLR2G; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 471027 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 746261 POLR2I; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 740555 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 100610062 DNA-directed RNA polymerase II subunit RPB11-a isoform X1 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 129144550 DNA-directed RNA polymerase II subunit RPB11-A-like isoform X1 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 100609886 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a isoform X2 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 741257 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 107967910 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 458860 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X2 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 465835 CUL4B; cullin-4B isoform X2 K10609 CUL4; cullin 4
F 107968010 CUL4A; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 451234 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 471534 ERCC8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 101058892 ERCC6; chimeric ERCC6-PGBD3 protein isoform X4 K10841 ERCC6; DNA excision repair protein ERCC-6
F 461063 UVSSA; UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 456364 ELOF1; transcription elongation factor 1 homolog isoform X1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 470526 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 456124 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 748842 GTF2H1; general transcription factor IIH subunit 1 isoform X2 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 461830 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 452352 GTF2H3; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 462549 GTF2H4; general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 738799 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 462378 CDK7; cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 739351 CCNH; cyclin-H K06634 CCNH; cyclin H
E 452954 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 454414 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 456680 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 472290 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 736976 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Other NER factors
E 747191 XPA; DNA repair protein complementing XP-A cells isoform X2 K10847 XPA; DNA-repair protein complementing XP-A cells
E 450179 ERCC1; DNA excision repair protein ERCC-1 isoform X6 K10849 ERCC1; DNA excision repair protein ERCC-1
E 453935 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 468936 LIG1; DNA ligase 1 isoform X4 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 450653 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 744812 CUL3; cullin-3 isoform X1 K03869 CUL3; cullin 3
E 466773 CUL5; LOW QUALITY PROTEIN: cullin-5 K10612 CUL5; cullin 5
E 107968511 elongin-C-like K03872 ELOC; elongin-C
E 100609698 elongin-C-like K03872 ELOC; elongin-C
E 744141 elongin-C-like K03872 ELOC; elongin-C
E 464236 ELOC; elongin-C isoform X1 K03872 ELOC; elongin-C
E 739191 elongin-B-like K03873 ELOB; elongin-B
E 107968666 ELOB; elongin-B isoform X1 K03873 ELOB; elongin-B
E 466850 elongin-B-like K03873 ELOB; elongin-B
E 456620 ELOA; elongin-A isoform X1 K15076 ELOA; elongin-A
E 468531 ELOA2; elongin-A2 K15076 ELOA; elongin-A
E 134808686 elongin-A3-like K15076 ELOA; elongin-A
E 129137899 elongin-A3 K15076 ELOA; elongin-A
E 134808675 elongin-A3 K15076 ELOA; elongin-A
E 129137902 elongin-A3 K15076 ELOA; elongin-A
E 134808676 elongin-A3 K15076 ELOA; elongin-A
E 129137900 elongin-A3 K15076 ELOA; elongin-A
E 134808677 elongin-A3 K15076 ELOA; elongin-A
E 129137895 elongin-A3 K15076 ELOA; elongin-A
E 134808678 elongin-A3 K15076 ELOA; elongin-A
E 134808603 elongin-A3 K15076 ELOA; elongin-A
E 129137896 elongin-A3 K15076 ELOA; elongin-A
E 134808604 elongin-A3 K15076 ELOA; elongin-A
E 129137897 elongin-A3 K15076 ELOA; elongin-A
E 134808679 elongin-A3 K15076 ELOA; elongin-A
E 129137904 elongin-A3 K15076 ELOA; elongin-A
E 134808680 elongin-A3 K15076 ELOA; elongin-A
E 473216 UBAP2; ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 457346 UBAP2L; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 107973458 MSH2; DNA mismatch repair protein Msh2 isoform X1 K08735 MSH2; DNA mismatch repair protein MSH2
E 735384 MSH3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 459218 MSH6; DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 459827 PMS1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 747104 MLH1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 463257 PMS2; mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 742579 LOW QUALITY PROTEIN: mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 453043 MLH3; DNA mismatch repair protein Mlh3 isoform X6 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 456228 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 472654 POLD2; DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 451422 POLD3; DNA polymerase delta subunit 3 isoform X2 K03504 POLD3; DNA polymerase delta subunit 3
E 451366 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 454414 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 456680 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 472290 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 736976 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D RFC (replication factor C)
E 461174 RFC1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 463467 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 100609026 RFC4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 741099 RFC5; replication factor C subunit 5 isoform X4 K10756 RFC3_5; replication factor C subunit 3/5
E 452533 RFC3; replication factor C subunit 3 isoform X4 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 458081 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 129137336 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 457856 EXO1; exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 749557 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 452518 HMGB1; high mobility group protein B1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 749521 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 107970066 LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1 K10802 HMGB1; high mobility group protein B1
E 736904 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 129143312 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 468936 LIG1; DNA ligase 1 isoform X4 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 467669 WDR76; WD repeat-containing protein 76 isoform X2 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 737902 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 107974853 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 464278 NBN; nibrin isoform X3 K10867 NBN; nibrin
D BRCA1-core complex
E 449497 BRCA1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 470638 BARD1; BRCA1-associated RING domain protein 1 isoform X3 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 449497 BRCA1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 461205 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 462299 UIMC1; BRCA1-A complex subunit RAP80 isoform X2 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 455827 BABAM1; BRISC and BRCA1-A complex member 1 isoform X3 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 459112 BABAM2; BRISC and BRCA1-A complex member 2 isoform X3 K12173 BRE; BRCA1-A complex subunit BRE
E 465951 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X2 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 449497 BRCA1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 454796 BRIP1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 460709 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X3 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 449497 BRCA1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 455333 RBBP8; DNA endonuclease RBBP8 isoform X2 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 737902 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 107974853 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 464278 NBN; nibrin isoform X3 K10867 NBN; nibrin
D BRCA complex
E 449497 BRCA1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 452526 BRCA2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 453988 PALB2; partner and localizer of BRCA2 isoform X2 K10897 PALB2; partner and localizer of BRCA2
E 453339 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 453339 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 467487 RAD51B; DNA repair protein RAD51 homolog 2 isoform X6 K10869 RAD51L1; RAD51-like protein 1
E 455162 RAD51C; DNA repair protein RAD51 homolog 3 isoform X2 K10870 RAD51L2; RAD51-like protein 2
E 468212 RAD51D; DNA repair protein RAD51 homolog 4 isoform X4 K10871 RAD51L3; RAD51-like protein 3
E 738997 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
D Rad52 family proteins
E 466911 RAD52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 468223 RDM1; RAD52 motif-containing protein 1 isoform X2 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 456563 RAD54L; DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 745605 RAD54L2; helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 472821 RAD54B; DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 465334 RECQL; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 472732 WRN; bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 453650 BLM; RecQ-like DNA helicase BLM isoform X2 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 464469 RECQL4; ATP-dependent DNA helicase Q4 isoform X3 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 454885 RECQL5; ATP-dependent DNA helicase Q5 isoform X5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 453650 BLM; RecQ-like DNA helicase BLM isoform X2 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 458682 TOP3B; DNA topoisomerase 3-beta-1 isoform X6 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 472968 RMI1; RecQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 738486 RMI2; RecQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 454414 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 456680 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 472290 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 736976 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Protein phosphatase 4
E 739184 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 455291 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100612020 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 738645 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X3 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 459246 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X5 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 473543 PPP4R3C; protein PPP4R3C K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 739423 SMEK1; serine/threonine-protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 107966179 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 467540 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 451331 AP5B1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 467465 AP5M1; AP-5 complex subunit mu-1 isoform X2 K19023 AP5M1; AP-5 complex subunit mu-1
E 458066 AP5S1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 472273 AP5Z1; AP-5 complex subunit zeta-1 isoform X2 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 464519 SMC5; structural maintenance of chromosomes protein 5 isoform X3 K22803 SMC5; structural maintenance of chromosomes protein 5
E 459046 SMC6; structural maintenance of chromosomes protein 6 isoform X5 K22804 SMC6; structural maintenance of chromosomes protein 6
E 745515 LRATD1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 454004 NSMCE1; non-structural maintenance of chromosomes element 1 homolog isoform X3 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 464387 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 745658 NSMCE3; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 742274 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 461750 SLF1; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
D Other HR factors
E 747125 EME1; crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 467868 EME2; probable crossover junction endonuclease EME2 isoform X3 K10883 EME2; crossover junction endonuclease EME2
E 452996 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 466667 MUS81; crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 747549 SEM1; 26S proteasome complex subunit SEM1 isoform X1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 129144156 26S proteasome complex subunit SEM1-like K10881 SHFM1; 26 proteasome complex subunit DSS1
E 107976787 SWI5; DNA repair protein SWI5 homolog isoform X1 K10991 SWI5; DNA repair protein Swi5/Sae3
E 736041 SFR1; swi5-dependent recombination DNA repair protein 1 homolog isoform X4 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 104002574 SLX1A; structure-specific endonuclease subunit SLX1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 453866 SLX4; structure-specific endonuclease subunit SLX4 isoform X2 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 470313 GEN1; flap endonuclease GEN homolog 1 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 453391 SPG11; spatacsin isoform X1 K19026 SPG11; spatacsin
E 452989 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 451765 RAD51AP1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 104005784 RAD51-associated protein 1-like K20778 RAD51AP1; RAD51-associated protein 1
E 740309 MORF4L1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 461609 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 458223 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 472365 FIGNL1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 464159 SPIDR; DNA repair-scaffolding protein isoform X2 K22806 SPIDR; DNA repair-scaffolding protein
E 740794 LRATD2; protein LRATD2 K22810 FAM84B; protein FAM84B
E 463228 BRAT1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 458603 CFAP410; cilia- and flagella-associated protein 410 isoform X2 K23456 CFAP410; cilla- and flagella-associated protein
E 738335 HDGFL2; hepatoma-derived growth factor-related protein 2 isoform X4 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 100614106 ZSWIM7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 455727 SWSAP1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 466716 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 474030 HSF2BP; heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 462893 MMS22L; protein MMS22-like isoform X2 K26125 MMS22L; protein MMS22-like
E 464464 TONSL; tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 461121 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 452182 PARPBP; PCNA-interacting partner isoform X4 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 465902 XRCC6; X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 458868 LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 449614 XRCC5; X-ray repair cross-complementing protein 5 isoform X2 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 464165 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X2 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 737902 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 107974853 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 452653 LIG4; DNA ligase 4 isoform X2 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 471491 XRCC4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 742646 NHEJ1; non-homologous end-joining factor 1 isoform X2 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 450687 POLL; DNA polymerase lambda isoform X9 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 737708 POLM; DNA-directed DNA/RNA polymerase mu isoform X15 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 466167 DNTT; DNA nucleotidylexotransferase isoform X2 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 737210 POLB; DNA polymerase beta isoform X4 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 465037 APTX; aprataxin isoform X8 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 459293 APLF; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 450319 DCLRE1C; protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 462475 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 455319 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 104004025 PWWP domain-containing DNA repair factor 4-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 455548 PWWP3A; PWWP domain-containing DNA repair factor 3A isoform X3 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 738431 PWWP3B; PWWP domain-containing DNA repair factor 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 129138658 PWWP domain-containing DNA repair factor 4-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 748817 PAXX; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 463748 CYREN; cell cycle regulator of non-homologous end joining isoform X1 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 458086 SHLD1; shieldin complex subunit 1 isoform X3 K26128 SHLD1; shieldin complex subunit 1
C FA (Fanconi anemia) pathway
D FA core complex
E 454393 FANCA; Fanconi anemia group A protein isoform X3 K10888 FANCA; fanconi anemia group A protein
E 737001 FANCB; Fanconi anemia group B protein isoform X2 K10889 FANCB; fanconi anemia group B protein
E 465257 FANCC; Fanconi anemia group C protein isoform X4 K10890 FANCC; fanconi anemia group C protein
E 747546 FANCE; Fanconi anemia group E protein isoform X1 K10892 FANCE; fanconi anemia group E protein
E 749534 FANCF; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 465067 FANCG; Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 459251 FANCL; E3 ubiquitin-protein ligase FANCL isoform X2 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 452885 FANCM; Fanconi anemia group M protein isoform X2 K10896 FANCM; fanconi anemia group M protein
E 455926 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X2 K10898 FAAP24; fanconi anemia-associated protein
E 454959 FAAP100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 460942 HES1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 100534602 CENPS; centromere protein S isoform X3 K11511 APITD1; centromere protein S
E 454980 CENPX; centromere protein X isoform X5 K15360 STRA13; centromere protein X
E 457628 UBE2T; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 453650 BLM; RecQ-like DNA helicase BLM isoform X2 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 458682 TOP3B; DNA topoisomerase 3-beta-1 isoform X6 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 472968 RMI1; RecQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 738486 RMI2; RecQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 460163 FANCD2; Fanconi anemia group D2 protein isoform X5 K10891 FANCD2; fanconi anemia group D2 protein
E 453636 FANCI; Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 449497 BRCA1; breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 452526 BRCA2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 454796 BRIP1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 453988 PALB2; partner and localizer of BRCA2 isoform X2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 453282 FAN1; fanconi-associated nuclease 1 isoform X2 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 453339 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 455162 RAD51C; DNA repair protein RAD51 homolog 3 isoform X2 K10870 RAD51L2; RAD51-like protein 2
E 453818 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 456901 USP1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 460277 WDR48; WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 738446 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit isoform X4 K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 735723 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 458987 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 747492 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 460205 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X2 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 459847 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 451992 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X2 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 100614028 RNF8; E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 743342 RNF168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 466707 RNF169; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 453257 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X3 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 455213 WRAP53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 736109 TPRN; taperin K24164 TPRN; taperin
E 107971950 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X7 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 461912 WDR70; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 467669 WDR76; WD repeat-containing protein 76 isoform X2 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 462720 POLH; DNA polymerase eta isoform X2 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 455429 POLI; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 461803 POLK; DNA polymerase kappa isoform X7 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 742931 REV1; DNA repair protein REV1 isoform X4 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 462942 REV3L; DNA polymerase zeta catalytic subunit isoform X2 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 739657 POLN; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 737175 UBE2A; ubiquitin-conjugating enzyme E2 A isoform X3 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 462065 UBE2B; ubiquitin-conjugating enzyme E2 B isoform X2 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 460144 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 460766 HLTF; helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 100538342 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 104005338 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 101056789 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 452125 UBE2N; ubiquitin-conjugating enzyme E2 N isoform X3 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 100615866 UBE2NL; LOW QUALITY PROTEIN: putative ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 107966362 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 458081 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 129137336 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 452182 PARPBP; PCNA-interacting partner isoform X4 K27412 PARPBP; PCNA-interacting partner
D 456494 SPRTN; DNA-dependent metalloprotease SPRTN isoform X2 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 737113 GCNA; germ cell nuclear acidic protein isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 466893 RAD9A; cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 452238 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 463402 HUS1; checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 743518 HUS1B; checkpoint protein HUS1B K10996 HUS1B; checkpoint protein HUS1B
D 461928 RAD1; cell cycle checkpoint protein RAD1 isoform X2 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 461832 RAD17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 463467 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100609026 RFC4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 741099 RFC5; replication factor C subunit 5 isoform X4 K10756 RFC3_5; replication factor C subunit 3/5
D 452533 RFC3; replication factor C subunit 3 isoform X4 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 461928 RAD1; cell cycle checkpoint protein RAD1 isoform X2 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 452431 TIMELESS; protein timeless homolog isoform X2 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 453525 TIPIN; TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 456746 CLSPN; claspin isoform X3 K25773 CLSPN; claspin
C Triple T complex
D 453818 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 458235 TTI1; TELO2-interacting protein 1 homolog isoform X3 K20403 TTI1; TELO2-interacting protein 1
D 747397 TTI2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 462560 BAG6; large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 473855 UBL4A; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 457124 UBL4B; ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 463209 GET4; Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 460745 ATR; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 742205 ATRIP; ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 451530 ATM; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 455214 TP53; cellular tumor antigen p53 isoform X2 K04451 TP53; tumor protein p53
D 739836 CHEK1; serine/threonine-protein kinase Chk1 isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 458733 CHEK2; serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 460341 CDC25A; M-phase inducer phosphatase 1 isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 458064 CDC25B; M-phase inducer phosphatase 2 isoform X2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 746151 CDC25C; M-phase inducer phosphatase 3 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 472830 YWHAZ; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 458272 YWHAB; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 470302 YWHAQ; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 104006265 14-3-3 protein theta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 741140 14-3-3 protein zeta/delta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 129138643 14-3-3 protein zeta/delta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 458778 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 463489 YWHAG; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 454409 YWHAE; 14-3-3 protein epsilon isoform X3 K06630 YWHAE; 14-3-3 protein epsilon
D 454608 PHD finger protein 14-like K06630 YWHAE; 14-3-3 protein epsilon
D 459638 14-3-3 protein epsilon-like K06630 YWHAE; 14-3-3 protein epsilon
D 451076 NAV2; neuron navigator 2 isoform X3 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 466440 WEE1; wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 463870 WEE2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 455098 PER1; period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 460057 PER2; period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 457907 PER3; period circadian protein homolog 3 isoform X11 K21945 PER3; period circadian protein 3
D 471959 MDC1; mediator of DNA damage checkpoint protein 1 isoform X3 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 465817 PLS3; plastin-3 isoform X1 K17336 PLS3; plastin-3
D 453628 AEN; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 456546 PLK3; serine/threonine-protein kinase PLK3 isoform X1 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 455553 PLK5; inactive serine/threonine-protein kinase PLK5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 745999 NEK5; serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 471345 NEK1; serine/threonine-protein kinase Nek1 isoform X8 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 460434 NEK4; serine/threonine-protein kinase Nek4 isoform X5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 745900 NEK10; serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 460982 NEK11; serine/threonine-protein kinase Nek11 isoform X2 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 746652 DONSON; protein downstream neighbor of Son isoform X2 K22422 DONSON; protein downstream neighbor of Son
D 456437 KANK3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 469206 KANK4; KN motif and ankyrin repeat domain-containing protein 4 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 746002 KANK2; KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100610121 KLLN; killin K23389 KLLN; killin
D 454584 SLFN11; schlafen family member 11 K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 472807 CHMP4C; charged multivesicular body protein 4C K24782 CHMP4C; charged multivesicular body protein 4C
D 468565 VPS4B; vacuolar protein sorting-associated protein 4B isoform X2 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 743569 VPS4A; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 453341 ZFYVE19; abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 457781 SDE2; splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 460619 POLQ; DNA polymerase theta isoform X4 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 454446 MYBBP1A; myb-binding protein 1A isoform X1 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 471370 PRIMPOL; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 742742 TREX1; three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 738230 TREX2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 450747 DCLRE1A; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 469419 DCLRE1B; 5' exonuclease Apollo isoform X2 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 748728 EXO5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 743058 ENDOV; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 459629 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 468765 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 isoform X3 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 461278 HELQ; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 473349 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 451228 PRPF19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 462736 CDC5L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 457143 BCAS2; pre-mRNA-splicing factor SPF27 isoform X1 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 461557 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 741013 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 129136271 nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 463225 NUDT1; oxidized purine nucleoside triphosphate hydrolase isoform X1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 741929 NUDT18; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 467675 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 450974 RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 472832 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 459024 RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X3 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 737624 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X4 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 452217 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 451953 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 749794 MPG; DNA-3-methyladenine glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 456539 MUTYH; adenine DNA glycosylase isoform X7 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 468087 NTHL1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 741448 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X2 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 741448 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X2 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 741013 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 129136271 nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 467675 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024