+D	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Prokaryotic Defense System - Proteus mirabilis CYPV1</h2>
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A<b>CRISPR-Cas system</b>
B  Universal Cas proteins
C    AOB99_10860 subtype I-E CRISPR-associated endonuclease Cas1	K15342 cas1; CRISP-associated protein Cas1 
C    AOB99_10855 single-stranded DNA endonuclease	K09951 cas2; CRISPR-associated protein Cas2 
B  Type I CRISPR-Cas system
C    Type I signiture cas proteins
C    Subtype I-A factors
C    Subtype I-B factors
C    Subtype I-C factors
C    Subtype I-D factors
C    Subtype I-E factors
D      AOB99_10885 CRISPR-associated protein Cse1	K19123 casA; CRISPR system Cascade subunit CasA 
D      AOB99_10880 hypothetical protein	K19046 casB; CRISPR system Cascade subunit CasB 
D      AOB99_10870 CRISPR-associated protein Cas5	K19125 casD; CRISPR system Cascade subunit CasD 
D      AOB99_10865 hypothetical protein	K19126 casE; CRISPR system Cascade subunit CasE 
C    Subtype I-F factors
C    Subtype I-U factors
B  Type II CRISPR-Cas system
C    Type II signiture cas proteins
C    Subtype II-A factors
C    Subtype II-B factors
B  Type III CRISPR-Cas system
C    Type III signiture cas proteins
C    Subtype III-A factors
C    Subtype III-B factors
C    Subtype III-U factors
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A<b>Restriction and modification system (R-M system)</b>
B  Type I R-M system
B  Type II R-M system
C    Restriction endonucleases
C    DNA methyltransferases
D      AOB99_16620 DNA adenine methylase	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
B  Type III R-M system
B  Type IV R-M system
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A<b>Toxin-antitoxin system (TA system)</b>
B  Type I TA system
C    Hok-Sok
C    SymE-SymR
C    Ldr-Rdl
C    TisB-IstR
C    Ibs-Sib
C    ShoB-OhsC
C    RalR-RalA
B  Type II TA system
C    MazF-MazE
C    ChpB-ChpS
C    YhaV-PrlF
C    RelE/StbE-RelB/StbD
D      AOB99_15600 hypothetical protein	K18923 stbD; antitoxin StbD 
C    YafQ-dinJ
D      AOB99_00965 mRNA interferase YafQ	K19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-] 
C    YoeB-YefM
C    HipA-HipB
D      AOB99_00080 toxin HipA	K07154 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] 
D      AOB99_03125 phosphatidylinositol kinase	K07154 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] 
D      AOB99_17095 serine/threonine protein kinase	K07154 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] 
D      AOB99_15625 XRE family transcriptional regulator	K15773 hipB; HTH-type transcriptional regulator / antitoxin HipB 
D      AOB99_17100 XRE family transcriptional regulator	K15773 hipB; HTH-type transcriptional regulator / antitoxin HipB 
C    HicA-HicB
D      AOB99_07050 hypothetical protein	K18843 hicB; antitoxin HicB 
C    YafO-YafN
C    PspC-PspB
D      AOB99_08800 phage shock protein C	K03973 pspC; phage shock protein C 
D      AOB99_08805 pspB; phage shock protein B	K03970 pspB; phage shock protein B 
C    CcdB-CcdA
C    ParE-ParD
D      AOB99_01235 plasmid stabilization protein	K19092 parE1_3_4; toxin ParE1/3/4 
D      AOB99_05135 plasmid stabilization protein	K19092 parE1_3_4; toxin ParE1/3/4 
D      AOB99_05130 antitoxin	K07746 parD1_3_4; antitoxin ParD1/3/4 
C    Doc-Phd
D      AOB99_00090 toxin	K07341 doc; death on curing protein 
D      AOB99_00095 antitoxin	K19165 phd; antitoxin Phd 
C    HigB-HigA
C    MqsR-MqsA
C    VapC-VapB
D      AOB99_03260 antitoxin	K18829 mvpT; antitoxin VapB 
C    PezT-PezA
C    YobL-YobK
C    YokI-YokJ
C    YqcG-YqcF
C    YxiD-YxxD
C    FitB-FitA
C    BC_0920-BC_0921
C    SpoIISA-SpoIISB
C    Tse6-Tsi6
C    Type II TA system related factors
D      AOB99_10365 bssS; transcriptional regulator	K12148 bssS; biofilm regulator BssS 
D      AOB99_12155 cell division protein FtsZ	K03531 ftsZ; cell division protein FtsZ 
D      AOB99_02420 rod shape-determining protein MreB	K03569 mreB; rod shape-determining protein MreB and related proteins 
D      AOB99_13665 DNA topoisomerase IV	K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] 
D      AOB99_13670 DNA topoisomerase IV	K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] 
D      AOB99_11145 gltX; glutamine--tRNA ligase	K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] 
B  Type III TA system
C    AbiQ system
B  Type IV TA system
C    YeeV-YeeU
D      AOB99_16275 toxin	K18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins 
D      AOB99_16280 antitoxin	K18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins 
C    CptA-CptB
D      AOB99_11900 hypothetical protein	K19168 cptA; toxin CptA 
D      AOB99_11910 hypothetical protein	K09159 cptB; antitoxin CptB 
C    AbiEii-AbiEi
B  Type V TA system
C    GhoT-GhoS
C    Other GhoT/OrtT toxin family protein
D      AOB99_10515 hypothetical protein	K28274 ortT; orphan toxin OrtT 
B  Type VI TA system
C    SocB-SocA
B  Type VII TA system
C    Hha-TomB
D      AOB99_03465 transcriptional regulator	K05839 hha; haemolysin expression modulating protein 
D      AOB99_03470 hypothetical protein	K19162 tomB; hha toxicity modulator TomB 
C    TglT-TakA
C    HepT-MntA
B  Type VIII TA system
C    SdsR-RyeA
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A<b>DNA phosphothiolation system</b>
B  Sulfur modification proteins
C    AOB99_11365 cysteine desulfurase IscS	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
B  DNA phosphorothioation-dependent restriction proteins
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#Last updated: May 19, 2025