+F Repair protein KO
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DNA Repair and Recombination Proteins - Penaeus vannamei (Pacific white shrimp)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 113823240 agt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 138859082 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 113828592 obe; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 113823876 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 113823021 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 113805765 uncharacterized protein K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 113800830 uncharacterized protein K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 113821442 trithorax group protein osa isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 113810601 uncharacterized protein K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 113804317 Smug; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 113821671 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 138864034 neurofilament heavy polypeptide-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 113819526 Ogg1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 113829181 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 113806144 endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 113812227 Nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 113815766 DNA repair nuclease APEX1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 113824052 DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 113812937 PolD1; DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 113819157 PolD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 113821183 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 113815859 PolE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 113812128 Chrac-14; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 113803782 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 113811712 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 113811291 Fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 113819869 DNAlig1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 113818909 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 113804867 LOW QUALITY PROTEIN: DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 113809960 gkt; LOW QUALITY PROTEIN: probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 113816347 Aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 113817009 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 113818188 PNKP; uncharacterized protein F21D5.5 isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 113800274 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 113811705 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 113813482 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 138861081 poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 113810772 poly [ADP-ribose] polymerase 2 isoform X1 K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
E 113813697 protein mono-ADP-ribosyltransferase PARP3-like K10798 PARP3_4; protein mono-ADP-ribosyltransferase 3/4 [EC:2.4.2.-]
E 113815759 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP3_4; protein mono-ADP-ribosyltransferase 3/4 [EC:2.4.2.-]
E 113820743 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP3_4; protein mono-ADP-ribosyltransferase 3/4 [EC:2.4.2.-]
E 113829160 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP3_4; protein mono-ADP-ribosyltransferase 3/4 [EC:2.4.2.-]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 113802762 Xpc; DNA repair protein complementing XP-C cells homolog isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 113820273 Rad23; UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 113818542 Roc1a; RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 113821299 Cul4; cullin-4A K10609 CUL4; cullin 4
F 113810662 pic; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 113814039 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 113804694 Polr2B; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 113822077 Polr2C; DNA-directed RNA polymerase II subunit RPB3 isoform X1 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 113818194 Polr2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 113817808 Polr2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 113805455 Polr2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 113821224 Polr2G; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 113817375 Polr2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 113800194 Polr2I; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 113829158 Polr2J; DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 113818542 Roc1a; RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 113821299 Cul4; cullin-4A K10609 CUL4; cullin 4
F 113810662 pic; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 113818710 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 113807013 DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 113805889 UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 113803427 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 113827401 general transcription and DNA repair factor IIH helicase/translocase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 113827402 general transcription and DNA repair factor IIH helicase/translocase subunit XPB-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 113828622 Xpd; general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 113809950 Ssl1; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 113817051 Tfb4; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 113809198 mrn; general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 113828092 general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 113801965 Cdk7; cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 113808264 CycH; cyclin-H isoform X1 K06634 CCNH; cyclin H
E 113802955 CDK-activating kinase assembly factor MAT1 isoform X2 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 113827271 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 113823431 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113804775 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 113817753 Xpac; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 113804184 Ercc1; DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 113820725 mei-9; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 113807010 mus201; DNA excision repair protein ERCC-5 homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 113819869 DNAlig1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 113824798 Mms19; MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 113828513 Ciao1; probable cytosolic iron-sulfur protein assembly protein CIAO1 isoform X3 K24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1
E 113800840 galla-1; cytosolic iron-sulfur assembly component 2A K26403 CIAO2; cytosolic iron-sulfur assembly component 2
E 113808020 galla-2; von Hippel-Lindau-like protein isoform X1 K26403 CIAO2; cytosolic iron-sulfur assembly component 2
E 113818053 Cul3; cullin-3 K03869 CUL3; cullin 3
E 113819186 Cul5; cullin-5 isoform X1 K10612 CUL5; cullin 5
E 113828949 EloC; elongin-C K03872 ELOC; elongin-C
E 113825554 EloB; elongin-B K03873 ELOB; elongin-B
E 113828229 EloA; transcription elongation factor B polypeptide 3 isoform X1 K15076 ELOA; elongin-A
E 113806953 lig; protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 113820839 spel1; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 113803547 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 138865020 Mlh1; DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 113799998 Pms2; mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 113827587 DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 113812937 PolD1; DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 113819157 PolD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 113821183 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 113827271 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 113823431 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113804775 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 113803514 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 113818852 RfC4; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 113826318 RfC38; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 113811712 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 113810831 tos; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 113800274 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 113819869 DNAlig1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 113823879 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 113818231 mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 113815953 rad50; DNA repair protein RAD50.L isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
E 113802497 serine-rich adhesin for platelets isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 113828142 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 113802497 serine-rich adhesin for platelets isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 113826418 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 113808271 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 113828337 lys-63-specific deubiquitinase BRCC36 isoform X2 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 113802497 serine-rich adhesin for platelets isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 113819229 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 113828616 mus101; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 113802497 serine-rich adhesin for platelets isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 113818231 mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 113815953 rad50; DNA repair protein RAD50.L isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 113802497 serine-rich adhesin for platelets isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 113814891 spn-A; DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 113814891 spn-A; DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 113813156 DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 113812613 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 113828358 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 113817025 Xrcc2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 113810396 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 138864541 uncharacterized protein K10873 RAD52; DNA repair and recombination protein RAD52
E 113819934 RAD52 motif-containing protein 1 isoform X2 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 113810275 okr; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 113812022 DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 113800062 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 113804199 ATP-dependent DNA helicase RecQ K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 113830626 Blm; recQ-like DNA helicase Blm isoform X4 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113823187 RecQ4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 113830626 Blm; recQ-like DNA helicase Blm isoform X4 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113807124 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113816028 Top3beta; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113823963 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 113823503 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 113827271 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 113823431 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113804775 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 113806078 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 113809190 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 113800535 PPP4R2r; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 113827923 flfl; serine/threonine-protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E 113801325 SMC5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 113812695 SMC6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 113824083 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 113829286 non-structural maintenance of chromosomes element 3 homolog isoform X1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 113829759 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 113823511 Nse4; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 113810827 uncharacterized protein K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
D Other HR factors
E 113816501 mms4; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 113805241 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 113822426 exonuclease 3'-5' domain-containing protein 2-like isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 113829633 exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 113809665 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 113807103 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 113804612 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 113804252 slx1; structure-specific endonuclease subunit slx1 isoform X2 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 113809610 microtubule-associated protein futsch isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 113828451 uncharacterized protein K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 113803797 spatacsin K19026 SPG11; spatacsin
E 113804599 Sptz; uncharacterized protein Sptz K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 113820800 MRG15; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 113816659 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 113820869 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 113810137 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 113815745 uncharacterized protein K22806 SPIDR; DNA repair-scaffolding protein
E 113818768 dynein axonemal assembly factor 11 isoform X3 K23456 CFAP410; cilla- and flagella-associated protein
E 113806690 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 113802934 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 113809329 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 113805748 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 113814802 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
E 113810893 uncharacterized protein K27803 HROB; homologous recombination OB-fold protein
E 113809376 DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 113825348 uncharacterized protein isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 113807876 Irbp; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 113809110 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 113810248 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 113805347 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 113818231 mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 113815953 rad50; DNA repair protein RAD50.L isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 113827965 DNAlig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 113815317 non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 113811705 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 113825768 DNA-directed DNA/RNA polymerase mu isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
D Other NHEJ factors
E 113816347 Aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 113817009 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 113813304 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 113802170 jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
C FA (Fanconi anemia) pathway
D FA core complex
E 113820792 uncharacterized protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 113807675 Fancl; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 113829359 Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 138865611 transcription factor HES-2-like K06054 HES1; hairy and enhancer of split 1
E 138865021 centromere protein S-like isoform X1 K11511 APITD1; centromere protein S
E 113804843 centromere protein X K15360 STRA13; centromere protein X
E 113806765 ubiquitin-conjugating enzyme E2 T isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 113830626 Blm; recQ-like DNA helicase Blm isoform X4 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113807124 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113816028 Top3beta; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113823963 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 113823503 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 113817520 Fancd2; Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 113810862 FANCI; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 113802497 serine-rich adhesin for platelets isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 113819229 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 113823203 fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 113814891 spn-A; DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 113812613 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 113816604 uncharacterized protein isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 113800501 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 113803807 PpV; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
D Ubiquitin ligases
E 113824668 E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 113810941 E3 ubiquitin-protein ligase rnf168 isoform X1 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 113821475 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 113817727 WDR79; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 113816173 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 113823879 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
E 113817358 abasic site processing protein HMCES K28434 HMCES; abasic site processing protein HMCES
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 113812796 DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 113815008 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 113812272 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D 113807918 Ubc6; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 113823358 E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 113808879 Uev1A; ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 113808371 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 113811712 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 113805158 PCNA-associated factor K28763 PCLAF; PCNA-associated factor
D 113814802 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 113816104 DNA-dependent metalloprotease dvc-1 isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 113828243 DNA-dependent metalloprotease SPRTN isoform X2 K24051 SPRTN; SprT-like domain-contaning protein Spartan
B Check point factors
C Rad9-Hus1-Rad1 complex
D 113808580 Rad9; cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 113821887 Hus1-like; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 113824542 Rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 113803514 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 113818852 RfC4; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 113826318 RfC38; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 113824542 Rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 113819875 timeout; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 113813220 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 113814194 claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 113815003 Tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 113819714 TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 113811235 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 113818570 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C SOSS complex
D 113826738 IntS3; integrator complex subunit 3 isoform X1 K13140 INTS3; integrator complex subunit 3 (SOSS complex subunit A)
D 113830389 SOSS complex subunit B1-B isoform X1 K28889 NABP; SOSS complex subunit B
C Other check point factors
D 113801784 mei-41; serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 113807048 tefu; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 113828090 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 113829798 serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 113800052 M-phase inducer phosphatase isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 113803691 14-3-3zeta; 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 113826778 14-3-3epsilon; 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 113812565 protein sickie isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 113800896 Wee1; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 113828937 per; period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 113811784 uncharacterized protein K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 113819468 uncharacterized protein K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 113814334 hd; protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 113805650 KN motif and ankyrin repeat domains 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 113819147 Vps4; vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 113817810 splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 113816727 bc10; apoptosis inducing factor BLCAP K29062 BLCAP; apoptosis inducing factor BLCAP
B Other factors with a suspected DNA repair function
C DNA polymerases
D 113826796 myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 113822429 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 113803765 uncharacterized protein K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 113826789 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
C Helicases
D 113802827 helicase POLQ-like isoform X2 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 113818567 Prp19; pre-mRNA-processing factor 19 isoform X1 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 113826782 Cdc5; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 113812169 Tango4; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 113806645 oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 113803116 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 113824641 RnrL; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 113823240 agt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 113823876 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 113823021 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 113804317 Smug; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 113810601 uncharacterized protein K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 113821671 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 113812227 Nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 113815267 mtSSB; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 113815267 mtSSB; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 23, 2026