+F Repair protein KO
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DNA Repair and Recombination Proteins - Plasmodium vinckei vinckei
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PVVCY_1101410 deoxyribodipyrimidine photo-lyase, putative K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E PVVCY_1003300 uracil-DNA glycosylase, putative K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PVVCY_1303290 DNA-3-methyladenine glycosylase, putative K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E PVVCY_0902820 A/G-specific adenine glycosylase, putative K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PVVCY_1203050 endonuclease III homologue, putative K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E PVVCY_1305010 apurinic/apyrimidinic endonuclease Apn1, putative K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F PVVCY_0500170 DNA polymerase delta catalytic subunit, putative K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F PVVCY_0400700 DNA polymerase delta small subunit, putative K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F PVVCY_1103020 DNA polymerase epsilon catalytic subunit A, putative K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F PVVCY_1405100 DNA polymerase epsilon subunit B, putative K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
E PVVCY_1103900 proliferating cell nuclear antigen 1, putative K04802 PCNA; proliferating cell nuclear antigen
E PVVCY_1404350 proliferating cell nuclear antigen 2, putative K04802 PCNA; proliferating cell nuclear antigen
E PVVCY_0800640 flap endonuclease 1, putative K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E PVVCY_1400430 DNA ligase I, putative K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
E PVVCY_1104030 bifunctional polynucleotide phosphatase/kinase, putative K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F PVVCY_1201090 DNA repair protein RAD23, putative K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F PVVCY_1000790 E3 ubiquitin-protein ligase RBX1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E NER4 complex
F PVVCY_1406580 DNA repair protein rhp16, putative K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F PVVCY_1000870 DNA-directed RNA polymerase II subunit RPB1, putative K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F PVVCY_0301330 DNA-directed RNA polymerase II subunit RPB2, putative K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F PVVCY_0802140 DNA-directed RNA polymerase II subunit RPB3, putative K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F PVVCY_0300410 DNA-directed RNA polymerase II 16 kDa subunit, putative K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F PVVCY_1104170 DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F PVVCY_0400250 DNA-directed RNA polymerases I, II, and III subunit RPABC2, putative K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F PVVCY_0501200 DNA-directed RNA polymerase II subunit RPB7, putative K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F PVVCY_1403150 DNA-directed RNA polymerases I, II, and III subunit RPABC3, putative K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F PVVCY_0200310 DNA-directed RNA polymerase II subunit RPB9, putative K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F PVVCY_1000710 DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F PVVCY_1400510 DNA-directed RNA polymerase II subunit RPB11, putative K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F PVVCY_1305890 DNA-directed RNA polymerases I, II, and III subunit RPABC4, putative K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F PVVCY_1000790 E3 ubiquitin-protein ligase RBX1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E Other TCR factor
F PVVCY_0801300 transcription elongation factor 1, putative K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E PVVCY_0502090 DNA repair helicase RAD25, putative K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E PVVCY_0803250 TFIIH basal transcription factor complex helicase XPD subunit, putative K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E PVVCY_1401500 general transcription factor IIH subunit 2, putative K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E PVVCY_1103120 RNA polymerase II transcription factor B subunit 4, putative K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E PVVCY_1405960 RNA polymerase II transcription factor B subunit 2, putative K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E PVVCY_1300750 RNA polymerase II transcription factor B subunit 5, putative K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E PVVCY_1201360 MO15-related protein kinase, putative K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E PVVCY_1302910 cyclin, putative K06634 CCNH; cyclin H
E PVVCY_1101270 CDK-activating kinase assembly factor, putative K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E PVVCY_0800750 replication protein A1, large subunit, putative K07466 RFA1; replication factor A1
E PVVCY_1300770 replication factor A protein 3, putative K10740 RPA3; replication factor A3
D Other NER factors
E PVVCY_0300200 ERCC1 nucleotide excision repair protein, putative K10849 ERCC1; DNA excision repair protein ERCC-1
E PVVCY_1104570 DNA repair endonuclease, putative K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E PVVCY_0300460 DNA repair protein RAD2, putative K10846 ERCC5; DNA excision repair protein ERCC-5
E PVVCY_1400430 DNA ligase I, putative K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E PVVCY_1000560 DNA mismatch repair protein MSH2, putative K08735 MSH2; DNA mismatch repair protein MSH2
E PVVCY_1002200 DNA mismatch repair protein MSH2, putative K08735 MSH2; DNA mismatch repair protein MSH2
E PVVCY_1100600 DNA mismatch repair protein MSH6, putative K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E PVVCY_0901610 DNA mismatch repair protein MLH, putative K08734 MLH1; DNA mismatch repair protein MLH1
E PVVCY_0201020 DNA mismatch repair protein PMS1, putative K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E PVVCY_0500170 DNA polymerase delta catalytic subunit, putative K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E PVVCY_0400700 DNA polymerase delta small subunit, putative K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E PVVCY_0800750 replication protein A1, large subunit, putative K07466 RFA1; replication factor A1
E PVVCY_1300770 replication factor A protein 3, putative K10740 RPA3; replication factor A3
D RFC (replication factor C)
E PVVCY_0301690 replication factor C subunit 1, putative K10754 RFC1; replication factor C subunit 1
E PVVCY_1405730 replication factor C subunit 4, putative K10755 RFC2_4; replication factor C subunit 2/4
E PVVCY_0301560 replication factor C subunit 2, putative K10755 RFC2_4; replication factor C subunit 2/4
E PVVCY_1302830 replication factor C subunit 3, putative K10756 RFC3_5; replication factor C subunit 3/5
E PVVCY_0900980 replication factor C subunit 5, putative K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E PVVCY_1103900 proliferating cell nuclear antigen 1, putative K04802 PCNA; proliferating cell nuclear antigen
E PVVCY_1404350 proliferating cell nuclear antigen 2, putative K04802 PCNA; proliferating cell nuclear antigen
E PVVCY_0602290 exonuclease I, putative K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E PVVCY_1400430 DNA ligase I, putative K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E PVVCY_0200540 double-strand break repair protein MRE11, putative K10865 MRE11; double-strand break repair protein MRE11
E PVVCY_0100590 DNA repair protein RAD50, putative K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
E PVVCY_0200540 double-strand break repair protein MRE11, putative K10865 MRE11; double-strand break repair protein MRE11
E PVVCY_0100590 DNA repair protein RAD50, putative K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E PVVCY_0900680 DNA repair protein RAD51, putative K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E PVVCY_0900680 DNA repair protein RAD51, putative K04482 RAD51; DNA repair protein RAD51
D Rad52 family proteins
D Rad54 family proteins
E PVVCY_1202780 DNA repair and recombination protein RAD54, putative K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
D RecQ family DNA helicases
E PVVCY_0801690 ATP-dependent DNA helicase Q1, putative K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E PVVCY_0801690 ATP-dependent DNA helicase Q1, putative K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E PVVCY_1306310 DNA topoisomerase 3, putative K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E PVVCY_0800750 replication protein A1, large subunit, putative K07466 RFA1; replication factor A1
E PVVCY_1300770 replication factor A protein 3, putative K10740 RPA3; replication factor A3
D Protein phosphatase 4
E PVVCY_0802610 serine/threonine protein phosphatase 4, putative K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
D AP-5 complex
E PVVCY_1200730 AP-5 complex subunit sigma-1, putative K19024 AP5S1; AP-5 complex subunit sigma-1
D SMC5-SMC6 complex
E PVVCY_0902180 structural maintenance of chromosomes protein 5, putative K22803 SMC5; structural maintenance of chromosomes protein 5
D Other HR factors
E PVVCY_0601960 conserved Plasmodium protein, unknown function K10881 SHFM1; 26 proteasome complex subunit DSS1
E PVVCY_1405570 phosphohydrolase, putative K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E PVVCY_1200860 metallopeptidase, putative K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
E PVVCY_0200540 double-strand break repair protein MRE11, putative K10865 MRE11; double-strand break repair protein MRE11
E PVVCY_0100590 DNA repair protein RAD50, putative K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
E PVVCY_0801690 ATP-dependent DNA helicase Q1, putative K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E PVVCY_1306310 DNA topoisomerase 3, putative K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E PVVCY_0900680 DNA repair protein RAD51, putative K04482 RAD51; DNA repair protein RAD51
C Other DSBR factors
D Protein phosphatase 6
E PVVCY_0401330 serine/threonine protein phosphatase 6, putative K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
D Ubiquitin ligases
D Others
E PVVCY_1303300 WD repeat-containing protein 79, putative K23314 WRAP53; telomerase Cajal body protein 1
E PVVCY_0501780 WD repeat-containing protein 70, putative K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D PVVCY_1402670 ubiquitin-conjugating enzyme, putative K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D PVVCY_1000770 ubiquitin-conjugating enzyme, putative K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D PVVCY_1305950 DNA repair protein RAD5, putative K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D PVVCY_0400480 ubiquitin-conjugating enzyme E2, putative K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D PVVCY_1204260 ubiquitin-conjugating enzyme E2 N, putative K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D PVVCY_1103900 proliferating cell nuclear antigen 1, putative K04802 PCNA; proliferating cell nuclear antigen
D PVVCY_1404350 proliferating cell nuclear antigen 2, putative K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
D PVVCY_1405730 replication factor C subunit 4, putative K10755 RFC2_4; replication factor C subunit 2/4
D PVVCY_0301560 replication factor C subunit 2, putative K10755 RFC2_4; replication factor C subunit 2/4
D PVVCY_1302830 replication factor C subunit 3, putative K10756 RFC3_5; replication factor C subunit 3/5
D PVVCY_0900980 replication factor C subunit 5, putative K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
D PVVCY_1300430 conserved protein, unknown function K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D PVVCY_1103920 14-3-3 protein, putative K06630 YWHAE; 14-3-3 protein epsilon
D PVVCY_0701240 14-3-3 protein, putative K06630 YWHAE; 14-3-3 protein epsilon
D PVVCY_1302270 vacuolar protein sorting-associated protein 4, putative K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
D PVVCY_1302390 exonuclease V, mitochondrial, putative K17815 EXO5; exonuclease V [EC:3.1.-.-]
C Helicases
C PSO4 complex
D PVVCY_0400750 pre-mRNA-processing factor 19, putative K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D PVVCY_0501790 myb2 transcription factor, putative K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D PVVCY_1203010 pre-mRNA-splicing factor CWF7, putative K12861 BCAS2; pre-mRNA-splicing factor SPF27
D PVVCY_0400160 pre-mRNA-splicing factor PRP46, putative K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D PVVCY_0902510 deoxyuridine 5'-triphosphate nucleotidohydrolase, putative K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D PVVCY_0601170 ribonucleoside-diphosphate reductase large subunit, putative K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D PVVCY_1201500 ribonucleotide reductase small subunit, putative K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D PVVCY_1004200 ribonucleotide reductase small subunit, putative K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D PVVCY_1101410 deoxyribodipyrimidine photo-lyase, putative K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E PVVCY_1003300 uracil-DNA glycosylase, putative K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E PVVCY_1303290 DNA-3-methyladenine glycosylase, putative K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E PVVCY_0902820 A/G-specific adenine glycosylase, putative K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E PVVCY_1203050 endonuclease III homologue, putative K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E PVVCY_1101460 ATP-dependent DNA helicase UvrD, putative K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F PVVCY_1303840 DNA-directed RNA polymerase, alpha subunit, putative K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F PVVCY_1400780 DNA-directed RNA polymerase alpha chain, putative K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E PVVCY_1101460 ATP-dependent DNA helicase UvrD, putative K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E PVVCY_1100930 single-stranded DNA-binding protein, putative K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F PVVCY_1404030 DNA gyrase subunit A, putative K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F PVVCY_1405620 DNA gyrase subunit B, putative K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D PVVCY_1100930 single-stranded DNA-binding protein, putative K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D PVVCY_0902510 deoxyuridine 5'-triphosphate nucleotidohydrolase, putative K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024