+F Repair protein KO
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DNA Repair and Recombination Proteins - Plutella xylostella (diamondback moth)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 105382955 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 105390588 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 105391466 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 105398448 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 105381116 methyl-CpG-binding domain protein 4-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 105384249 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 105387586 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 105385388 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 105395912 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 105389275 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 105393752 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 105382062 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 105390773 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 105382516 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 105382745 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 105380709 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 105382396 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 105396035 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 105386329 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 105389980 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 105392618 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 105386421 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 105381652 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 105390684 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 105391346 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 125488489 poly [ADP-ribose] polymerase-like isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 105385243 DNA repair protein complementing XP-C cells homolog isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 119693655 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
F 105386267 caltractin isoform X1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 105397966 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 105390222 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 105392169 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 105389151 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 105387798 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 119691020 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 105393013 DNA-directed RNA polymerase II subunit Rpb4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 105392149 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 105393148 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 105391630 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 105391936 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 105398642 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 105393696 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 105380425 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 105389295 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 105397966 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 105390222 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 105392169 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 105394855 DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 105391200 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 105381685 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 105381029 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 119690346 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 105388296 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 105389558 general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 105384029 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 119693535 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 105382385 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 105386385 cyclin-H K06634 CCNH; cyclin H
E 119692078 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 105386699 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 105381648 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D Other NER factors
E 105384454 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 105386921 DNA excision repair protein ERCC-5 homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 105382396 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 105386146 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 105381980 cullin-5 K10612 CUL5; cullin 5
E 105388639 elongin-C K03872 ELOC; elongin-C
E 105383959 elongin-B K03873 ELOB; elongin-B
E 105383863 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 105390604 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 105383955 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 105392667 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 105392077 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 105381942 uncharacterized protein LOC105381942 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 105385388 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 105395912 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 105389275 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 105386699 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 105381648 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D RFC (replication factor C)
E 105385143 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 105392702 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 105395505 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 105392896 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 105387488 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 105382745 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 105382163 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 105390684 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 105382396 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 105392955 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 105394335 nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 105385130 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105397228 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 105385130 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105387833 BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 105397302 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 105397206 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 105395681 lys-63-specific deubiquitinase BRCC36 isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 105385130 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
D BRCA1-C complex
E 105385130 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105392955 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 105394335 nibrin K10867 NBN; nibrin
D BRCA complex
E 105385130 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105392937 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 105392937 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 105380368 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 105382230 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 105396504 uncharacterized protein LOC105396504 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 105381323 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 105385631 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105394593 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 105386698 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 105385631 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105386671 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 105381080 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 105386699 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 105381648 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D Protein phosphatase 4
E 119693819 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 105397192 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 105393631 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E 105382582 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 105390662 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 105382099 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
D Other HR factors
E 105392228 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 105380473 structure-specific endonuclease subunit SLX1 homolog K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 105396561 spatacsin K19026 SPG11; spatacsin
E 105398526 zinc finger FYVE domain-containing protein 26 homolog K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 105382793 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 105392162 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 105389777 uncharacterized protein LOC105389777 K23112 BRAT1; BRCA1-associated ATM activator 1
E 105384290 zinc finger CCCH domain-containing protein 13 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 105386883 zinc finger SWIM domain-containing protein 7-like K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 105388400 tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 105392343 DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 105395371 DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 105383312 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 105394451 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 105392955 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 105392096 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 119690362 general transcription factor 3C polypeptide 3 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
E 105396035 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 105386421 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 105381192 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 105381488 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 105390365 centromere protein S K11511 APITD1; centromere protein S
E 105390702 centromere protein X K15360 STRA13; centromere protein X
E 105381511 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 105385631 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105386671 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 105381080 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 105390434 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 105380176 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 105385130 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
D Other FA pathway factors
E 105392937 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 105396357 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 105391036 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 105398558 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
D Ubiquitin ligases
E 105395626 probable E3 ubiquitin-protein ligase bre1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
D Others
E 105392947 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
E 105386684 zinc finger CW-type PWWP domain protein 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 105389796 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 105392161 DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 105386981 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 105388835 DNA repair protein Rev1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 105384483 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 105383376 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 105385066 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 105382572 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 105382745 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 105388917 DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 105382893 uncharacterized protein LOC105382893 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 105382871 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 105394368 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 105386884 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 105381694 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 105392702 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 105395505 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 105392896 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 105387488 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 105386884 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 105387918 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 105393219 chromosome segregation in meiosis protein 3 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
C Triple T complex
D 105383168 uncharacterized protein LOC105383168 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 105380236 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 105390268 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 105391707 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 105395200 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 105385913 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 105388996 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 105381643 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 105389875 M-phase inducer phosphatase isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 105387118 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 105388367 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 105398384 protein sickie K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 105383174 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 105396316 myosin-11 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 105383517 plastin-3 isoform X1 K17336 PLS3; plastin-3
D 119694148 vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 105382452 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 105387057 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
C Nucleases
D 105384302 DNA cross-link repair 1A protein isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 105390699 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 105390448 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 105387829 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 105384456 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 105393496 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 105380293 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 105383187 oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 105381986 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 105383380 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 105393854 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 105380993 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 105382587 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491373 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491374 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491375 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491376 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491377 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491378 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491379 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491380 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491381 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491382 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125491383 ribonucleoside-diphosphate reductase small chain-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 105391466 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 105398448 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 105391066 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 105391066 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 105383380 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024