+E Replication protein KO
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DNA Replication Proteins - Rosa chinensis (China rose)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 112193206 origin of replication complex subunit 1A K02603 ORC1; origin recognition complex subunit 1
D 112172707 origin of replication complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 112176760 origin of replication complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 112199871 LOW QUALITY PROTEIN: origin of replication complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 112187552 origin of replication complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 112188498 origin of replication complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 112197408 origin of replication complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 112179973 CDT1-like protein a, chloroplastic isoform X1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 112169317 CDT1-like protein a, chloroplastic K10727 CDT1; chromatin licensing and DNA replication factor 1
D 112184970 cell division control protein 6 homolog B K02213 CDC6; cell division control protein 6
D 112165584 cell division control protein 6 homolog B isoform X1 K02213 CDC6; cell division control protein 6
D 112198892 cell division control protein 6 homolog B K02213 CDC6; cell division control protein 6
D 112198333 DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 112166531 DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 112173086 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 112186878 DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 112201691 DNA replication licensing factor MCM6 isoform X1 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 112176932 DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 112174133 G2/mitotic-specific cyclin C13-1 isoform X1 K06627 CCNA; cyclin-A
D 112172928 cyclin-A3-2 K06627 CCNA; cyclin-A
D 112174192 cyclin-A3-1 K06627 CCNA; cyclin-A
D 112173162 cyclin-A1-1 K06627 CCNA; cyclin-A
D 112173352 cyclin-A2-2 isoform X1 K06627 CCNA; cyclin-A
D 112173485 putative cyclin-A3-1 K06627 CCNA; cyclin-A
D 112173557 putative cyclin-A3-1 K06627 CCNA; cyclin-A
D 112172480 cyclin-A1-4 isoform X2 K06627 CCNA; cyclin-A
D 112183629 cyclin-A1-1 K06627 CCNA; cyclin-A
D 112188745 cyclin-A2-4 isoform X1 K06627 CCNA; cyclin-A
D 112190816 cell division control protein 2 homolog K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 112190827 cell division control protein 2 homolog K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 112192645 cell division control protein 2 homolog K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 112174818 uncharacterized protein LOC112174818 isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 112176094 uncharacterized protein LOC112176094 isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 112189208 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 112189702 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 112181610 DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 112181664 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 112198528 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 112180779 BRCT domain-containing protein At4g02110 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 112169946 DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 112199902 ATP-dependent DNA helicase Q-like 5 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 112173365 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 112192685 probable DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 112169553 probable DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 112174006 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 112186501 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 112197554 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 112180880 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 112198392 probable DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 112168225 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 112175095 DNA polymerase epsilon subunit B isoform X4 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 112168159 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D 112187222 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 112192174 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
D 112168381 uncharacterized protein LOC112168381 K03504 POLD3; DNA polymerase delta subunit 3
D 112168379 nucleolar protein dao-5 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 112203493 nucleolar protein dao-5 K03504 POLD3; DNA polymerase delta subunit 3
D 112188178 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
C RPA (replication protein A)
D 112176557 replication protein A 70 kDa DNA-binding subunit E K07466 RFA1; replication factor A1
D 112184823 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
D 112179066 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
D 112172835 replication protein A 32 kDa subunit A isoform X1 K10739 RFA2; replication factor A2
D 112196412 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
D 112193589 replication protein A 14 kDa subunit B K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 112164646 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 112173232 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 112176132 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 112187419 uncharacterized protein LOC112187419 K10756 RFC3_5; replication factor C subunit 3/5
D 112168874 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 112195302 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 112194216 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 112167878 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 112172945 ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 112166514 uncharacterized protein C12B10.15c K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 112168051 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 112170247 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 112165739 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 112197634 DNA replication ATP-dependent helicase/nuclease JHS1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 112195432 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 112166827 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 112180415 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 112176622 DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 112168234 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 112172591 uncharacterized protein LOC112172591 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 112179548 DNA (cytosine-5)-methyltransferase CMT2 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 112185654 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 112165730 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 112199415 DNA (cytosine-5)-methyltransferase CMT3 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 112197185 DNA (cytosine-5)-methyltransferase CMT3 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 112187809 DNA (cytosine-5)-methyltransferase CMT3 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 112191724 uncharacterized protein LOC112191724 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 112169404 G2/mitotic-specific cyclin-2 isoform X1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 112166816 G2/mitotic-specific cyclin S13-7 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 112180030 G2/mitotic-specific cyclin S13-7 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 112173237 G2/mitotic-specific cyclin S13-7 isoform X1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 112164783 G2/mitotic-specific cyclin S13-7 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 112166598 putative cyclin-B3-1 isoform X1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 112199986 cyclin-SDS K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 112189476 G2/mitotic-specific cyclin-2 K21777 CCNB; G2/mitotic-specific cyclin-B, other
C Telomere proteins
D Shelterin complex
E 112164600 uncharacterized protein LOC112164600 K11111 TERF2; telomeric repeat-binding factor 2
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
E 112169973 CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 112193410 CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 112181460 telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 112193188 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 112176155 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 112174321 H/ACA ribonucleoprotein complex subunit 3-like protein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 112179117 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 112181460 telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 112177121 small nuclear ribonucleoprotein-associated protein B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 112173170 small nuclear ribonucleoprotein SmD1b K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 112177145 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 112187432 probable small nuclear ribonucleoprotein Sm D2 isoform X1 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 112170381 small nuclear ribonucleoprotein SmD3b K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 112187655 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 112198235 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 112175616 probable small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 112194115 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 112191604 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 112194546 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 112173232 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 112176132 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 112187419 uncharacterized protein LOC112187419 K10756 RFC3_5; replication factor C subunit 3/5
D 112168874 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 112195302 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 112194216 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 112167817 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 112176015 nijmegen breakage syndrome 1 protein isoform X1 K10867 NBN; nibrin
C Other termination factors
D 112169915 serine/threonine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 112193113 ATP-dependent DNA helicase Q-like SIM K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 112180399 ATP-dependent DNA helicase Q-like 4A isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 112187369 ATP-dependent DNA helicase Q-like 3 isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 112178839 DNA repair endonuclease UVH1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 112174599 poly [ADP-ribose] polymerase 1 isoform X2 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 112203797 protein ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 112173558 poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 112176505 G-patch domain-containing protein 1 K11135 PINX1; Pin2-interacting protein X1
D 112185453 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 112178588 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 112188715 telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 112174462 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 112182225 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 112164916 transcription factor Pur-alpha 1 isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 112165853 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 112181973 replication stress response regulator SDE2 isoform X1 K25059 SDE2; replication stress response regulator SDE2
D 112189214 replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 112174641 DNA topoisomerase 1 alpha K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 112196532 DNA topoisomerase 1 alpha isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 112171627 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 112179575 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 112189487 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 112198005 DNA topoisomerase 3-beta isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 112176618 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
D Other elongation factors
E 112165370 DNA polymerase I B, chloroplastic/mitochondrial K02335 polA; DNA polymerase I [EC:2.7.7.7]
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
D RFC (replication factor C)
D Other elongation factors
E 112197634 DNA replication ATP-dependent helicase/nuclease JHS1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 112195432 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 112168234 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
C 112188815 DNA gyrase subunit A, chloroplastic/mitochondrial K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
C 112186591 DNA gyrase subunit B, chloroplastic/mitochondrial K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C 112168312 DNA topoisomerase 6 subunit B isoform X1 K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022