+C Two-component system KO #

  Two-Component System - Cupriavidus pinatubonensis JMP134

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AOmpR family B PhoR-PhoB (phosphate starvation response) C Reut_A2161 PAS/PAC sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] C Reut_A2162 Phosphate regulon transcriptional regulatory protein phoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB B SenX3-RegX3 (phosphate starvation response) B PhoQ-PhoP (magnesium transport) B EnvZ-OmpR (osmotic stress response) C Reut_A0391 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] C Reut_A0574 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] C Reut_A1367 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] C Reut_A0390 Response regulator receiver:Transcriptional regulatory protein, C-terminal K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR C Reut_A0573 two component transcriptional regulator, winged helix family K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR C Reut_A1368 two component transcriptional regulator, winged helix family K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR B RstB-RstA B CpxA-CpxR (envelope stress response) B CssS-CssR (secretion stress response) B CreC-CreB (phosphate regulation) C Reut_A0184 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3] C Reut_A0185 two component transcriptional regulator, winged helix family K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB B BaeS-BaeR (envelope stress response) B BasS-BasR (antimicrobial peptide resistance) B CusS-CusR (copper tolerance) C Reut_A1814 Heavy metal sensor kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C Reut_A2491 heavy metal sensor signal transduction histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C Reut_B3962 heavy metal sensor signal transduction histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C Reut_A1815 two component heavy metal response transcriptional regulator, winged helix family K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR C Reut_A2490 Heavy metal response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR C Reut_B3961 Heavy metal response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR B QseC-QseB (quorum sensing) C Reut_A1338 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] C Reut_A1337 two component transcriptional regulator, winged helix family K07666 qseB; two-component system, OmpR family, response regulator QseB B KdpD-KdpE (potassium transport) C Reut_A2290 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal:Osmosensitive K+ channel His kinase sensor:UspA K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] C Reut_A2289 Response regulator receiver:Transcriptional regulatory protein, C-terminal K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE B TorS-TorR (TMAO respiration) B ArcB-ArcA (anoxic redox control) B TctE-TctD (tricarboxylic acid transport) C Reut_A2102 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] C Reut_A3436 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] C Reut_A2101 two component transcriptional regulator, winged helix family K07774 tctD; two-component system, OmpR family, response regulator TctD C Reut_A3437 two component transcriptional regulator, winged helix family K07774 tctD; two-component system, OmpR family, response regulator TctD B ResE-ResD (aerobic and anaerobic respiration) B VicK-VicR (cell wall metabolism) B MprB-MprA (maintenance of persistent infection) B MtrB-MtrA (osmotic stress response) B PrrB-PrrA (intracellular multiplication) B TrcS-TrcR B NrsS-NrsR (nickel tolerance) B ManS-ManR (manganese homeostasis) B NblS-NblR (photosynthesis) B SasA-RpaAB (circadian timing mediating) B SaeS-SaeR (staphylococcal virulence regulation) B BceS-BceR (bacitracin transport) B BraS-BraR (bacitracin transport) B GraS-GraR (cationic antimicrobial peptide transport) B YxdK-YxdJ (antimicrobial peptide response) B ChvG-ChvI (acidity sensing) B CiaH-CiaR B ParS-ParR (polymyxin-adaptive resistance) B AdeS-AdeR B VanS-VanR (VanB type vancomycin resistance) B VanS-VanR (VanE type vancomycin resistance) B VanS-VanR (actinomycete type vancomycin resistance) B ArlS-ArlR (virulence regulation) B Ihk-Irr (virulence regulation) B PfeS-PfeR (enterobactin-dependent iron acquisition) B NisK-NisR (lantibiotic biosynthesis) B Unclassified C Reut_B5169 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C Reut_B5325 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C Reut_A0526 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator C Reut_A3326 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator C Reut_A3389 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator C Reut_B3909 Response regulator receiver:Transcriptional regulatory protein, C-terminal K02483 K02483; two-component system, OmpR family, response regulator C Reut_B4049 Response regulator receiver:Transcriptional regulatory protein, C-terminal K02483 K02483; two-component system, OmpR family, response regulator C Reut_B5168 Response regulator receiver:Transcriptional regulatory protein, C-terminal K02483 K02483; two-component system, OmpR family, response regulator C Reut_B5326 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator # ANarL family B NarX-NarL (nitrate respiration) C Reut_B5065 GAF:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase, dimerization and phosphoacceptor region K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3] C Reut_B5066 regulatory protein, LuxR:Response regulator receiver K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL B NarQ-NarP (nitrate respiration) B UhpB-UhpA (hexose phosphates uptake) C Reut_A1786 signal transduction histidine kinase, glucose-6-phosphate specific K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] B FusK-FusR (virulence regulation) C Reut_A1785 two component transcriptional regulator, LuxR family K20264 fusR; two-component system, NarL family, response regulator FusR B RcsC-RcsD-RcsB (capsule synthesis) C Reut_B3666 Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A, N-terminal K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] C Reut_A1693 regulatory protein, LuxR:Response regulator receiver K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB C Reut_B3619 regulatory protein, LuxR:Response regulator receiver K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB C Reut_B3667 two component transcriptional regulator, LuxR family K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB C Reut_B5845 regulatory protein, LuxR:Response regulator receiver K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB B BarA-UvrY (central carbon metabolism) B ComP-ComA (competence) B EvgS-EvgA (acid and drug tolerance) C Reut_B4472 PAS K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] C Reut_B4470 two component transcriptional regulator, LuxR family K07690 evgA; two-component system, NarL family, response regulator EvgA C Reut_B5536 regulatory protein, LuxR:Response regulator receiver K07690 evgA; two-component system, NarL family, response regulator EvgA C Reut_A0522 regulatory protein, LuxR:Response regulator receiver K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ B DegS-DegU (multicellular behavior control) B DesK-DesR (membrane lipid fluidity regulation) B VraS-VraR (cell-wall peptidoglycan synthesis) B LiaS-LiaR (cell wall stress response) B DevS-DevR (redox response) B NreB-NreC (dissimilatory nitrate/nitrite reduction) B YdfH-YdfI B SalK-SalR B PprA–PprB (biofilm formation) B Unclassified C Reut_A3418 ATP-binding region, ATPase-like:Histidine kinase, dimerization and phosphoacceptor region K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] # ASpo family B KinABCDE-Spo0FA (sporulation control) # ACitB family B CitA-CitB (citrate fermentation) B CitS-CitT (magnesium-citrate transport) B DcuS-DcuR (C4-dicarboxylate metabolism) B DctS-DctR (C4-dicarboxylate transport) B MalK-MalR (malate transport) B Unclassified # ALytTR family B LysS-LysR B AlgZ-AlgR (alginate production) B NatK-NatR (sodium extrusion) B AgrC-AgrA (exoprotein synthesis) B AgrC2-AgrA2 (virulence regulation) B ComD-ComE (competence) B BtsS-BtsR (pyruvate reutilization) B PyrS-PyrR (pyruvate reutilization) B Unclassified # ANtrC family B GlnL-GlnG (nitrogen regulation) C Reut_A2055 signal transduction histidine kinase, nitrogen specific, NtrB K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] C Reut_A2054 Helix-turn-helix, Fis-type:Nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG B NtrY-NtrX (nitrogen regulation) C Reut_A3403 multi-sensor signal transduction histidine kinase K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3] C Reut_A3402 Helix-turn-helix, Fis-type K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX B HydH-HydG (metal tolerance) C Reut_A1698 Helix-turn-helix, Fis-type K07713 zraR; two-component system, NtrC family, response regulator HydG C Reut_B5076 Helix-turn-helix, Fis-type K07713 zraR; two-component system, NtrC family, response regulator HydG B AtoS-AtoC (cPHB biosynthesis) B PilS-PilR (type 4 fimbriae synthesis) C Reut_A2944 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3] C Reut_A2943 Helix-turn-helix, Fis-type K02667 pilR; two-component system, NtrC family, response regulator PilR B GlrK-GlrR (amino sugar metabolism) B PgtB-PgtA (phosphoglycerate transport) B DctB-DctD (C4-dicarboxylate transport) C Reut_A0276 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] C Reut_A0275 Helix-turn-helix, Fis-type K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD B KinB-AlgB (alginate production) B HupT-HupR (hydrogenase synthesis regulation) B Unclassified # ACheA family B CheA-CheYBV (chemotaxis) C Reut_A1958 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Hpt K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] C Reut_B5608 CheW-like protein:ATP-binding region, ATPase-like:Signal transducing histidine kinase, homodimeric:Hpt K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] C Reut_A1955 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY C Reut_B5599 Response regulator receiver K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY C Reut_B5613 Response regulator receiver K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY C Reut_A0607 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] C Reut_B5612 Protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] C Reut_B4915 PAS K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] C Reut_B5191 CheB methylesterase:MCP methyltransferase, CheR-type K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] C Reut_B4985 Response regulator receiver:CheW-like protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV B ChpA-ChpB/PilGH (chemosensory) C Reut_A2619 Response regulator receiver:CheW-like protein:ATP-binding region, ATPase-like:Hpt K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator) C Reut_A2623 Response regulator receiver K02657 pilG; twitching motility two-component system response regulator PilG C Reut_A2622 Response regulator receiver K02658 pilH; twitching motility two-component system response regulator PilH B PixL-PixGH (positive phototaxis) B WspE-WspRF (chemosensory) C Reut_B3649 Response regulator receiver:CheW-like protein:ATP-binding region, ATPase-like:Hpt K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE C Reut_B3647 response regulator receiver modulated diguanylate cyclase K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65] C Reut_B3648 Protein-glutamate methylesterase K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61] B Cph1-Rcp1 (light response) # ACell cycle family B PleC-PleD (cell fate control) B CckA-CtrA/CpdR (cell cycle control) B Hk1-Rrp1 (glycerol uptake and utilization) # ALux family B LuxQN/CqsS-LuxU-LuxO (quorum sensing) # ALuxR family B DctS-DctR (C4-dicarboxylate transport) B TtrS-TtrR (tetrathionate respiration) B FixL-FixJ (nitrogen fixation) B SsrA-SsrB # AOther families B FlrB-FlrC (polar flagellar synthesis) B AauS-AauR (acidic amino acids utilization) C Reut_A2668 histidine kinase K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3] C Reut_A2669 two component, sigma54 specific, transcriptional regulator, Fis family K17061 aauR; two-component system, response regulator AauR B SLN1-YPD1-SSK1/SKN7 (osmosensing) B RpfC-RpfG (cell-to-cell signaling) B GlnK-GlnL (glutamine utilization) B HspS-HspR (hexose phosphates uptake) B YesM-YesN B CikA B RegB-RegA (redox response) C Reut_A0173 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3] C Reut_A0172 Helix-turn-helix, Fis-type K15012 regA; two-component system, response regulator RegA B FitF-FitH (insecticidal toxin regulation) B PhcS-PhcRQ C Reut_A2814 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal K19621 phcS; two-component system, sensor histidine kinase PhcS [EC:2.7.13.3] C Reut_A2813 response regulator receiver sensor signal transduction histidine kinase K19622 phcR; two-component system, response regulator PhcR C Reut_A2812 Response regulator receiver K19623 phcQ; two-component system, probable response regulator PhcQ B SagS-HptB-HsbR (swarming activity and biofilm formation) B PdtaS-PdtaR B NasS-NasT C Reut_A0331 Response regulator receiver:ANTAR K07183 nasT; two-component system, response regulator / RNA-binding antiterminator B Unclassified C Reut_B5346 PAS K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] ! #
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#Last updated: October 8, 2024