+C Two-component system KO
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Two-Component System - Rubrivivax gelatinosus
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C RGE_33130 phoR; phosphate regulon sensor protein PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C RGE_33140 phoB; phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
C RGE_45010 response regulator receiver protein CheY-like K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
C RGE_18310 sensor protein K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C RGE_26890 ompB; osmolarity sensor protein OmpB K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C RGE_18300 two component transcriptional regulator, winged helix family K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
C RGE_26880 ompR; DNA-binding response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C RGE_05420 creC; sensory histidine kinase CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C RGE_05430 creB; DNA-binding response regulator CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C RGE_09040 baeS; putative signal transduction histidine-protein kinase BaeS K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C RGE_09050 baeR; DNA-binding transcriptional regulator BaeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
C RGE_30140 qseC; sensor protein QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C RGE_09270 qseC; sensor protein QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C RGE_09260 qseB; transcriptional regulatory protein QseB K07666 qseB; two-component system, OmpR family, response regulator QseB
C RGE_30130 qseB; two-component system response regulator QseB K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C RGE_20680 kdpD; two-component system, sensor kinase protein KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C RGE_20670 kdpE; two-component system response regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
C RGE_29550 sensor protein K18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]
C RGE_29540 two component transcriptional regulator, winged helix family K18144 adeR; two-component system, OmpR family, response regulator AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C RGE_07370 sensor protein K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C RGE_18450 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator
C RGE_27080 response regulator receiver protein CheY-like K02483 K02483; two-component system, OmpR family, response regulator
C RGE_16520 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator
C RGE_31800 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator
C RGE_46610 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator
C RGE_07380 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator
C RGE_17290 two-component response regulatory protein K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C RGE_40500 integral membrane sensor signal transduction histidine kinase K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C RGE_40700 sensor protein K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C RGE_23360 integral membrane sensor signal transduction histidine kinase K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
C RGE_40490 gacA; two component transcriptional regulator, LuxR family K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
C RGE_23350 two component transcriptional regulator, LuxR family K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
C RGE_10170 two component transcriptional regulator, LuxR family K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
C RGE_39320 two component transcriptional regulator, LuxR family K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C RGE_20130 putative periplasmic sensor hybrid histidine kinase K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
C RGE_19330 integral membrane sensor signal transduction histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
C RGE_19340 two component transcriptional regulator, LuxR family K07693 desR; two-component system, NarL family, response regulator DesR
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
C RGE_23190 citA; sensor kinase CitA K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C RGE_23200 citB; transcriptional regulator CitB K07702 dpiA; two-component system, CitB family, response regulator CitB
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C RGE_36500 algZ; two-component system sensor protein, alginate biosynthesis K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C RGE_36490 algR; two component transcriptional regulator, LytTR family K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C RGE_17570 lytS; two-component system, LytT family, sensor histidine kinase LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C RGE_07120 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator
C RGE_17560 lytT; two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C RGE_14390 ntrB; signal transduction histidine kinase, nitrogen specific, NtrB K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C RGE_14400 ntrC; nitrogen metabolism transcriptional regulator NtrC K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
C RGE_44620 ntrY; nitrogen regulation protein NtrY K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
C RGE_44610 two component transcriptional regulator, Fis family K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
C RGE_09900 atoS; signal transduction histidine-protein kinase AtoS K07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3]
C RGE_09890 atoC; acetoacetate metabolism regulatory protein AtoC K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
C RGE_42350 pilS; two-component system sensor kinase PilS K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C RGE_42340 pilR; two-component system response regulator PilR K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
C RGE_36080 PAS/PAC sensor hybrid histidine kinase K19661 hupT; two-component system, NtrC family, sensor histidine kinase HupT/HoxJ [EC:2.7.13.3]
C RGE_35940 hupR; hydrogenase transcriptional regulator HupR K19641 hupR; two-component system, NtrC family, response regulator HupR/HoxA
B Unclassified
C RGE_04050 two component, sigma54 specific, transcriptional regulator, Fis family K02481 flgR; two-component system, NtrC family, response regulator
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ACheA family
B CheA-CheYBV (chemotaxis)
C RGE_39360 cheA; chemotaxis sensor histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C RGE_37450 cheA; chemotaxis sensor histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C RGE_07060 response regulator receiver protein CheY-like K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C RGE_17080 cheY; chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C RGE_05050 response regulator receiver protein CheY-like K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C RGE_39350 cheY; chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C RGE_37470 response regulator receiver protein CheY-like K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C RGE_35440 cheB; protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C RGE_37400 cheB; protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C RGE_36420 methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61]
C RGE_46370 methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61]
B ChpA-ChpB/PilGH (chemosensory)
C RGE_42070 pilL; PilL protein K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C RGE_42110 pilG; twitching motility, CheY-like protein PilG K02657 pilG; twitching motility two-component system response regulator PilG
C RGE_42100 pilH; twitching motility protein PilH K02658 pilH; twitching motility two-component system response regulator PilH
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
C RGE_45240 PAS/PAC sensor hybrid histidine kinase K11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3]
C RGE_45230 two component transcriptional regulator, LuxR family K11712 dctR; two-component system, LuxR family, response regulator DctR
B TtrS-TtrR (tetrathionate respiration)
C RGE_28830 histidine kinase K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]
B FixL-FixJ (nitrogen fixation)
C RGE_28820 two component transcriptional regulator, LuxR family K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C RGE_07350 sensor protein K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C RGE_22740 PAS/PAC sensor hybrid histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C RGE_14770 sensor protein K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C RGE_36800 integral membrane sensor signal transduction histidine kinase K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
C RGE_17410 Hpt domain protein K20976 hptB; histidine phosphotransfer protein HptB
B PdtaS-PdtaR
C RGE_17390 response regulator receiver protein CheY-like K22010 pdtaR; two-component system, response regulator PdtaR
B NasS-NasT
B Unclassified
C RGE_14010 PAS/PAC sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C RGE_23260 PAS/PAC sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C RGE_24820 PAS/PAC sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C RGE_05780 PAS/PAC sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C RGE_08830 PAS/PAC sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C RGE_22590 PAS/PAC sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C RGE_22850 PAS/PAC sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C RGE_01590 multi-sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C RGE_42940 PAS/PAC sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023