+E Replication protein KO
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DNA Replication Proteins - Rissa tridactyla (black-legged kittiwake)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 128913268 ORC1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 128912441 ORC2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 128907431 ORC3; origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 128912251 ORC4; origin recognition complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 128915136 ORC5; origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 128908827 ORC6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 128909600 CDT1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 128903521 CDC6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 128915872 MCM2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 128907906 MCM3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 128905306 MCM4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 128904507 MCM5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 128912915 MCM6; DNA replication licensing factor MCM6 isoform X1 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 128910349 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 128917401 CCNA1; cyclin-A1 K06627 CCNA; cyclin-A
D 128905232 CCNE2; G1/S-specific cyclin-E2 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 128909448 CCNE1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
C DDK (Dbf-4 dependent kinase)
D 128914086 CDC7; cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 128905698 DBF4; protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
D 128919303 DBF4B; protein DBF4 homolog B isoform X1 K06629 DBF4; protein DBF4
C GINS complex
D 128907060 GINS1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 128909500 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 128909176 GINS3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 128919577 GINS4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 128904839 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 128903608 RECQL4; ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 128917284 CDC45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 128907106 MCM8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 128907133 MCM9; DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 128904476 MCM10; protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 128901950 HELB; DNA helicase B isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 128909678 CINP; cyclin-dependent kinase 2-interacting protein isoform X1 K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 128906271 MTBP; mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 128915208 TICRR; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 128916240 POLA1; DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 128901828 POLA2; DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 128903207 PRIM1; DNA primase small subunit isoform X1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 128907207 PRIM2; DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 128917155 POLE; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 128908993 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 128917470 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 128900656 POLE4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 128900087 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 128917807 POLD3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 128908884 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 128915076 POLG; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 128918137 POLG2; DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 128912530 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 128918994 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
D 128904744 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 128910431 RFC1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 128911687 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 128913132 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 128901016 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 128903650 RFC5; LOW QUALITY PROTEIN: replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 128906634 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 128914428 RNASEH2B; ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 128903934 RNASEH2C; LOW QUALITY PROTEIN: ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 128900162 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 128911922 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 128909628 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 128907149 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 128912320 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 128918040 ATAD5; ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 128907401 DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 128916804 DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 128905998 GMNN; geminin K10749 GMNN; geminin
D 128903116 MCIDAS; multicilin K26119 MCIDAS; multicilin
D 128902420 CCNB1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 128914894 CCNB2; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 128911204 CDK1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 128909447 POT1; protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 128904996 TERF1; telomeric repeat-binding factor 1 isoform X1 K11110 TERF1; telomeric repeat-binding factor 1
E 128908538 TERF2; telomeric repeat-binding factor 2 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 128901848 TINF2; TERF1-interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 128908667 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 128909465 ACD; adrenocortical dysplasia protein homolog isoform X1 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 128908339 TERB1; telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 128914523 TERB2; telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 128917158 uncharacterized protein LOC128917158 K25751 MAJIN; membrane-anchored junction protein
E 128917160 membrane-anchored junction protein-like K25751 MAJIN; membrane-anchored junction protein
E 128917267 membrane-anchored junction protein-like K25751 MAJIN; membrane-anchored junction protein
E 128917281 membrane-anchored junction protein-like isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 128912886 CTC1; CST complex subunit CTC1 isoform X1 K23311 CTC1; CST complex subunit CTC1
E 128911572 STN1; CST complex subunit STN1 isoform X1 K23312 STN1; CST complex subunit STN1
E 128917794 TEN1; CST complex subunit TEN1 isoform X1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 128912503 SMG6; telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 128900896 SMG5; nonsense-mediated mRNA decay factor SMG5 isoform X1 K11125 SMG5; protein SMG5
D 128906202 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 128909979 GAR1; H/ACA ribonucleoprotein complex subunit 1 isoform X1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 128916082 NHP2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 128915342 DKC1; H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 128906202 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 128916598 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 128905248 SNRPD1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 128901755 SNRPD2; LOW QUALITY PROTEIN: small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 128917014 SNRPD3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 128900228 SNRPE; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 128914484 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 128919621 SNRPG; small nuclear ribonucleoprotein G isoform X1 K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 128911687 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 128913132 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 128901016 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 128903650 RFC5; LOW QUALITY PROTEIN: replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 128910039 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
D 128916168 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 128905995 NBN; nibrin K10867 NBN; nibrin
C Other termination factors
D 128907125 ATM; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 128909875 WRN; LOW QUALITY PROTEIN: bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 128915258 BLM; recQ-like DNA helicase BLM K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 128905305 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 128913938 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 128907370 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 128910346 TNKS; poly [ADP-ribose] polymerase tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 128910913 TNKS2; poly [ADP-ribose] polymerase tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 128906730 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 128916773 RTEL1; regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 128913907 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 128912290 RIF1; telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 128913987 PIF1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 128916106 PURA; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 128909868 PURG; purine-rich element-binding protein gamma isoform X1 K21800 PURG; purine-rich element-binding protein gamma
D 128907387 SDE2; splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 128916424 RTF2; replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 128906155 TOP1MT; DNA topoisomerase I, mitochondrial K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 128916410 TOP1; DNA topoisomerase 1 isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 128905140 TOP2B; DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 128919079 TOP2A; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 128913371 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 128917110 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 128910335 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 128906634 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 128906634 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 128911922 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 128909628 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025