+C GAG KO #

  Glycosaminoglycan Binding Proteins - Rana temporaria (common frog)

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AHeparan sulfate / Heparin B Cytokines C 120933040 uncharacterized protein LOC120933040 K04519 IL1B; interleukin 1 beta C 120933041 uncharacterized protein LOC120933041 K04519 IL1B; interleukin 1 beta C 120933042 IL1B; interleukin-1 beta K04519 IL1B; interleukin 1 beta C 120933043 interleukin-1 beta-like K04519 IL1B; interleukin 1 beta C 120928638 IL10; interleukin-10 K05443 IL10; interleukin 10 C 120930493 IL12B; interleukin-12 subunit beta K05425 IL12B; interleukin 12B C 120913274 TNF; tumor necrosis factor K03156 TNF; tumor necrosis factor superfamily, member 2 B Chemokines C ------ CCL12; C-C motif chemokine 12 [MMU:20293] [KO:K14624] C 120915656 interleukin-8-like isoform X1 K10030 IL8; interleukin 8 C 120915686 interleukin-8-like K10030 IL8; interleukin 8 C 120924965 interleukin-8-like K10030 IL8; interleukin 8 C 120916578 C-X-C motif chemokine 10-like K12671 CXCL10; C-X-C motif chemokine 10 C 120916583 uncharacterized protein LOC120916583 isoform X1 K12671 CXCL10; C-X-C motif chemokine 10 C 120916596 C-X-C motif chemokine 11-like K12671 CXCL10; C-X-C motif chemokine 10 C 120916603 C-X-C motif chemokine 10-like isoform X1 K12671 CXCL10; C-X-C motif chemokine 10 C 120924968 C-X-C motif chemokine 10-like K12671 CXCL10; C-X-C motif chemokine 10 C 120909118 CXCL12; stromal cell-derived factor 1 isoform X1 K10031 CXCL12; C-X-C motif chemokine 12 B Adhesion molecules of cell surface C 120945517 SELL; L-selectin isoform X1 K06495 SELL; selectin, lymphocyte C 120945516 SELE; E-selectin K06496 SELP; selectin, platelet C 120945518 E-selectin-like isoform X1 K06496 SELP; selectin, platelet C 120942724 uncharacterized protein LOC120942724 K06461 ITGAM; integrin alpha M C 120942900 integrin alpha-M-like K06461 ITGAM; integrin alpha M C 120915466 NCAM1; neural cell adhesion molecule 1 isoform X1 K06491 NCAM; neural cell adhesion molecule C 120927856 NCAM2; neural cell adhesion molecule 2 isoform X1 K06491 NCAM; neural cell adhesion molecule C 120919401 PECAM1; platelet endothelial cell adhesion molecule K06471 PECAM1; platelet/endothelial cell adhesion molecule B Morphogens C 120909121 bone morphogenetic protein 2-B-like K21283 BMP2; bone morphogenetic protein 2 C 120924945 bone morphogenetic protein 2-like K21283 BMP2; bone morphogenetic protein 2 C 120938036 BMP2; bone morphogenetic protein 2 K21283 BMP2; bone morphogenetic protein 2 C 120921208 BMP4; bone morphogenetic protein 4 K04662 BMP4; bone morphogenetic protein 4 C 120919508 BMP7; bone morphogenetic protein 7 K16621 BMP7; bone morphogenetic protein 7 C 120931390 bone morphogenetic protein 7-like K16621 BMP7; bone morphogenetic protein 7 C 120941069 SHH; sonic hedgehog protein K11988 SHH; sonic hedgehog C 120928559 WNT1; proto-oncogene Wnt-1 K03209 WNT1; wingless-type MMTV integration site family, member 1 C 120927055 WNT2B; protein Wnt-2b K00182 WNT2; wingless-type MMTV integration site family, member 2 C 120931869 WNT2; protein Wnt-2 K00182 WNT2; wingless-type MMTV integration site family, member 2 C 120919261 WNT3; LOW QUALITY PROTEIN: proto-oncogene Wnt-3 K00312 WNT3; wingless-type MMTV integration site family, member 3 C 120939814 WNT3A; protein Wnt-3a K00312 WNT3; wingless-type MMTV integration site family, member 3 C 120915622 WNT4; protein Wnt-4 K00408 WNT4; wingless-type MMTV integration site family, member 4 C 120932706 WNT5B; protein Wnt-5b K00444 WNT5; wingless-type MMTV integration site family, member 5 C 120945241 WNT5A; protein Wnt-5a isoform X1 K00444 WNT5; wingless-type MMTV integration site family, member 5 C 120944204 WNT6; protein Wnt-6 K00445 WNT6; wingless-type MMTV integration site family, member 6 C 120913020 protein Wnt-7b-like K00572 WNT7; wingless-type MMTV integration site family, member 7 C 120932924 WNT7B; protein Wnt-7b isoform X1 K00572 WNT7; wingless-type MMTV integration site family, member 7 C 120945270 protein Wnt-7a isoform X1 K00572 WNT7; wingless-type MMTV integration site family, member 7 C 120944842 WNT8A; protein Wnt-8a K00714 WNT8; wingless-type MMTV integration site family, member 8 C 120947208 WNT8B; protein Wnt-8b K00714 WNT8; wingless-type MMTV integration site family, member 8 C 120919262 WNT9B; protein Wnt-9b K01064 WNT9; wingless-type MMTV integration site family, member 9 C 120939812 WNT9A; protein Wnt-9a K01064 WNT9; wingless-type MMTV integration site family, member 9 C 120929581 WNT10B; protein Wnt-10b K01357 WNT10; wingless-type MMTV integration site family, member 10 C 120944203 WNT10A; protein Wnt-10a K01357 WNT10; wingless-type MMTV integration site family, member 10 C 120914400 protein Wnt-11b-like K01384 WNT11; wingless-type MMTV integration site family, member 11 C 120928924 WNT11; protein Wnt-11 K01384 WNT11; wingless-type MMTV integration site family, member 11 C 120931852 WNT16; protein Wnt-16 K01558 WNT16; wingless-type MMTV integration site family, member 16 B Growth factors/receptors C 120916800 AREG; amphiregulin K09782 AREG; amphiregulin C 120916790 BTC; probetacellulin isoform X1 K09783 BTC; betacellulin C 120932310 FGF1; fibroblast growth factor 1 K18496 FGF1; fibroblast growth factor 1 C 120918763 FGF2; fibroblast growth factor 2 K18497 FGF2; fibroblast growth factor 2 C 120914385 FGF5; fibroblast growth factor 5 K04358 FGF; fibroblast growth factor C 120916862 FGF4; fibroblast growth factor 4 K04358 FGF; fibroblast growth factor C 120917106 FGF3; fibroblast growth factor 3 K04358 FGF; fibroblast growth factor C 120921899 FGF16; fibroblast growth factor 16 K04358 FGF; fibroblast growth factor C 120922384 FGF20; fibroblast growth factor 20 K04358 FGF; fibroblast growth factor C 120928074 FGF10; fibroblast growth factor 10 K04358 FGF; fibroblast growth factor C 120929231 FGF9; fibroblast growth factor 9 K04358 FGF; fibroblast growth factor C 120931322 FGF7; fibroblast growth factor 7 K04358 FGF; fibroblast growth factor C 120932373 FGF18; fibroblast growth factor 18 K04358 FGF; fibroblast growth factor C 120932647 FGF6; fibroblast growth factor 6 K04358 FGF; fibroblast growth factor C 120947018 FGF8; fibroblast growth factor 8 isoform X1 K04358 FGF; fibroblast growth factor C 120913654 FGF13; fibroblast growth factor 13 isoform X1 K22413 FGF11_12_13; fibroblast growth factor 11/12/13 C 120933749 FGF11; fibroblast growth factor 11 K22413 FGF11_12_13; fibroblast growth factor 11/12/13 C 120936848 FGF12; fibroblast growth factor 12 isoform X1 K22413 FGF11_12_13; fibroblast growth factor 11/12/13 C 120926329 FGF14; fibroblast growth factor 14 isoform X1 K23920 FGF14; fibroblast growth factor 14 C 120916863 FGF19; fibroblast growth factor 19 K22603 FGF19; fibroblast growth factor 19 C 120916079 FGF21; fibroblast growth factor 21 K22429 FGF21; fibroblast growth factor 21 C 120930868 FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 K22428 FGF23; fibroblast growth factor 23 C 120933172 FGFR1; fibroblast growth factor receptor 1 isoform X1 K04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1] C 120947029 FGFR2; fibroblast growth factor receptor 2 isoform X1 K05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1] C 120931733 HGF; hepatocyte growth factor isoform X1 K05460 HGF; hepatocyte growth factor C 120917128 MDK; midkine K06828 MDK; midkine C 120916507 insulin-like growth factor III isoform X1 K13769 IGF2; insulin-like growth factor 2 C 120917285 IGF2; insulin-like growth factor II isoform X1 K13769 IGF2; insulin-like growth factor 2 C 120914715 NRG1; pro-neuregulin-1, membrane-bound isoform isoform X1 K05455 NRG1; neuregulin 1 C 120920371 HDGF; hepatoma-derived growth factor isoform X1 K16641 HDGF; hepatoma-derived growth factor C 120943462 PDGFA; platelet-derived growth factor subunit A isoform X1 K04359 PDGFA; platelet-derived growth factor subunit A C 120945372 PDGFB; platelet-derived growth factor subunit B K17386 PDGFB; platelet-derived growth factor subunit B C 120913378 TGFB1; transforming growth factor beta-1 proprotein K13375 TGFB1; transforming growth factor beta-1 C 120937894 TGFB2; LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein K13376 TGFB2; transforming growth factor beta-2 C 120932880 PTN; pleiotrophin K16642 PTN; pleiotrophin C 120938083 VEGFA; vascular endothelial growth factor A isoform X1 K05448 VEGFA; vascular endothelial growth factor A B Extracellular matrix molecules C 120920103 fibrinogen alpha chain-like K03903 FGA; fibrinogen alpha chain C 120920084 FGB; fibrinogen beta chain K03904 FGB; fibrinogen beta chain C 120920112 FGG; fibrinogen gamma chain isoform X1 K03905 FGG; fibrinogen gamma chain C 120943877 FN1; fibronectin isoform X1 K05717 FN1; fibronectin 1 C 120931330 FBN1; fibrillin-1 K06825 FBN1; fibrillin 1 C 120915216 fibrillin-2-like K23342 FBN2_3; fibrillin 2/3 C 120932470 FBN2; fibrillin-2 K23342 FBN2_3; fibrillin 2/3 C ------ LAMA5; laminin, alpha 5 [HSA:3911] [KO:K06240] C 120913063 TNC; LOW QUALITY PROTEIN: tenascin K06252 TN; tenascin C 120913239 TNXB; tenascin-X isoform X1 K06252 TN; tenascin C 120945855 tenascin-R-like K06252 TN; tenascin C 120945857 tenascin-N-like isoform X1 K06252 TN; tenascin C 120920380 SMOC1; SPARC-related modular calcium-binding protein 1 isoform X1 K24354 SMOC; SPARC-related modular calcium-binding protein C 120920536 THBS1; thrombospondin-1 K16857 THBS1; thrombospondin 1 C 120913194 cartilage oligomeric matrix protein K04659 THBS2S; thrombospondin 2/3/4/5 C 120929244 THBS4; thrombospondin-4 K04659 THBS2S; thrombospondin 2/3/4/5 C 120937577 THBS2; thrombospondin-2 K04659 THBS2S; thrombospondin 2/3/4/5 C 120927578 VTN; vitronectin K06251 VTN; vitronectin C 120918537 COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain K06236 COL1A; collagen type I alpha C 120939897 COL1A2; collagen alpha-2(I) chain isoform X1 K06236 COL1A; collagen type I alpha C 120929392 COL2A1; collagen alpha-1(II) chain isoform X1 K19719 COL2A; collagen type II alpha C 120943708 COL3A1; collagen alpha-1(III) chain K19720 COL3A; collagen type III alpha C 120913726 COL4A5; collagen alpha-5(IV) chain isoform X1 K06237 COL4A; collagen type IV alpha C 120913727 COL4A6; collagen alpha-6(IV) chain isoform X1 K06237 COL4A; collagen type IV alpha C 120926367 COL4A2; collagen alpha-2(IV) chain K06237 COL4A; collagen type IV alpha C 120926368 COL4A1; collagen alpha-1(IV) chain K06237 COL4A; collagen type IV alpha C 120913823 COL5A1; collagen alpha-1(V) chain isoform X1 K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha C 120913886 collagen alpha-1(I) chain-like isoform X1 K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha C 120914224 COL27A1; collagen alpha-1(XXVII) chain isoform X1 K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha C 120914304 COL11A2; collagen alpha-2(XI) chain isoform X1 K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha C 120933272 COL5A3; collagen alpha-3(V) chain isoform X1 K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha C 120943707 COL5A2; collagen alpha-2(V) chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha C 120945611 COL11A1; collagen alpha-1(XI) chain isoform X1 K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha C 120945957 COL24A1; collagen alpha-1(XXIV) chain K19721 COL5AS; collagen type V/XI/XXIV/XXVII, alpha C 120940282 COL6A6; collagen alpha-6(VI) chain K06238 COL6A; collagen type VI alpha C 120943886 COL6A3; collagen alpha-3(VI) chain isoform X1 K06238 COL6A; collagen type VI alpha C 120943933 COL6A2; collagen alpha-2(VI) chain isoform X1 K06238 COL6A; collagen type VI alpha C 120943934 COL6A1; collagen alpha-1(VI) chain K06238 COL6A; collagen type VI alpha C 120908943 COL13A1; collagen alpha-1(XIII) chain isoform X1 K16617 COL13A; collagen type XIII alpha C 120943939 COL18A1; collagen alpha-1(XVIII) chain isoform X1 K06823 COL18A; collagen type XVIII alpha C 120917832 COL25A1; collagen alpha-1(XXV) chain isoform X1 K24356 COL25A; collagen type XXV alpha C 120940229 COLQ; acetylcholinesterase collagenic tail peptide isoform X1 K26586 COLQ; acetylcholinesterase collagenic tail peptide B Axon guidance molecules C 120913612 EFNA2; ephrin-A2 K05462 EFNA; ephrin-A C 120920363 ephrin-A4-like K05462 EFNA; ephrin-A C 120920953 ephrin-A3-like K05462 EFNA; ephrin-A C 120931552 EFNA5; ephrin-A5 isoform X1 K05462 EFNA; ephrin-A C 120915264 netrin-1-like K06843 NTN1; netrin 1 C 120919105 NTN1; netrin-1 isoform X1 K06843 NTN1; netrin 1 C 120943365 NTN3; netrin-3 K06843 NTN1; netrin 1 C 120909838 SLIT1; slit homolog 1 protein K06838 SLIT1; slit 1 C 120924317 SLIT2; LOW QUALITY PROTEIN: slit homolog 2 protein K06839 SLIT2; slit 2 C ------ SEMA5A; semaphorin 5A [HSA:9037] [KO:K06841] B Coagulation and fibrinolysis C 120917137 F2; prothrombin K01313 F2; coagulation factor II (thrombin) [EC:3.4.21.5] C 120926383 F10; coagulation factor X K01314 F10; coagulation factor X [EC:3.4.21.6] C 120945863 SERPINC1; antithrombin-III K03911 SERPINC1; antithrombin III C 120936265 SERPIND1; heparin cofactor 2 K03912 SERPIND1; heparin cofactor II C 120933479 SERPINE1; plasminogen activator inhibitor 1 K03982 SERPINE1; plasminogen activator inhibitor 1 C 120936585 SERPINE2; glia-derived nexin K16643 SERPINE2; glia-derived nexin C 120933163 PLAT; tissue-type plasminogen activator K01343 PLAT; tissue plasminogen activator [EC:3.4.21.68] C 120910440 PLAU; urokinase-type plasminogen activator K01348 PLAU; urokinase plasminogen activator [EC:3.4.21.73] B Enzymes C 120915912 HPSE; heparanase K07964 HPSE; heparanase [EC:3.2.1.166] C 120946669 HPSE2; inactive heparanase-2 K07965 HPSE2; heparanase 2 [EC:3.2.1.-] C 120931837 hyaluronidase-like K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 120944794 hyaluronidase-2-like K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 120944795 hyaluronidase-1-like K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 120944967 hyaluronidase-2-like K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 120944968 hyaluronidase-2-like K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 120944969 hyaluronidase-2-like K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 120944970 hyaluronidase-1-like K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 120914637 LPL; lipoprotein lipase K01059 LPL; lipoprotein lipase [EC:3.1.1.34] C 120924305 SOD3; extracellular superoxide dismutase [Cu-Zn] K16627 SOD3; superoxide dismutase, Cu-Zn family [EC:1.15.1.1] C 120924306 extracellular superoxide dismutase [Cu-Zn]-like K16627 SOD3; superoxide dismutase, Cu-Zn family [EC:1.15.1.1] B Microbial pathogens C ------ Dengue virus, envelope protein C ------ Foot-and-mouth disease virus - type O, VP3 C ------ penetrin C ------ Borrelia burgdorferi C ------ Chlamydia trachomatis C ------ Neisseria gonorrhoeae C ------ Leishmania amazonensis B Others C 120918635 ANXA5; annexin A5 K16646 ANXA5; annexin A5 C 120915115 APOA5; apolipoprotein A-V K09025 APOA5; apolipoprotein A-V C 120936289 APOB; apolipoprotein B-100 K14462 APOB; apolipoprotein B C 120927870 amyloid-beta precursor protein isoform X1 K04520 APP; amyloid beta A4 protein C 120936191 CTSB; cathepsin B K01363 CTSB; cathepsin B [EC:3.4.22.1] C 120909938 mast cell protease 1A-like K01319 CTSG; cathepsin G [EC:3.4.21.20] C 120932994 major prion protein homolog K05634 PRNP; prion protein C 120913399 SLC8A2; sodium/calcium exchanger 2 K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger) C 120917602 sodium/calcium exchanger 1-like isoform X1 K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger) C 120920932 SLC8A3; sodium/calcium exchanger 3 isoform X1 K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger) C 120937689 sodium/calcium exchanger 1 isoform X1 K05849 SLC8A; solute carrier family 8 (sodium/calcium exchanger) # AHyaluronan B Cell surface receptors C 120924334 CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 K01242 CD38; ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20] C 120917075 CD44; CD44 antigen isoform X1 K06256 CD44; CD44 antigen C 120932396 HMMR; hyaluronan mediated motility receptor K06267 HMMR; hyaluronan-mediated motility receptor C 120920062 TLR2; toll-like receptor 2 K10159 TLR2; toll-like receptor 2 C 120920265 toll-like receptor 2 K10159 TLR2; toll-like receptor 2 C 120920459 toll-like receptor 2 K10159 TLR2; toll-like receptor 2 C 120932459 CD14; monocyte differentiation antigen CD14 K10159 TLR2; toll-like receptor 2 C 120913060 TLR4; toll-like receptor 4 K10160 TLR4; toll-like receptor 4 C 120915136 LAYN; layilin isoform X1 K10077 LAYN; layilin C 120946184 STAB1; stabilin-1 K19020 STAB1; stabilin-1 C 120932120 STAB2; stabilin-2 K19013 STAB2; stabilin-2 C 120931210 cell migration-inducing and hyaluronan-binding protein isoform X1 K19031 CEMIP; cell migration-inducing and hyaluronan-binding protein [EC:3.2.1.35] C 120931208 cell surface hyaluronidase-like isoform X1 K22144 TEME2; cell surface hyaluronidase [EC:3.2.1.35] C 120943284 CEMIP2; cell surface hyaluronidase K22144 TEME2; cell surface hyaluronidase [EC:3.2.1.35] B Extracellular matrix or blood plasma proteins C 120931192 ACAN; aggrecan core protein isoform X1 K06792 AGC1; aggrecan 1 C 120920894 BCAN; brevican core protein isoform X1 K06795 BCAN; brevican C 120926589 complement component 1 Q subcomponent-binding protein, mitochondrial K15414 C1QBP; complement component 1 Q subcomponent-binding protein, mitochondrial C 120940282 COL6A6; collagen alpha-6(VI) chain K06238 COL6A; collagen type VI alpha C 120943886 COL6A3; collagen alpha-3(VI) chain isoform X1 K06238 COL6A; collagen type VI alpha C 120943933 COL6A2; collagen alpha-2(VI) chain isoform X1 K06238 COL6A; collagen type VI alpha C 120943934 COL6A1; collagen alpha-1(VI) chain K06238 COL6A; collagen type VI alpha C 120920103 fibrinogen alpha chain-like K03903 FGA; fibrinogen alpha chain C 120920084 FGB; fibrinogen beta chain K03904 FGB; fibrinogen beta chain C 120920112 FGG; fibrinogen gamma chain isoform X1 K03905 FGG; fibrinogen gamma chain C 120946833 HABP2; hyaluronan-binding protein 2 K08648 HABP2; hyaluronan binding protein 2 [EC:3.4.21.-] C 120930527 HAPLN1; hyaluronan and proteoglycan link protein 1 K06848 HAPLN1; hyaluronan and proteoglycan link protein 1 C 120920589 HAPLN2; hyaluronan and proteoglycan link protein 2 isoform X1 K06851 HAPLN2; hyaluronan and proteoglycan link protein 2 C 120909036 HAPLN4; hyaluronan and proteoglycan link protein 4 K06853 HAPLN4; hyaluronan and proteoglycan link protein 4 C 120928851 HPX; hemopexin K18977 HPX; hemopexin C 120931684 ITIH2; inter-alpha-trypsin inhibitor heavy chain H2 K19015 ITIH2; inter-alpha-trypsin inhibitor heavy chain H2 C 120945301 inter-alpha-trypsin inhibitor heavy chain H3-like isoform X1 K24513 ITIH3; inter-alpha-trypsin inhibitor heavy chain H3 C 120945304 inter-alpha-trypsin inhibitor heavy chain H3-like isoform X1 K24513 ITIH3; inter-alpha-trypsin inhibitor heavy chain H3 C 120945305 inter-alpha-trypsin inhibitor heavy chain H3-like K24513 ITIH3; inter-alpha-trypsin inhibitor heavy chain H3 C 120909046 NCAN; neurocan core protein isoform X1 K06794 NCAN; neurocan core protein C 120937050 IMPG1; interphotoreceptor matrix proteoglycan 1 isoform X1 K19016 IMPG1; interphotoreceptor matrix proteoglycan 1 C 120926542 IMPG2; interphotoreceptor matrix proteoglycan 2 K19017 IMPG2; interphotoreceptor matrix proteoglycan 2 C 120944113 TNFAIP6; tumor necrosis factor-inducible gene 6 protein K19018 TNFAIP6; tumor necrosis factor-inducible gene 6 protein C 120930517 VCAN; versican core protein isoform X1 K06793 VCAN; versican core protein B Intracellular proteins C 120933288 CDC37; hsp90 co-chaperone Cdc37 K09554 CDC37; cell division cycle protein 37 C 120941775 HABP4; intracellular hyaluronan-binding protein 4 K19019 HABP4; intracellular hyaluronan-binding protein 4 ! #
#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 22, 2023