+F Repair protein KO
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DNA Repair and Recombination Proteins - Rhincodon typus (whale shark)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 109916259 alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 109938449 CPD photolyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 109916258 unga; uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 109929409 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 109918209 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 109917112 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 109933570 mbd4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 109924303 ogg1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 109919802 neil1; endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 109920269 neil3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 109926487 apex1; DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 109918764 DNA-(apurinic or apyrimidinic site) endonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 109932747 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 109924554 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
F 125488301 DNA polymerase delta subunit 4-like isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 109932784 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 109915148 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 109919937 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D Short Patch-BER factors
E 109927978 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 109913896 lig3; DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 109926966 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 109916378 aplf; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 109923288 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 109920100 parp3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 109927430 UV excision repair protein RAD23 homolog B-like isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 109913939 UV excision repair protein RAD23 homolog A isoform X2 K10839 RAD23; UV excision repair protein RAD23
F 109917661 caltractin isoform X1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 109921792 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 109919737 cul4b; cullin-4B K10609 CUL4; cullin 4
F 109931898 cullin-4A-like isoform X1 K10609 CUL4; cullin 4
F 109936417 ddb1; DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 109921440 polr2a; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 109913092 polr2b; DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 109913855 polr2c; DNA-directed RNA polymerase II subunit RPB3 isoform X2 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 109911749 polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 109931451 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 109926359 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 109925300 polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 109936978 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 109922352 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 109934226 polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 109922194 polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 109928920 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 109921792 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 109919737 cul4b; cullin-4B K10609 CUL4; cullin 4
F 109931898 cullin-4A-like isoform X1 K10609 CUL4; cullin 4
F 109936417 ddb1; DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 109911930 ercc8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 109930571 ercc6; DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 109928166 uvssa; UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 109918767 elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 109918457 ercc3; general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 109912262 gtf2h1; general transcription factor IIH subunit 1 isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 109925322 gtf2h2; general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 109936922 gtf2h3; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 109934881 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 109927171 cdk7; cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 109912981 ccnh; cyclin-H K06634 CCNH; cyclin H
D RPA (replication factor A)
E 109928753 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 109926749 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 109916282 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 109928459 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 109919094 ercc4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 109912804 ercc5; LOW QUALITY PROTEIN: DNA excision repair protein ERCC-5 K10846 ERCC5; DNA excision repair protein ERCC-5
E 109918076 cullin-3 K03869 CUL3; cullin 3
E 109927222 cullin-5 K10612 CUL5; cullin 5
E 109929894 elongin-C K03872 ELOC; elongin-C
E 109921977 eloa; elongin-A K15076 ELOA; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 109919222 msh6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 109912928 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 109938420 DNA mismatch repair protein Mlh3-like K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 109932747 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 109924554 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E 125488301 DNA polymerase delta subunit 4-like isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 109928753 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 109926749 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 109916282 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 109930648 rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 109911328 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 109921607 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 109928766 rfc5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 109928781 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 109919937 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 109933426 exo1; exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 109934547 wdr76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 109927708 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
E 109911421 bard1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 109914313 abraxas1; BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 109917305 uimc1; BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 109925791 babam1; BRISC and BRCA1-A complex member 1 isoform X1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 109912372 babam2; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 109934582 brcc3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 109911210 topbp1; DNA topoisomerase 2-binding protein 1 isoform X4 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 109930323 rbbp8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 109927708 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 109928012 brca2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 109910485 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 109926827 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 109926827 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 109918318 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 109913898 rad51d; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 109918559 xrcc2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
D Rad52 family proteins
E 109910504 rdm1; RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 109919474 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 109937785 rad54l2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 109918075 recql; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 109920152 recql4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 109927305 top3b; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 109936290 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 109928753 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 109926749 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 109916282 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 109926399 ppp4cb; serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 109915231 serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 109933177 serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 109910730 smek1; serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 109929137 serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
E 109915298 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 109927850 ap5m1; AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 109921383 ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
D SMC5-SMC6 complex
E 109910892 smc5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 109918860 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 109917031 lratd1; protein LRATD1 isoform X2 K22805 FAM84A; protein FAM84A
E 109935184 nsmce4a; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 109934318 slf1; SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
D Other HR factors
E 109930174 eme1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 109919570 exd2; exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 109911583 sfr1; swi5-dependent recombination DNA repair protein 1 homolog isoform X3 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 109937898 slx4; structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 109918871 flap endonuclease GEN homolog 1 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 109936306 zfyve26; zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 109921349 rad51ap1; RAD51-associated protein 1 isoform X3 K20778 RAD51AP1; RAD51-associated protein 1
E 109914164 morf4l1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 109936149 fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 109915382 lratd2a; protein LRATD2a K22810 FAM84B; protein FAM84B
E 109910410 brat1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 109937221 cfap410; cilia and flagella associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 109922130 hdgfl2; hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 109924531 zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 109920562 swsap1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 109935986 heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 109917858 mms22l; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 109924648 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 109926127 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 109913073 bod1l1; biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 109914144 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 109920701 xrcc6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
D MRX complex
E 109927708 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 109916029 lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
E 109923288 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 109913711 dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 109929373 polm; DNA-directed DNA/RNA polymerase mu isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 109927978 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 109926966 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 109916378 aplf; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 109921344 dclre1c; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 109916521 tdp2b; tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 109929510 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 109932916 paxx; protein PAXX K25772 PAXX; protein PAXX
E 109935906 jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 109918403 shld2; shieldin complex subunit 2 isoform X1 K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 109928365 Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 125484334 Fanconi anemia group B protein-like K10889 FANCB; fanconi anemia group B protein
E 109916203 fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 109910437 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 109928837 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 109916873 Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 109923078 transcription factor HES-1-B K06054 HES1; hairy and enhancer of split 1
E 109927433 her9; hairy-related 9 isoform X1 K06054 HES1; hairy and enhancer of split 1
E 109936797 cenps; centromere protein S K11511 APITD1; centromere protein S
E 109913521 cenpx; centromere protein X K15360 STRA13; centromere protein X
E 109915210 ube2t; ubiquitin-conjugating enzyme E2 T isoform X2 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 109927305 top3b; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 109936290 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 109911117 fancd2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
D Downstream FA components
E 109928012 brca2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 109910485 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 109921528 fan1; fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 109926827 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 109918318 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 109928650 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 109914306 usp1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 109912774 wdr48b; WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 109913842 ppp6c; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 109932364 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 109923447 ppp6r3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 109920960 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
D Ubiquitin ligases
E 109915406 rnf169; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 109930649 herc2; E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 109914028 wrap53; telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 109914696 tprn; taperin isoform X2 K24164 TPRN; taperin
E 109934547 wdr76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 109922790 polh; DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 109917358 poli; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 109927862 rev1; DNA repair protein REV1 isoform X2 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 109917016 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 109912237 ubiquitin-conjugating enzyme E2 A-like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 109915414 ube2a; ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 109930318 rad18; E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 109933931 hltf; helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 109913875 ube2v2; ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 109916065 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
C Other TLS factors
D 109919937 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 109914144 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 109935500 gcna; germ cell nuclear acidic protein isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 109913845 cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 109931638 rad17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 109911328 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 109921607 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 109928766 rfc5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 109928781 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
D 109923130 tipin; TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 109911726 claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 109928650 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 125481546 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 109938118 tti2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 109936080 bag6l; large proline-rich protein BAG6 isoform X4 K23390 BAG6; large proline-rich protein BAG6
D 109927796 get4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 109934427 atr; serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 109919260 ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 109934178 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 109911275 chek2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 125484053 cdc25b; M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 109928665 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 109915867 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 109927423 14-3-3 protein zeta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 109935218 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 125482572 14-3-3 protein beta/alpha-A-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 109918614 14-3-3 protein gamma-B K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 109924564 14-3-3 protein gamma-1-like K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 109916686 ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 K06630 YWHAE; 14-3-3 protein epsilon
D 109921278 wee1; wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 109920944 wee1-like protein kinase 2-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 109919168 per2; period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 109920124 pls3; plastin-3 K17336 PLS3; plastin-3
D 109935193 apoptosis-enhancing nuclease-like isoform X1 K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 109913305 serine/threonine-protein kinase PLK2-like K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 109935032 nek1; serine/threonine-protein kinase Nek1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 109932445 LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 109919878 serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 109927532 nek10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 109913858 serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 109913467 protein downstream neighbor of Son isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 109932754 protein downstream neighbor of Son-like K22422 DONSON; protein downstream neighbor of Son
D 109920764 KN motif and ankyrin repeat domain-containing protein 4-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 109928448 KN motif and ankyrin repeat domain-containing protein 2-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 109936475 kank1a; KN motif and ankyrin repeat domain-containing protein 1a isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 109925781 KN motif and ankyrin repeat domain-containing protein 2-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 109930206 vps4b; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 109924156 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 109912710 zfyve19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 109919562 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 109930395 polq; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 109911324 mybbp1a; myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 109921223 primpol; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 109917900 dclre1b; 5' exonuclease Apollo isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 109931139 exo5; exonuclease V isoform X1 K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 109914772 endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 109927675 ankle1; ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 109917324 ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 109938691 bcas2; pre-mRNA-splicing factor SPF27 isoform X1 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 109916206 plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 109930092 nudt1; oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 109922636 nudt18; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 109912825 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 109936713 rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 109921474 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 109915267 rrm2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 109938449 CPD photolyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 109916258 unga; uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 109918209 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 109917112 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 109937489 ssbp1; single-stranded DNA-binding protein, mitochondrial isoform X4 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 109937489 ssbp1; single-stranded DNA-binding protein, mitochondrial isoform X4 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 109912825 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024