+F Repair protein KO
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DNA Repair and Recombination Proteins - Ruminococcus bicirculans (ex Wegman et al. 2014)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E RBI_I01399 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E RBI_I01394 conserved hypothetical protein K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E RBI_I00417 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D RBI_I01322 conserved hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D RBI_I00107 dut; dUTP pyrophosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E RBI_I01399 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E RBI_I01992 tag; DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E RBI_I00417 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E RBI_I01376 probable deoxyribonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E RBI_I01270 recJ; single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E RBI_I00959 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E RBI_I02039 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E RBI_I01100 uvrA; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
E RBI_I01099 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
E RBI_I01460 uvrC; UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
E RBI_I00972 pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E RBI_I02039 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E RBI_I00959 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F RBI_I00727 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F RBI_I00728 rpoC; DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F RBI_I01915 rpoA; DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F RBI_I01004 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F RBI_I00136 mfd; Transcription-repair coupling factor (superfamily II helicase) K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E RBI_II00054 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E RBI_I01642 conserved hypothetical protein K03555 mutS; DNA mismatch repair protein MutS
E RBI_I00962 mutS2; MutS2 family protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E RBI_II00056 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E RBI_I01342 xseA; Exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E RBI_I01343 xseB; Exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E RBI_I01148 dnaE; DNA Polymerase III E K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E RBI_II00041 polC; DNA polymerase III PolC, alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E RBI_I00002 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E RBI_II00184 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E RBI_I01484 holB; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E RBI_I01690 hypothetical protein K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E RBI_I00739 dnaX; DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E RBI_I00959 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E RBI_I00972 pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E RBI_II00278 ssb; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E RBI_I01246 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E RBI_II00519 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E RBI_II00599 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E RBI_I00263 Putative DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E RBI_I00272 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E RBI_I01505 vsr; DNA mismatch endonuclease, patch repair protein K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E RBI_I01159 helicase, RecD/TraA family protein K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E RBI_II00115 recA; Recombination protein RecA K03553 recA; recombination protein RecA
E RBI_II00623 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E RBI_II00624 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E RBI_II00622 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E RBI_I01005 priA; primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E RBI_II00115 recA; Recombination protein RecA K03553 recA; recombination protein RecA
E RBI_I01486 radA; DNA repair protein RadA/Sms K04485 radA; DNA repair protein RadA/Sms
E RBI_I00004 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E RBI_I01532 hypothetical protein K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E RBI_II00200 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E RBI_I01270 recJ; single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E RBI_I00963 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E RBI_I00737 recR; Recombination protein RecR K06187 recR; recombination protein RecR
E RBI_I01349 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E RBI_II00623 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E RBI_II00624 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E RBI_II00622 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E RBI_I01354 addA; ATP-dependent nuclease subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E RBI_I01017 hypothetical protein K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E RBI_I01353 addB; ATP-dependent nuclease subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
E RBI_II00220 cas1; CRISPR-associated endonuclease Cas1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F RBI_II00267 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F RBI_I00008 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F RBI_II00266 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F RBI_I00006 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F RBI_I01360 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F RBI_I00420 himA; integration host factor, alpha subunit K03530 hupB; DNA-binding protein HU-beta
F RBI_II00246 hip; Integration host factor, beta subunit K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F RBI_I01270 recJ; single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F RBI_I00963 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F RBI_I00737 recR; Recombination protein RecR K06187 recR; recombination protein RecR
F RBI_I00959 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F RBI_I00834 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F RBI_I01100 uvrA; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
F RBI_I01099 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D RBI_I00632 DNA-repair protein K03502 umuC; DNA polymerase V
C Other SOS response factors
D RBI_II00115 recA; Recombination protein RecA K03553 recA; recombination protein RecA
D RBI_I02019 lexA; Repressor LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D RBI_II00559 Putative bacteriophage repressor protein CI K01356 lexA; repressor LexA [EC:3.4.21.88]
D RBI_I01349 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D RBI_II00278 ssb; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D RBI_II00116 recX; Regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D RBI_I01999 conserved hypothetical protein K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
C Modulation of nucleotide pools
D RBI_I01322 conserved hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D RBI_I00107 dut; dUTP pyrophosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
D RBI_I00061 conserved hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024