+E Replication protein KO
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DNA Replication Proteins - Rhagoletis zephyria (snowberry fruit fly)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 108359530 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 108366486 LOW QUALITY PROTEIN: origin recognition complex subunit 2-like K02604 ORC2; origin recognition complex subunit 2
D 108358782 origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 108361190 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 108371956 origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 108360547 origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 108363954 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 108368824 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 108381634 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 108378779 DNA replication licensing factor Mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 108381565 DNA replication licensing factor mcm2-like K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 108370916 zygotic DNA replication licensing factor mcm3-like K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 108364922 DNA replication licensing factor Mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 108359569 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 108360754 DNA replication licensing factor Mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 108374584 DNA replication licensing factor mcm5-A-like K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 108379179 DNA replication licensing factor MCM6-like K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 108362681 DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 108377851 DNA replication licensing factor MCM7-like K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
D 108372031 DNA replication licensing factor Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 108358972 G2/mitotic-specific cyclin-A K06627 CCNA; cyclin-A
D 108360155 G1/S-specific cyclin-E-like isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 108366538 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 108369281 cyclin-dependent kinase 2-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 108380424 cyclin-dependent kinase 2-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 108372245 cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 108379814 DNA replication complex GINS protein PSF1-like isoform X1 K10732 GINS1; GINS complex subunit 1
D 108372375 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 108372761 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 108369426 probable DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 108365208 probable DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 108354631 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 108378843 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 108380735 LOW QUALITY PROTEIN: uncharacterized protein LOC108380735 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 108362774 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 108365905 uncharacterized protein LOC108365905 isoform X1 K26052 CINP; cyclin-dependent kinase 2-interacting protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 108359305 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 108367474 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 108373795 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 108357155 DNA primase small subunit-like K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 108366051 DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 108366321 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 108365984 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 108373200 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 108359320 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 108370702 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
C DNA polymerase gamma complex (mitochondrial)
D 108367597 DNA polymerase subunit gamma-1, mitochondrial-like K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 108371932 DNA polymerase subunit gamma-1, mitochondrial K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D 108373619 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 108381427 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 108365672 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
D 108368783 uncharacterized protein LOC108368783 K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 108373112 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 108377455 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 108360540 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 108356570 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 108358559 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 108367120 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 108369645 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 108374994 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 108376163 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 108369801 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 108381397 ribonuclease H2 subunit A-like K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 108363837 ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 108356133 uncharacterized protein LOC108356133 isoform X1 K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 108379337 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 108362683 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 108368918 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 108358285 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 108365782 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 108383079 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 108361643 ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 108366623 DNA (cytosine-5)-methyltransferase 1-like K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 108368516 geminin isoform X1 K10749 GMNN; geminin
D 108376339 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 108377127 G2/mitotic-specific cyclin-B2-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 108374453 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 108374693 G2/mitotic-specific cyclin-B3-like K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 108355742 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
D 108358567 cyclin-dependent kinase 1-A-like K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 108362539 telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 108357931 protein SMG5 K11125 SMG5; protein SMG5
D Dyskerin complex
E 108374668 probable H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 108379306 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 108382759 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 108357124 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 108367271 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 108379106 H/ACA ribonucleoprotein complex subunit 3-like K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 108368867 H/ACA ribonucleoprotein complex subunit 4 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
E 108369018 H/ACA ribonucleoprotein complex subunit 4-like K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D Sm core complex
E 108366543 small nuclear ribonucleoprotein-associated protein B-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 108363235 small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 108362018 probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 108356517 probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 108354280 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 108380057 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 108373512 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 108359909 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 108382809 small nuclear ribonucleoprotein Sm D3-like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 108373994 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 108363847 small nuclear ribonucleoprotein F isoform X1 K11098 SNRPF; small nuclear ribonucleoprotein F
E 108376454 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 108370313 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 108377455 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 108360540 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 108356570 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 108358559 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 108367120 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 108369645 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 108374994 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 108375868 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
D 108359028 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D 108366977 serine/threonine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 108369305 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 108375802 Bloom syndrome protein-like K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 108373682 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 108362246 poly [ADP-ribose] polymerase isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 108369616 LOW QUALITY PROTEIN: tankyrase K10799 TNKS; tankyrase [EC:2.4.2.30]
D 108354567 tankyrase-2-like K10799 TNKS; tankyrase [EC:2.4.2.30]
D 108372757 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 108369403 uncharacterized protein LOC108369403 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108370129 ATP-dependent DNA helicase pif1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108363815 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108365104 uncharacterized protein LOC108365104 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108365526 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108357904 uncharacterized protein LOC108357904 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108358978 ATP-dependent DNA helicase pif1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108370072 transcriptional activator protein Pur-beta-like K21772 PURA; transcriptional activator protein Pur-alpha
D 108358139 transcriptional activator protein Pur-beta-like K21772 PURA; transcriptional activator protein Pur-alpha
D 108371116 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 108358707 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 108370951 protein RTF2 homolog isoform X1 K25186 RTF2; replication termination factor 2
D 108374504 protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 108379020 DNA topoisomerase 1-like isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 108379391 DNA topoisomerase 1-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 108370746 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 108371315 DNA topoisomerase 2-alpha-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 108360599 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 108380593 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 108365578 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 108375821 DNA topoisomerase 3-beta-1-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 108361449 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 108376163 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 108369801 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 108376163 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 108369801 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 108368918 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 108358285 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 108383079 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
C 108370723 DNA gyrase subunit A-like K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022