+F Repair protein KO
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DNA Repair and Recombination Proteins - Salvelinus sp. IW2-2015 (Arctic char)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111952028 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 111958162 alkbh2; LOW QUALITY PROTEIN: DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 111962104 alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 111964613 LOW QUALITY PROTEIN: activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 111972823 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 111979718 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 111957980 ung; uracil-DNA glycosylase isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 112071100 ccno; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 111962111 G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 111962113 G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 111972058 G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 111972059 G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 112070258 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 111981121 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 111970180 smug1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 111976058 mutyh; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 112080770 methyl-CpG-binding domain protein 4-like isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 111976907 ogg1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 112075900 neil1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 111965830 neil3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 112078805 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E 112078093 LOW QUALITY PROTEIN: endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 112071636 apex1; LOW QUALITY PROTEIN: DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 111966632 DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
E 111976292 DNA-(apurinic or apyrimidinic site) lyase 2-like K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 112074650 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 111958053 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 111950751 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 112080848 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 111957852 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 111968945 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 112080629 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 111976114 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
F 111952111 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 111974502 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111957517 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111956555 probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 111973246 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 111975092 LOW QUALITY PROTEIN: DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 111974593 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 111965187 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 111958857 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 111950255 lig3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 111968418 tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 111975108 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 112080817 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111960305 pnkp; bifunctional polynucleotide phosphatase/kinase isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 112078642 high mobility group-T protein K10802 HMGB1; high mobility group protein B1
E 111964455 high mobility group-T protein isoform X1 K10802 HMGB1; high mobility group protein B1
E 111949578 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 112073878 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 111972730 parp1; poly [ADP-ribose] polymerase 1 isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 111956633 parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 111966407 poly [ADP-ribose] polymerase 3-like isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 111970130 parp3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 111959623 parp4; poly [ADP-ribose] polymerase 4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 111966281 xpc; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 111975318 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 111980860 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 111980871 UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 111961245 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 112070923 LOW QUALITY PROTEIN: UV excision repair protein RAD23 homolog A-like K10839 RAD23; UV excision repair protein RAD23
F 111952469 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 112072990 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111965561 RING-box protein 1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111981970 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111965865 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 111967617 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 111974035 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 111969195 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 112077473 ddb2; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 111955018 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 111960406 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 111967520 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 111965769 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 111962299 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 111952882 DNA-directed RNA polymerase II subunit RPB3 isoform X1 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 112072680 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111949842 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111952958 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 111956378 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 111981688 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 111981640 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 111966041 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 112068516 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 111957308 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 111960678 polr2i; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 112073761 DNA-directed RNA polymerases I, II, and III subunit RPABC5-like K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 111969482 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 111982040 polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 112073746 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 112072990 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111965561 RING-box protein 1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111981970 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111965865 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 111967617 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 111974035 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 111969195 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 111958087 ercc8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 111951672 LOW QUALITY PROTEIN: DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 111967316 uvssa; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 111980159 elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 112075101 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 111981813 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 111949602 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 111949639 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 112074572 gtf2h1; general transcription factor IIH subunit 1 isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 112068933 gtf2h2c; general transcription factor IIH subunit 2-like protein K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 111974934 gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 112071921 gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 111972614 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 111974735 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 111958019 cyclin-H isoform X1 K06634 CCNH; cyclin H
E 111973712 cyclin-H-like K06634 CCNH; cyclin H
E 111963338 mnat1; CDK-activating kinase assembly factor MAT1 isoform X1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
E 111968663 CDK-activating kinase assembly factor MAT1-like isoform X1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 111958671 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111982657 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111955910 replication protein A 32 kDa subunit-A isoform X1 K10739 RFA2; replication factor A2
E 111965214 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111958742 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111955161 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 111955938 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 111971590 LOW QUALITY PROTEIN: DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 111958293 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 112068282 LOW QUALITY PROTEIN: DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 112074083 ercc1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 111967912 ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 111975092 LOW QUALITY PROTEIN: DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 111967730 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 111978703 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 111979235 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 111982838 cullin-3 K03869 CUL3; cullin 3
E 111960619 cullin-3 isoform X2 K03869 CUL3; cullin 3
E 111949487 cullin-5 K10612 CUL5; cullin 5
E 112072674 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 111980579 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 111950661 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 112072668 elongin-C-like K03872 ELOC; elongin-C
E 112075996 elongin-C K03872 ELOC; elongin-C
E 111980434 elongin-B K03873 ELOB; elongin-B
E 111977673 elongin-B-like K03873 ELOB; elongin-B
E 112075686 elongin-B-like K03873 ELOB; elongin-B
E 111955985 elongin-A K15076 ELOA; elongin-A
E 111968103 elongin-A isoform X1 K15076 ELOA; elongin-A
E 112080540 elongin-A-like isoform X1 K15076 ELOA; elongin-A
E 111970419 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 111957473 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 111962711 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 111973886 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 111967793 msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 111974598 msh3; LOW QUALITY PROTEIN: DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 111968060 msh6; LOW QUALITY PROTEIN: DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 112070426 pms1; PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 111951949 mlh1; DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 111967949 pms2; mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 111963281 mlh3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 112074650 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 111958053 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 111950751 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 112080848 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 111958671 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111982657 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111955910 replication protein A 32 kDa subunit-A isoform X1 K10739 RFA2; replication factor A2
E 111965214 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111958742 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111955161 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 111955938 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 111950408 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 111975599 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 111972217 LOW QUALITY PROTEIN: replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
E 111957520 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 111974502 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111957517 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111951786 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 112078642 high mobility group-T protein K10802 HMGB1; high mobility group protein B1
E 111964455 high mobility group-T protein isoform X1 K10802 HMGB1; high mobility group protein B1
E 111949578 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 111975092 LOW QUALITY PROTEIN: DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 111969542 LOW QUALITY PROTEIN: WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 112071176 mre11; LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111980702 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 111964810 nbn; LOW QUALITY PROTEIN: nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 111977731 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 111959807 bard1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 111977731 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 111981299 BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 111962832 BRCA1-A complex subunit Abraxas 1-like K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 111950586 BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 111980744 BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 112072341 babam1; LOW QUALITY PROTEIN: BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 112068334 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 112068772 babam2; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 111964149 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 111950548 lys-63-specific deubiquitinase BRCC36 isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 111977731 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 111949483 brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 111953403 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 111973211 DNA topoisomerase 2-binding protein 1-A isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 111977731 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 111953493 rbbp8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 112071176 mre11; LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111980702 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 111964810 nbn; LOW QUALITY PROTEIN: nibrin K10867 NBN; nibrin
D BRCA complex
E 111977731 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 111960628 brca2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 111973380 LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
E 111954551 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 111973380 LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
E 111954551 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 111954496 rad51b; DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 111950562 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 111950256 rad51d; DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 112080151 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 111953303 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 111954529 xrcc3; DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 112069650 rad52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 111982082 rdm1; RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 111976145 rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 111977012 helicase ARIP4-like K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 112070378 helicase ARIP4-like K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 112070395 helicase ARIP4-like K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 111966287 helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 111970732 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 112075427 rad54b; LOW QUALITY PROTEIN: DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 111951399 recql; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 111951129 ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 111961934 wrn; Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 111962427 blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 112081027 ATP-dependent DNA helicase Q4-like isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 111980319 ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
E 112070684 ATP-dependent DNA helicase Q5-like isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 111962427 blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111949896 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111974189 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 111980513 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
E 111981071 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
E 111981434 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 111958671 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111982657 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111955910 replication protein A 32 kDa subunit-A isoform X1 K10739 RFA2; replication factor A2
E 111965214 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111958742 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111955161 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 111955938 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 111982020 serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 111971470 serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 111961655 serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 111953406 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 111972779 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 111966598 serine/threonine-protein phosphatase 4 regulatory subunit 2-A K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 111969845 serine/threonine-protein phosphatase 4 regulatory subunit 2-B K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 111976481 serine/threonine-protein phosphatase 4 regulatory subunit 2-A K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 111969517 serine/threonine-protein phosphatase 4 regulatory subunit 2-B isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 111978176 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 111952045 ppp4r3b; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 112068543 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 3-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 111972482 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 111954254 ppp4r4; serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 111967386 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 111963308 AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
D SMC5-SMC6 complex
E 111961642 smc5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 111963546 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 111973422 smc6; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 112074886 protein FAM84A-like K22805 FAM84A; protein FAM84A
E 112077169 protein FAM84A-like K22805 FAM84A; protein FAM84A
E 111981714 non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 111979923 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 111957727 slf1; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 111977786 uncharacterized protein LOC111977786 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
E 111968083 serine/arginine repetitive matrix protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 111978330 eme1; crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 112076611 exd2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 112072896 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 112076423 mus81; LOW QUALITY PROTEIN: crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 111955298 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 112068413 sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 111961264 swi5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 111951967 sfr1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 111960077 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 112077014 structure-specific endonuclease subunit SLX4-like K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 111973423 gen1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 111962086 spg11; spatacsin isoform X1 K19026 SPG11; spatacsin
E 111949380 RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 111962625 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1-like K20778 RAD51AP1; RAD51-associated protein 1
E 111951262 RAD51-associated protein 1-like isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 111956402 LOW QUALITY PROTEIN: mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 111976926 samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 111977768 fignl1; fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 111952081 fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 111979267 spidr; DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein
E 112079969 protein FAM84B-like K22810 FAM84B; protein FAM84B
E 112078024 brat1; BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 112076272 cunh21orf2; protein C21orf2 K23456 CFAP410; cilla- and flagella-associated protein
E 111975677 hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 111972128 hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 111981785 zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 111980986 ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 111950412 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 111980801 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 112077336 hsf2bp; LOW QUALITY PROTEIN: heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 111958875 mms22l; protein MMS22-like K26125 MMS22L; protein MMS22-like
E 112068094 tonsl; tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 111965914 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 111951501 LOW QUALITY PROTEIN: PCNA-interacting partner-like isoform X1 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 111967893 X-ray repair cross-complementing protein 5 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 111977744 X-ray repair cross-complementing protein 5 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 112077365 xrcc5; LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 111972800 prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 112071176 mre11; LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111980702 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 111953692 DNA ligase 4-like K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 111971045 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 111974165 DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 111963882 xrcc4; DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 112073392 nhej1; non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 112073878 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 111960904 LOW QUALITY PROTEIN: DNA-directed DNA/RNA polymerase mu-like K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 111977656 DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 111951682 DNA nucleotidylexotransferase-like K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 111974593 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 111975108 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 112080817 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111951695 dclre1c; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 112076584 tdp2; LOW QUALITY PROTEIN: tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 111965040 tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 111950283 tyrosyl-DNA phosphodiesterase 2-like K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 111953281 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 111956469 PWWP domain-containing protein MUM1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 111979463 PWWP domain-containing protein MUM1 isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 111976066 PWWP domain-containing protein MUM1 isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 111975014 protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 111957476 protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 111973762 uncharacterized protein LOC111973762 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 112074220 jmjd8; jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 112080802 fam35a; protein FAM35A isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 111974932 uncharacterized protein FLJ26957 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 111962308 fanca; Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 111959906 fancb; Fanconi anemia group B protein isoform X1 K10889 FANCB; fanconi anemia group B protein
E 111974364 fancc; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 111966844 fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 112068472 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 111973831 fancg; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 111951628 fancl; E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 112080452 fancm; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 111962691 faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 111967960 faap100; Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 111978856 transcription factor HES-1-B-like K06054 HES1; hairy and enhancer of split 1
E 112068442 transcription factor HES-4-B-like K06054 HES1; hairy and enhancer of split 1
E 111966415 transcription factor HES-4-B isoform X1 K06054 HES1; hairy and enhancer of split 1
E 111957049 transcription factor HES-1-A-like K06054 HES1; hairy and enhancer of split 1
E 111953081 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 111975857 transcription factor HES-1-B K06054 HES1; hairy and enhancer of split 1
E 111970154 centromere protein S-like K11511 APITD1; centromere protein S
E 112074957 ube2t; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 111962427 blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111949896 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111974189 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 111980513 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
E 111981071 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
E 111981434 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 111966436 fancd2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 111962480 fanci; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 111977731 brca1; breast cancer type 1 susceptibility protein isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 111960628 brca2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 111949483 brip1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 112068489 fan1; LOW QUALITY PROTEIN: fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 111973380 LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
E 111954551 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 111950562 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 111976966 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 111971234 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 112080674 ubiquitin carboxyl-terminal hydrolase 1-like isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 111953560 wdr48; WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
E 112073458 WD repeat-containing protein 48-like isoform X1 K15361 WDR48; WD repeat-containing protein 48
E 111973054 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 111963769 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 111974198 serine/threonine-protein phosphatase 6 catalytic subunit-like K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 112080616 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 111957669 serine/threonine-protein phosphatase 6 catalytic subunit isoform X1 K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 111951395 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 111962542 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 111952728 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 111949529 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 2-like isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 111952404 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 111962252 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 111976904 ankrd44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 111959504 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 111970233 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
E 111965184 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
E 111966709 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
E 111977099 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 111954463 rnf8; E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 111949638 rnf168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 111960625 E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 111949494 E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
D Others
E 111953400 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 112069797 LOW QUALITY PROTEIN: telomerase Cajal body protein 1-like K23314 WRAP53; telomerase Cajal body protein 1
E 111961633 taperin-like K24164 TPRN; taperin
E 111963999 taperin K24164 TPRN; taperin
E 111961442 LOW QUALITY PROTEIN: WD repeat-containing protein 70-like K24752 WDR70; WD repeat-containing protein 70
E 111969542 LOW QUALITY PROTEIN: WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 111951899 polh; DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 111974509 DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 111958249 polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 111959590 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
D 111971818 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 112068186 DNA polymerase zeta catalytic subunit-like isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 111954145 LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 111980525 poln; LOW QUALITY PROTEIN: DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 111959595 ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 111979280 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 111967628 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 111965878 ube2a; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 111981901 ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 112069676 ubiquitin-conjugating enzyme E2 B-like isoform X1 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 111970134 E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 111966369 E3 ubiquitin-protein ligase RAD18-like isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 111967994 hltf; helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 111976476 ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111979191 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111970474 ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111956539 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111966693 ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111962032 ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111962492 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 111952597 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 111981871 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 111981880 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 111974502 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 111957517 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 111951501 LOW QUALITY PROTEIN: PCNA-interacting partner-like isoform X1 K27412 PARPBP; PCNA-interacting partner
D 111973363 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 112073417 protein piccolo-like K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 111965744 rad9a; cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 111957695 rad9b; cell cycle checkpoint control protein RAD9B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 111953892 hus1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 111980942 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 112068937 rad17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 111950408 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 111975599 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 111972217 LOW QUALITY PROTEIN: replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 111957520 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 111980942 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 111965549 timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 112079653 tipin; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 111955980 claspin isoform X1 K25773 CLSPN; claspin
D 111955237 claspin-like isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 111976966 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 111976721 tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 111974072 tti2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 111955023 LOW QUALITY PROTEIN: large proline-rich protein BAG6-like K23390 BAG6; large proline-rich protein BAG6
D 111956131 large proline-rich protein BAG6-like isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 111958785 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 111965158 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 111975139 ubiquitin-like protein 4A-A K23388 UBL4; ubiquitin-like protein 4
D 111957489 ubiquitin-like protein 4A-B K23388 UBL4; ubiquitin-like protein 4
D 111967729 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
D 111978097 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 112075769 LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 111958113 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 111954968 cellular tumor antigen p53 isoform X1 K04451 TP53; tumor protein p53
D 111960314 cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 111950504 cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 112078987 chek1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 111974924 serine/threonine-protein kinase Chk2-like isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 111957639 serine/threonine-protein kinase Chk2-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 112075629 M-phase inducer phosphatase 1-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 112074015 LOW QUALITY PROTEIN: M-phase inducer phosphatase 1-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 111964299 M-phase inducer phosphatase 1-B isoform X1 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 111961416 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111976607 14-3-3 protein beta/alpha-2 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111954322 14-3-3 protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111968887 14-3-3 protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111966164 14-3-3 protein beta/alpha-2 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111973241 14-3-3 protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111963104 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111969654 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 112070312 14-3-3 protein gamma-1-like K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 111964098 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 111961526 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 112080497 14-3-3 protein gamma-2-like K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 111980742 14-3-3 protein gamma-1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 111949457 14-3-3 protein gamma-2 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 111949377 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 111950376 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 111980334 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 111960497 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 111974302 LOW QUALITY PROTEIN: neuron navigator 2-like K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 111962127 wee1-like protein kinase 1-B K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 111971924 wee1-like protein kinase 1-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 111969505 LOW QUALITY PROTEIN: wee1-like protein kinase 1-A isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 111962613 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 111964140 period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 111950178 period circadian protein homolog 1 K21944 PER1; period circadian protein 1
D 112069870 period circadian protein homolog 1-like isoform X1 K21944 PER1; period circadian protein 1
D 111979352 LOW QUALITY PROTEIN: period circadian protein homolog 2-like K02633 PER2; period circadian protein 2
D 111957278 LOW QUALITY PROTEIN: period circadian protein homolog 2-like K02633 PER2; period circadian protein 2
D 111970583 per3; LOW QUALITY PROTEIN: period circadian protein homolog 3 K21945 PER3; period circadian protein 3
D 111964959 mediator of DNA damage checkpoint protein 1-like K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 111950166 plastin-3 K17336 PLS3; plastin-3
D 111980301 plastin-3-like K17336 PLS3; plastin-3
D 111962099 apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 111972048 LOW QUALITY PROTEIN: apoptosis-enhancing nuclease-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 111956832 serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 111956843 serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 111969961 nek4; serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 111975637 LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek1-like K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 111968081 serine/threonine-protein kinase Nek4-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 111959724 serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 111958675 LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek10-like K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 112077224 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 111957305 LOW QUALITY PROTEIN: protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 111980451 KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111957179 KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111961829 KN motif and ankyrin repeat domain-containing protein 1-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 112070670 zinc finger CCCH domain-containing protein 14-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111975488 KN motif and ankyrin repeat domain-containing protein 1-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111952633 KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111978900 KN motif and ankyrin repeat domain-containing protein 2-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 112070243 KN motif and ankyrin repeat domain-containing protein 2-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 112074315 KN motif and ankyrin repeat domain-containing protein 1-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111971374 KN motif and ankyrin repeat domain-containing protein 4-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111975565 KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111953557 charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 111979228 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111962305 vacuolar protein sorting-associated protein 4A isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111975638 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111972171 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111952946 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111968786 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 111961003 sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 111980308 LOW QUALITY PROTEIN: myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 111951142 mybbp1a; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 111971529 primpol; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 111976273 dclre1a; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 112071892 dclre1b; LOW QUALITY PROTEIN: 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 111982524 exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 111950086 exonuclease V-like isoform X1 K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 111982447 endov; endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 111952862 ankle1; ankyrin repeat and LEM domain-containing protein 1 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 111961403 helq; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 111973779 ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 111967406 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 111971646 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 111965628 pre-mRNA-processing factor 19 isoform X1 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 112068277 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 111968625 cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 111966510 bcas2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 111977147 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 112079216 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
D 111958465 LOW QUALITY PROTEIN: pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 111981419 nudt1; 7,8-dihydro-8-oxoguanine triphosphatase isoform X1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 111973665 nudt18; 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 112078471 dut; LOW QUALITY PROTEIN: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 111980701 ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111950589 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111954357 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 111972586 rrm2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111952028 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 111979718 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 111957980 ung; uracil-DNA glycosylase isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111970180 smug1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 112070258 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 111981121 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 111976058 mutyh; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 112078805 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E 112078093 LOW QUALITY PROTEIN: endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 111951323 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
E 111951325 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 111951323 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
D 111951325 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 112078471 dut; LOW QUALITY PROTEIN: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024