+C	Peptidoglycan biosynthesis and degradation proteins	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Peptidoglycan Biosynthesis and Degradation Proteins - Staphylococcus aureus subsp. aureus MW2 (CA-MRSA)</h2>
%<!-- w=600, -->
!
A<b>Precursor biosynthesis</b>
B  Transferase/Dehydrogenase
C    MW2024 murA; UDP-N-acetylglucosamine 1-carboxyvinyl transferase 1	K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] 
C    MW2048 murZ; UDP-N-acetylglucosamine 1-carboxylvinyl transferase 2	K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] 
C    MW0700 ORFID:MW0700; hypothetical protein, similar to UDP-N-acetylenolpyruvoylglucosamine reductase	K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] 
B  Amino acid ligase
C    MW1683 murC; UDP-N-Aacerylmuramate-alanine ligase	K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] 
C    MW1066 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase	K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] 
C    MW0899 murE; UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase	K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] 
C    MW2006 ddlA; D-alanine-D-alanine ligase	K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] 
C    MW2180 fmhB; FmhB protein	K11693 femX; peptidoglycan pentaglycine glycine transferase (the first glycine) [EC:2.3.2.16] 
C    MW1261 femA; factor essential for expression of methicillin resistance	K11694 femA; peptidoglycan pentaglycine glycine transferase (the second and third glycine) [EC:2.3.2.17] 
C    MW1262 femB; FemB protein	K11695 femB; peptidoglycan pentaglycine glycine transferase (the fourth and fifth glycine) [EC:2.3.2.18] 
B  Racemase
C    MW1994 alr; alanine racemase	K01775 alr; alanine racemase [EC:5.1.1.1] 
C    MW1287 ORFID:MW1287; hypothetical protein, similar to alanine racemase	K01775 alr; alanine racemase [EC:5.1.1.1] 
C    MW1033 murI; glutamate racemase	K01776 murI; glutamate racemase [EC:5.1.1.3] 
B  Carboxypeptidase
B  Glycosyltransferase
C    MW1065 mraY; phospho-N-muramic acid-pentapeptide translocase	K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] 
C    MW1307 murG; undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase	K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] 
B  Diphosphatase
C    MW0645 bacA; ORFID:MW0645; bacitracin resistance protein (putative undecaprenol kinase) homologue	K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] 
C    MW1306 conserved hypothetcial protein	K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] 
B  Flippase
#
A<b>Peptidoglycan biosynthesis and degradation</b>
B  Glycosyltransferase/DD-Transpeptidase (Class A PBP)
C    MW1340 pbp2; PBP2	K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] 
B  DD-Transpeptidase (Class B PBP)
C    MW0031 mecA; penicillin binding protein 2 prime	K02545 mecA; penicillin-binding protein 2 prime [EC:3.4.16.4] 
C    MW1064 pbpA; penicillin-binding protein 1	K12552 pbpA; penicillin-binding protein 1 [EC:3.4.-.-] 
C    MW1504 pbp3; penicillin-binding protein 3	K12553 pbp3; penicillin-binding protein 3 [EC:3.4.-.-] 
B  DD-Carboxypeptidase/DD-Endopeptidase (Low molecular weight PBP)
C    MW0604 pbp4; penicillin binding protein 4	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
B  Glycosyltransferase
C    MW1672 sgtA; probable transglycosylase	K12551 sgtA; monofunctional glycosyltransferase [EC:2.4.99.28] 
C    MW1814 sgtB; ORFID:MW1814; hypothetical protein, similar to penicillin-binding protein 1A/1B	K04478 sgtB; monofunctional glycosyltransferase [EC:2.4.99.28] 
B  Transpeptidase
B  Carboxypeptidase
B  Endopeptidase
C    MW0188 ORFID:MW0188; hypothetical protein, similar to lysostaphin precursor	K21472 lytH; peptidoglycan LD-endopeptidase LytH [EC:3.4.-.-] 
C    MW0252 lytM; peptidoglycan hydrolase	K08259 lytM; lysostaphin [EC:3.4.24.75] 
B  Sortase
C    MW2448 srtA; sortase	K07284 srtA; sortase A [EC:3.4.22.70] 
C    MW1017 srtB; NPQTN specific sortase B	K08600 srtB; sortase B [EC:3.4.22.71] 
B  Lytic transglycosylase
B  Amidase
C    MW1582 N-acetylmuramoyl-L-alanine amidase	K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 
B  Structural protein
!
#<hr>
#[ <a href="/kegg/brite.html">BRITE</a> | <a href="/kegg/kegg2.html">KEGG2</a> | <a href="/kegg/">KEGG</a> ]<br>
#Last updated: January 30, 2024