+C Two-component system KO
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Two-Component System - Sandaracinus amylolyticus
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C DB32_002045 Phosphate regulon sensor protein PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C DB32_003164 Phosphate regulon sensor protein PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C DB32_002046 Phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
C DB32_005812 PAS/PAC sensor hybrid histidine kinase K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
C DB32_001093 histidine kinase K07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3]
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
C DB32_007363 DNA-binding response regulator K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
C DB32_002056 Copper-sensing two-component system response regulator CpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
C DB32_003266 Two-component sensor histidine kinase K14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]
C DB32_000191 DNA-binding response regulator ChvI K14981 chvI; two-component system, OmpR family, response regulator ChvI
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C DB32_000192 Phosphate regulon sensor protein PhoR K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C DB32_002057 Copper sensory histidine kinase CpxA K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C DB32_004615 Phosphate regulon sensor protein PhoR K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C DB32_005646 histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C DB32_008391 Osmosensitive K+ channel histidine kinase KdpD K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C DB32_008901 periplasmic sensor signal transduction histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C DB32_003267 two-component response regulator K02483 K02483; two-component system, OmpR family, response regulator
C DB32_003580 Phosphate regulon transcriptional regulatory protein PhoB K02483 K02483; two-component system, OmpR family, response regulator
C DB32_004633 DNA-binding heavy metal response regulator K02483 K02483; two-component system, OmpR family, response regulator
C DB32_004668 response regulator K02483 K02483; two-component system, OmpR family, response regulator
C DB32_005134 Histidine kinase K02483 K02483; two-component system, OmpR family, response regulator
C DB32_005773 hypothetical protein K02483 K02483; two-component system, OmpR family, response regulator
C DB32_007936 Chemotaxis protein methyltransferase CheR K02483 K02483; two-component system, OmpR family, response regulator
C DB32_008036 Chemotaxis regulator K02483 K02483; two-component system, OmpR family, response regulator
C DB32_008900 Phosphate regulon transcriptional regulatory protein PhoB K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
C DB32_001369 DNA-binding response regulator, LuxR family K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
C DB32_006464 Sensor histidine kinase K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B BtsS-BtsR (pyruvate reutilization)
B PyrS-PyrR (pyruvate reutilization)
B Unclassified
C DB32_002595 two-component response regulator K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C DB32_002179 Flagellar sensor histidine kinase FleS K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]
C DB32_002176 Response regulator of zinc sigma-54-dependent two-component system K07713 zraR; two-component system, NtrC family, response regulator HydG
C DB32_004535 Response regulator of zinc sigma-54-dependent two-component system K07713 zraR; two-component system, NtrC family, response regulator HydG
C DB32_006400 two component, sigma54 specific, transcriptional regulator, Fis family K07713 zraR; two-component system, NtrC family, response regulator HydG
C DB32_006510 Response regulator of zinc sigma-54-dependent two-component system K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
C DB32_000585 Nitrogen regulation protein NtrX K07714 atoC; two-component system, NtrC family, response regulator AtoC
C DB32_001349 Sigma-54 dependent transcriptional regulator K07714 atoC; two-component system, NtrC family, response regulator AtoC
C DB32_005424 Type IV fimbriae expression regulatory protein PilR K07714 atoC; two-component system, NtrC family, response regulator AtoC
C DB32_005661 Response regulator of zinc sigma-54-dependent two-component system K07714 atoC; two-component system, NtrC family, response regulator AtoC
C DB32_006463 Response regulator of zinc sigma-54-dependent two-component system K07714 atoC; two-component system, NtrC family, response regulator AtoC
C DB32_006607 Response regulator of zinc sigma-54-dependent two-component system K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
C DB32_004292 Sensor histidine kinase K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C DB32_004030 Response regulator of zinc sigma-54-dependent two-component system K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
C DB32_008684 Osmosensitive K+ channel histidine kinase KdpD K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C DB32_008685 Response regulator of zinc sigma-54-dependent two-component system K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C DB32_005727 sensory box sensor histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C DB32_001902 Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C DB32_003137 Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C DB32_004454 Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C DB32_004503 Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C DB32_005718 Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C DB32_003949 Chemotaxis protein methyltransferase CheR K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C DB32_004502 Chemotaxis regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C DB32_005711 Chemotaxis regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C DB32_005719 Chemotaxis regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C DB32_008028 Hypothetical protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C DB32_001901 Chemotaxis response regulator protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C DB32_003138 Chemotaxis response regulator protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C DB32_004453 Chemotaxis response regulator protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C DB32_004508 Chemotaxis response regulator protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C DB32_005713 Chemotaxis response regulator protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
C DB32_001364 Two-component response regulator K11443 divK; two-component system, cell cycle response regulator DivK
C DB32_007344 Signal transduction response regulator K11443 divK; two-component system, cell cycle response regulator DivK
B CckA-CtrA/CpdR (cell cycle control)
C DB32_000316 sensory box histidine kinase/response regulator K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
C DB32_000953 sensory box histidine kinase/response regulator K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
C DB32_007075 sensory box histidine kinase/response regulator K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
C DB32_007274 sensory box histidine kinase/response regulator K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C DB32_007247 Sensor histidine kinase PrrB (RegB) K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C DB32_007246 Dna binding response regulator PrrA K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C DB32_003139 Sensor histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: October 8, 2024