+C	Peptidoglycan biosynthesis and degradation proteins	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Peptidoglycan Biosynthesis and Degradation Proteins - Staphylococcus aureus subsp. aureus ST228/15532 (MRSA)</h2>
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A<b>Precursor biosynthesis</b>
B  Transferase/Dehydrogenase
C    SAI3T3_1015470 murA1; UDP-N-acetylglucosamine=1-carboxyvinyltransferase1	K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] 
C    SAI3T3_1015640 murZ; UDP-N-acetylglucosamine=1-carboxyvinyltransferase2	K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] 
C    SAI3T3_1005740 murB; UDP-N-acetylenolpyruvoylglucosamine reductase	K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] 
B  Amino acid ligase
C    SAI3T3_1012770 murC; UDP-N-acetylmuramate--L-alanine ligase	K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] 
C    SAI3T3_1008400 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase	K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] 
C    SAI3T3_1007210 UDP-N-acetylmuramyl-tripeptide synthetase	K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] 
C    SAI3T3_1015360 ddl; D-alanine--D-alanine ligase	K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] 
C    SAI3T3_1016700 Methicillin resistance protein	K11693 femX; peptidoglycan pentaglycine glycine transferase (the first glycine) [EC:2.3.2.16] 
C    SAI3T3_1009900 Factor essential for expression of methicillin resistance	K11694 femA; peptidoglycan pentaglycine glycine transferase (the second and third glycine) [EC:2.3.2.17] 
C    SAI3T3_1009910 femB; Glycine interpeptide bridge formation protein FemB	K11695 femB; peptidoglycan pentaglycine glycine transferase (the fourth and fifth glycine) [EC:2.3.2.18] 
B  Racemase
C    SAI3T3_1010130 alr1; Alanine racemase 1	K01775 alr; alanine racemase [EC:5.1.1.1] 
C    SAI3T3_1015240 alr; Alanine racemase	K01775 alr; alanine racemase [EC:5.1.1.1] 
C    SAI3T3_1008200 murI; Glutamate racemase	K01776 murI; glutamate racemase [EC:5.1.1.3] 
B  Carboxypeptidase
B  Glycosyltransferase
C    SAI3T3_1008390 mraY; Phospho-N-acetylmuramoyl-pentapeptide-transferase	K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] 
C    SAI3T3_1010260 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] 
B  Diphosphatase
C    SAI3T3_1005300 uppP; Undecaprenyl-diphosphatase	K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] 
B  Flippase
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A<b>Peptidoglycan biosynthesis and degradation</b>
B  Glycosyltransferase/DD-Transpeptidase (Class A PBP)
C    SAI3T3_1010470 pbp2; Glycosyl transferase, family 51	K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] 
B  DD-Transpeptidase (Class B PBP)
C    SAI3T3_1000270 mecA; Penicillin-binding protein 2 prime	K02545 mecA; penicillin-binding protein 2 prime [EC:3.4.16.4] 
C    SAI3T3_1008380 pbpA; Penicillin-binding protein 1	K12552 pbpA; penicillin-binding protein 1 [EC:3.4.-.-] 
C    SAI3T3_1011250 pbp3; Penicillin-binding protein 3	K12553 pbp3; penicillin-binding protein 3 [EC:3.4.-.-] 
B  DD-Carboxypeptidase/DD-Endopeptidase (Low molecular weight PBP)
C    SAI3T3_1004960 pbp4; Penicillin binding protein 4	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
B  Glycosyltransferase
C    SAI3T3_1012670 sgtA; Probable transglycosylase	K12551 sgtA; monofunctional glycosyltransferase [EC:2.4.99.28] 
C    SAI3T3_1014190 Putative Monofunctional biosynthetic peptidoglycan transglycosylase	K04478 sgtB; monofunctional glycosyltransferase [EC:2.4.99.28] 
C    SAI3T3_1007920 Cell cycle protein	K03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28] 
C    SAI3T3_1015370 Rod shape determining protein RodA	K05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28] 
B  Transpeptidase
B  Carboxypeptidase
B  Endopeptidase
C    SAI3T3_1001590 M23 family peptidase	K21472 lytH; peptidoglycan LD-endopeptidase LytH [EC:3.4.-.-] 
C    SAI3T3_1002140 lytM; M23 family lysostaphin	K08259 lytM; lysostaphin [EC:3.4.24.75] 
B  Sortase
C    SAI3T3_1018830 srtA; Sortase	K07284 srtA; sortase A [EC:3.4.22.70] 
C    SAI3T3_1008080 NPQTN specific sortase B	K08600 srtB; sortase B [EC:3.4.22.71] 
B  Lytic transglycosylase
B  Amidase
C    SAI3T3_1011850 lytH; Probable cell wall amidase LytH	K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 
B  Structural protein
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#Last updated: May 15, 2025