+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptomyces coelicolor
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
E SCO6275 SC1G7.01c; type I polyketide synthase K23365 cpkA; 5-hydroxydodecatetraenal polyketide synthase CpkA [EC:2.3.1.281]
E SCO6274 SC2C4.04c; type I polyketide synthase K23366 cpkB; 5-hydroxydodecatetraenal polyketide synthase CpkB [EC:2.3.1.281]
E SCO6273 SC2C4.03c; type I polyketide synthase K23367 cpkC; 5-hydroxydodecatetraenal polyketide synthase CpkC [EC:2.3.1.281]
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E SCO5318 SC6G9.15; polyketide beta-ketoacyl synthase alpha K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
E SCO5317 SC6G9.16; polyketide beta-ketoacyl synthase beta K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
E SCO5316 SC6G9.17; acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein
E SCO5315 SC6G9.18; polyketide cyclase K14670 whiEVI; aromatase
E SCO5314 SC6G9.19; whiE protein VII K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E SCO5087 actIORF1; actinorhodin polyketide beta-ketoacyl synthase subunit alpha K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SCO5088 actIORF2; actinorhodin polyketide beta-ketoacyl synthase subunit beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SCO5089 actIORF3; actinorhodin polyketide synthase K05553 actI3; minimal PKS acyl carrier protein
E SCO1272 2SCG18.19c; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E SCO5086 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E SCO5090 actVII; actinorhodin polyketide synthase bifunctional cyclase/dehydratase K05554 actVII; aromatase [EC:4.2.1.-]
E SCO5091 actIV; cyclase K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E SCO5087 actIORF1; actinorhodin polyketide beta-ketoacyl synthase subunit alpha K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SCO5088 actIORF2; actinorhodin polyketide beta-ketoacyl synthase subunit beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SCO5089 actIORF3; actinorhodin polyketide synthase K05553 actI3; minimal PKS acyl carrier protein
E SCO1272 2SCG18.19c; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E SCO5086 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-]
D Decaketide PKS
E SCO5087 actIORF1; actinorhodin polyketide beta-ketoacyl synthase subunit alpha K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SCO5088 actIORF2; actinorhodin polyketide beta-ketoacyl synthase subunit beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E SCO5089 actIORF3; actinorhodin polyketide synthase K05553 actI3; minimal PKS acyl carrier protein
E SCO1272 2SCG18.19c; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E SCO5086 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-]
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D SCO1206 2SCG58.06; 1,3,6,8-tetrahydroxynaphthalene synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]
D SCO7221 SC2H12.20c; polyketide synthase K16232 gcs; germicidin synthase
D SCO7671 SC4C2.06c; transferase K16167 bpsA; alkylresorcinol/alkylpyrone synthase
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D SCO3218 SCE8.11c; hypothetical protein K05375 mbtH; MbtH protein
D SCO0489 SCF34.08c; hypothetical protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D SCO6673 SC5A7.23; hypothetical protein K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]
D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Bacillibactin synthetase
D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
D SCO7683 SC4C2.18; non-ribosomal peptide synthase K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69]
C Mycobactin synthetase
C Vibriobactin synthetase
D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D SCO7681 SC4C2.16c; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
B Ketoreductase
C SCO5072 SCBAC20F6.15; hydroxylacyl-CoA dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]
B Oxygenase
C SCO5080 actVA5; hydrolase K14630 actVA5; two-component flavin-dependent monooxygenase [EC:1.14.14.-]
C SCO5081 actVA6; hypothetical protein K14632 actVA6; C-6 monooxygenase
C SCO7417 SC6D11.13c; cytochrome P450-family protein K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C SCO2884 SCE6.21; cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C SCO5319 SC6G9.14; whiE protein II K14673 whiEII; putative monooxygenase
C SCO5321 SC6G9.12c; polyketide hydroxylase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C SCO7452 SC5C11.09c; O-methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
C SCO7670 SC4C2.05c; hypothetical protein K16168 bpsB; methyltransferase
B Glycosyltransferase
B Halogenase
C SCO1275 2SCG18.22; halogenase K14257 ctcP; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]
B beta-Branched incorporating proteins
B Others
C SCO5071 SCBAC20F6.14c; hydroxylacyl-CoA dehydrogenase K14626 actVIA; actinorhodin biosynthesis protein ActVIA
C SCO5074 SCBAC20F6.17; dehydratase K14627 actVI3; dehydratase [EC:4.2.1.-]
C SCO5023 SCK15.25; hypothetical protein K14628 actVI2; enoyl reductase
C SCO5075 ORF4; oxidoreductase K14629 actVI4; enoyl reductase
C SCO5092 actVB; actinorhodin polyketide dimerase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-]
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ANonribosomal peptide tailoring proteins
B Reductase
C SCO7685 SC4C2.20; hypothetical protein K12241 pchG; pyochelin biosynthesis protein PchG
B Thioesterase
C SCO7687 SC4C2.22; thioesterase K12242 pchC; pyochelin biosynthesis protein PchC
B Oxygenase
B Glycosyltransferase
B Aminotransferase
C SCO3227 SCE63.06; aminotransferase K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]
B Others
C SCO3229 SCE63.04; 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]
C SCO3228 SCE63.05; glycolate oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: June 19, 2024