+F Repair protein KO
#
DNA Repair and Recombination Proteins - Streptomyces coelicolor
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SCO1969 SC3C9.04; putative DNA-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SCO6151 SC1A9.15; putative methylated-DNA-protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SCO6462 SC9B5.29; putative methylated-DNA-protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SCO0842 SCF43A.32; putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E SCO1114 ung; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SCO1343 ung; uracil-DNA glycosylase (EC 3.2.2.-) K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SCO1792 SCI51.32c; putative DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E SCO3355 SCE94.06; putative adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SCO3569 SCH17.03c; putative endonuclease K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D SCO3260 SCE39.10; MutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCO4143 SCD84.10c; putative mutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCO5102 SCBAC28G1.28; putative mutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCO5637 SC6A9.30c; mutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCO5868 SC2E9.09; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SCO1969 SC3C9.04; putative DNA-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SCO6151 SC1A9.15; putative methylated-DNA-protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SCO6462 SC9B5.29; putative methylated-DNA-protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SCO0842 SCF43A.32; putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D SCO0184 SCJ1.33; conserved hypothetical protein SCJ1.33 K06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13]
D SCO1040 SCG20A.20c; putative DNA repair protein K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E SCO1114 ung; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SCO1343 ung; uracil-DNA glycosylase (EC 3.2.2.-) K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SCO1255 mug; G/U mismatch-specific DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E SCO1990 SC7H2.04c; conserved hypothetical protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E SCO4495 SCD35.02; putative DNA polymerase related protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E SCO6150 SC1A9.14; putative ADA-like regulatory protein K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E SCO6461 SC9B5.28; putative ADA-like regulatory protein K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E SCO1792 SCI51.32c; putative DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E SCO3355 SCE94.06; putative adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SCO5143 tag; DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E SCO0945 SCM10.34c; putative formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SCO5573 SC7A1.17; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SCO2626 SCC80.11c; putative DNA repair hydrolase (fragment) K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SCO5760 SC7C7.15c; DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SCO3569 SCH17.03c; putative endonuclease K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E SCO3174 SCE87.25c; putative exodeoxyribonuclease (EC 3.1.11.2) (putative secreted protein) K01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]
E SCO6341 SC3A7.09; putative exonuclease K01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]
E SCO2111 SC6E10.05; putative endonuclease K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E SCO6726 SC5F2A.09; putative endonuclease K05982 nfi; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
D DNA ligase
E SCO5494 SC8D9.06; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E SCO7522 SCBAC25F8.14c; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E SCO2003 SC7H2.17c; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E SCO0918 SCM10.06; putative excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E SCO1958 uvrA; ABC excision nuclease subunit A K03701 uvrA; excinuclease ABC subunit A
E SCO1966 uvrB; ABC excision nuclease subunit B K03702 uvrB; excinuclease ABC subunit B
E SCO1953 uvrC; ABC excision nuclease subunit C K03703 uvrC; excinuclease ABC subunit C
E SCO4797 SCD63A.08; putative ATP-dependent DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCO5184 2SC3B6.08; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCO5188 2SC3B6.12; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCO2003 SC7H2.17c; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E SCO5494 SC8D9.06; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E SCO7522 SCBAC25F8.14c; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F SCO4654 SCD82.26; DNA-directed RNA polymerase beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F SCO4655 SCD82.27; DNA-directed RNA polymerase beta' chain (fragment) K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F SCO4729 SC6G4.07; DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F SCO1478 SC9C5.02c; putative DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F SCO3109 SCE41.18c; putative transcriptional-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E SCO5056 SCK7.29c; putative exoribonuclease large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E SCO5055 SCK7.28c; putative exoribonuclease K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E SCO2064 SC4G6.33c; DNA polymerase III alpha chain K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E SCP1.224c dnaE; putative DNA polymerase III, alpha chain (EC 2.7.7.7) K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E SCO3878 SCH18.15c; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E SCP1.119 dnaN; putative DNA-polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E SCO2564 SCC123.02c; putative DNA-binding protein K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E SCO3541 SCH5.03c; putative DNA polymerase K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E SCO1534 SCL2.24; putative DNA polymerase III K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SCO1827 SCI8.12; putative DNA polymerase III, epsilon chain (EC 2.7.7.7). K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SCO6084 SCBAC1A6.08; putative DNA polymerase K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SCO4067 dnaZ; DNA polymerase III subunit gamma K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E SCO5494 SC8D9.06; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E SCO7522 SCBAC25F8.14c; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E SCO4797 SCD63A.08; putative ATP-dependent DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCO5184 2SC3B6.08; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCO5188 2SC3B6.12; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCO2683 SCC61A.04c; putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E SCO3907 ssb; putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E SCO2737 SCC57A.08c; putative deoxyribonuclease. K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E SCO5769 recA; recombinase A K03553 recA; recombination protein RecA
E SCO1519 SCL2.09c; holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA
E SCO1518 SCL2.08c; holliday junction DNA helicase K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SCO1520 SCL2.10c; crossover junction endodeoxyribonuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E SCO1475 SCL6.32c; putative primosomal protein n' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E SCO1300 SCBAC36F5.11c; putative exonuclease K03546 sbcC; DNA repair protein SbcC/Rad50
E SCO1301 SCBAC36F5.12c; putative exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E SCO5769 recA; recombinase A K03553 recA; recombination protein RecA
E SCO3351 SCE94.02; putative DNA repair protein K04485 radA; DNA repair protein RadA/Sms
E SCO3876 SCH18.13c; DNA replication protein K03629 recF; DNA replication and repair protein RecF
E SCO5566 SC7A1.10; putative ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E SCO2510 SCC121.13c; conserved hypothetical protein SCC121.13c K03584 recO; DNA repair protein RecO (recombination protein O)
E SCO3618 SC66T3.29c; putative recomination protein K06187 recR; recombination protein RecR
E SCO1780 SCI51.20c; putative DNA repair protein K03631 recN; DNA repair protein RecN (Recombination protein N)
E SCO1519 SCL2.09c; holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA
E SCO1518 SCL2.08c; holliday junction DNA helicase K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SCO1520 SCL2.10c; crossover junction endodeoxyribonuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E SCO1300 SCBAC36F5.11c; putative exonuclease K03546 sbcC; DNA repair protein SbcC/Rad50
E SCO1301 SCBAC36F5.12c; putative exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E SCO0601 SCF55.25c; putative secreted protein K10979 ku; DNA end-binding protein Ku
E SCO5309 SC6G9.24c; conserved hypothetical protein K10979 ku; DNA end-binding protein Ku
E SCP1.285c putative conserved secreted protein K10979 ku; DNA end-binding protein Ku
E SCP1.68 putative conserved secreted protein K10979 ku; DNA end-binding protein Ku
E SCO5308 SC6G9.25; conserved hypothetical protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E SCO6498 SC1E6.07; conserved hypothetical protein SC1E6.07 K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E SCO7345 SC4G10.24c; probable ATP-dependent DNA ligase. K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F SCO3873 SCH18.10c; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SCO5836 SC9B10.03c; DNA gyrase-like protein K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SCO3874 SCH18.11c; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SCO5822 putative DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SCO3543 SCH5.06c; probable DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F SCO2950 SCE59.09c; DNA-binding protein Hu (hs1) K03530 hupB; DNA-binding protein HU-beta
F SCO5556 SC1C2.37; histone-like DNA binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F SCO2510 SCC121.13c; conserved hypothetical protein SCC121.13c K03584 recO; DNA repair protein RecO (recombination protein O)
F SCO3618 SC66T3.29c; putative recomination protein K06187 recR; recombination protein RecR
F SCO5494 SC8D9.06; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
F SCO7522 SCBAC25F8.14c; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F SCO4577 SCD16A.06c; putative helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SCO5815 putative ATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SCO0918 SCM10.06; putative excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F SCO1958 uvrA; ABC excision nuclease subunit A K03701 uvrA; excinuclease ABC subunit A
F SCO1966 uvrB; ABC excision nuclease subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D SCO1380 SC10A9.22c; putative DNA damage inducible protein K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D SCO5769 recA; recombinase A K03553 recA; recombination protein RecA
D SCO5803 lexA; SOS regulatory protein K01356 lexA; repressor LexA [EC:3.4.21.88]
D SCO1780 SCI51.20c; putative DNA repair protein K03631 recN; DNA repair protein RecN (Recombination protein N)
D SCO1739 SCI11.28c; putative DNA polymerase III, alpha chain K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D SCO2683 SCC61A.04c; putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D SCO3907 ssb; putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D SCO5770 SC4H8.09; RecX, putative regulatory protein K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D SCO5802 SC4H2.23; putative ATP-dependent helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D SCO5761 SC7C7.16c; putative ATP-dependent DNA helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
D SCO6640 SC4G2.14; putative ATP-dependent helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D SCO3260 SCE39.10; MutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCO4143 SCD84.10c; putative mutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCO5102 SCBAC28G1.28; putative mutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCO5637 SC6A9.30c; mutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCO1775 SCI51.15c; conserved hypothetical protein K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D SCO5868 SC2E9.09; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SCO5226 SC7E4.23c; ribonucleotide-diphosphate reductase large chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SCO5805 nrdJ; ribonucleotide reductase K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SCO5225 SC7E4.22c; ribonucleotide-diphosphate reductase small chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: July 29, 2025