+F Repair protein KO
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DNA Repair and Recombination Proteins - Staphylococcus delphini
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D NCTC12225_00874 ogt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E NCTC12225_02404 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E NCTC12225_00551 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E NCTC12225_00952 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E NCTC12225_01553 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D NCTC12225_00285 nudG; MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC12225_01208 ytkD; nucleoside triphosphatase YtkD K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D NCTC12225_00874 ogt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E NCTC12225_02404 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E NCTC12225_00551 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E NCTC12225_00952 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E NCTC12225_01347 tag; DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E NCTC12225_01321 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E NCTC12225_01553 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E NCTC12225_01450 nfo; endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E NCTC12225_01070 yorK; phage putative phosphoesterase K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E NCTC12225_01370 recJ; ssDNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E NCTC12225_00906 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E NCTC12225_01320 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E NCTC12225_02208 uvrA_1; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E NCTC12225_02209 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E NCTC12225_01890 uvrC; excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E NCTC12225_01978 helD; Helicase IV K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E NCTC12225_00905 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E NCTC12225_01320 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E NCTC12225_00906 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F NCTC12225_02449 rpoB; DNA-directed RNA polymerase beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F NCTC12225_02448 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F NCTC12225_00675 rpoA; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F NCTC12225_00765 rpoE; DNA-directed RNA polymerase subunit delta K03048 rpoE; DNA-directed RNA polymerase subunit delta
F NCTC12225_01826 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F NCTC12225_02511 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E NCTC12225_01703 mutS_2; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E NCTC12225_01892 mutS2; recombination and DNA strand exchange inhibitor protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E NCTC12225_01702 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E NCTC12225_01489 xseA; exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E NCTC12225_01490 xseB; exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E NCTC12225_01121 dnaE_1; DNA polymerase III, alpha subunit, truncation K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E NCTC12225_01122 dnaE_2; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E NCTC12225_01310 dnaE_3; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E NCTC12225_01751 polC_2; DNA polymerase III subunit alpha K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E NCTC12225_00002 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E NCTC12225_01420 holA; DNA polymerase III subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E NCTC12225_02531 dnaX_1; DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E NCTC12225_00925 polC_1; DNA polymerase III polC-type K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E NCTC12225_02540 dnaX_2; DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E NCTC12225_00906 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E NCTC12225_01978 helD; Helicase IV K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E NCTC12225_00905 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E NCTC12225_02671 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E NCTC12225_00798 ssbB; ssDNA-binding protein K03111 ssb; single-strand DNA-binding protein
E NCTC12225_00035 fokIM_1; modification methylase FokI K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E NCTC12225_01679 Site-specific DNA methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E NCTC12225_01391 recD_2; RecD/TraA family helicase K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E NCTC12225_01715 recA; protein RecA K03553 recA; recombination protein RecA
E NCTC12225_01364 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E NCTC12225_01365 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E NCTC12225_01824 priA; primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E NCTC12225_01634 sbcC; exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E NCTC12225_01635 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E NCTC12225_01715 recA; protein RecA K03553 recA; recombination protein RecA
E NCTC12225_02469 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E NCTC12225_00005 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E NCTC12225_01805 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E NCTC12225_01070 yorK; phage putative phosphoesterase K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E NCTC12225_01370 recJ; ssDNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E NCTC12225_01440 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E NCTC12225_02538 recR; Recombination protein RecR K06187 recR; recombination protein RecR
E NCTC12225_01494 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E NCTC12225_01557 recU; recombination protein U K03700 recU; recombination protein U
E NCTC12225_01364 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E NCTC12225_01365 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D AddAB pathway proteins
E NCTC12225_02098 rexA; exonuclease RexA K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E NCTC12225_02099 rexB; exonuclease RexB K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
E NCTC12225_00074 cas1_1; Cas1 family protein K15342 cas1; CRISP-associated protein Cas1
E NCTC12225_00696 cas1_2; CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E NCTC12225_01634 sbcC; exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E NCTC12225_01635 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F NCTC12225_00007 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F NCTC12225_00006 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F NCTC12225_01766 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F NCTC12225_01040 phage DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
F NCTC12225_01534 hu; DNA-binding protein II HBsu K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F NCTC12225_01070 yorK; phage putative phosphoesterase K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F NCTC12225_01370 recJ; ssDNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F NCTC12225_01440 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F NCTC12225_02538 recR; Recombination protein RecR K06187 recR; recombination protein RecR
F NCTC12225_00906 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F NCTC12225_02243 recQ2; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F NCTC12225_01525 recQ1; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F NCTC12225_02208 uvrA_1; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F NCTC12225_02209 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D NCTC12225_00924 dinB; DNA-directed DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D NCTC12225_01616 umuC; DNA-damage repair protein K03502 umuC; DNA polymerase V
C Other SOS response factors
D NCTC12225_01715 recA; protein RecA K03553 recA; recombination protein RecA
D NCTC12225_01641 lexA; SOS regulatory protein LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D NCTC12225_01494 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D NCTC12225_02671 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D NCTC12225_00798 ssbB; ssDNA-binding protein K03111 ssb; single-strand DNA-binding protein
D NCTC12225_00947 recX; regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
D NCTC12225_01893 polX; DNA-dependent DNA polymerase beta chain K02347 polX; DNA polymerase (family X)
C DNA helicases
D NCTC12225_01550 dinG; DnaQ family exonuclease/DinG family helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D NCTC12225_00285 nudG; MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC12225_01208 ytkD; nucleoside triphosphatase YtkD K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC12225_02232 nrdE_2; ribonucleoside-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D NCTC12225_01147 nrdE_1; ribonucleoside-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D NCTC12225_02231 nrdF; ribonucleoside-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D NCTC12225_01148 nrdF1; ribonucleoside-diphosphate reductase subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D NCTC12225_01309 nrnA; DHH subfamily phosphodiesterase K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024