+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces drozdowiczii

% ! APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E NEH16_29480 ketosynthase chain-length factor K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E NEH16_29485 acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E NEH16_29495 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E NEH16_32495 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_30130 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_32490 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_30125 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E NEH16_32485 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E NEH16_30120 fabG; 3-oxoacyl-ACP reductase FabG K12420 actIII; ketoreductase [EC:1.1.1.-] E NEH16_32460 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] E NEH16_32480 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E NEH16_32495 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_30130 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_32490 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_30125 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E NEH16_32485 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E NEH16_30120 fabG; 3-oxoacyl-ACP reductase FabG K12420 actIII; ketoreductase [EC:1.1.1.-] E NEH16_32460 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] E NEH16_30140 TcmI family type II polyketide cyclase K15926 jadI; cyclase D Decaketide PKS E NEH16_32495 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_30130 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_32490 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E NEH16_30125 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E NEH16_32485 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E NEH16_30120 fabG; 3-oxoacyl-ACP reductase FabG K12420 actIII; ketoreductase [EC:1.1.1.-] E NEH16_32460 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D NEH16_01120 MbtH family NRPS accessory protein K05375 mbtH; MbtH protein D NEH16_02030 MbtH family protein K05375 mbtH; MbtH protein D NEH16_06750 MbtH family protein K05375 mbtH; MbtH protein D NEH16_28860 MbtH family protein K05375 mbtH; MbtH protein D NEH16_29755 MbtH family NRPS accessory protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Bacillibactin synthetase D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Myxochelin synthetase D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] # APolyketide tailoring proteins B Hydrolase C NEH16_31875 acyl-CoA thioesterase K15315 sgcE10; enediyne core biosynthesis thioesterase C NEH16_31910 hypothetical protein K15315 sgcE10; enediyne core biosynthesis thioesterase B Ketoreductase B Oxygenase C NEH16_29380 bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase K16022 rif19; flavoprotein hydroxylase C NEH16_06560 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C NEH16_13740 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C NEH16_31755 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C NEH16_30870 epoxide hydrolase K21159 sgcF; epoxide hydrolase C NEH16_31840 epoxide hydrolase K21159 sgcF; epoxide hydrolase C NEH16_31990 epoxide hydrolase K21159 sgcF; epoxide hydrolase C NEH16_32465 FAD-dependent oxidoreductase K14252 oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233] C NEH16_31700 FAD-dependent monooxygenase K14256 oxyS; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC:1.14.13.38 1.14.13.234] C NEH16_29470 cupin domain-containing protein K14673 whiEII; putative monooxygenase C NEH16_29460 FAD-dependent monooxygenase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C NEH16_29500 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-] B Glycosyltransferase C NEH16_32015 DUF1205 domain-containing protein K14368 eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278] B Halogenase C NEH16_27960 chlorinating enzyme K15650 cmaB; non-haem Fe2+, alpha-ketoglutarate-dependent halogenase B beta-Branched incorporating proteins B Others C NEH16_31935 DUF1702 family protein K21160 sgcE2; enediyne biosynthesis protein E2 C NEH16_31930 DUF1702 family protein K21161 sgcE3; enediyne biosynthesis protein E3 C NEH16_31925 VCBS repeat-containing protein K21162 sgcE4; enediyne biosynthesis protein E4 C NEH16_31920 enediyne biosynthesis protein K21163 sgcE5; enediyne biosynthesis protein E5 C NEH16_31900 cytochrome P450 K21164 sgcE7; enediyne biosynthesis protein E7 C NEH16_31885 DUF5987 family protein K21165 sgcE8; enediyne biosynthesis protein E8 C NEH16_31880 GMC family oxidoreductase K21166 sgcE9; enediyne biosynthesis protein E9 C NEH16_31870 TIGR03084 family metal-binding protein K21167 sgcE11; enediyne biosynthesis protein E11 C NEH16_31860 condensation domain-containing protein K21186 sgcC5; condensation enzyme C NEH16_32010 condensation domain-containing protein K21186 sgcC5; condensation enzyme C NEH16_31905 flavin reductase family protein K21185 sgcE6; flavin reductase # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase B Aminotransferase C NEH16_31425 PLP-dependent aminotransferase family protein K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] B Others C NEH16_05975 amino acid racemase K01779 racD; aspartate racemase [EC:5.1.1.13] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: June 19, 2024