+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptomyces drozdowiczii
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E NEH16_29480 ketosynthase chain-length factor K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
E NEH16_29485 acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein
E NEH16_29495 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E NEH16_32495 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_30130 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_32490 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_30125 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E NEH16_32485 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E NEH16_30120 fabG; 3-oxoacyl-ACP reductase FabG K12420 actIII; ketoreductase [EC:1.1.1.-]
E NEH16_32460 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E NEH16_32480 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E NEH16_32495 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_30130 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_32490 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_30125 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E NEH16_32485 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E NEH16_30120 fabG; 3-oxoacyl-ACP reductase FabG K12420 actIII; ketoreductase [EC:1.1.1.-]
E NEH16_32460 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E NEH16_30140 TcmI family type II polyketide cyclase K15926 jadI; cyclase
D Decaketide PKS
E NEH16_32495 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_30130 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_32490 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E NEH16_30125 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E NEH16_32485 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E NEH16_30120 fabG; 3-oxoacyl-ACP reductase FabG K12420 actIII; ketoreductase [EC:1.1.1.-]
E NEH16_32460 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D NEH16_01120 MbtH family NRPS accessory protein K05375 mbtH; MbtH protein
D NEH16_02030 MbtH family protein K05375 mbtH; MbtH protein
D NEH16_06750 MbtH family protein K05375 mbtH; MbtH protein
D NEH16_28860 MbtH family protein K05375 mbtH; MbtH protein
D NEH16_29755 MbtH family NRPS accessory protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Bacillibactin synthetase
D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D NEH16_28205 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
C NEH16_31875 acyl-CoA thioesterase K15315 sgcE10; enediyne core biosynthesis thioesterase
C NEH16_31910 hypothetical protein K15315 sgcE10; enediyne core biosynthesis thioesterase
B Ketoreductase
B Oxygenase
C NEH16_29380 bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase K16022 rif19; flavoprotein hydroxylase
C NEH16_06560 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C NEH16_13740 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C NEH16_31755 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C NEH16_30870 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C NEH16_31840 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C NEH16_31990 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C NEH16_32465 FAD-dependent oxidoreductase K14252 oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]
C NEH16_31700 FAD-dependent monooxygenase K14256 oxyS; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC:1.14.13.38 1.14.13.234]
C NEH16_29470 cupin domain-containing protein K14673 whiEII; putative monooxygenase
C NEH16_29460 FAD-dependent monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C NEH16_29500 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
B Glycosyltransferase
C NEH16_32015 DUF1205 domain-containing protein K14368 eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278]
B Halogenase
C NEH16_27960 chlorinating enzyme K15650 cmaB; non-haem Fe2+, alpha-ketoglutarate-dependent halogenase
B beta-Branched incorporating proteins
B Others
C NEH16_31935 DUF1702 family protein K21160 sgcE2; enediyne biosynthesis protein E2
C NEH16_31930 DUF1702 family protein K21161 sgcE3; enediyne biosynthesis protein E3
C NEH16_31925 VCBS repeat-containing protein K21162 sgcE4; enediyne biosynthesis protein E4
C NEH16_31920 enediyne biosynthesis protein K21163 sgcE5; enediyne biosynthesis protein E5
C NEH16_31900 cytochrome P450 K21164 sgcE7; enediyne biosynthesis protein E7
C NEH16_31885 DUF5987 family protein K21165 sgcE8; enediyne biosynthesis protein E8
C NEH16_31880 GMC family oxidoreductase K21166 sgcE9; enediyne biosynthesis protein E9
C NEH16_31870 TIGR03084 family metal-binding protein K21167 sgcE11; enediyne biosynthesis protein E11
C NEH16_31860 condensation domain-containing protein K21186 sgcC5; condensation enzyme
C NEH16_32010 condensation domain-containing protein K21186 sgcC5; condensation enzyme
C NEH16_31905 flavin reductase family protein K21185 sgcE6; flavin reductase
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
B Aminotransferase
C NEH16_31425 PLP-dependent aminotransferase family protein K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]
B Others
C NEH16_05975 amino acid racemase K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: June 19, 2024