+C	Two-component system	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Two-Component System - Shigella dysenteriae Sd197</h2>
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A<b>OmpR family</b>
B  PhoR-PhoB (phosphate starvation response)
C    SDY_0338 phoB; positive response regulator for pho regulon	K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB 
B  SenX3-RegX3 (phosphate starvation response)
B  PhoQ-PhoP (magnesium transport)
C    SDY_2023 phoQ; sensor protein PhoQ	K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] 
C    SDY_2022 phoP; transcriptional regulatory protein	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
B  EnvZ-OmpR (osmotic stress response)
C    SDY_3672 envZ; protein histidine kinase/phosphatase sensor for OmpR	K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] 
C    SDY_3671 ompR; response regulator affecting transcription of ompC and ompF	K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR 
B  RstB-RstA
C    SDY_1825 rstB; sensor histidine protein kinase	K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] 
C    SDY_1824 rstA; response transcriptional regulatory protein	K07661 rstA; two-component system, OmpR family, response regulator RstA 
B  CpxA-CpxR (envelope stress response)
C    SDY_3835 cpxA; histidine protein kinase	K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3] 
C    SDY_3834 cpxR; transcriptional regulator in 2-component system	K07662 cpxR; two-component system, OmpR family, response regulator CpxR 
B  CssS-CssR (secretion stress response)
B  CreC-CreB (phosphate regulation)
C    SDY_4659 creB; catabolic regulation response regulator	K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB 
B  BaeS-BaeR (envelope stress response)
C    SDY_2187 baeS; sensor protein for BaeR	K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3] 
C    SDY_2186 baeR; transcriptional response regulatory protein	K07664 baeR; two-component system, OmpR family, response regulator BaeR 
B  BasS-BasR (antimicrobial peptide resistance)
C    SDY_4101 basS; sensor protein for basR	K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3] 
B  CusS-CusR (copper tolerance)
B  QseC-QseB (quorum sensing)
C    SDY_3213 qseC; quorum sensing Escherichia coli regulator C	K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] 
C    SDY_3214 ygiX; putative 2-component transcriptional regulator	K07666 qseB; two-component system, OmpR family, response regulator QseB 
B  KdpD-KdpE (potassium transport)
C    SDY_0629 kdpE; regulator of kdp operon	K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE 
B  TorS-TorR (TMAO respiration)
C    SDY_0969 torR; response transcriptional regulator for torA	K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR 
B  ArcB-ArcA (anoxic redox control)
C    SDY_3391 arcB; aerobic respiration sensor-response protein	K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3] 
C    SDY_4662 arcA; negative response regulator of genes in aerobic pathways	K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA 
B  TctE-TctD (tricarboxylic acid transport)
B  ResE-ResD (aerobic and anaerobic respiration)
B  VicK-VicR (cell wall metabolism)
B  MprB-MprA (maintenance of persistent infection)
B  MtrB-MtrA (osmotic stress response)
B  PrrB-PrrA (intracellular multiplication)
B  TrcS-TrcR
B  NrsS-NrsR (nickel tolerance)
B  ManS-ManR (manganese homeostasis)
B  NblS-NblR (photosynthesis)
B  SasA-RpaAB (circadian timing mediating)
B  SaeS-SaeR (staphylococcal virulence regulation)
B  BceS-BceR (bacitracin transport)
B  BraS-BraR (bacitracin transport)
B  GraS-GraR (cationic antimicrobial peptide transport)
B  YxdK-YxdJ (antimicrobial peptide response)
B  ChvG-ChvI (acidity sensing)
B  CiaH-CiaR
B  ParS-ParR (polymyxin-adaptive resistance)
B  AdeS-AdeR
B  VanS-VanR (VanB type vancomycin resistance)
B  VanS-VanR (VanE type vancomycin resistance)
B  VanS-VanR (actinomycete type vancomycin resistance)
B  ArlS-ArlR (virulence regulation)
B  Ihk-Irr (virulence regulation)
B  PfeS-PfeR (enterobactin-dependent iron acquisition)
B  NisK-NisR (lantibiotic biosynthesis)
B  Unclassified
C    SDY_1039 yedW; putative 2-component transcriptional regulator	K02483 K02483; two-component system, OmpR family, response regulator 
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A<b>NarL family</b>
B  NarX-NarL (nitrate respiration)
C    SDY_1276 narX; nitrate/nitrate sensor	K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3] 
C    SDY_1275 narL; NarL	K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL 
B  NarQ-NarP (nitrate respiration)
C    SDY_2653 narQ; sensor for nitrate reductase system	K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3] 
C    SDY_0885 narP; nitrate/nitrite response regulator	K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP 
B  UhpB-UhpA (hexose phosphates uptake)
C    SDY_4149 uhpB; sensor histidine protein kinase phosphorylates UhpA	K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] 
C    SDY_4150 uhpA; response regulator, positive activator of uhpT transcription	K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA 
B  FusK-FusR (virulence regulation)
C    SDY_0506 putative response regulator	K20264 fusR; two-component system, NarL family, response regulator FusR 
B  RcsC-RcsD-RcsB (capsule synthesis)
C    SDY_0856 rcsC; sensor for ctr capsule biosynthesis	K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] 
C    SDY_0858 yojN; putative 2-component sensor protein	K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3] 
C    SDY_0857 rcsB; positive response regulator for colanic capsule biosynthesis	K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB 
B  BarA-UvrY (central carbon metabolism)
C    SDY_3003 barA; sensor-regulator	K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] 
C    SDY_1104 uvrY; putative 2-component transcriptional regulator	K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY 
B  ComP-ComA (competence)
B  EvgS-EvgA (acid and drug tolerance)
C    SDY_4478 evgS; putative sensor for regulator EvgA	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    SDY_4477 evgA; putative positive transcription regulator	K07690 evgA; two-component system, NarL family, response regulator EvgA 
B  DegS-DegU (multicellular behavior control)
B  DesK-DesR (membrane lipid fluidity regulation)
B  VraS-VraR (cell-wall peptidoglycan synthesis)
B  LiaS-LiaR (cell wall stress response)
B  DevS-DevR (redox response)
B  NreB-NreC (dissimilatory nitrate/nitrite reduction)
B  YdfH-YdfI
B  SalK-SalR
B  PprA–PprB (biofilm formation)
B  Unclassified
#
A<b>Spo family</b>
B  KinABCDE-Spo0FA (sporulation control)
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A<b>CitB family</b>
B  CitA-CitB (citrate fermentation)
B  CitS-CitT (magnesium-citrate transport)
B  DcuS-DcuR (C4-dicarboxylate metabolism)
C    SDY_4238 yjdH; putative 2-component sensor protein	K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3] 
C    SDY_4237 yjdG; putative 2-component transcriptional regulator	K07703 dcuR; two-component system, CitB family, response regulator DcuR 
B  DctS-DctR (C4-dicarboxylate transport)
B  MalK-MalR (malate transport)
B  Unclassified
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A<b>LytTR family</b>
B  LysS-LysR
B  AlgZ-AlgR (alginate production)
B  NatK-NatR (sodium extrusion)
B  AgrC-AgrA (exoprotein synthesis)
B  AgrC2-AgrA2 (virulence regulation)
B  ComD-ComE (competence)
B  BtsS-BtsR (pyruvate reutilization)
C    SDY_2163 yehU; putative 2-component sensor protein	K27882 btsS; two-component system, LytTR family, low-concentration pyruvate sensor kinase [EC:2.7.13.3] 
C    SDY_2164 yehT; conserved hypothetical protein	K27883 btsR; two-component system, LytTR family, low-concentration pyruvate response regulator 
B  PyrS-PyrR (pyruvate reutilization)
C    SDY_2579 putative sensor protein	K27884 pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase [EC:2.7.13.3] 
B  Unclassified
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A<b>NtrC family</b>
B  GlnL-GlnG (nitrogen regulation)
C    SDY_3874 glnL; histidine protein kinase sensor for GlnG regulator	K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] 
C    SDY_3875 glnG; response regulator for gln	K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG 
B  NtrY-NtrX (nitrogen regulation)
B  HydH-HydG (metal tolerance)
C    SDY_3723 hydH; sensor kinase for HydG hydrogenase 3 activity	K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3] 
C    SDY_3722 hydG; sensor HydH response regulator of hydrogenase 3 activity	K07713 zraR; two-component system, NtrC family, response regulator HydG 
B  AtoS-AtoC (cPHB biosynthesis)
B  PilS-PilR (type 4 fimbriae synthesis)
B  GlrK-GlrR (amino sugar metabolism)
C    SDY_2746 yfhK; putative 2-component sensor protein	K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3] 
C    SDY_2744 yfhA; putative 2-component transcriptional regulator	K07715 glrR; two-component system, NtrC family, response regulator GlrR 
B  PgtB-PgtA (phosphoglycerate transport)
B  DctB-DctD (C4-dicarboxylate transport)
B  KinB-AlgB (alginate production)
B  HupT-HupR (hydrogenase synthesis regulation)
B  Unclassified
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A<b>CheA family</b>
B  CheA-CheYBV (chemotaxis)
B  ChpA-ChpB/PilGH (chemosensory)
B  PixL-PixGH (positive phototaxis)
B  WspE-WspRF (chemosensory)
B  Cph1-Rcp1 (light response)
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A<b>Cell cycle family</b>
B  PleC-PleD (cell fate control)
B  CckA-CtrA/CpdR (cell cycle control)
B  Hk1-Rrp1 (glycerol uptake and utilization)
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A<b>Lux family</b>
B  LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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A<b>LuxR family</b>
B  DctS-DctR (C4-dicarboxylate transport)
B  TtrS-TtrR (tetrathionate respiration)
B  FixL-FixJ (nitrogen fixation)
B  SsrA-SsrB
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A<b>Other families</b>
B  FlrB-FlrC (polar flagellar synthesis)
B  AauS-AauR (acidic amino acids utilization)
B  SLN1-YPD1-SSK1/SKN7 (osmosensing)
B  RpfC-RpfG (cell-to-cell signaling)
B  GlnK-GlnL (glutamine utilization)
B  HspS-HspR (hexose phosphates uptake)
B  YesM-YesN
B  CikA
B  RegB-RegA (redox response)
B  FitF-FitH (insecticidal toxin regulation)
B  PhcS-PhcRQ
B  SagS-HptB-HsbR (swarming activity and biofilm formation)
B  PdtaS-PdtaR
B  NasS-NasT
B  Unclassified
C    SDY_1287 hnr; Hnr protein	K02485 rssB; two-component system, response regulator 
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#Last updated: October 8, 2024