+C Two-component system KO
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Two-Component System - Salmonella enterica subsp. enterica serovar Typhi Ty21a
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C TY21A_12510 phoR; phosphate regulon sensor protein K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C TY21A_12515 transcriptional regulator PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C TY21A_08590 sensor protein PhoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C TY21A_08585 DNA-binding transcriptional regulator PhoP K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C TY21A_20370 envZ; osmolarity sensor protein K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C TY21A_20365 ompR; osmolarity response regulator K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C TY21A_06790 sensor protein RstB K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C TY21A_06810 DNA-binding transcriptional regulator RstA K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C TY21A_17990 cpxA; two-component sensor protein K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C TY21A_17985 DNA-binding transcriptional regulator CpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C TY21A_23560 sensory histidine kinase CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C TY21A_23555 DNA-binding response regulator CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C TY21A_03755 signal transduction histidine-protein kinase BaeS K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C TY21A_03750 DNA-binding transcriptional regulator BaeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
C TY21A_21350 sensor protein BasS/PmrB K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]
C TY21A_21355 DNA-binding transcriptional regulator BasR K07771 basR; two-component system, OmpR family, response regulator BasR
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
C TY21A_15680 sensor protein QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C TY21A_15675 DNA-binding transcriptional regulator QseB K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C TY21A_11025 sensor protein KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C TY21A_11030 DNA-binding transcriptional activator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
C TY21A_18690 hybrid sensory histidine kinase TorS K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]
B ArcB-ArcA (anoxic redox control)
C TY21A_16445 aerobic respiration control sensor protein ArcB K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
C TY21A_23600 two-component response regulator K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
C TY21A_13565 putative two-component system sensor kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C TY21A_13570 transcriptional regulator K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C TY21A_09285 histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C TY21A_09280 transcriptional regulatory protein YedW K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C TY21A_08515 nitrate/nitrite sensor protein NarX K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C TY21A_08520 transcriptional regulator NarL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
C TY21A_01955 nitrate/nitrite sensor protein NarQ K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
C TY21A_03145 transcriptional regulator NarP K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
B UhpB-UhpA (hexose phosphates uptake)
C TY21A_18900 sensory histidine kinase UhpB K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C TY21A_18895 DNA-binding transcriptional activator UhpA K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C TY21A_03020 hybrid sensory kinase in two-component regulatory system with RcsB and YojN K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C TY21A_03030 phosphotransfer intermediate protein in two-component regulatory system with RcsBC K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
C TY21A_03025 transcriptional regulator RcsB K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C TY21A_14505 hybrid sensory histidine kinase BarA K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C TY21A_04770 response regulator K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C TY21A_11725 transcriptional regulator FimZ K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
C TY21A_00285 sensor kinase CitA K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C TY21A_11370 sensor kinase DpiB K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C TY21A_00280 transcriptional regulatory protein CitB K07702 dpiA; two-component system, CitB family, response regulator CitB
C TY21A_11365 dpiA; two-component response regulator DpiA K07702 dpiA; two-component system, CitB family, response regulator CitB
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
C TY21A_21415 sensory histidine kinase DcuS K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3]
C TY21A_21410 DNA-binding transcriptional activator DcuR K07703 dcuR; two-component system, CitB family, response regulator DcuR
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C TY21A_03550 putative two-component system sensor kinase K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C TY21A_03555 putative two-component response-regulatory protein YehT K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C TY21A_18290 glnL; nitrogen regulation protein NR(II) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C TY21A_18295 glnG; nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C TY21A_17470 transcriptional regulatory protein ZraR K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
C TY21A_01485 putative sensor kinase protein K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C TY21A_01495 putative transcriptional regulator K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
C TY21A_02355 phosphoglycerate transport system sensor protein PgtB K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3]
C TY21A_02360 phosphoglycerate transport system transcriptional regulatory protein PgtA K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C TY21A_04870 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C TY21A_04895 chemotaxis regulatory protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C TY21A_04890 chemotaxis-specific methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C TY21A_02795 putative receptor/regulator protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
C TY21A_06380 hypothetical protein K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]
C TY21A_06385 response regulator K13041 ttrR; two-component system, LuxR family, response regulator TtrR
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
C TY21A_06410 putative two-component sensor kinase K14978 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA
C TY21A_06405 putative two-component response regulator K14979 ssrB; two-component system, LuxR family, secretion system response regulator SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C TY21A_08455 response regulator of RpoS K02485 rssB; two-component system, response regulator
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023