+F Repair protein KO
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DNA Repair and Recombination Proteins - Serinicoccus hydrothermalis
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SGUI_1454 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SGUI_2127 Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E SGUI_2732 Uracil-DNA glycosylase, family 1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SGUI_0158 DNA-3-methyladenine glycosylase II K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E SGUI_1442 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SGUI_1502 Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E SGUI_2758 DNA repair helicase K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D SGUI_2988 putative mutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_0621 MutT-like domain protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_2304 putative MutT/NUDIX-family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_1610 MutT-like domain protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_1624 Putative ATP/GTP-binding protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_0589 Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SGUI_1454 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SGUI_2127 Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D SGUI_0742 Photolyase protein family K06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13]
C BER (base exicision repair)
D DNA glycosylases
E SGUI_2732 Uracil-DNA glycosylase, family 1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SGUI_3266 G:T/U mismatch-specific uracil/thymine DNA-glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E SGUI_1327 Uracil-DNA glycosylase, family 5 K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E SGUI_1455 Methylated-DNA--protein-cysteine methyltransferase K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E SGUI_0158 DNA-3-methyladenine glycosylase II K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E SGUI_1442 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SGUI_2998 DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E SGUI_3252 Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SGUI_1713 Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SGUI_1075 Formamidopyrimidine-DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SGUI_3141 Formamidopyrimidine-DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SGUI_1762 Formamidopyrimidine-DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SGUI_1502 Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E SGUI_1807 Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E SGUI_1552 Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E SGUI_1549 Endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
D DNA ligase
E SGUI_1207 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E SGUI_0226 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E SGUI_0242 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E SGUI_1602 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E SGUI_0235 Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E SGUI_0244 Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E SGUI_3021 ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGUI_3024 ATP-dependent DNA helicase UvrD/PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGUI_3070 ATP-dependent DNA helicase UvrD/PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGUI_0226 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E SGUI_1207 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F SGUI_2892 DNA-directed RNA polymerase beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F SGUI_2893 DNA-directed RNA polymerase beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F SGUI_2929 DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F SGUI_0199 DNA-directed RNA polymerase omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F SGUI_1335 Transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E SGUI_2948 Exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E SGUI_2947 Exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E SGUI_0865 DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E SGUI_1871 DNA polymerase III beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E SGUI_0981 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E SGUI_1477 DNA polymerase III delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E SGUI_1929 DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SGUI_0819 DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SGUI_1522 DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E SGUI_1207 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E SGUI_3021 ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGUI_3024 ATP-dependent DNA helicase UvrD/PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGUI_3070 ATP-dependent DNA helicase UvrD/PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGUI_1911 Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E SGUI_1151 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
E SGUI_0363 single-strand binding protein/Primosomal replication protein n K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E SGUI_2349 Exodeoxyribonuclease V beta chain K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E SGUI_2350 Exodeoxyribonuclease V gamma chain K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E SGUI_2348 Exodeoxyribonuclease V alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E SGUI_3157 RecA protein K03553 recA; recombination protein RecA
E SGUI_0446 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E SGUI_0445 Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SGUI_0447 Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E SGUI_0202 Helicase PriA essential for oriC/DnaA-independent DNA replication K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E SGUI_3157 RecA protein K03553 recA; recombination protein RecA
E SGUI_1440 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E SGUI_1869 DNA recombination and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E SGUI_3245 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E SGUI_0076 DNA recombination and repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E SGUI_1520 Recombination protein RecR K06187 recR; recombination protein RecR
E SGUI_0165 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E SGUI_0446 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E SGUI_0445 Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SGUI_0447 Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E SGUI_2513 ATPase component BioM of energizing module of biotin ECF transporter K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E SGUI_1448 Ku domain protein K10979 ku; DNA end-binding protein Ku
E SGUI_1449 ATP-dependent DNA ligase clustered with Ku protein, LigD K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E SGUI_1450 ATP-dependent DNA ligase clustered with Ku protein, LigD K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F SGUI_1865 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SGUI_0613 Topoisomerase IV subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SGUI_1866 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SGUI_0790 Topoisomerase IV subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SGUI_1486 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F SGUI_1073 Hypothetical protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F SGUI_2147 DNA-binding protein HBsu K03530 hupB; DNA-binding protein HU-beta
F SGUI_3234 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F SGUI_0076 DNA recombination and repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F SGUI_1520 Recombination protein RecR K06187 recR; recombination protein RecR
F SGUI_1207 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F SGUI_0960 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SGUI_0242 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F SGUI_1602 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F SGUI_0235 Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D SGUI_1116 DNA polymerase-like protein K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D SGUI_0292 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D SGUI_0799 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D SGUI_3157 RecA protein K03553 recA; recombination protein RecA
D SGUI_0965 SOS-response repressor and protease LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D SGUI_0165 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D SGUI_0800 DNA polymerase III alpha subunit K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D SGUI_1911 Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D SGUI_1151 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D SGUI_0363 single-strand binding protein/Primosomal replication protein n K03111 ssb; single-strand DNA-binding protein
D SGUI_3158 Regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D SGUI_0983 DinG family ATP-dependent helicase YoaA K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D SGUI_3145 putative ATP-dependent helicase lhr K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D SGUI_2988 putative mutT-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_0621 MutT-like domain protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_2304 putative MutT/NUDIX-family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_1610 MutT-like domain protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_1624 Putative ATP/GTP-binding protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGUI_2592 putative hydrolase mutT1 K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]
D SGUI_0172 ADP-ribose pyrophosphatase K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D SGUI_0589 Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SGUI_0947 Ribonucleotide reductase of class II (coenzyme B12-dependent) K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SGUI_0534 Ribonucleotide reductase of class Ia (aerobic), alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SGUI_0535 Ribonucleotide reductase of class Ia (aerobic), beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024