+D	AMR gene	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Antimicrobial Resistance Genes - Streptomyces pratensis</h2>
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A<b>Gene variants</b>
B  beta-Lactamase genes
C    Class A [MT]
C    Class D [MT]
C    Class C [MT]
C    Class B [MT]
B  Aminoglycoside resistance genes
C    N-Acetyltransferases
D      Sfla_4027 Aminoglycoside N(3')-acetyltransferase	K00662 aacC; aminoglycoside 3-N-acetyltransferase [EC:2.3.1.81] 
D      Sfla_5543 Aminoglycoside N(3')-acetyltransferase	K00662 aacC; aminoglycoside 3-N-acetyltransferase [EC:2.3.1.81] 
C    Other acetyltransferases
C    O-Nucleotidyltransferases
C    O-Phosphotransferases
D      Sfla_6555 Streptomycin 6-kinase	K12570 aphD; streptomycin 6-kinase [EC:2.7.1.72] 
D      Sfla_1647 aminoglycoside/hydroxyurea antibiotic resistance kinase	K04343 strB; streptomycin 6-kinase [EC:2.7.1.72] 
D      Sfla_2816 Streptomycin 6-kinase	K04343 strB; streptomycin 6-kinase [EC:2.7.1.72] 
C    16S rRNA methyltransferases
B  Tetracycline resistance genes
C    Transporters
D      Sfla_4576 ABC-2 type transporter	K18233 oleC5; oleandomycin transport system permease protein 
C    Others
B  Macrolide resistance genes
C    23S rRNA methyltransferases
C    Transporters
D      Sfla_5945 ABC transporter related protein	K18230 tylC; macrolide transport system ATP-binding/permease protein 
D      Sfla_4577 daunorubicin resistance ABC transporter ATPase subunit	K18232 oleC4; oleandomycin transport system ATP-binding protein 
C    Others
D      Sfla_6582 hydrolase	K18235 vgb; virginiamycin B lyase [EC:4.2.99.-] 
D      Sfla_5895 streptogramin A acetyl transferase	K18234 vat; virginiamycin A acetyltransferase [EC:2.3.1.-] 
B  Phenicol resistance genes
C    Transporters
D      Sfla_2770 major facilitator superfamily MFS_1	K18553 cmlR; MFS transporter, DHA1 family, chloramphenicol resistance protein 
D      Sfla_4582 major facilitator superfamily MFS_1	K18553 cmlR; MFS transporter, DHA1 family, chloramphenicol resistance protein 
C    Acetyltransferases
C    Phosphotransferase
C    23S rRNA methyltransferase
B  Sulfonamide resistance genes
C    Dihydropteroate synthase
B  Trimethoprim resistance genes
C    Dihydrofolate reductases
B  Quinolone resistance genes
C    Transporter
D      Sfla_4046 major facilitator superfamily MFS_1	K08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein 
D      Sfla_5071 major facilitator superfamily MFS_1	K08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein 
D      Sfla_5269 major facilitator superfamily MFS_1	K08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein 
C    Other
B  Rifamycin resistance genes
C    ADP-ribosyl transferases
C    Oxygenases
B  Fosfomycin resistance genes
C    Transferases
C    Others
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A<b>Gene sets</b>
B  beta-Lactam resistance modules
C    Methicillin resistance [MD:M00625]
C    beta-Lactam resistance, Bla system [MD:M00627]
D      Sfla_5747 peptidase M48 Ste24p	K02172 blaR1; bla regulator protein blaR1 
D      Sfla_0196 Beta-lactamase	K17836 penP; beta-lactamase class A [EC:3.5.2.6] 
C    Imipenem resistance, repression of porin OprD [MD:M00745]
B  Vancomycin resistance modules
C    Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]
D      Sfla_2712 Endonuclease/exonuclease/phosphatase	K18353 vanJ; vancomycin resistance protein VanJ 
D      Sfla_4581 Endonuclease/exonuclease/phosphatase	K18353 vanJ; vancomycin resistance protein VanJ 
D      Sfla_5472 D-Ala-D-Ala dipeptidase	K08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] 
C    Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]
D      B  Tetracycline resistance
C    Tetracycline resistance, efflux pump Tet38 [MD:M00704]
B  CAMP resistance modules
C    Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]
C    Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]
C    Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]
C    Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]
B  Multipdrug resistance modules
C    Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]
C    Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]
D      Sfla_5268 regulatory protein TetR	K18294 nfxB; TetR/AcrR family transcriptional regulator, mexCD-oprJ operon repressor 
C    Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]
C    Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]
C    Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]
C    Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]
C    Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]
C    Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]
C    Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]
C    Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]
C    Multidrug resistance, efflux pump AbcA [MD:M00700]
C    Multidrug resistance, efflux pump NorB [MD:M00702]
C    Multidrug resistance, efflux pump QacA [MD:M00714]
D      Sfla_4046 major facilitator superfamily MFS_1	K08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein 
D      Sfla_5071 major facilitator superfamily MFS_1	K08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein 
D      Sfla_5269 major facilitator superfamily MFS_1	K08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein 
C    Multidrug resistance, efflux pump MepA [MD:M00705]
C    Multidrug resistance, repression of porin OmpF [MD:M00746]
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#Last updated: December 28, 2017