+F Repair protein KO
#
DNA Repair and Recombination Proteins - Shigella flexneri 2457T (serotype 2a)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D S1435 ogt; O-6-alkylguanine-DNA/cysteine-protein methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D S0602 phrB; deoxyribodipyrimidine photolyase (photoreactivation) K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E S2815 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E S3161 mutY; adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E S1790 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D S0098 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D S4089 dut; deoxyuridinetriphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D S1435 ogt; O-6-alkylguanine-DNA/cysteine-protein methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D S2427 ada; O6-methylguanine-DNA methyltransferase; transcription activator/repressor K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D S0602 phrB; deoxyribodipyrimidine photolyase (photoreactivation) K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D S2426 alkB; alkylated DNA repair protein K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E S2815 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E S2258 alkA; 3-methyl-adenine DNA glycosylase II K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E S3161 mutY; adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E S4186 tag; 3-methyl-adenine DNA glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E S4094 mutM; formamidopyrimidine DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E S0596 nei; endonuclease VIII and DNA N-glycosylase with an AP lyase activity K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E S1790 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E S1594 xthA; exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E S2373 nfo; endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E S3665 nfi; endonuclease V (deoxyinosine 3 endonuclease) K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E S3077 recJ; ssDNA exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E S2612 lig; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E S4082 yicF; putative enzyme K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E S3813 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E S3583 uvrA; excision nuclease subunit A K03701 uvrA; excinuclease ABC subunit A
E S0770 uvrB; excision nuclease subunit B K03702 uvrB; excinuclease ABC subunit B
E S2052 uvrC; excinuclease ABC, subunit C K03703 uvrC; excinuclease ABC subunit C
E S1602 putative excinuclease subunit K05984 cho; excinuclease Cho [EC:3.1.25.-]
E S3865 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E S3813 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E S2612 lig; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E S4082 yicF; putative enzyme K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F S3675 rpoB; RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F S3674 rpoC; RNA polymerase, beta prime subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F S4435 rpoA; RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F S4080 rpoZ; RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F S1198 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E S2944 mutS; methyl-directed mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E S4593 mutL; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E S3039 mutH; methyl-directed mismatch repair protein K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E S2193 sbcB; exonuclease I, 3 --> 5 specific; deoxyribophosphodiesterase K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E S2727 xseA; exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E S0367 xseB; exonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E S1920 hypothetical protein K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E S0177 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E S4008 dnaN; DNA polymerase III, beta-subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E S4491 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E S0663 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E S1183 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E S0209 dnaQ; DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E S0422 dnaX; DNA polymerase III, tau and gamma subunits; DNA elongation factor III K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E S4675 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E S1918 holE; DNA polymerase III, theta subunit K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E S2612 lig; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E S4082 yicF; putative enzyme K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E S3865 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E S3584 ssb; ssDNA-binding protein K03111 ssb; single-strand DNA-binding protein
E S4357 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E S2099 vsr; DNA mismatch endonuclease, patch repair protein K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E S3028 recB; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E S3030 recC; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E S3027 recD; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E S2913 recA; DNA-dependent ATPase, DNA- and ATP-dependent coprotease K03553 recA; recombination protein RecA
E S1937 ruvA; Holliday junction helicase subunit B K03550 ruvA; holliday junction DNA helicase RuvA
E S1936 ruvB; Holliday junction helicase subunit A K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E S1939 ruvC; Holliday junction nuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E S2140 putative crossover junction endodeoxyribonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E S1987 putative crossover junction endodeoxyribonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E S1665 rus; endodeoxyribonuclease RUS (Holliday junction resolvase) K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E S3734 priA; primosomal protein N (factor Y), putative helicase K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E S4626 priB; primosomal replication protein N K02686 priB; primosomal replication protein N
E S0419 priC; primosomal replication protein N K04067 priC; primosomal replication protein N''
E S4663 dnaT; primosomal protein i K02317 dnaT; DNA replication protein DnaT
E S2193 sbcB; exonuclease I, 3 --> 5 specific; deoxyribophosphodiesterase K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E S0342 sbcC; ATP-dependent dsDNA exonuclease K03546 sbcC; DNA repair protein SbcC/Rad50
E S0343 sbcD; ATP-dependent dsDNA exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E S2913 recA; DNA-dependent ATPase, DNA- and ATP-dependent coprotease K03553 recA; recombination protein RecA
E S4692 sms; probable ATP-dependent protease K04485 radA; DNA repair protein RadA/Sms
E S4007 recF; Rec protein K03629 recF; DNA replication and repair protein RecF
E S4077 recG; DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E S3077 recJ; ssDNA exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E S2800 recO; RecO protein K03584 recO; DNA repair protein RecO (recombination protein O)
E S0424 recR; recombination protein RecR K06187 recR; recombination protein RecR
E S2853 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E S0339 yaiD; hypothetical protein K03554 rdgC; recombination associated protein RdgC
E S1937 ruvA; Holliday junction helicase subunit B K03550 ruvA; holliday junction DNA helicase RuvA
E S1936 ruvB; Holliday junction helicase subunit A K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E S1939 ruvC; Holliday junction nuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E S2400 yejH; putative ATP-dependent helicase K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E S0342 sbcC; ATP-dependent dsDNA exonuclease K03546 sbcC; DNA repair protein SbcC/Rad50
E S0343 sbcD; ATP-dependent dsDNA exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
E S4487 yjgR; hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F S2444 gyrA; DNA gyrase, subunit A, type II topoisomerase K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F S4006 gyrB; DNA gyrase subunit B, type II topoisomerase K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F S1361 topA; DNA topoisomerase type I, omega protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F S3663 hupA; DNA-binding protein HU-alpha (HU-2) K05787 hupA; DNA-binding protein HU-alpha
F S0391 hupB; DNA-binding protein HU-beta, NS1 (HU-1) K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F S1955 putative exodeoxyribonuclease VIII K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F S3077 recJ; ssDNA exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F S2800 recO; RecO protein K03584 recO; DNA repair protein RecO (recombination protein O)
F S0424 recR; recombination protein RecR K06187 recR; recombination protein RecR
F S2612 lig; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
F S4082 yicF; putative enzyme K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F S3516 fis; site-specific DNA inversion stimulation factor; DNA-binding protein K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F S1636 himA; integration host factor (IHF), alpha subunit K04764 ihfA; integration host factor subunit alpha
F S0972 himD; integration host factor (IHF), beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F S2193 sbcB; exonuclease I, 3 --> 5 specific; deoxyribophosphodiesterase K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F S3855 recQ; ATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F S3583 uvrA; excision nuclease subunit A K03701 uvrA; excinuclease ABC subunit A
F S0770 uvrB; excision nuclease subunit B K03702 uvrB; excinuclease ABC subunit B
F S1323 hns; DNA-binding protein HLP-II (HU, BH2, HD, NS); pleiotropic regulator K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D S0300 dinP; damage-inducible protein P K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D S1261 umuC; mutagenesis and repair protein K03502 umuC; DNA polymerase V
D S1260 umuD; mutagenesis and repair protein K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D S2913 recA; DNA-dependent ATPase, DNA- and ATP-dependent coprotease K03553 recA; recombination protein RecA
D S3569 lexA; regulator for SOS(lexA) regulon K01356 lexA; repressor LexA [EC:3.4.21.88]
D S2853 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D S0057 polB; DNA polymerase II K02336 polB; DNA polymerase II [EC:2.7.7.7]
D S3584 ssb; ssDNA-binding protein K03111 ssb; single-strand DNA-binding protein
D S4084 dinD; DNA-damage-inducible protein K14623 dinD; DNA-damage-inducible protein D
D S1145 dinI; damage-inducible protein I K12149 dinI; DNA-damage-inducible protein I
D S1946 hypothetical bacteriophage protein K12149 dinI; DNA-damage-inducible protein I
D S2328 DNA-damage-inducible protein K12149 dinI; DNA-damage-inducible protein I
D S2912 oraA; regulator, OraA protein K03565 recX; regulatory protein
D S4333 yhgA; hypothetical protein K01157 rpnA; recombination-promoting nuclease RpnA [EC:3.1.21.-]
D S2516 yfcI; hypothetical protein K24087 rpnB; recombination-promoting nuclease RpnB [EC:3.1.21.-]
D S0131 yadD; hypothetical protein K24088 rpnC; recombination-promoting nuclease RpnC [EC:3.1.21.-]
D S2459 yfaD; hypothetical protein K24090 rpnE; recombination-promoting nuclease RpnE
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D S3908 rep; rep helicase K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D S1030 helD; DNA helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D S0790 dinG; probable ATP-dependent helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D S1535 putative enzyme K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D S0098 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D S4089 dut; deoxyuridinetriphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D S2449 nrdA; ribonucleoside diphosphate reductase 1, alpha subunit, B1 K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D S2889 nrdE; ribonucleoside-diphosphate reductase 2, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D S2450 nrdB; ribonucleoside-diphosphate reductase 1, beta subunit, B2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D S2890 nrdF; ribonucleoside-diphosphate reductase 2, beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024