+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces griseofuscus

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS E HEP81_07912 type I polyketide synthase K10817 eryAI; 6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94] E HEP81_07911 type I polyketide synthase K24563 eryAII; 6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94] E HEP81_07910 type I polyketide synthase K24564 eryAIII; 6-deoxyerythronolide B synthase EryAIII [EC:2.3.1.94] D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E HEP81_04216 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E HEP81_04217 PKSA beta-ketoacylsynthase subunit beta K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E HEP81_04218 acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E HEP81_04219 PKSA cyclase I K14670 whiEVI; aromatase E HEP81_04220 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E HEP81_07943 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E HEP81_07942 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E HEP81_07941 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E HEP81_07937 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] E HEP81_07936 actinorhodin polyketide synthase bifunctional cyclase/dehydratase K05554 actVII; aromatase [EC:4.2.1.-] E HEP81_07940 cyclase K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E HEP81_07943 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E HEP81_07942 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E HEP81_07941 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E HEP81_07937 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] D Decaketide PKS E HEP81_07943 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E HEP81_07942 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E HEP81_07941 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E HEP81_07937 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D HEP81_06602 type III polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D HEP81_00498 MbtH family protein K05375 mbtH; MbtH protein D HEP81_00815 MbtH-like protein K05375 mbtH; MbtH protein D HEP81_01304 MbtH family protein K05375 mbtH; MbtH protein D HEP81_01749 MbtH family protein K05375 mbtH; MbtH protein D HEP81_06657 MbtH family protein K05375 mbtH; MbtH protein D HEP81_07541 MbtH family NRPS accessory protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D HEP81_01231 4'-phosphopantetheinyl transferase superfamily protein K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7] C Bacillibactin synthetase C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase C Myxochelin synthetase C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase C Isonitrile lipopeptide synthase # APolyketide tailoring proteins B Hydrolase B Ketoreductase B Oxygenase C HEP81_07903 cytochrome P450 K14366 eryF; 6-deoxyerythronolide B hydroxylase [EC:1.14.15.35] C HEP81_01125 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C HEP81_01693 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C HEP81_07958 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C HEP81_05515 epoxide hydrolase K21159 sgcF; epoxide hydrolase C HEP81_07938 FAD-dependent oxidoreductase K14252 oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233] C HEP81_04215 cupin domain-containing protein K14673 whiEII; putative monooxygenase C HEP81_04213 polyketide hydroxylase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C HEP81_04221 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-] B Glycosyltransferase C HEP81_07917 glycosyl transferase family protein K14367 eryBV; erythronolide mycarosyltransferase [EC:2.4.1.328] C HEP81_07908 activator-dependent family glycosyltransferase K14368 eryCIII; 3-alpha-mycarosylerythronolide B desosaminyl transferase [EC:2.4.1.278] C HEP81_07909 eryCII; Cytochrome P450 family protein EryCII K15997 eryCII; 3-alpha-mycarosylerythronolide B desosaminyl transferase auxiliary protein B Halogenase B beta-Branched incorporating proteins C HEP81_07892 fabD; ACP S-malonyltransferase K15327 pksC; polyketide biosynthesis malonyl-CoA-[acyl-carrier-protein] transacylase B Others # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase B Aminotransferase B Others C HEP81_07478 (S)-2-hydroxy-acid oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] C HEP81_00490 aspartate racemase K01779 racD; aspartate racemase [EC:5.1.1.13] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2025