+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptomyces aurantiacus
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
D GCM10017557_73720 ppsA; phthiocerol synthesis polyketide synthase type I PpsA K15320 ATX; 6-methylsalicylic acid synthase [EC:2.3.1.165]
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
C C7-C14 cyclized polyketide type
D Octaketide PKS
E GCM10017557_73750 fabF; beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E GCM10017557_73760 actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E GCM10017557_73770 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
D Nonaketide PKS
E GCM10017557_73750 fabF; beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E GCM10017557_73760 actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E GCM10017557_73770 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E GCM10017557_73870 cyclase K14250 oxyN; cyclase
D Decaketide PKS
E GCM10017557_73750 fabF; beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E GCM10017557_73760 actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E GCM10017557_73770 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E GCM10017557_73870 cyclase K14250 oxyN; cyclase
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D GCM10017557_72060 1,3,6,8-tetrahydroxynaphthalene synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D GCM10017557_10650 mbtH; MbtH protein K05375 mbtH; MbtH protein
D GCM10017557_15500 protein mbtH K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D GCM10017557_12500 4'-phosphopantetheinyl transferase K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]
D GCM10017557_45820 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D GCM10017557_45790 hypothetical protein K02364 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72]
C Bacillibactin synthetase
D GCM10017557_45820 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
D GCM10017557_45820 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D GCM10017557_45820 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D GCM10017557_04900 hypothetical protein K15653 mxcG; nonribosomal peptide synthetase MxcG
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D GCM10017557_45820 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
B Ketoreductase
B Oxygenase
C GCM10017557_33360 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C GCM10017557_56600 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C GCM10017557_76590 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase
C GCM10017557_73860 hypothetical protein K14253 oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232]
C GCM10017557_73940 oxygenase K14252 oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]
B Methylase
C GCM10017557_73740 O-methyltransferase K21192 mdpB1; methyltransferase [EC:2.1.1.-]
C GCM10017557_73840 O-methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
C GCM10017557_51030 hypothetical protein K14628 actVI2; enoyl reductase
C GCM10017557_51070 hypothetical protein K14628 actVI2; enoyl reductase
C GCM10017557_73680 hypothetical protein K14631 actVB; flavin reductase ActVB [EC:1.5.1.-]
C GCM10017557_73710 dhbE; 2,3-dihydroxybenzoate-AMP ligase K21191 mdpB2; CoA ligase [EC:6.2.1.-]
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
C GCM10017557_01070 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
C GCM10017557_03400 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
B Aminotransferase
B Others
C GCM10017557_05590 nifS; isopenicillin-N epimerase K04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17]
C GCM10017557_81720 alpha-hydroxy-acid oxidizing enzyme K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: June 19, 2024