+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces glaucescens

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E SGLAU_28820 curA; Putative polyketide beta-ketoacyl synthase 1 K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E SGLAU_28825 curB; Putative polyketide beta-ketoacyl synthase 2 K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E SGLAU_28830 hypothetical protein K14669 whiEV; minimal PKS acyl carrier protein E SGLAU_28970 putative cyclase/dehydrase K14670 whiEVI; aromatase E SGLAU_28835 curF; Putative polyketide cyclase K14670 whiEVI; aromatase E SGLAU_28990 hypothetical protein K14671 whiEVII; cyclase E SGLAU_28840 putative polyketide synthesis cyclase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E SGLAU_28980 putative tetracenomycin C polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26355 tcmK; Tetracenomycin C polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_28975 putative beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26360 tcmL; Tetracenomycin C polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26365 tcmM; protein of unknown function, TcmM K05553 actI3; minimal PKS acyl carrier protein D Nonaketide PKS E SGLAU_28980 putative tetracenomycin C polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26355 tcmK; Tetracenomycin C polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_28975 putative beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26360 tcmL; Tetracenomycin C polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26365 tcmM; protein of unknown function, TcmM K05553 actI3; minimal PKS acyl carrier protein D Decaketide PKS E SGLAU_28980 putative tetracenomycin C polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26355 tcmK; Tetracenomycin C polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_28975 putative beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26360 tcmL; Tetracenomycin C polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SGLAU_26365 tcmM; protein of unknown function, TcmM K05553 actI3; minimal PKS acyl carrier protein E SGLAU_26370 tcmN; Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN K15886 tcmN; multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235] B Type III PKS C Plant type C Fungal type C Bacterial type D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D SGLAU_04490 hypothetical protein K05375 mbtH; MbtH protein D SGLAU_31240 hypothetical protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D SGLAU_04525 putative Triostin synthetase I K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D SGLAU_04655 dhbE; putative 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Bacillibactin synthetase D SGLAU_04525 putative Triostin synthetase I K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D SGLAU_04655 dhbE; putative 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase D SGLAU_04470 nrps1C; putative non-ribosomal peptide synthase component K12239 pchE; L-cysteine---[L-cysteinyl-carrier protein] ligase PchE [EC:6.2.1.69] D SGLAU_04650 nrps1E; putative non-ribosomal peptide synthase component K12239 pchE; L-cysteine---[L-cysteinyl-carrier protein] ligase PchE [EC:6.2.1.69] D SGLAU_04465 nrps1B; putative non-ribosomal peptide synthase K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69] D SGLAU_04640 nrps1D; putative tyrocidine synthetase 3 K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69] C Mycobactin synthetase C Vibriobactin synthetase D SGLAU_04525 putative Triostin synthetase I K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D SGLAU_04655 dhbE; putative 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Myxochelin synthetase D SGLAU_04525 putative Triostin synthetase I K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D SGLAU_04655 dhbE; putative 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase D SGLAU_04525 putative Triostin synthetase I K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D SGLAU_04655 dhbE; putative 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] # APolyketide tailoring proteins B Hydrolase B Ketoreductase B Oxygenase C SGLAU_31595 cytochrome P450-family protein K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C SGLAU_25545 cyp17; cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C SGLAU_30935 Putative epoxide hydrolase K21159 sgcF; epoxide hydrolase C SGLAU_02745 putative epoxide hydrolase, melanin type secondary metabolite synthesis protein K21159 sgcF; epoxide hydrolase C SGLAU_26340 tcmH; Tetracenomycin polyketide synthesis hydroxylase TcmH K15969 tcmH; tetracenomycin F1 monooxygenase [EC:1.13.12.21] C SGLAU_26335 tcmG; Tetracenomycin polyketide synthesis hydroxylase TcmG K15972 tcmG; tetracenomycin A2 monooxygenase-dioxygenase [EC:1.14.13.200] C SGLAU_26350 tcmJ; Tetracenomycin polyketide synthesis protein TcmJ, putative B-ring cyclase K14673 whiEII; putative monooxygenase C SGLAU_28985 hypothetical protein K14673 whiEII; putative monooxygenase C SGLAU_28815 curC; putative polyketide synthase CurC K14673 whiEII; putative monooxygenase C SGLAU_28850 Putative polyketide hydroxylase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C SGLAU_26370 tcmN; Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN K15886 tcmN; multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235] C SGLAU_26375 tcmO; Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO K15970 tcmO; 8-O-methyltransferase C SGLAU_26330 tcmP; Tetracenomycin polyketide synthesis O-methyltransferase TcmP K15971 tcmP; O-methyltransferase [EC:2.1.1.-] B Glycosyltransferase B Halogenase C SGLAU_28900 putative GDP dissociation inhibitor K14257 ctcP; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-] C SGLAU_28930 putative GDP dissociation inhibitor K14257 ctcP; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-] B beta-Branched incorporating proteins B Others C SGLAU_04550 putative oxidase K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] C SGLAU_26345 tcmI; D-ring cyclase TcmI K15968 tcmI; tetracenomycin F2 cyclase [EC:4.2.1.154] # ANonribosomal peptide tailoring proteins B Reductase C SGLAU_04460 putative oxidoreductase K12241 pchG; pyochelin biosynthesis protein PchG B Thioesterase B Oxygenase B Glycosyltransferase B Aminotransferase B Others ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024