+F Repair protein KO
#
DNA Repair and Recombination Proteins - Streptomyces glaucescens
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SGLAU_26490 methylated-DNA-protein-cysteinemethyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SGLAU_27195 methylated-DNA-protein-cysteinemethyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SGLAU_08880 DNA-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SGLAU_02875 phr; Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E SGLAU_04095 ung1; Uracil-DNA glycosylase 1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SGLAU_05355 ung2; Uracil-DNA glycosylase 2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SGLAU_07930 Putative 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E SGLAU_18990 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SGLAU_18470 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E SGLAU_15330 ATP-dependent DNA helicase K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D SGLAU_15985 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGLAU_25085 DNA hydrolase with mutT domain-containing protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGLAU_21825 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGLAU_25275 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SGLAU_26490 methylated-DNA-protein-cysteinemethyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SGLAU_27195 methylated-DNA-protein-cysteinemethyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SGLAU_08880 DNA-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SGLAU_02875 phr; Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D SGLAU_03785 alkylated DNA repair protein K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E SGLAU_04095 ung1; Uracil-DNA glycosylase 1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SGLAU_05355 ung2; Uracil-DNA glycosylase 2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SGLAU_05065 G/U mismatch-specific DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E SGLAU_08995 hypothetical protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E SGLAU_19510 uracil-DNA glycosylase, family 4 K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E SGLAU_26485 ADA-like regulatory protein K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E SGLAU_27190 alkA; putative bifunctional transcriptional activator/DNA repair enzyme AlkA K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E SGLAU_07930 Putative 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E SGLAU_18990 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SGLAU_22035 DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E SGLAU_29200 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SGLAU_24030 mutM; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SGLAU_11985 nei1; Endonuclease 8 1 K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SGLAU_24815 nei; putative endonuclease 8 2 K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SGLAU_18470 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E SGLAU_27020 exonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E SGLAU_14485 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E SGLAU_09620 nfo; putative endonuclease 4 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E SGLAU_28120 nfi; Endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
D DNA ligase
E SGLAU_23595 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E SGLAU_09060 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E SGLAU_08800 uvrA; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
E SGLAU_29330 excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E SGLAU_08865 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
E SGLAU_08765 uvrC; UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
E SGLAU_20620 uvrD1; ATP-dependent DNA helicase UvrD1 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGLAU_03625 hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGLAU_22245 ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGLAU_22265 uvrD2; ATP-dependent DNA helicase UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGLAU_09060 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E SGLAU_23595 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F SGLAU_20035 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F SGLAU_20040 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F SGLAU_20265 rpoA1; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F SGLAU_05935 DNA-directed RNA polymerase omega chain protein K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F SGLAU_14165 mfd; Transcription-repair-coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E SGLAU_21750 xseA; Exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E SGLAU_21745 hypothetical protein K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E SGLAU_09360 dnaE; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E SGLAU_17035 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E SGLAU_11680 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E SGLAU_18615 DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E SGLAU_08120 DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SGLAU_26175 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SGLAU_03640 hypothetical protein K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SGLAU_06200 exonuclease K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SGLAU_16360 DNA polymerase subunit K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E SGLAU_23595 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E SGLAU_20620 uvrD1; ATP-dependent DNA helicase UvrD1 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGLAU_03625 hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGLAU_22245 ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGLAU_22265 uvrD2; ATP-dependent DNA helicase UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SGLAU_16895 ssb2; Single-stranded DNA-binding protein 2 K03111 ssb; single-strand DNA-binding protein
E SGLAU_12250 ssb1; Single-stranded DNA-binding protein 1 K03111 ssb; single-strand DNA-binding protein
E SGLAU_12975 DNA mismatch endonuclease vsr K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E SGLAU_12495 RecD/TraA family helicase K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E SGLAU_24855 recA; Protein RecA K03553 recA; recombination protein RecA
E SGLAU_06125 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E SGLAU_06120 ruvB; Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SGLAU_06130 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E SGLAU_05920 primosome assembly protein PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E SGLAU_00115 exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E SGLAU_05170 exonuclease K03546 sbcC; DNA repair protein SbcC/Rad50
E SGLAU_00120 nuclease SbcCD K03547 sbcD; DNA repair protein SbcD/Mre11
E SGLAU_05180 exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E SGLAU_24855 recA; Protein RecA K03553 recA; recombination protein RecA
E SGLAU_19005 radA; DNA repair protein K04485 radA; DNA repair protein RadA/Sms
E SGLAU_17045 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E SGLAU_23995 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E SGLAU_11470 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E SGLAU_18300 recR; Recombination protein RecR K06187 recR; recombination protein RecR
E SGLAU_07860 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E SGLAU_06125 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E SGLAU_06120 ruvB; Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SGLAU_06130 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E SGLAU_00115 exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E SGLAU_05170 exonuclease K03546 sbcC; DNA repair protein SbcC/Rad50
E SGLAU_00120 nuclease SbcCD K03547 sbcD; DNA repair protein SbcD/Mre11
E SGLAU_05180 exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
E SGLAU_16430 hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E SGLAU_22870 putative DNA repair protein K10979 ku; DNA end-binding protein Ku
E SGLAU_03430 secreted protein K10979 ku; DNA end-binding protein Ku
E SGLAU_27360 DNA polymerase LigD, polymerase domain-containing protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E SGLAU_02470 ATP-dependent DNA ligase K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E SGLAU_22865 DNA polymerase LigD, polymerase domain-containing protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F SGLAU_17060 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SGLAU_25150 DNA topoisomerase IV subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SGLAU_17055 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SGLAU_25115 DNA topoisomerase IV subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SGLAU_18605 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F SGLAU_13365 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
F SGLAU_23925 hup2; DNA-binding protein HU 2 K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F SGLAU_11470 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F SGLAU_18300 recR; Recombination protein RecR K06187 recR; recombination protein RecR
F SGLAU_23595 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F SGLAU_25075 ATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SGLAU_30810 RecQ familyATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SGLAU_19735 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SGLAU_08800 uvrA; UvrABC system protein A K03701 uvrA; excinuclease ABC subunit A
F SGLAU_29330 excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F SGLAU_08865 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D SGLAU_05495 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D SGLAU_32835 hypothetical protein K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D SGLAU_24855 recA; Protein RecA K03553 recA; recombination protein RecA
D SGLAU_25010 putative LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D SGLAU_07860 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D SGLAU_07675 DNA polymerase subunit III K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D SGLAU_16895 ssb2; Single-stranded DNA-binding protein 2 K03111 ssb; single-strand DNA-binding protein
D SGLAU_12250 ssb1; Single-stranded DNA-binding protein 1 K03111 ssb; single-strand DNA-binding protein
D SGLAU_24860 recombination regulator RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
D SGLAU_02855 PHP domain-containing protein K02347 polX; DNA polymerase (family X)
C DNA helicases
D SGLAU_25005 putative ATP-dependent helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D SGLAU_10430 putative ATP-dependent helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
D SGLAU_24820 ATP-dependent DNA helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D SGLAU_15985 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGLAU_25085 DNA hydrolase with mutT domain-containing protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGLAU_21825 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SGLAU_07825 ADP-ribose pyrophosphatase K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D SGLAU_25275 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SGLAU_22475 putative ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SGLAU_25020 nrdJ; Vitamin B12-dependent ribonucleotide reductase K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SGLAU_22470 putative ribonucleoside-diphosphate reductase, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024