+C Peptidases and inhibitors KO
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Peptidases and Inhibitors - Shewanella sp. MR-4
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AAspartic peptidases
B Family A1: pepsin family
B Family A2: retropepsin family
B Family A5: thermopsin family
B Family A8: signal peptidase II family
C Shewmr4_2956 signal peptidase II. Aspartic peptidase. MEROPS family A08 K03101 lspA; signal peptidase II [EC:3.4.23.36]
B Family A22: presenilin family
B Family A24: type IV prepilin peptidase family
C Shewmr4_0418 type 4 prepilin peptidase 1. Aspartic peptidase. MEROPS family A24A K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
B Family A25: gpr protease family
B Family A26: omptin family
B Family A28
B Family A31: HybD endopeptidase family
C Shewmr4_1819 hydrogenase expression/formation protein K03605 hyaD; hydrogenase maturation protease [EC:3.4.23.-]
B Family A36
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ACysteine peptidases
B Family C1: papain family
B Family C2: calpain family
B Family C3: picornain family
B Family C4: NIa protease family
B Family C5
B Family C9
B Family C10: streptopain family
B Family C11: clostripain family
B Family C12: ubiquitin C-terminal hydrolase family
B Family C13: legumain family
B Family C14: caspase family
B Family C15: pyroglutamyl peptidase I family
B Family C16
B Family C19: ubiquitin-specific protease family
B Family C25: gingipain family
B Family C26: gamma-glutamyl hydrolase family
C Shewmr4_1235 GMP synthase (glutamine-hydrolyzing) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
C Shewmr4_2920 peptidase C26 K07010 K07010; putative glutamine amidotransferase
B Family C27
B Family C30
B Family C37
B Family C39
B Family C40
C Shewmr4_0061 NLP/P60 protein K13694 mepS; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13]
B Family C44
C Shewmr4_1430 amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C Shewmr4_2872 glutamate synthase (NADPH) large subunit K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
C Shewmr4_3920 glutamine--fructose-6-phosphate transaminase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C Shewmr4_2934 Glutamine--fructose-6-phosphate transaminase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C Shewmr4_2384 asparagine synthase (glutamine-hydrolyzing) K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
B Family C45
B Family C46: hedgehog family
B Family C47: staphopain family
B Family C48: Ulp1 endopeptidase family
B Family C50: separase family
B Family C54: Aut2 peptidase family
B Family C55: YopJ protease family
B Family C56: PfpI endopeptidase family
C Shewmr4_2815 intracellular protease, PfpI family K05520 yhbO; deglycase [EC:3.5.1.124]
B Family C57: vaccinia virus I7 peptidase family
B Family C58
B Family C59
B Family C60
C Shewmr4_2199 sortase family protein K07284 srtA; sortase A [EC:3.4.22.70]
B Family C63
B Family C64
B Family C65
B Family C67
B Family C69
B Family C70
B Family C75
B Family C76
B Family C78
B Family C79
B Family C82
C Shewmr4_3091 ErfK/YbiS/YcfS/YnhG family protein K19235 ybiS; L,D-transpeptidase YbiS
C Shewmr4_2320 Peptidoglycan-binding domain 1 protein K21470 ycbB; L,D-transpeptidase YcbB
C Shewmr4_1831 Peptidoglycan-binding domain 1 protein K21470 ycbB; L,D-transpeptidase YcbB
B Family C83
B Family C85
B Family C86
B Family C88
B Family C89
B Family C97
B Family C98
B Family C110
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AGlutamic peptidases
B Family G1
B Family G4
B Family G5: prenyl protease 2 family
C Shewmr4_3298 Abortive infection protein K07052 K07052; CAAX protease family protein
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AMetallo peptidases
B Family M1
C Shewmr4_2267 peptidase M1, membrane alanine aminopeptidase K01254 LTA4H; leukotriene-A4 hydrolase [EC:3.3.2.6]
C Shewmr4_2706 peptidase M1, membrane alanine aminopeptidase K01254 LTA4H; leukotriene-A4 hydrolase [EC:3.3.2.6]
C Shewmr4_1674 aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
C Shewmr4_3040 aminopeptidase N. Metallo peptidase. MEROPS family M01 K01256 pepN; aminopeptidase N [EC:3.4.11.2]
B Family M2
C Shewmr4_2051 Peptidyl-dipeptidase A K01283 ACE; peptidyl-dipeptidase A [EC:3.4.15.1]
B Family M3
C Shewmr4_3842 oligopeptidase A. Metallo peptidase. MEROPS family M03A K01414 prlC; oligopeptidase A [EC:3.4.24.70]
C Shewmr4_1355 peptidyl-dipeptidase Dcp. Metallo peptidase. MEROPS family M03A K01284 dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5]
C Shewmr4_1525 peptidyl-dipeptidase Dcp. Metallo peptidase. MEROPS family M03A K01284 dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5]
C Shewmr4_2302 peptidyl-dipeptidase Dcp. Metallo peptidase. MEROPS family M03A K01284 dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5]
B Family M4: thermolysin family
C Shewmr4_2515 vibriolysin. Metallo peptidase. MEROPS family M04 K08604 hap; vibriolysin [EC:3.4.24.25]
B Family M5: mycolysin family
B Family M6: immune inhibitor A family
C Shewmr4_0125 peptidase M6, immune inhibitor A K09607 ina; immune inhibitor A [EC:3.4.24.-]
B Family M7: snapalysin family
B Family M8: leishmanolysin family
B Family M9
B Family M10
B Family M12: astacin/adamalysin family
B Family M13: neprilysin family
C Shewmr4_0499 Endothelin-converting enzyme 1 K07386 pepO; putative endopeptidase [EC:3.4.24.-]
C Shewmr4_3179 Endothelin-converting enzyme 1 K07386 pepO; putative endopeptidase [EC:3.4.24.-]
C Shewmr4_0433 Endothelin-converting enzyme 1 K07386 pepO; putative endopeptidase [EC:3.4.24.-]
B Family M14: carboxypeptidase A family
B Family M15: zinc D-Ala-D-Ala carboxypeptidase family
B Family M16: pitrilysin family
C Shewmr4_3417 peptidase M16 domain protein K07263 pqqL; zinc protease [EC:3.4.24.-]
C Shewmr4_2981 peptidase M16 domain protein K07263 pqqL; zinc protease [EC:3.4.24.-]
C Shewmr4_3742 peptidase M16 domain protein K07263 pqqL; zinc protease [EC:3.4.24.-]
C Shewmr4_3094 peptidase M16 domain protein K07263 pqqL; zinc protease [EC:3.4.24.-]
B Family M17: leucyl aminopeptidase family
C Shewmr4_0802 Leucyl aminopeptidase K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
C Shewmr4_0949 peptidase M17, leucyl aminopeptidase domain protein K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
C Shewmr4_2827 PepA aminopeptidase. Metallo peptidase. MEROPS family M17 K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
C Shewmr4_0732 PepB aminopeptidase. Metallo peptidase. MEROPS family M17 K07751 pepB; PepB aminopeptidase [EC:3.4.11.23]
B Family M18
B Family M19: membrane dipeptidase family
B Family M20
C Shewmr4_1857 succinyldiaminopimelate desuccinylase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
C Shewmr4_0948 Xaa-His dipeptidase. Metallo peptidase. MEROPS family M20C K01270 pepD; dipeptidase D [EC:3.4.13.-]
C Shewmr4_2301 dipeptidase, putative K01270 pepD; dipeptidase D [EC:3.4.13.-]
B Family M23
C Shewmr4_0288 peptidase M23B K21472 lytH; peptidoglycan LD-endopeptidase LytH [EC:3.4.-.-]
C Shewmr4_2448 peptidase M23B K19304 mepM; murein DD-endopeptidase [EC:3.4.24.-]
B Family M24
C Shewmr4_0884 methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C Shewmr4_2642 methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C Shewmr4_0019 Xaa-Pro dipeptidase. Metallo peptidase. MEROPS family M24B K01271 pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]
C Shewmr4_2807 peptidase M24 K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]
B Family M26
B Family M27
B Family M28: aminopeptidase Y family
B Family M29: aminopeptidase T family
B Family M32: carboxypeptidase Taq family
C Shewmr4_2819 Carboxypeptidase Taq K01299 E3.4.17.19; carboxypeptidase Taq [EC:3.4.17.19]
B Family M34: anthrax lethal factor family
B Family M35: deuterolysin family
B Family M36: fungalysin family
B Family M38: beta-aspartyl dipeptidase family
B Family M41: FtsH endopeptidase family
C Shewmr4_1019 membrane protease FtsH catalytic subunit K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
B Family M42: glutamyl aminopeptidase family
B Family M43: cytophagalysin family
B Family M44
B Family M48: Ste24 endopeptidase family
C Shewmr4_2351 HtpX peptidase. Metallo peptidase. MEROPS family M48B K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
C Shewmr4_2347 peptidase M48, Ste24p K01423 bepA; beta-barrel assembly-enhancing protease [EC:3.4.-.-]
B Family M49: dipeptidyl-peptidase III family
B Family M50: S2P protease family
C Shewmr4_2634 RseP peptidase. Metallo peptidase. MEROPS family M50B K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
B Family M54
B Family M55: DppA aminopeptidase family
B Family M56
B Family M67
B Family M72
B Family M73
B Family M74
B Family M80
B Family M82
B Family M85
B Family M88
C Shewmr4_0443 conserved hypothetical protein K21429 impA; immunomodulating metalloprotease
B Family M90
C Shewmr4_1210 protein of unknown function DUF980 K09933 mtfA; MtfA peptidase
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AAsparagine peptide lyases
B Family N1
B Family N8
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AMixed peptidases
B Family P1: DmpA aminopeptidase family
B Family P2
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ASerine peptidases
B Family S1: chymotrypsin family
C Shewmr4_3272 DegS. Serine peptidase. MEROPS family S01B K04691 hhoB; serine protease DegS [EC:3.4.21.-]
B Family S3: togavirin family
B Family S6
B Family S7: flavivirin family
B Family S8: subtilisin family
C Shewmr4_1390 peptidase S8 and S53, subtilisin, kexin, sedolisin K14645 K14645; serine protease [EC:3.4.21.-]
B Family S9: prolyl oligopeptidase family
C Shewmr4_2104 Prolyl oligopeptidase K01322 PREP; prolyl oligopeptidase [EC:3.4.21.26]
C Shewmr4_2373 prolyl oligopeptidase. Serine peptidase. MEROPS family S09A K01322 PREP; prolyl oligopeptidase [EC:3.4.21.26]
C Shewmr4_0650 dipeptidyl-peptidase IV. Serine peptidase. MEROPS family S09B K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5]
C Shewmr4_0136 oligopeptidase B. Serine peptidase. MEROPS family S09A K01354 ptrB; oligopeptidase B [EC:3.4.21.83]
B Family S10
B Family S11: D-Ala-D-Ala carboxypeptidase A family
C Shewmr4_0987 penicillin-binding protein 6. Serine peptidase. MEROPS family S11 K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C Shewmr4_0828 murein-DD-endopeptidase. Serine peptidase. MEROPS family S11 K07262 pbpG; serine-type D-Ala-D-Ala endopeptidase (penicillin-binding protein 7) [EC:3.4.21.-]
B Family S12: D-Ala-D-Ala carboxypeptidase B family
B Family S13: D-Ala-D-Ala peptidase C family
C Shewmr4_1932 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]
B Family S14: ClpP endopeptidase family
C Shewmr4_2495 ATP-dependent Clp protease proteolytic subunit ClpP K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
B Family S15
B Family S16: lon protease family
C Shewmr4_2493 Lon-A peptidase. Serine peptidase. MEROPS family S16 K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
C Shewmr4_1546 conserved hypothetical ATP-dependent protease K04770 lonH; Lon-like ATP-dependent protease [EC:3.4.21.-]
B Family S21: assemblin family
B Family S24: LexA family
C Shewmr4_3789 SOS-response transcriptional repressor, LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
C Shewmr4_1782 putative prophage repressor K03503 umuD; DNA polymerase V [EC:3.4.21.-]
B Family S26: signal peptidase I family
C Shewmr4_1481 signal peptidase I. Serine peptidase. MEROPS family S26A K03100 lepB; signal peptidase I [EC:3.4.21.89]
C Shewmr4_2849 signal peptidase I. Serine peptidase. MEROPS family S26A K03100 lepB; signal peptidase I [EC:3.4.21.89]
B Family S28
B Family S31
B Family S32
B Family S33
C Shewmr4_0317 prolyl aminopeptidase. Serine peptidase. MEROPS family S33 K01259 pip; proline iminopeptidase [EC:3.4.11.5]
B Family S41: C-terminal processing peptidase family
C Shewmr4_0043 C-terminal processing peptidase-3. Serine peptidase. MEROPS family S41A K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
C Shewmr4_1673 C-terminal processing peptidase-1. Serine peptidase. MEROPS family S41A K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
C Shewmr4_1143 peptidase S41 K08676 tri; tricorn protease [EC:3.4.21.-]
B Family S45
B Family S49: protease IV family
C Shewmr4_1909 signal peptide peptidase SppA, 67K type K04773 sppA; protease IV [EC:3.4.21.-]
C Shewmr4_1470 sohB peptidase. Serine peptidase. MEROPS family S49 K04774 sohB; serine protease SohB [EC:3.4.21.-]
B Family S50
B Family S51
C Shewmr4_2352 alpha-aspartyl dipeptidase. Serine peptidase. MEROPS family S51 K05995 pepE; dipeptidase E [EC:3.4.13.21]
B Family S53
B Family S54: Rhomboid family
C Shewmr4_3903 Rhomboid family protein K02441 glpG; rhomboid protease GlpG [EC:3.4.21.105]
B Family S55: SpoIVB peptidase family
B Family S62
B Family S66
B Family S77: phage prohead processing peptidase family
B Family S78
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AThreonine peptidases
B Family T1: proteasome family
C Shewmr4_3521 HslV component of HslUV peptidase. Threonine peptidase. MEROPS family T01B K01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]
B Family T2
C Shewmr4_1837 peptidase T2, asparaginase 2 K13051 ASRGL1; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5]
B Family T3: gamma-glutamyltransferase family
C Shewmr4_2297 gamma-glutamyltransferase 1. Threonine peptidase. MEROPS family T03 K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C Shewmr4_3344 gamma-glutamyltransferase 2. Threonine peptidase. MEROPS family T03 K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
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APeptidases of unknown catalytic type
B Family U32
C Shewmr4_1064 peptidase U32 K08303 prtC; U32 family peptidase [EC:3.4.-.-]
C Shewmr4_3138 peptidase U32 K24847 rlhA; 23S rRNA 5-hydroxycytidine C2501 synthase
C Shewmr4_1060 peptidase U32 K24845 ubiV; O2-independent ubiquinone biosynthesis protein UbiV
C Shewmr4_1061 peptidase U32 K24844 ubiU; O2-independent ubiquinone biosynthesis protein UbiU
B Family U62
C Shewmr4_3455 microcin-processing peptidase 1. Unknown type peptidase. MEROPS family U62 K03592 pmbA; PmbA protein
C Shewmr4_3465 microcin-processing peptidase 2. Unknown type peptidase. MEROPS family U62 K03568 tldD; TldD protein
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APeptidase inhibitors
B Family I1: Kazal family
B Family I2: Kunitz - BPTI family
B Family I4: serpin family
B Family I11: ecotin family
C Shewmr4_1947 proteinase inhibitor I11, ecotin K08276 eco; ecotin
B Family I17: WAP-type family
B Family I25: cystatin family
B Family I27: calpastatin family
B Family I32: IAP family
B Family I34: IA3 family
B Family I35: timp family
B Family I39: alpha2M family
B Family I47: latexin family
B Family I49: proSAAS family
B Family I51: IC family
B Family I57: staphostatin B family
B Family I63
B Family I80
B Family I87
C Shewmr4_0601 HflC protein K04087 hflC; modulator of FtsH protease HflC
C Shewmr4_0600 HflK protein K04088 hflK; modulator of FtsH protease HflK
B Family I93
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2024
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Classification taken and modified from MEROPS