+C	Two-component system	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Two-Component System - Shewanella khirikhana</h2>
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A<b>OmpR family</b>
B  PhoR-PhoB (phosphate starvation response)
C    STH12_00623 phoR; Phosphate regulon sensor protein PhoR	K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] 
C    STH12_00622 phoB_2; Phosphate regulon transcriptional regulatory protein PhoB	K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB 
B  SenX3-RegX3 (phosphate starvation response)
B  PhoQ-PhoP (magnesium transport)
C    STH12_03238 phoQ_3; Sensor protein PhoQ	K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] 
C    STH12_01189 phoQ_1; Virulence sensor histidine kinase PhoQ	K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] 
C    STH12_03237 copR_1; Transcriptional activator protein CopR	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
C    STH12_01190 phoP_1; Transcriptional regulatory protein PhoP	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
B  EnvZ-OmpR (osmotic stress response)
C    STH12_03458 envZ; Osmolarity sensor protein EnvZ	K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] 
C    STH12_03457 ompR_2; Transcriptional regulatory protein OmpR	K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR 
B  RstB-RstA
B  CpxA-CpxR (envelope stress response)
C    STH12_03371 cpxA_2; Sensor protein CpxA	K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3] 
C    STH12_03370 phoP_3; Alkaline phosphatase synthesis transcriptional regulatory protein PhoP	K07662 cpxR; two-component system, OmpR family, response regulator CpxR 
C    STH12_01395 mprA_2; Response regulator MprA	K07662 cpxR; two-component system, OmpR family, response regulator CpxR 
B  CssS-CssR (secretion stress response)
B  CreC-CreB (phosphate regulation)
B  BaeS-BaeR (envelope stress response)
B  BasS-BasR (antimicrobial peptide resistance)
B  CusS-CusR (copper tolerance)
B  QseC-QseB (quorum sensing)
B  KdpD-KdpE (potassium transport)
B  TorS-TorR (TMAO respiration)
C    STH12_00519 torS; Sensor protein TorS	K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3] 
C    STH12_00517 torR; TorCAD operon transcriptional regulatory protein TorR	K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR 
B  ArcB-ArcA (anoxic redox control)
C    STH12_00133 arcA; Aerobic respiration control protein ArcA	K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA 
B  TctE-TctD (tricarboxylic acid transport)
B  ResE-ResD (aerobic and anaerobic respiration)
B  VicK-VicR (cell wall metabolism)
B  MprB-MprA (maintenance of persistent infection)
B  MtrB-MtrA (osmotic stress response)
B  PrrB-PrrA (intracellular multiplication)
B  TrcS-TrcR
B  NrsS-NrsR (nickel tolerance)
B  ManS-ManR (manganese homeostasis)
B  NblS-NblR (photosynthesis)
B  SasA-RpaAB (circadian timing mediating)
B  SaeS-SaeR (staphylococcal virulence regulation)
B  BceS-BceR (bacitracin transport)
B  BraS-BraR (bacitracin transport)
B  GraS-GraR (cationic antimicrobial peptide transport)
B  YxdK-YxdJ (antimicrobial peptide response)
B  ChvG-ChvI (acidity sensing)
B  CiaH-CiaR
B  ParS-ParR (polymyxin-adaptive resistance)
B  AdeS-AdeR
B  VanS-VanR (VanB type vancomycin resistance)
B  VanS-VanR (VanE type vancomycin resistance)
B  VanS-VanR (actinomycete type vancomycin resistance)
B  ArlS-ArlR (virulence regulation)
B  Ihk-Irr (virulence regulation)
B  PfeS-PfeR (enterobactin-dependent iron acquisition)
B  NisK-NisR (lantibiotic biosynthesis)
B  Unclassified
C    STH12_02677 rstB_2; Sensor protein RstB	K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 
C    STH12_02918 phoP_2; Transcriptional regulatory protein PhoP	K02483 K02483; two-component system, OmpR family, response regulator 
C    STH12_03487 cusR; Transcriptional regulatory protein CusR	K02483 K02483; two-component system, OmpR family, response regulator 
C    STH12_00165 ompR_1; Transcriptional regulatory protein OmpR	K02483 K02483; two-component system, OmpR family, response regulator 
C    STH12_01695 creB; Transcriptional regulatory protein CreB	K02483 K02483; two-component system, OmpR family, response regulator 
C    STH12_02676 rstA; Transcriptional regulatory protein RstA	K02483 K02483; two-component system, OmpR family, response regulator 
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A<b>NarL family</b>
B  NarX-NarL (nitrate respiration)
B  NarQ-NarP (nitrate respiration)
C    STH12_00179 narX; Nitrate/nitrite sensor protein NarX	K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3] 
C    STH12_00178 narL; Nitrate/nitrite response regulator protein NarL	K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP 
B  UhpB-UhpA (hexose phosphates uptake)
C    STH12_03737 desK_2; Sensor histidine kinase DesK	K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] 
B  FusK-FusR (virulence regulation)
B  RcsC-RcsD-RcsB (capsule synthesis)
B  BarA-UvrY (central carbon metabolism)
C    STH12_00570 barA_3; Signal transduction histidine-protein kinase BarA	K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] 
C    STH12_01267 uvrY; Response regulator UvrY	K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY 
B  ComP-ComA (competence)
B  EvgS-EvgA (acid and drug tolerance)
B  DegS-DegU (multicellular behavior control)
B  DesK-DesR (membrane lipid fluidity regulation)
C    STH12_03308 desK_1; Sensor histidine kinase DesK	K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3] 
C    STH12_03309 degU_4; Transcriptional regulatory protein DegU	K07693 desR; two-component system, NarL family, response regulator DesR 
B  VraS-VraR (cell-wall peptidoglycan synthesis)
B  LiaS-LiaR (cell wall stress response)
B  DevS-DevR (redox response)
B  NreB-NreC (dissimilatory nitrate/nitrite reduction)
B  YdfH-YdfI
B  SalK-SalR
B  PprA–PprB (biofilm formation)
B  Unclassified
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A<b>Spo family</b>
B  KinABCDE-Spo0FA (sporulation control)
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A<b>CitB family</b>
B  CitA-CitB (citrate fermentation)
B  CitS-CitT (magnesium-citrate transport)
B  DcuS-DcuR (C4-dicarboxylate metabolism)
B  DctS-DctR (C4-dicarboxylate transport)
B  MalK-MalR (malate transport)
B  Unclassified
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A<b>LytTR family</b>
B  LysS-LysR
B  AlgZ-AlgR (alginate production)
B  NatK-NatR (sodium extrusion)
B  AgrC-AgrA (exoprotein synthesis)
B  AgrC2-AgrA2 (virulence regulation)
B  ComD-ComE (competence)
B  Unclassified
C    STH12_03523 putative sensor-like histidine kinase	K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] 
C    STH12_00851 yehU_1; Sensor histidine kinase YehU	K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] 
C    STH12_03984 yehT_3; Transcriptional regulatory protein YehT	K02477 K02477; two-component system, LytTR family, response regulator 
C    STH12_04204 yehT_4; Transcriptional regulatory protein YehT	K02477 K02477; two-component system, LytTR family, response regulator 
C    STH12_00850 yehT_1; Transcriptional regulatory protein YehT	K02477 K02477; two-component system, LytTR family, response regulator 
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A<b>NtrC family</b>
B  GlnL-GlnG (nitrogen regulation)
C    STH12_03363 glnL; Nitrogen regulation protein NR(II)	K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] 
C    STH12_03364 ntrC_4; Nitrogen assimilation regulatory protein	K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG 
B  NtrY-NtrX (nitrogen regulation)
B  HydH-HydG (metal tolerance)
B  AtoS-AtoC (cPHB biosynthesis)
B  PilS-PilR (type 4 fimbriae synthesis)
B  GlrK-GlrR (amino sugar metabolism)
B  PgtB-PgtA (phosphoglycerate transport)
C    STH12_03166 pgtB; Phosphoglycerate transport system sensor protein PgtB	K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3] 
C    STH12_03167 dctD_2; C4-dicarboxylate transport transcriptional regulatory protein DctD	K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA 
B  DctB-DctD (C4-dicarboxylate transport)
C    STH12_01963 dctB; C4-dicarboxylate transport sensor protein DctB	K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] 
C    STH12_01964 dctD_1; C4-dicarboxylate transport transcriptional regulatory protein DctD	K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD 
B  KinB-AlgB (alginate production)
B  HupT-HupR (hydrogenase synthesis regulation)
B  Unclassified
C    STH12_03802 zraS_3; Sensor protein ZraS	K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] 
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A<b>CheA family</b>
B  CheA-CheYBV (chemotaxis)
C    STH12_03439 cheA_2; Chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    STH12_02043 cheA_1; Chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    STH12_03438 cheY_4; Chemotaxis protein CheY	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    STH12_00010 cheY_1; Chemotaxis protein CheY	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    STH12_02045 cheY_3; Chemotaxis protein CheY	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    STH12_03443 cheB; Chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    STH12_02042 cheB1; Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    STH12_01727 cheV_1; Chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    STH12_01940 cheV_2; Chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    STH12_02086 cheV_3; Chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
B  ChpA-ChpB/PilGH (chemosensory)
B  PixL-PixGH (positive phototaxis)
B  WspE-WspRF (chemosensory)
B  Cph1-Rcp1 (light response)
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A<b>Cell cycle family</b>
B  PleC-PleD (cell fate control)
B  CckA-CtrA/CpdR (cell cycle control)
B  Hk1-Rrp1 (glycerol uptake and utilization)
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A<b>Lux family</b>
B  LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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A<b>LuxR family</b>
B  DctS-DctR (C4-dicarboxylate transport)
B  TtrS-TtrR (tetrathionate respiration)
C    STH12_04214 ttrS; Tetrathionate sensor histidine kinase TtrS	K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3] 
C    STH12_04213 todT_2; Response regulator protein TodT	K13041 ttrR; two-component system, LuxR family, response regulator TtrR 
B  FixL-FixJ (nitrogen fixation)
B  SsrA-SsrB
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A<b>Other families</b>
B  FlrB-FlrC (polar flagellar synthesis)
C    STH12_02066 kinA_2; Sporulation kinase A	K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3] 
C    STH12_02065 zraR_2; Transcriptional regulatory protein ZraR	K10943 flrC; two-component system, response regulator FlrC 
B  AauS-AauR (acidic amino acids utilization)
B  SLN1-YPD1-SSK1/SKN7 (osmosensing)
B  RpfC-RpfG (cell-to-cell signaling)
B  GlnK-GlnL (glutamine utilization)
B  HspS-HspR (hexose phosphates uptake)
B  YesM-YesN
B  CikA
B  RegB-RegA (redox response)
C    STH12_04205 regB; Sensor histidine kinase RegB	K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3] 
C    STH12_04206 regA; Photosynthetic apparatus regulatory protein RegA	K15012 regA; two-component system, response regulator RegA 
B  FitF-FitH (insecticidal toxin regulation)
B  PhcS-PhcRQ
B  SagS-HptB-HsbR (swarming activity and biofilm formation)
B  PdtaS-PdtaR
B  NasS-NasT
B  Unclassified
C    STH12_02822 ycf3; Photosystem I assembly protein Ycf3	K19694 chiS; two-component system, sensor histidine kinase ChiS 
C    STH12_02838 barA_6; Signal transduction histidine-protein kinase BarA	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
C    STH12_03466 barA_7; Signal transduction histidine-protein kinase BarA	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
C    STH12_00040 barA_1; Signal transduction histidine-protein kinase BarA	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
C    STH12_01986 barA_4; Signal transduction histidine-protein kinase BarA	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
C    STH12_02189 mprA_3; Response regulator MprA	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
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#Last updated: December 14, 2023