+D	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Prokaryotic Defense System - Streptococcus mutans NN2025 (serotype c)</h2>
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A<b>CRISPR-Cas system</b>
B  Universal Cas proteins
C    SmuNN2025_0609 hypothetical protein	K15342 cas1; CRISP-associated protein Cas1 
C    SmuNN2025_0695 hypothetical protein	K15342 cas1; CRISP-associated protein Cas1 
C    SmuNN2025_0610 DNA polymerase III alpha subunit	K09951 cas2; CRISPR-associated protein Cas2 
C    SmuNN2025_0696 hypothetical protein	K09951 cas2; CRISPR-associated protein Cas2 
B  Type I CRISPR-Cas system
C    Type I signiture cas proteins
D      SmuNN2025_0603 Predicted helicases	K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4] 
C    Subtype I-A factors
C    Subtype I-B factors
C    Subtype I-C factors
C    Subtype I-D factors
C    Subtype I-E factors
D      SmuNN2025_0604 hypothetical protein	K19123 casA; CRISPR system Cascade subunit CasA 
D      SmuNN2025_0605 hypothetical protein	K19046 casB; CRISPR system Cascade subunit CasB 
D      SmuNN2025_0606 hypothetical protein	K19124 casC; CRISPR system Cascade subunit CasC 
D      SmuNN2025_0607 hypothetical protein	K19125 casD; CRISPR system Cascade subunit CasD 
D      SmuNN2025_0608 transcriptional regulator	K19126 casE; CRISPR system Cascade subunit CasE 
C    Subtype I-F factors
C    Subtype I-U factors
B  Type II CRISPR-Cas system
C    Type II signiture cas proteins
D      SmuNN2025_0694 hypothetical protein	K09952 csn1; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-] 
C    Subtype II-A factors
D      SmuNN2025_0697 hypothetical protein	K19137 csn2; CRISPR-associated protein Csn2 
C    Subtype II-B factors
B  Type III CRISPR-Cas system
C    Type III signiture cas proteins
C    Subtype III-A factors
C    Subtype III-B factors
C    Subtype III-U factors
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A<b>Restriction and modification system (R-M system)</b>
B  Type I R-M system
C    SmuNN2025_0363 type I restriction-modification system methyltransferase subunit	K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] 
B  Type II R-M system
C    Restriction endonucleases
D      SmuNN2025_1466 putative type II restriction endonuclease	K01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4] 
C    DNA methyltransferases
D      SmuNN2025_1468 dam; putative site-specific DNA-methyltransferase	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
D      SmuNN2025_0178 hypothetical protein	K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] 
D      SmuNN2025_1467 putative adenine-specific DNA methylase	K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] 
B  Type III R-M system
B  Type IV R-M system
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A<b>Toxin-antitoxin system (TA system)</b>
B  Type I TA system
C    Hok-Sok
C    SymE-SymR
C    Ldr-Rdl
C    TisB-IstR
C    Ibs-Sib
C    ShoB-OhsC
C    RalR-RalA
B  Type II TA system
C    MazF-MazE
D      SmuNN2025_0145 putative ppGpp-regulated growth inhibitor	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      SmuNN2025_0795 transcriptional regulator	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      SmuNN2025_0144 conserved hypothetical protein	K07172 mazE; antitoxin MazE 
C    ChpB-ChpS
C    YhaV-PrlF
C    RelE/StbE-RelB/StbD
D      SmuNN2025_0373 plasmid addiction system poison protein	K06218 relE; mRNA interferase RelE/StbE 
C    YafQ-dinJ
C    YoeB-YefM
C    HipA-HipB
C    HicA-HicB
C    YafO-YafN
C    PspC-PspB
C    CcdB-CcdA
C    ParE-ParD
C    Doc-Phd
C    HigB-HigA
D      SmuNN2025_0802 Plasmid maintenance system antidote protein	K21498 higA-1; antitoxin HigA-1 
C    MqsR-MqsA
C    VapC-VapB
C    PezT-PezA
C    YobL-YobK
C    YokI-YokJ
C    YqcG-YqcF
C    YxiD-YxxD
C    FitB-FitA
C    BC_0920-BC_0921
C    SpoIISA-SpoIISB
C    Tse6-Tsi6
C    Type II TA system related factors
D      SmuNN2025_1420 ftsZ; putative cell division protein	K03531 ftsZ; cell division protein FtsZ 
D      SmuNN2025_0845 parC; topoisomerase IV subunit A	K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] 
D      SmuNN2025_0843 parE; putative DNA topoisomerase IV subunit B	K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] 
B  Type III TA system
C    AbiQ system
B  Type IV TA system
C    YeeV-YeeU
C    CptA-CptB
C    AbiEii-AbiEi
B  Type V TA system
C    GhoT-GhoS
C    Other GhoT/OrtT toxin family protein
B  Type VI TA system
C    SocB-SocA
B  Type VII TA system
C    Hha-TomB
C    TglT-TakA
C    HepT-MntA
B  Type VIII TA system
C    SdsR-RyeA
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A<b>DNA phosphothiolation system</b>
B  Sulfur modification proteins
C    SmuNN2025_0984 putative iron-sulfur cofactor synthesis protein	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
C    SmuNN2025_1173 putative aminotransferase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
B  DNA phosphorothioation-dependent restriction proteins
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#Last updated: May 19, 2025