+F Repair protein KO
#
DNA Repair and Recombination Proteins - Serratia marcescens WW4
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SMWW4_v1c25620 ogt; O-6-alkylguanine-DNA:cysteine-protein methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SMWW4_v1c12160 phr; FAD-binding deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E SMWW4_v1c37840 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SMWW4_v1c41450 mutY; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SMWW4_v1c22640 nth; DNA glycosylase and apyrimidinic (AP) lyase K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D SMWW4_v1c07570 mutT; nucleoside triphosphate pyrophosphohydrolase, marked preference for dGTP K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SMWW4_v1c14060 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SMWW4_v1c33300 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SMWW4_v1c00210 MutT family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SMWW4_v1c47760 dut; deoxyuridinetriphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SMWW4_v1c25620 ogt; O-6-alkylguanine-DNA:cysteine-protein methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SMWW4_v1c09430 AraC family transcriptional regulator K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D SMWW4_v1c12160 phr; FAD-binding deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D SMWW4_v1c32050 alkB; alkylated DNA repair protein K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E SMWW4_v1c37840 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SMWW4_v1c42250 mug; G/U mismatch-specific DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E SMWW4_v1c36570 alkA; 3-methyl-adenine DNA glycosylase II K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E SMWW4_v1c41450 mutY; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SMWW4_v1c00550 tag; 3-methyl-adenine DNA glycosylase I, constitutive K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E SMWW4_v1c47710 mutM; formamidopyrimidine/5-formyluracil/5-hydroxymethyluracil DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SMWW4_v1c12250 nei; endonuclease VIII/5-formyluracil/5-hydroxymethyluracil DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SMWW4_v1c22640 nth; DNA glycosylase and apyrimidinic (AP) lyase K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E SMWW4_v1c27280 xthA; exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E SMWW4_v1c33250 nfo; endonuclease IV with intrinsic 3'-5' exonuclease activity K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E SMWW4_v1c02940 nfi; endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E SMWW4_v1c40000 recJ; ssDNA exonuclease, 5' --> 3'-specific K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E SMWW4_v1c35550 ligA; DNA ligase, NAD(+)-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E SMWW4_v1c48050 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E SMWW4_v1c44090 uvrA; ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC K03701 uvrA; excinuclease ABC subunit A
E SMWW4_v1c12860 uvrB; excinulease of nucleotide excision repair, DNA damage recognition component K03702 uvrB; excinuclease ABC subunit B
E SMWW4_v1c17970 uvrC; excinuclease UvrABC, endonuclease subunit K03703 uvrC; excinuclease ABC subunit C
E SMWW4_v1c18090 cho; endonuclease of nucleotide excision repair K05984 cho; excinuclease Cho [EC:3.1.25.-]
E SMWW4_v1c01950 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SMWW4_v1c48050 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E SMWW4_v1c35550 ligA; DNA ligase, NAD(+)-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F SMWW4_v1c02790 rpoB; RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F SMWW4_v1c02800 rpoC; RNA polymerase, beta prime subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F SMWW4_v1c44830 rpoA; RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F SMWW4_v1c47860 rpoZ; RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F SMWW4_v1c20190 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E SMWW4_v1c08120 mutS; methyl-directed mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E SMWW4_v1c03710 mutL; methyl-directed mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E SMWW4_v1c39460 mutH; methyl-directed mismatch repair protein K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E SMWW4_v1c33090 sbcB; exonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E SMWW4_v1c37060 xseA; exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E SMWW4_v1c10230 xseB; exonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E SMWW4_v1c18980 exoX; DNA exonuclease X K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E SMWW4_v1c38940 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E SMWW4_v1c00330 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E SMWW4_v1c04930 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E SMWW4_v1c11730 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E SMWW4_v1c18710 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E SMWW4_v1c08600 dnaQ; DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SMWW4_v1c10740 dnaX; DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E SMWW4_v1c06410 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E SMWW4_v1c33080 hypothetical protein K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E SMWW4_v1c35550 ligA; DNA ligase, NAD(+)-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E SMWW4_v1c01950 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SMWW4_v1c44080 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E SMWW4_v1c45560 dam; DNA adenine methyltransferase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E SMWW4_v1c39350 recB; exonuclease V (RecBCD complex), beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E SMWW4_v1c39370 recC; exonuclease V (RecBCD complex), gamma chain K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E SMWW4_v1c39340 recD; exonuclease V (RecBCD complex), alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E SMWW4_v1c08250 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
E SMWW4_v1c27910 ruvA; component of RuvABC resolvasome, regulatory subunit K03550 ruvA; holliday junction DNA helicase RuvA
E SMWW4_v1c27900 ruvB; ATP-dependent DNA helicase, component of RuvABC resolvasome K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SMWW4_v1c27920 ruvC; component of RuvABC resolvasome, endonuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E SMWW4_v1c47200 priA; primosome factor n' (replication factor Y) K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E SMWW4_v1c10710 priC; primosomal replication protein N'' K04067 priC; primosomal replication protein N''
E SMWW4_v1c33090 sbcB; exonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E SMWW4_v1c09950 sbcC; exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E SMWW4_v1c09960 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E SMWW4_v1c08250 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
E SMWW4_v1c06580 radA; DNA repair protein K04485 radA; DNA repair protein RadA/Sms
E SMWW4_v1c00340 recF; gap repair protein K03629 recF; DNA replication and repair protein RecF
E SMWW4_v1c47890 recG; ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E SMWW4_v1c40000 recJ; ssDNA exonuclease, 5' --> 3'-specific K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E SMWW4_v1c37680 recO; gap repair protein K03584 recO; DNA repair protein RecO (recombination protein O)
E SMWW4_v1c10760 recR; gap repair protein K06187 recR; recombination protein RecR
E SMWW4_v1c37870 recN; recombination and repair protein K03631 recN; DNA repair protein RecN (Recombination protein N)
E SMWW4_v1c09900 rdgC; nucleoid-associated ssDNA and dsDNA binding protein K03554 rdgC; recombination associated protein RdgC
E SMWW4_v1c27910 ruvA; component of RuvABC resolvasome, regulatory subunit K03550 ruvA; holliday junction DNA helicase RuvA
E SMWW4_v1c27900 ruvB; ATP-dependent DNA helicase, component of RuvABC resolvasome K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SMWW4_v1c27920 ruvC; component of RuvABC resolvasome, endonuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E SMWW4_v1c33500 yejH; putative ATP-dependent DNA or RNA helicase K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E SMWW4_v1c09950 sbcC; exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E SMWW4_v1c09960 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E SMWW4_v1c45390 hypothetical protein, DUF853 family K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F SMWW4_v1c33770 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SMWW4_v1c00350 gyrB; DNA gyrase, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SMWW4_v1c26540 topA; DNA topoisomerase I, omega subunit K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F SMWW4_v1c02960 hupA; HU, DNA-binding transcriptional regulator, alpha subunit K05787 hupA; DNA-binding protein HU-alpha
F SMWW4_v1c10410 hupB; DNA-binding protein HU-beta K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F SMWW4_v1c19120 exodeoxyribonuclease K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F SMWW4_v1c40000 recJ; ssDNA exonuclease, 5' --> 3'-specific K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F SMWW4_v1c37680 recO; gap repair protein K03584 recO; DNA repair protein RecO (recombination protein O)
F SMWW4_v1c10760 recR; gap repair protein K06187 recR; recombination protein RecR
F SMWW4_v1c35550 ligA; DNA ligase, NAD(+)-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F SMWW4_v1c43890 fis; global DNA-binding transcriptional dual regulator K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F SMWW4_v1c21770 ihfA; integration host factor (IHF), DNA-binding protein, alpha subunit K04764 ihfA; integration host factor subunit alpha
F SMWW4_v1c16930 ihfB; integration host factor (IHF), DNA-binding protein, beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F SMWW4_v1c33090 sbcB; exonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F SMWW4_v1c02010 recQ; ATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SMWW4_v1c44090 uvrA; ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC K03701 uvrA; excinuclease ABC subunit A
F SMWW4_v1c12860 uvrB; excinulease of nucleotide excision repair, DNA damage recognition component K03702 uvrB; excinuclease ABC subunit B
F SMWW4_v1c27190 hns; global DNA-binding transcriptional dual regulator H-NS K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D SMWW4_v1c08870 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D SMWW4_v1c30420 umuC; DNA polymerase V, subunit C K03502 umuC; DNA polymerase V
D SMWW4_v1c19610 SOS mutagenesis and repair protein UmuD K03503 umuD; DNA polymerase V [EC:3.4.21.-]
D SMWW4_v1c30430 umuD; DNA polymerase V, subunit D K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D SMWW4_v1c08250 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
D SMWW4_v1c44280 lexA; DNA-binding transcriptional repressor of SOS regulon K01356 lexA; repressor LexA [EC:3.4.21.88]
D SMWW4_v1c37870 recN; recombination and repair protein K03631 recN; DNA repair protein RecN (Recombination protein N)
D SMWW4_v1c07170 polB; DNA polymerase II K02336 polB; DNA polymerase II [EC:2.7.7.7]
D SMWW4_v1c44080 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D SMWW4_v1c18540 dinI; DNA damage-inducible protein I K12149 dinI; DNA-damage-inducible protein I
D SMWW4_v1c08260 recX; regulatory protein for RecA K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D SMWW4_v1c01660 rep; DNA helicase and single-stranded DNA-dependent ATPase K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D SMWW4_v1c17410 helD; DNA helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D SMWW4_v1c14400 dinG; ATP-dependent DNA helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D SMWW4_v1c27760 hypothetical protein K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D SMWW4_v1c07570 mutT; nucleoside triphosphate pyrophosphohydrolase, marked preference for dGTP K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SMWW4_v1c14060 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SMWW4_v1c33300 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SMWW4_v1c00210 MutT family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SMWW4_v1c47760 dut; deoxyuridinetriphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SMWW4_v1c33790 nrdA; ribonucleoside-diphosphate reductase 1 alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SMWW4_v1c38470 nrdE; ribonucleoside-diphosphate reductase 2, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SMWW4_v1c33800 nrdB; ribonucleoside-diphosphate reductase 1 beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D SMWW4_v1c38480 nrdF; ribonucleoside-diphosphate reductase 2, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024