+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptomyces nitrosporeus
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
D CP967_12660 acyltransferase domain-containing protein K15320 ATX; 6-methylsalicylic acid synthase [EC:2.3.1.165]
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E CP967_32640 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
E CP967_32645 ketosynthase chain-length factor K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
E CP967_32650 acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein
E CP967_32655 polyketide cyclase K14670 whiEVI; aromatase
E CP967_32660 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E CP967_10260 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP967_10255 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP967_10250 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP967_10395 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E CP967_10325 cyclase K05554 actVII; aromatase [EC:4.2.1.-]
E CP967_06770 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-]
E CP967_10405 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E CP967_10260 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP967_10255 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP967_10250 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP967_10395 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
D Decaketide PKS
E CP967_10260 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP967_10255 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP967_10250 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP967_10395 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
D CP967_04420 amino acid adenylation domain-containing protein K15395 ftdB; hybrid polyketide synthase / nonribosomal peptide synthetase FtdB
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D CP967_01520 MbtH family protein K05375 mbtH; MbtH protein
D CP967_07080 MbtH family protein K05375 mbtH; MbtH protein
D CP967_19575 hypothetical protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D CP967_00455 4'-phosphopantetheinyl transferase superfamily protein K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]
D CP967_19495 4'-phosphopantetheinyl transferase superfamily protein K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]
D CP967_01500 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D CP967_01515 amino acid adenylation domain-containing protein K02364 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72]
C Bacillibactin synthetase
D CP967_01500 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
D CP967_01500 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D CP967_01500 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D CP967_01500 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
B Ketoreductase
B Oxygenase
C CP967_02920 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C CP967_04280 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C CP967_14380 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C CP967_15145 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C CP967_22285 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C CP967_19910 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CP967_00240 enoyl-CoA hydratase/isomerase family protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
C CP967_32635 cupin domain-containing protein K14673 whiEII; putative monooxygenase
C CP967_32625 monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C CP967_12565 radical SAM protein K21224 kedN5; radical SAM C-methyltransferase
C CP967_32665 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
B Aminotransferase
B Others
C CP967_00240 enoyl-CoA hydratase/isomerase family protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: June 19, 2024