+F Repair protein KO
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DNA Repair and Recombination Proteins - Sitophilus oryzae (rice weevil)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 115883112 uncharacterized protein LOC115883112 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 115881898 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 115885602 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 115886636 uncharacterized protein LOC115886636 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 115887130 uncharacterized protein LOC115887130 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 115890094 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 115884852 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 115876371 uncharacterized protein LOC115876371 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 115888081 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 115886034 DNA-(apurinic or apyrimidinic site) lyase-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 115891039 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 115879353 DNA polymerase delta small subunit isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 115874869 uncharacterized protein LOC115874869 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 115884963 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 115881218 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 115880623 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 115888320 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 115885314 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 115874147 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 115885097 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 115875944 DNA polymerase beta-like isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 115888268 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 115886820 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 115890726 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 115878372 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 115888463 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 115874515 high mobility group protein DSP1-like isoform X1 K10802 HMGB1; high mobility group protein B1
E 115879905 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 115882196 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 115874588 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 115874647 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 115887124 cullin-4B K10609 CUL4; cullin 4
F 115888932 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 115885360 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 115885415 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 115884804 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 115878889 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 115877497 transcriptional adapter 2A K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 115877601 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 115878331 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 115881755 DNA-directed RNA polymerases I, II, and III subunit RPABC2-like K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 115886409 DNA-directed RNA polymerases I, II, and III subunit RPABC2-like K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 115875173 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 115878352 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 115888662 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 115886566 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 115874647 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 115887124 cullin-4B K10609 CUL4; cullin 4
F 115888932 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 115881215 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 115886753 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 115889885 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 115889652 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 115876406 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 115877990 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 115880165 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 115889141 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 115883587 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 115885349 cyclin-H K06634 CCNH; cyclin H
E 115885419 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 115880325 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 115888426 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 115883041 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Other NER factors
E 115876683 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 115889618 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 115878661 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 115877473 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 115885097 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 115889613 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 115880485 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 115884546 cullin-5 K10612 CUL5; cullin 5
E 115889363 elongin-C K03872 ELOC; elongin-C
E 115881392 elongin-B K03873 ELOB; elongin-B
E 115882717 transcription elongation factor B polypeptide 3 isoform X1 K15076 ELOA; elongin-A
E 115884877 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 115886714 DNA mismatch repair protein Msh2 isoform X1 K08735 MSH2; DNA mismatch repair protein MSH2
E 115879733 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 115877079 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 115882169 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 115891039 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 115879353 DNA polymerase delta small subunit isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 115874869 uncharacterized protein LOC115874869 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 115880325 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 115888426 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 115883041 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 115881490 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 115880865 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 115881473 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 115874769 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 115886297 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 115885314 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 115875112 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 115874515 high mobility group protein DSP1-like isoform X1 K10802 HMGB1; high mobility group protein B1
E 115885097 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 115888759 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115875809 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 115880385 nibrin-like K10867 NBN; nibrin
E 115877477 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 115884928 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
E 115876385 uncharacterized protein LOC115876385 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 115884449 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 115886439 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 115878272 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 115875909 DNA topoisomerase 2-binding protein 1-A isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 115888759 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115875809 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 115880385 nibrin-like K10867 NBN; nibrin
E 115877477 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 115874797 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 115874797 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 115890327 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 115874911 uncharacterized protein LOC115874911 K10879 XRCC2; DNA-repair protein XRCC2
E 115876275 DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 115881628 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 115888533 uncharacterized protein LOC115888533 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 115876668 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 115880496 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 115878344 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 115880895 ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 115884909 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 115878344 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 115888746 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 115885256 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 115887884 recQ-mediated genome instability protein 1-like isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 115880325 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 115888426 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 115883041 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 115879992 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 115880903 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 115885272 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 115890441 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 115875255 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 115884277 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 115880301 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 115876509 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 115878214 E3 SUMO-protein ligase NSE2-like K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 115878217 E3 SUMO-protein ligase NSE2-like K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 115890233 melanoma-associated antigen B10-like K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 115886762 EP300-interacting inhibitor of differentiation 3-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 115882048 probable crossover junction endonuclease EME2 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 115891202 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 115881746 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 115883800 structure-specific endonuclease subunit slx1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 115891762 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 115879816 LOW QUALITY PROTEIN: spatacsin K19026 SPG11; spatacsin
E 115876505 zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 115876189 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 115882732 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 115888225 uncharacterized protein LOC115888225 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 115881796 uncharacterized protein LOC115881796 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 115886080 uncharacterized protein LOC115886080 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 115878021 protein tilB homolog K23456 CFAP410; cilla- and flagella-associated protein
E 115889036 zinc finger SWIM domain-containing protein 7-like K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 115884702 BRCA2-interacting transcriptional repressor EMSY-like K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 115880466 BRCA2-interacting transcriptional repressor EMSY-like K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 115886604 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 115877322 tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 115881286 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 115875969 uncharacterized protein LOC115875969 isoform X1 K27803 HROB; homologous recombination OB-fold protein
E 115874145 DNA helicase MCM8-like isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 115881891 DNA helicase MCM9-like K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
E 115885392 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 115890027 uncharacterized protein LOC115890027 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 115889531 uncharacterized protein LOC115889531 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 115884364 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 115888759 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115875809 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 115890526 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 115887929 uncharacterized protein LOC115887929 K10886 XRCC4; DNA-repair protein XRCC4
E 115882741 uncharacterized protein LOC115882741 K10980 NHEJ1; non-homologous end-joining factor 1
E 115875252 uncharacterized protein LOC115875252 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 115875944 DNA polymerase beta-like isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 115887191 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 115880013 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 115886430 uncharacterized protein LOC115886430 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 115880820 transcription factor HES-2-like K06054 HES1; hairy and enhancer of split 1
E 115880822 enhancer of split m7 protein-like K06054 HES1; hairy and enhancer of split 1
E 115880221 centromere protein S-like K11511 APITD1; centromere protein S
E 115886140 centromere protein X-like K15360 STRA13; centromere protein X
E 115882327 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 115878344 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 115888746 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 115885256 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 115887884 recQ-mediated genome instability protein 1-like isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 115889510 Fanconi anemia group D2 protein homolog K10891 FANCD2; fanconi anemia group D2 protein
E 115889526 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 115874940 fanconi-associated nuclease 1-like isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 115874797 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 115890327 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 115879720 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 115888228 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 115891729 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 115879958 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 115877102 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 115881043 E3 ubiquitin-protein ligase RNF8-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 115879814 E3 ubiquitin-protein ligase RNF168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 115882783 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 115874253 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
E 115891429 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 115887836 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 115882734 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 115888648 LOW QUALITY PROTEIN: DNA repair protein REV1-like K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
D 115889677 DNA repair protein REV1-like K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 115881359 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 115891087 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 115878176 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 115878706 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 115882365 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 115885314 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 115883907 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 115879674 uncharacterized protein LOC115879674 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 115885053 cell cycle checkpoint control protein RAD9A isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 115889300 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 115880120 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 115874344 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 115880865 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 115881473 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 115874769 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 115886297 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 115880120 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 115878283 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 115874803 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 115888083 claspin-like K25773 CLSPN; claspin
C Triple T complex
D 115883981 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 115878160 large proline-rich protein bag6-A isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 115884297 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 115881778 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 115875404 serine/threonine-protein kinase ATR-like isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 115874995 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 115884493 serine/threonine-protein kinase grp isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 115884314 serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 115875922 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 115876641 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 115876934 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 115876727 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 115877107 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 115888857 protein sickie isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 115883097 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 115879660 LOW QUALITY PROTEIN: period circadian protein-like K02633 PER2; period circadian protein 2
D 115891578 period circadian protein-like isoform X1 K02633 PER2; period circadian protein 2
D 115890464 mediator of DNA damage checkpoint protein 1-like isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 115887162 plastin-2 K17336 PLS3; plastin-3
D 115885400 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 115876702 KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 115888440 suppressor protein of bem1/bed5 double mutants-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 115885871 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 115889026 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 115888494 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 115880831 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 115878530 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 115878495 uncharacterized protein LOC115878495 isoform X1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 115876498 ankyrin repeat and LEM domain-containing protein 1-like K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 115887239 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 115891822 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 115880845 LOW QUALITY PROTEIN: cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 115875440 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 115876181 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 115884432 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 115878620 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115879644 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115888942 probable deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115889123 probable deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115890611 probable deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115890941 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115891237 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115882117 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115883236 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115874072 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115874651 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115875529 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115875705 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115886147 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115887637 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115887808 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115874541 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 115874542 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 115877285 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 115883112 uncharacterized protein LOC115883112 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 115886636 uncharacterized protein LOC115886636 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 115884852 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 115890094 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 115880236 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 115880236 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 115878620 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115879644 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115888942 probable deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115889123 probable deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115890611 probable deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115890941 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115891237 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115882117 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115883236 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115874072 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115874651 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115875529 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115875705 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115886147 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115887637 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115887808 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024