+C Peptidases and inhibitors KO
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Peptidases and Inhibitors - Streptomyces parvulus
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AAspartic peptidases
B Family A1: pepsin family
B Family A2: retropepsin family
B Family A5: thermopsin family
B Family A8: signal peptidase II family
C Spa2297_08475 signal peptidase II K03101 lspA; signal peptidase II [EC:3.4.23.36]
B Family A22: presenilin family
B Family A24: type IV prepilin peptidase family
C Spa2297_19150 hypothetical protein K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
B Family A25: gpr protease family
B Family A26: omptin family
B Family A28
B Family A31: HybD endopeptidase family
B Family A36
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ACysteine peptidases
B Family C1: papain family
B Family C2: calpain family
B Family C3: picornain family
B Family C4: NIa protease family
B Family C5
B Family C9
B Family C10: streptopain family
B Family C11: clostripain family
B Family C12: ubiquitin C-terminal hydrolase family
B Family C13: legumain family
B Family C14: caspase family
B Family C15: pyroglutamyl peptidase I family
C Spa2297_31290 pyroglutamyl-peptidase I K01304 pcp; pyroglutamyl-peptidase [EC:3.4.19.3]
B Family C16
B Family C19: ubiquitin-specific protease family
B Family C25: gingipain family
B Family C26: gamma-glutamyl hydrolase family
C Spa2297_20180 glutamine-hydrolyzing GMP synthase K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
C Spa2297_30625 aminotransferase K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
C Spa2297_06230 gamma-glutamyl-gamma-aminobutyrate hydrolase K07010 K07010; putative glutamine amidotransferase
B Family C27
B Family C30
B Family C37
B Family C39
B Family C40
C Spa2297_00475 hypothetical protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C Spa2297_08785 hypothetical protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C Spa2297_08790 hypothetical protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C Spa2297_15185 glycoside hydrolase K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C Spa2297_19190 glycoside hydrolase K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C Spa2297_20225 hypothetical protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C Spa2297_20240 glycoside hydrolase K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C Spa2297_22370 hypothetical protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
B Family C44
C Spa2297_15765 amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C Spa2297_08245 glutamate synthase subunit alpha K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
C Spa2297_02980 hypothetical protein K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C Spa2297_11820 glutamine--fructose-6-phosphate aminotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C Spa2297_19985 glutamine--fructose-6-phosphate aminotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C Spa2297_31780 asparagine synthase (glutamine-hydrolyzing) K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
B Family C45
B Family C46: hedgehog family
B Family C47: staphopain family
B Family C48: Ulp1 endopeptidase family
B Family C50: separase family
B Family C54: Aut2 peptidase family
B Family C55: YopJ protease family
B Family C56: PfpI endopeptidase family
C Spa2297_27130 protease K05520 yhbO; deglycase [EC:3.5.1.124]
B Family C57: vaccinia virus I7 peptidase family
B Family C58
B Family C59
B Family C60
C Spa2297_16710 class E sortase K07284 srtA; sortase A [EC:3.4.22.70]
B Family C63
B Family C64
B Family C65
B Family C67
B Family C69
B Family C70
B Family C75
B Family C76
B Family C78
B Family C79
B Family C82
B Family C83
B Family C85
B Family C86
B Family C88
B Family C89
B Family C97
B Family C98
B Family C110
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AGlutamic peptidases
B Family G1
B Family G4
B Family G5: prenyl protease 2 family
C Spa2297_25945 CAAX protease K07052 K07052; CAAX protease family protein
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AMetallo peptidases
B Family M1
C Spa2297_08210 aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
C Spa2297_11160 aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
C Spa2297_11195 aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
B Family M2
B Family M3
B Family M4: thermolysin family
C Spa2297_10450 peptidase K20273 zmpA; zinc metalloprotease ZmpA
B Family M5: mycolysin family
B Family M6: immune inhibitor A family
C Spa2297_12495 protease K09607 ina; immune inhibitor A [EC:3.4.24.-]
B Family M7: snapalysin family
C Spa2297_01580 ABC transporter substrate-binding protein K01416 snpA; snapalysin [EC:3.4.24.77]
C Spa2297_31685 peptidase K01416 snpA; snapalysin [EC:3.4.24.77]
B Family M8: leishmanolysin family
B Family M9
B Family M10
B Family M12: astacin/adamalysin family
B Family M13: neprilysin family
B Family M14: carboxypeptidase A family
B Family M15: zinc D-Ala-D-Ala carboxypeptidase family
C Spa2297_23100 peptidase M15 K08640 E3.4.17.14; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
C Spa2297_03320 dipeptidase K08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]
C Spa2297_05150 D-alanyl-D-alanine dipeptidase K08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]
B Family M16: pitrilysin family
B Family M17: leucyl aminopeptidase family
C Spa2297_09005 leucyl aminopeptidase K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
B Family M18
B Family M19: membrane dipeptidase family
C Spa2297_13250 membrane dipeptidase K01273 DPEP; membrane dipeptidase [EC:3.4.13.19]
B Family M20
C Spa2297_21665 succinyl-diaminopimelate desuccinylase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
C Spa2297_03560 dipeptidase K23980 tpdA; cysteinylglycine-S-conjugate dipeptidase [EC:3.4.13.23]
B Family M23
B Family M24
C Spa2297_09460 type I methionyl aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C Spa2297_19905 type I methionyl aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C Spa2297_26730 type I methionyl aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C Spa2297_16170 Xaa-Pro aminopeptidase K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]
B Family M26
B Family M27
B Family M28: aminopeptidase Y family
C Spa2297_19400 peptidase M28 K19702 E3.4.11.24; aminopeptidase S [EC:3.4.11.24]
B Family M29: aminopeptidase T family
B Family M32: carboxypeptidase Taq family
B Family M34: anthrax lethal factor family
B Family M35: deuterolysin family
B Family M36: fungalysin family
B Family M38: beta-aspartyl dipeptidase family
B Family M41: FtsH endopeptidase family
C Spa2297_18180 cell division protein FtsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
B Family M42: glutamyl aminopeptidase family
B Family M43: cytophagalysin family
B Family M44
B Family M48: Ste24 endopeptidase family
C Spa2297_19495 zinc metalloprotease HtpX K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
B Family M49: dipeptidyl-peptidase III family
B Family M50: S2P protease family
B Family M54
B Family M55: DppA aminopeptidase family
C Spa2297_26995 peptide ABC transporter substrate-binding protein K16203 dppA1; D-amino peptidase [EC:3.4.11.-]
B Family M56
C Spa2297_03675 hypothetical protein K02172 blaR1; bla regulator protein blaR1
C Spa2297_19305 hypothetical protein K02172 blaR1; bla regulator protein blaR1
B Family M67
B Family M72
B Family M73
B Family M74
B Family M80
B Family M82
C Spa2297_15640 hypothetical protein K24131 prsW; protease PrsW [EC:3.4.-.-]
B Family M85
B Family M88
B Family M90
B Family M98
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AAsparagine peptide lyases
B Family N1
B Family N8
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AMixed peptidases
B Family P1: DmpA aminopeptidase family
B Family P2
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ASerine peptidases
B Family S1: chymotrypsin family
C Spa2297_15400 protease K08372 pepD; putative serine protease PepD [EC:3.4.21.-]
C Spa2297_16135 protease K08372 pepD; putative serine protease PepD [EC:3.4.21.-]
C Spa2297_21710 protease K08372 pepD; putative serine protease PepD [EC:3.4.21.-]
C Spa2297_06855 streptogrisin K18545 sprB; streptogrisin B [EC:3.4.21.81]
C Spa2297_29320 streptogrisin B precursor K18545 sprB; streptogrisin B [EC:3.4.21.81]
C Spa2297_01775 peptidase S1 K18546 sprC; streptogrisin C [EC:3.4.21.-]
C Spa2297_19710 serine protease K18546 sprC; streptogrisin C [EC:3.4.21.-]
C Spa2297_29545 serine protease K18546 sprC; streptogrisin C [EC:3.4.21.-]
C Spa2297_06850 streptogrisin K18547 sprD; streptogrisin D [EC:3.4.21.-]
C Spa2297_29945 protease K18547 sprD; streptogrisin D [EC:3.4.21.-]
C Spa2297_30040 protease K18547 sprD; streptogrisin D [EC:3.4.21.-]
B Family S3: togavirin family
B Family S6
B Family S7: flavivirin family
B Family S8: subtilisin family
B Family S9: prolyl oligopeptidase family
C Spa2297_21610 peptidase S9 K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5]
B Family S10
B Family S11: D-Ala-D-Ala carboxypeptidase A family
C Spa2297_03120 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C Spa2297_14235 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C Spa2297_16900 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C Spa2297_20465 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
B Family S12: D-Ala-D-Ala carboxypeptidase B family
B Family S13: D-Ala-D-Ala peptidase C family
C Spa2297_18160 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]
C Spa2297_26790 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]
B Family S14: ClpP endopeptidase family
C Spa2297_02280 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C Spa2297_02285 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C Spa2297_04500 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C Spa2297_11070 clpP; ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C Spa2297_11075 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
B Family S15
C Spa2297_28050 Xaa-Pro dipeptidyl-peptidase K01281 pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11]
B Family S16: lon protease family
C Spa2297_22325 endopeptidase La K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
C Spa2297_12560 hypothetical protein K07177 K07177; Lon-like protease
C Spa2297_21970 PDZ/DHR/GLGF domain-containing protein K07177 K07177; Lon-like protease
B Family S21: assemblin family
B Family S24: LexA family
C Spa2297_24565 repressor LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
B Family S26: signal peptidase I family
C Spa2297_23760 signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
C Spa2297_23765 signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
C Spa2297_23770 signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
B Family S28
B Family S31
B Family S32
B Family S33
C Spa2297_08060 prolyl aminopeptidase K01259 pip; proline iminopeptidase [EC:3.4.11.5]
C Spa2297_17850 epoxide hydrolase K27108 ephA_B; epoxide hydrolase A/B [EC:3.3.2.-]
B Family S41: C-terminal processing peptidase family
C Spa2297_12825 peptidase S41 K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
C Spa2297_10735 peptidase S41 K08676 tri; tricorn protease [EC:3.4.21.-]
C Spa2297_13785 peptidase S41 K08676 tri; tricorn protease [EC:3.4.21.-]
B Family S45
C Spa2297_13865 penicillin amidase K01434 pac; penicillin G amidase [EC:3.5.1.11]
C Spa2297_15905 penicillin amidase K01434 pac; penicillin G amidase [EC:3.5.1.11]
C Spa2297_32255 hypothetical protein K01434 pac; penicillin G amidase [EC:3.5.1.11]
B Family S49: protease IV family
B Family S50
B Family S51
C Spa2297_30720 dipeptidase E K05995 pepE; dipeptidase E [EC:3.4.13.21]
B Family S53
B Family S54: Rhomboid family
C Spa2297_08805 rhomboid family intramembrane serine protease K07059 rho2; rhomboid family protease [EC:3.4.21.105]
B Family S55: SpoIVB peptidase family
B Family S62
B Family S66
C Spa2297_27010 LD-carboxypeptidase K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
B Family S77: phage prohead processing peptidase family
B Family S78
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AThreonine peptidases
B Family T1: proteasome family
C Spa2297_06370 proteasome subunit alpha K03432 psmA; proteasome alpha subunit [EC:3.4.25.1]
C Spa2297_06375 proteasome subunit beta K03433 psmB; proteasome beta subunit [EC:3.4.25.1]
B Family T2
B Family T3: gamma-glutamyltransferase family
C Spa2297_26720 gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C Spa2297_26820 gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
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APeptidases of unknown catalytic type
B Family U32
B Family U62
C Spa2297_07225 peptidase C69 K03568 tldD; TldD protein
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APeptidase inhibitors
B Family I1: Kazal family
B Family I2: Kunitz - BPTI family
B Family I4: serpin family
B Family I11: ecotin family
B Family I17: WAP-type family
B Family I25: cystatin family
B Family I27: calpastatin family
B Family I32: IAP family
B Family I34: IA3 family
B Family I35: timp family
B Family I39: alpha2M family
B Family I47: latexin family
B Family I49: proSAAS family
B Family I51: IC family
B Family I57: staphostatin B family
B Family I63
B Family I80
B Family I87
B Family I93
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 20, 2025
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Classification taken and modified from MEROPS