+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptomyces platensis
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
E CP981_04550 type I polyketide synthase K16384 amphC; polyene macrolide polyketide synthase
D Pimaricinolide synthase
D Candicidin PKS
E CP981_04565 SDR family NAD(P)-dependent oxidoreductase K20787 fscC; candicidin polyketide synthase FscC
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E CP981_00305 hypothetical protein K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
E CP981_04100 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
E CP981_04095 ketosynthase chain-length factor K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
E CP981_04090 acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein
E CP981_04085 polyketide cyclase K14670 whiEVI; aromatase
E CP981_04080 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E CP981_11520 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_34530 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_11515 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_34525 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_11510 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP981_34520 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP981_11570 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E CP981_34485 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E CP981_11560 cyclase K05554 actVII; aromatase [EC:4.2.1.-]
E CP981_08290 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E CP981_11520 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_34530 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_11515 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_34525 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_11510 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP981_34520 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP981_11570 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E CP981_34485 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E CP981_34465 cyclase family protein K14250 oxyN; cyclase
D Decaketide PKS
E CP981_11520 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_34530 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_11515 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_34525 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E CP981_11510 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP981_34520 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E CP981_11570 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E CP981_34485 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E CP981_34465 cyclase family protein K14250 oxyN; cyclase
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D CP981_02965 type III polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D CP981_01750 MbtH family protein K05375 mbtH; MbtH protein
D CP981_21720 MbtH family protein K05375 mbtH; MbtH protein
D CP981_33510 MbtH family protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
C Bacillibactin synthetase
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
C Myxochelin synthetase
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
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APolyketide tailoring proteins
B Hydrolase
B Ketoreductase
B Oxygenase
C CP981_12975 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C CP981_07580 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CP981_34510 FAD-binding monooxygenase K14253 oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232]
C CP981_34475 oxygenase K14252 oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]
C CP981_34445 hypothetical protein K14256 oxyS; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC:1.14.13.38 1.14.13.234]
C CP981_04105 cupin domain-containing protein K14673 whiEII; putative monooxygenase
C CP981_04115 monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C CP981_04075 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
C CP981_34505 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
C CP981_34440 methyltransferase K14255 oxyT; 4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335]
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
C CP981_11565 nuclear transport factor 2 family protein K14626 actVIA; actinorhodin biosynthesis protein ActVIA
C CP981_11505 flavin reductase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-]
C CP981_35180 flavin reductase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-]
C CP981_34455 dapC; succinyldiaminopimelate transaminase K14254 oxyQ; aminotransferase
C CP981_34450 PPOX class F420-dependent oxidoreductase K21301 oxyR; 5a,11a-dehydrotetracycline reductase [EC:1.3.98.4]
C CP981_13855 flavin reductase K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36]
C CP981_21750 flavin reductase K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36]
C CP981_34515 asnB; asparagine synthase (glutamine-hydrolyzing) K14244 oxyD; amidotransferase [EC:6.3.5.-]
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
C CP981_09155 glycosyltransferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
C CP981_33240 glycosyltransferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
B Aminotransferase
B Others
C CP981_21650 aspartate/glutamate racemase family protein K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024