+D GENES KO
#
KEGG Orthology (KO) - Streptococcus pneumoniae Hungary19A 6 (serotype 19A)
%
!
A09100 Metabolism
B
B 09101 Carbohydrate metabolism
C 00010 Glycolysis / Gluconeogenesis [PATH:spv00010]
D SPH_0763 glucokinase (Glucose kinase) K25026 glk; glucokinase [EC:2.7.1.2]
D SPH_2257 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D SPH_1003 pfkA; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D SPH_0699 fba; fructose-1,6-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D SPH_1688 tpiA; triose-phosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D SPH_2168 gap; glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D SPH_0608 pgk; phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D SPH_1765 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D SPH_1222 eno; phosphopyruvate hydratase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D SPH_1004 pyk; pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D SPH_1335 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D SPH_2179 aldehyde-alcohol dehydrogenase 2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D SPH_0401 alcohol dehydrogenase, propanol-preferring K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D SPH_0172 aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3]
D SPH_2076 hydrolase K20866 yihX; glucose-1-phosphatase [EC:3.1.3.10]
D SPH_1610 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D SPH_1213 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9]
D SPH_0382 glycosyl hydrolase, family 1 K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D SPH_0677 beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D SPH_2175 beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
C 00020 Citrate cycle (TCA cycle)
C 00030 Pentose phosphate pathway [PATH:spv00030]
D SPH_2257 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D SPH_1358 zwf; glucose-6-phosphate dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
D SPH_1617 3-carboxymuconate cyclase K07404 pgl; 6-phosphogluconolactonase [EC:3.1.1.31]
D SPH_0482 gnd; 6-phosphogluconate dehydrogenase, decarboxylating K00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]
D SPH_2124 rpe; ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
D SPH_1729 tkt1; transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2183 tkt2; transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2319 transketolase, C-subunit K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2320 transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_0926 rpiA; ribose 5-phosphate isomerase A K01807 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]
D SPH_0942 deoC; deoxyribose-phosphate aldolase K01619 deoC; deoxyribose-phosphate aldolase [EC:4.1.2.4]
D SPH_0927 deoB; phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7]
D SPH_1610 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D SPH_0127 ribose-Phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D SPH_1186 ribose-Phosphate pyrophosphokinase (rppk) (phosphoribosylpyrophosphate synthetase) (p-rib-pp synthetase) (prpp synthetase) K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D SPH_0428 keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]
D SPH_1213 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9]
D SPH_0429 2-keto-3-deoxygluconate kinase K00874 kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]
D SPH_0699 fba; fructose-1,6-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D SPH_1003 pfkA; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C 00040 Pentose and glucuronate interconversions [PATH:spv00040]
D SPH_0252 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D SPH_2279 galU; UTP-glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D SPH_2188 orotidine 5'-phosphate decarboxylase / humps family, putative K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85]
D SPH_2187 hexulose-6-phosphate isomerase, putative K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22]
D SPH_2186 L-ribulose-5-phosphate 4-epimerase (Phosphoribuloseisomerase) K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]
D SPH_2124 rpe; ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
D SPH_2361 rhamnulokinase (Rhamnulose kinase) K00848 rhaB; rhamnulokinase [EC:2.7.1.5]
D SPH_1386 xylitol dehydrogenase K05352 tarJ; ribitol-5-phosphate 2-dehydrogenase (NADP+) [EC:1.1.1.405]
D SPH_1387 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K21030 tarI; D-ribitol-5-phosphate cytidylyltransferase [EC:2.7.7.40]
D SPH_2352 fucI; L-fucose isomerase K01818 fucI; L-fucose/D-arabinose isomerase [EC:5.3.1.25 5.3.1.3]
D SPH_2360 L-fuculose-1-phosphate aldolase K01628 fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]
C 00051 Fructose and mannose metabolism [PATH:spv00051]
D SPH_1829 fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4]
D SPH_0837 manA; mannose-6-phosphate isomerase, class I K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]
D SPH_2352 fucI; L-fucose isomerase K01818 fucI; L-fucose/D-arabinose isomerase [EC:5.3.1.25 5.3.1.3]
D SPH_2360 L-fuculose-1-phosphate aldolase K01628 fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]
D SPH_2361 rhamnulokinase (Rhamnulose kinase) K00848 rhaB; rhamnulokinase [EC:2.7.1.5]
D SPH_1003 pfkA; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D SPH_0507 mannitol-1-phosphate 5-dehydrogenase K00009 mtlD; mannitol-1-phosphate 5-dehydrogenase [EC:1.1.1.17]
D SPH_0980 pfkB; 1-phosphofructokinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56]
D SPH_0699 fba; fructose-1,6-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D SPH_1688 tpiA; triose-phosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D SPH_1730 D-allulose-6-phosphate 3-epimerase K17195 alsE; D-allulose-6-phosphate 3-epimerase [EC:5.1.3.-]
D SPH_1733 PTS system, IIA component K02768 fruB; fructose PTS system EIIA component [EC:2.7.1.202]
D SPH_0981 PTS system, Fru family, IIC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D SPH_1731 PTS system, IIC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D SPH_0170 phosphotransferase system sugar-specific EII component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D SPH_2358 PTS system, IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D SPH_0400 mannose-specific phosphotransferase system component iiab K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D SPH_0168 phosphotransferase system sugar-specific eiic component K02795 manY; mannose PTS system EIIC component
D SPH_0399 PTS system sorbose-specific EIIC component K02795 manY; mannose PTS system EIIC component
D SPH_2356 phosphotransferase system sugar-specific EII component K02795 manY; mannose PTS system EIIC component
D SPH_0169 PTS system, IID component K02796 manZ; mannose PTS system EIID component
D SPH_0398 PTS system, mannose/fructose/sorbose family, EIID component K02796 manZ; mannose PTS system EIID component
D SPH_2355 mannose permease iid component K02796 manZ; mannose PTS system EIID component
D SPH_0506 mannitol-specific phosphotransferase enzyme iia component K02798 cmtB; mannitol PTS system EIIA component [EC:2.7.1.197]
D SPH_0504 pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) K02800 mtlA; mannitol PTS system EIICBA or EIICB component [EC:2.7.1.197]
C 00052 Galactose metabolism [PATH:spv00052]
D SPH_0172 aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3]
D SPH_1969 galK; galactokinase K00849 galK; galactokinase [EC:2.7.1.6]
D SPH_1968 galT; galactose-1-phosphate uridylyltransferase K00965 galT; UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]
D SPH_1720 galE; UDP-glucose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D SPH_2279 galU; UTP-glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D SPH_1610 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D SPH_0763 glucokinase (Glucose kinase) K25026 glk; glucokinase [EC:2.7.1.2]
D SPH_0741 beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23]
D SPH_0166 beta-galactosidase K12308 bgaB; beta-galactosidase [EC:3.2.1.23]
D SPH_2015 alpha-galactosidase AgaN K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22]
D SPH_1309 lacC; tagatose-6-phosphate kinase K00917 lacC; tagatose 6-phosphate kinase [EC:2.7.1.144]
D SPH_1003 pfkA; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D SPH_1308 lacD; tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]
D SPH_1310 lacB; galactose-6-phosphate isomerase, LacB subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26]
D SPH_1311 lacA; galactose-6-phosphate isomerase, LacA subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26]
D SPH_0589 lacG1; 6-phospho-beta-galactosidase K01220 E3.2.1.85; 6-phospho-beta-galactosidase [EC:3.2.1.85]
D SPH_1304 lacG2; 6-phospho-beta-galactosidase K01220 E3.2.1.85; 6-phospho-beta-galactosidase [EC:3.2.1.85]
D SPH_0588 lactose-specific phosphotransferase enzyme iia component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D SPH_1306 lactose-specific phosphotransferase enzyme iia component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D SPH_0590 pts system lactose-specific eiicb component (eiicb-lac) (eii-lac) K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D SPH_1305 PTS system, lactose-specific IIC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D SPH_1832 sucrose-6-phosphate hydrolase (Sucrase) (Invertase) K01193 INV; beta-fructofuranosidase [EC:3.2.1.26]
D SPH_1909 sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26]
D SPH_0432 phosphotransferase system sugar-specific EII component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-]
D SPH_0434 N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
D SPH_0435 phosphotransferase system sugar-specific EII component K02746 agaW; N-acetylgalactosamine PTS system EIIC component
D SPH_0436 phosphotransferase system sugar-specific EII component K02747 agaE; N-acetylgalactosamine PTS system EIID component
D SPH_0171 AgaS K02082 agaS; D-galactosamine 6-phosphate deaminase/isomerase [EC:3.5.99.-]
C 00053 Ascorbate and aldarate metabolism [PATH:spv00053]
D SPH_0252 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D SPH_2189 ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D SPH_2190 ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D SPH_2322 phosphotransferase system, galactitol-specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D SPH_2191 ascorbate-specific PTS system enzyme IIC K03475 ulaA; ascorbate PTS system EIIC component
D SPH_2321 ascorbate-specific PTS system enzyme IIC K03475 ulaA; ascorbate PTS system EIIC component
D SPH_2184 probable L-ascorbate-6-phosphate lactonase UlaG (L-ascorbate utilization protein G) K03476 ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-]
D SPH_2188 orotidine 5'-phosphate decarboxylase / humps family, putative K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85]
D SPH_2187 hexulose-6-phosphate isomerase, putative K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22]
D SPH_2186 L-ribulose-5-phosphate 4-epimerase (Phosphoribuloseisomerase) K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]
C 00500 Starch and sucrose metabolism [PATH:spv00500]
D SPH_1830 pts system, sucrose-specific iibc component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211]
D SPH_1832 sucrose-6-phosphate hydrolase (Sucrase) (Invertase) K01193 INV; beta-fructofuranosidase [EC:3.2.1.26]
D SPH_1909 sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26]
D SPH_2011 sucrose phosphorylase (Sucrose glucosyltransferase)(Glucosyltransferase-A) (GTF-A) K00690 E2.4.1.7; sucrose phosphorylase [EC:2.4.1.7]
D SPH_2279 galU; UTP-glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D SPH_0366 phosphotransferase system sugar-specific eiia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_1926 lichenan-specific phosphotransferase enzyme iia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_2178 lichenan-specific phosphotransferase enzyme iia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_0367 phosphotransferase system sugar-specific eiib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_1927 lichenan-specific phosphotransferase enzyme iib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_2177 lichenan-specific phosphotransferase enzyme iib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_0368 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_0586 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_1925 phosphotransferase system K02761 celB; cellobiose PTS system EIIC component
D SPH_1929 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_2176 phosphotransferase system system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D SPH_0382 glycosyl hydrolase, family 1 K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D SPH_0677 beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D SPH_2175 beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D SPH_1215 glgC; glucose-1-phosphate adenylyltransferase K00975 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]
D SPH_1216 glgD; glucose-1-phosphate adenylyltransferase, GlgD subunit K00975 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]
D SPH_1217 glycogen synthase (Starch [bacterial glycogen]synthase) K00703 glgA; starch synthase [EC:2.4.1.21]
D SPH_1214 glgB; 1,4-alpha-glucan branching enzyme K00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]
D SPH_2295 glycogen phosphorylase K00688 PYG; glycogen phosphorylase [EC:2.4.1.1]
D SPH_1211 pulA; pullulanase, type I K01200 pulA; pullulanase [EC:3.2.1.41]
D SPH_1513 alpha-amylase (1,4-alpha-D-glucanglucanohydrolase) K01176 AMY; alpha-amylase [EC:3.2.1.1]
D SPH_1147 neopullulanase K01208 cd; cyclomaltodextrinase / maltogenic alpha-amylase / neopullulanase [EC:3.2.1.54 3.2.1.133 3.2.1.135]
D SPH_1270 neopullulanase K01208 cd; cyclomaltodextrinase / maltogenic alpha-amylase / neopullulanase [EC:3.2.1.54 3.2.1.133 3.2.1.135]
D SPH_2296 malQ; 4-alpha-glucanotransferase K00705 malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]
D SPH_0859 pts system, iibc component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208]
D SPH_0860 metal-dependent hydrolase K06896 mapP; maltose 6'-phosphate phosphatase [EC:3.1.3.90]
D SPH_2000 treP; pts system, trehalose-specific iibc component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201]
D SPH_1999 treC; alpha,alpha-phosphotrehalase K01226 treC; trehalose-6-phosphate hydrolase [EC:3.2.1.93]
D SPH_1610 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D SPH_0763 glucokinase (Glucose kinase) K25026 glk; glucokinase [EC:2.7.1.2]
D SPH_2257 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D SPH_1829 fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4]
C 00620 Pyruvate metabolism [PATH:spv00620]
D SPH_0569 pflB; formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54]
D SPH_2179 aldehyde-alcohol dehydrogenase 2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D SPH_0401 alcohol dehydrogenase, propanol-preferring K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D SPH_2197 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
D SPH_1191 pta; phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D SPH_1004 pyk; pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D SPH_0536 accA; acetyl-CoA carboxylase, carboxyl transferase, alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D SPH_0532 accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D SPH_0534 accC; acetyl-CoA carboxylase, biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D SPH_0535 accD; acetyl-CoA carboxylase, carboxyl transferase, beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D SPH_2116 acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7]
D SPH_0817 spxB; pyruvate oxidase K00158 spxB; pyruvate oxidase [EC:1.2.3.3]
D SPH_1335 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D SPH_1063 lactoylglutathione lyase K01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5]
D SPH_1755 metallo-beta-lactamase superfamily protein K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6]
D SPH_1155 ppc; phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]
D SPH_1374 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase) K01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13]
C 00630 Glyoxylate and dicarboxylate metabolism [PATH:spv00630]
D SPH_0204 phosphoglycolate phosphatase K01091 gph; phosphoglycolate phosphatase [EC:3.1.3.18]
D SPH_0611 glnA; glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D SPH_1127 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D SPH_1221 glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165]
D SPH_0428 keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]
C 00640 Propanoate metabolism [PATH:spv00640]
D SPH_2197 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
D SPH_1191 pta; phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D SPH_0569 pflB; formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54]
D SPH_0536 accA; acetyl-CoA carboxylase, carboxyl transferase, alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D SPH_0532 accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D SPH_0534 accC; acetyl-CoA carboxylase, biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D SPH_0535 accD; acetyl-CoA carboxylase, carboxyl transferase, beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D SPH_1335 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D SPH_0371 glycerol dehydrogenase (gldh) K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6]
C 00650 Butanoate metabolism [PATH:spv00650]
D SPH_2179 aldehyde-alcohol dehydrogenase 2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D SPH_0569 pflB; formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54]
D SPH_1836 hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
D SPH_2210 alcohol dehydrogenase, zinc-containing K18369 adh2; alcohol dehydrogenase [EC:1.1.1.-]
D SPH_0551 ilvB; acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
D SPH_0552 ilvN; acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6]
D SPH_1523 budA; alpha-acetolactate decarboxylase K01575 alsD; acetolactate decarboxylase [EC:4.1.1.5]
C 00660 C5-Branched dibasic acid metabolism [PATH:spv00660]
D SPH_0551 ilvB; acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
D SPH_0552 ilvN; acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6]
D SPH_1523 budA; alpha-acetolactate decarboxylase K01575 alsD; acetolactate decarboxylase [EC:4.1.1.5]
D SPH_1371 3-isopropylmalate dehydratase small subunit K01704 leuD; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]
D SPH_1373 leuB; 3-isopropylmalate dehydrogenase K00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]
C 00562 Inositol phosphate metabolism [PATH:spv00562]
D SPH_1534 inositol monophosphatase family protein K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D SPH_1688 tpiA; triose-phosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
B
B 09102 Energy metabolism
C 00190 Oxidative phosphorylation [PATH:spv00190]
D SPH_1621 atpA; ATP synthase F1, alpha subunit K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
D SPH_1619 atpD; ATP synthase F1, beta subunit K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
D SPH_1620 atpG; ATP synthase F1, gamma subunit K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma
D SPH_1622 atpH; ATP synthase F1, delta subunit K02113 ATPF1D; F-type H+-transporting ATPase subunit delta
D SPH_1618 atpC; ATP synthase F1, epsilon subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon
D SPH_1624 atpB; ATP synthase F0, A subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D SPH_1623 atpF; ATP synthase F0, B subunit K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D SPH_1625 conserved domain protein K02110 ATPF0C; F-type H+-transporting ATPase subunit c
D SPH_1459 V-type ATP synthase alpha chain (V-type ATPase subunitA) K02117 ATPVA; V/A-type H+/Na+-transporting ATPase subunit A [EC:7.1.2.2 7.2.2.1]
D SPH_1458 V-type ATP synthase beta chain (V-type ATPase subunitB) K02118 ATPVB; V/A-type H+/Na+-transporting ATPase subunit B
D SPH_1461 ATP synthase (C/AC39) subunit K02119 ATPVC; V/A-type H+/Na+-transporting ATPase subunit C
D SPH_1457 V-type ATPase, D subunit K02120 ATPVD; V/A-type H+/Na+-transporting ATPase subunit D
D SPH_1462 V-type sodium ATP synthase, subunit E K02121 ATPVE; V/A-type H+/Na+-transporting ATPase subunit E
D SPH_1460 ATP synthase (F/14-kDa) subunit K02122 ATPVF; V/A-type H+/Na+-transporting ATPase subunit F
D SPH_1465 conserved hypothetical protein K02107 ATPVG; V/A-type H+/Na+-transporting ATPase subunit G/H
D SPH_1464 ATP synthase subunit I K02123 ATPVI; V/A-type H+/Na+-transporting ATPase subunit I
D SPH_1463 V-type sodium ATP synthase subunit K (Na(+)-translocating ATPase subunit K) (Sodium ATPase proteolipid component) K02124 ATPVK; V/A-type H+/Na+-transporting ATPase subunit K
D SPH_1648 manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hydrolase) (PPase) K15986 ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]
C 00195 Photosynthesis
C 00196 Photosynthesis - antenna proteins
C 00710 Carbon fixation by Calvin cycle [PATH:spv00710]
D SPH_0608 pgk; phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D SPH_2168 gap; glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D SPH_0699 fba; fructose-1,6-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D SPH_1729 tkt1; transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2183 tkt2; transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2319 transketolase, C-subunit K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2320 transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_0926 rpiA; ribose 5-phosphate isomerase A K01807 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]
D SPH_1688 tpiA; triose-phosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D SPH_2124 rpe; ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
D SPH_1155 ppc; phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]
C 00720 Other carbon fixation pathways [PATH:spv00720]
D SPH_1155 ppc; phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]
D SPH_0536 accA; acetyl-CoA carboxylase, carboxyl transferase, alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D SPH_0532 accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D SPH_0534 accC; acetyl-CoA carboxylase, biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D SPH_0535 accD; acetyl-CoA carboxylase, carboxyl transferase, beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D SPH_1344 fhs; formate--tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3]
D SPH_0924 bifunctional protein FolD K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
D SPH_0685 metF; 5,10-methylenetetrahydrofolate reductase K00297 metF; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]
D SPH_1191 pta; phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D SPH_2197 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
C 00680 Methane metabolism [PATH:spv00680]
D SPH_1127 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D SPH_1222 eno; phosphopyruvate hydratase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D SPH_1155 ppc; phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]
D SPH_0699 fba; fructose-1,6-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D SPH_1003 pfkA; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D SPH_2197 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
D SPH_1191 pta; phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D SPH_1765 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
C 00910 Nitrogen metabolism [PATH:spv00910]
D SPH_1446 NAD(p)-specific glutamate dehydrogenase K00262 E1.4.1.4; glutamate dehydrogenase (NADP+) [EC:1.4.1.4]
D SPH_0611 glnA; glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D SPH_2342 arcC; carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2]
D SPH_0125 carbonate dehydratase K01673 cynT; carbonic anhydrase [EC:4.2.1.1]
C 00920 Sulfur metabolism [PATH:spv00920]
D SPH_1440 DHH subfamily 1 protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
D SPH_0687 cysE; serine O-acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]
D SPH_2408 cysK; cysteine synthase A K01738 cysK; cysteine synthase [EC:2.5.1.47]
D SPH_1690 metA; homoserine O-succinyltransferase K00651 metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]
D SPH_1637 cystathionine gamma-synthase (CGS) (O-succinylhomoserine(thiol)-lyase) K01739 metB; cystathionine gamma-synthase [EC:2.5.1.48]
B
B 09103 Lipid metabolism
C 00061 Fatty acid biosynthesis [PATH:spv00061]
D SPH_0536 accA; acetyl-CoA carboxylase, carboxyl transferase, alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D SPH_0532 accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D SPH_0534 accC; acetyl-CoA carboxylase, biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D SPH_0535 accD; acetyl-CoA carboxylase, carboxyl transferase, beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D SPH_0138 conserved domain protein K02078 acpP; acyl carrier protein
D SPH_0526 conserved domain protein K02078 acpP; acyl carrier protein
D SPH_0528 fabD; malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D SPH_0525 beta-ketoacyl-acyl carrier protein synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]
D SPH_0531 3-oxoacyl-[acyl-carrier-protein] synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D SPH_0529 fabG; 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D SPH_0895 3-ketoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D SPH_0533 fabZ; beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D SPH_0527 putative enoyl-(acyl-carrier-protein) reductase II K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]
D SPH_0523 enoyl-CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14]
C 00062 Fatty acid elongation
C 00071 Fatty acid degradation
D SPH_2179 aldehyde-alcohol dehydrogenase 2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D SPH_0401 alcohol dehydrogenase, propanol-preferring K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
C 00073 Cutin, suberine and wax biosynthesis
C 00074 Mycolic acid biosynthesis [PATH:spv00074]
D SPH_1803 acpS; holo-(acyl-carrier-protein) synthase K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]
D SPH_0138 conserved domain protein K02078 acpP; acyl carrier protein
D SPH_0526 conserved domain protein K02078 acpP; acyl carrier protein
D SPH_0528 fabD; malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
C 00100 Steroid biosynthesis
C 00120 Primary bile acid biosynthesis
C 00121 Secondary bile acid biosynthesis
C 00140 Steroid hormone biosynthesis
C 00561 Glycerolipid metabolism [PATH:spv00561]
D SPH_1221 glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165]
D SPH_1292 dhaK1; dihydroxyacetone kinase, DhaK subunit K05878 dhaK; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]
D SPH_1291 dihydroxyacetone kinase, L subunit K05879 dhaL; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]
D SPH_1290 dihydroxyacetone kinase, phosphotransfer subunit K05881 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121]
D SPH_0371 glycerol dehydrogenase (gldh) K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6]
D SPH_2381 glpK; glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30]
D SPH_0137 plsX; fatty acid/phospholipid synthesis protein PlsX K03621 plsX; phosphate acyltransferase [EC:2.3.1.274]
D SPH_0951 membrane protein, putative K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D SPH_1737 acyltransferase family protein K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
D SPH_1164 glycosyl transferase, group 1 K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]
D SPH_2015 alpha-galactosidase AgaN K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22]
C 00564 Glycerophospholipid metabolism [PATH:spv00564]
D SPH_2278 glycerol-3-phosphate dehydrogenase (NAD(P)+) K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]
D SPH_2380 alpha-glycerophosphate oxidase (Glycerol-3-phosphateoxidase) (Exported protein 6) K00105 E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21]
D SPH_0951 membrane protein, putative K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D SPH_1737 acyltransferase family protein K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
D SPH_1095 glycerophosphoryl diester phosphodiesterase family protein K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]
D SPH_2071 hypothetical protein K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]
D SPH_0379 cdsA; phosphatidate cytidylyltransferase K00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41]
D SPH_2417 pgsA; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase K00995 PGS1; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]
D SPH_0315 cardiolipin synthase K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]
C 00565 Ether lipid metabolism
C 00600 Sphingolipid metabolism [PATH:spv00600]
D SPH_0741 beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23]
D SPH_1924 sulfatase K01130 atsA; arylsulfatase [EC:3.1.6.1]
D SPH_1468 sialidase B (Neuraminidase B) K01186 NEU1; sialidase-1 [EC:3.2.1.18]
D SPH_1797 neuraminidase K01186 NEU1; sialidase-1 [EC:3.2.1.18]
D SPH_2015 alpha-galactosidase AgaN K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22]
D SPH_0164 beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_2334 N-acetyl-beta-D-glucosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
C 00590 Arachidonic acid metabolism
C 00591 Linoleic acid metabolism
C 00592 alpha-Linolenic acid metabolism
C 01040 Biosynthesis of unsaturated fatty acids
B
B 09104 Nucleotide metabolism
C 00230 Purine metabolism [PATH:spv00230]
D SPH_1090 ADP-ribose pyrophosphatase K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-]
D SPH_0927 deoB; phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7]
D SPH_1610 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D SPH_0127 ribose-Phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D SPH_1186 ribose-Phosphate pyrophosphokinase (rppk) (phosphoribosylpyrophosphate synthetase) (p-rib-pp synthetase) (prpp synthetase) K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D SPH_0153 purF; amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
D SPH_0158 purD; phosphoribosylamine--glycine ligase K01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13]
D SPH_0155 purN; phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
D SPH_0152 phosphoribosylformylglycinamidine synthase K01952 PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]
D SPH_0154 purM; phosphoribosylformylglycinamidine cyclo-ligase K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]
D SPH_0161 purK; phosphoribosylaminoimidazole carboxylase, ATPase subunit K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]
D SPH_0160 purE; phosphoribosylaminoimidazole carboxylase, catalytic subunit K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]
D SPH_0150 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]
D SPH_0163 purB; adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
D SPH_0157 purH; bifunctional purine biosynthesis protein PurH K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D SPH_1691 apt; adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]
D SPH_0929 purine nucleoside phosphorylase I, inosine and guanosine-specific K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]
D SPH_0934 deoD; purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]
D SPH_0012 hpt; hypoxanthine phosphoribosyltransferase K00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]
D SPH_2423 guaB; inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
D SPH_2100 nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D SPH_1996 non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family protein K01519 rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]
D SPH_1962 xpt; xanthine phosphoribosyltransferase K03816 xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]
D SPH_1562 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
D SPH_1365 guaC; guanosine monophosphate reductase K00364 guaC; GMP reductase [EC:1.7.1.7]
D SPH_1847 gmk; guanylate kinase K00942 gmk; guanylate kinase [EC:2.7.4.8]
D SPH_1300 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SPH_1301 ribonucleoside-diphosphate reductase, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D SPH_0317 nrdD; anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6]
D SPH_1753 spoT; guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]
D SPH_1188 GTP pyrophosphokinase K07816 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5]
D SPH_0025 purA; adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
D SPH_0344 adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D SPH_2342 arcC; carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2]
C 00240 Pyrimidine metabolism [PATH:spv00240]
D SPH_1391 carB; carbamoyl-phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D SPH_1392 carA; carbamoyl-phosphate synthase, small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D SPH_1393 pyrB; aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
D SPH_1281 dihydroorotase (DHOase) K01465 URA4; dihydroorotase [EC:3.5.2.3]
D SPH_1065 dihydroorotate dehydrogenase B, catalytic subunit K17828 pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]
D SPH_1064 dihydroorotate dehydrogenase electron transfer subunit K02823 pyrDII; dihydroorotate dehydrogenase electron transfer subunit
D SPH_0863 dihydroorotate dehydrogenase K00226 pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1]
D SPH_0786 pyrE; orotate phosphoribosyltransferase K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]
D SPH_0785 pyrF; orotidine 5'-phosphate decarboxylase K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]
D SPH_1048 pyrH; UMP kinase K09903 pyrH; uridylate kinase [EC:2.7.4.22]
D SPH_2100 nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D SPH_0605 pyrG; CTP synthase K01937 pyrG; CTP synthase [EC:6.3.4.2]
D SPH_1716 cmk; cytidylate kinase K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25]
D SPH_0321 phosphoribulokinase / Uridine kinase family K00876 udk; uridine kinase [EC:2.7.1.48]
D SPH_1326 udk; uridine kinase K00876 udk; uridine kinase [EC:2.7.1.48]
D SPH_1284 HAD superfamily (subfamily IA) hydrolase K25434 pynA; pyrimidine 5'-nucleotidase [EC:3.1.3.-]
D SPH_0847 upp; uracil phosphoribosyltransferase K00761 upp; uracil phosphoribosyltransferase [EC:2.4.2.9]
D SPH_1394 PyrR bifunctional protein K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]
D SPH_0941 pyrimidine-nucleoside phosphorylase (pynp) K00756 pdp; pyrimidine-nucleoside phosphorylase [EC:2.4.2.2]
D SPH_0943 cdd; cytidine deaminase K01489 cdd; cytidine deaminase [EC:3.5.4.5]
D SPH_0317 nrdD; anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6]
D SPH_1300 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SPH_1301 ribonucleoside-diphosphate reductase, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D SPH_0846 ComE operon protein 2 K01493 comEB; dCMP deaminase [EC:3.5.4.12]
D SPH_1043 tmk; thymidylate kinase K00943 tmk; dTMP kinase [EC:2.7.4.9]
D SPH_0122 deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SPH_1121 tdk; thymidine kinase K00857 tdk; thymidine kinase [EC:2.7.1.21]
D SPH_0764 thyA; thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45]
D SPH_2053 oxidoreductase, short chain dehydrogenase/reductase family K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-]
B
B 09105 Amino acid metabolism
C 00250 Alanine, aspartate and glutamate metabolism [PATH:spv00250]
D SPH_2141 L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1]
D SPH_2113 asnA; aspartate--ammonia ligase K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1]
D SPH_1658 aspartate aminotransferase (transaminase a) (aspat) K22457 E2.6.1.14; asparagine---oxo-acid transaminase [EC:2.6.1.14]
D SPH_2136 aminotransferase, class I and II K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D SPH_0215 argG; argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5]
D SPH_0216 argH; argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1]
D SPH_0025 purA; adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
D SPH_0163 purB; adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
D SPH_1393 pyrB; aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
D SPH_1446 NAD(p)-specific glutamate dehydrogenase K00262 E1.4.1.4; glutamate dehydrogenase (NADP+) [EC:1.4.1.4]
D SPH_0611 glnA; glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D SPH_1391 carB; carbamoyl-phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D SPH_1392 carA; carbamoyl-phosphate synthase, small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D SPH_0383 glmS; glutamine-fructose-6-phosphate transaminase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D SPH_0153 purF; amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C 00260 Glycine, serine and threonine metabolism [PATH:spv00260]
D SPH_0521 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4]
D SPH_1117 asd; aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D SPH_1493 homoserine dehydrogenase (HDH) K00003 hom; homoserine dehydrogenase [EC:1.1.1.3]
D SPH_1492 thrB; homoserine kinase K00872 thrB; homoserine kinase [EC:2.7.1.39]
D SPH_2222 thrC; threonine synthase K01733 thrC; threonine synthase [EC:4.2.3.1]
D SPH_1127 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D SPH_1221 glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165]
D SPH_1765 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D SPH_2053 oxidoreductase, short chain dehydrogenase/reductase family K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-]
D SPH_0205 sdaAA; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17]
D SPH_0206 sdaAB; L-serine dehydratase, iron-sulfur-dependent, beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17]
D SPH_0556 ilvA; threonine dehydratase K01754 E4.3.1.19; threonine dehydratase [EC:4.3.1.19]
D SPH_1932 trpA; tryptophan synthase, alpha subunit K01695 trpA; tryptophan synthase alpha chain [EC:4.2.1.20]
D SPH_1934 trpB; tryptophan synthase, beta subunit K01696 trpB; tryptophan synthase beta chain [EC:4.2.1.20]
C 00270 Cysteine and methionine metabolism [PATH:spv00270]
D SPH_0687 cysE; serine O-acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]
D SPH_2408 cysK; cysteine synthase A K01738 cysK; cysteine synthase [EC:2.5.1.47]
D SPH_1636 putative aminotransferase B K14155 patB; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
D SPH_0684 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase K00549 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14]
D SPH_0862 metK; methionine adenosyltransferase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D SPH_1027 speE; spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
D SPH_1092 mtnN; MTA/SAH nucleosidase K01243 mtnN; adenosylhomocysteine nucleosidase [EC:3.2.2.9]
D SPH_1487 chlorohydrolase K12960 mtaD; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [EC:3.5.4.31 3.5.4.28]
D SPH_0967 GAF domain-containing protein K08968 msrC; L-methionine (R)-S-oxide reductase [EC:1.8.4.14]
D SPH_0083 hypothetical protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_1233 methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_0450 luxS; S-ribosylhomocysteinase LuxS K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]
D SPH_0521 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4]
D SPH_1117 asd; aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D SPH_1493 homoserine dehydrogenase (HDH) K00003 hom; homoserine dehydrogenase [EC:1.1.1.3]
D SPH_1492 thrB; homoserine kinase K00872 thrB; homoserine kinase [EC:2.7.1.39]
D SPH_1690 metA; homoserine O-succinyltransferase K00651 metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]
D SPH_1637 cystathionine gamma-synthase (CGS) (O-succinylhomoserine(thiol)-lyase) K01739 metB; cystathionine gamma-synthase [EC:2.5.1.48]
D SPH_0955 ilvE; branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D SPH_1335 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D SPH_0205 sdaAA; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17]
D SPH_0206 sdaAB; L-serine dehydratase, iron-sulfur-dependent, beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17]
C 00280 Valine, leucine and isoleucine degradation [PATH:spv00280]
D SPH_0955 ilvE; branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D SPH_1836 hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
C 00290 Valine, leucine and isoleucine biosynthesis [PATH:spv00290]
D SPH_0556 ilvA; threonine dehydratase K01754 E4.3.1.19; threonine dehydratase [EC:4.3.1.19]
D SPH_1371 3-isopropylmalate dehydratase small subunit K01704 leuD; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]
D SPH_1373 leuB; 3-isopropylmalate dehydrogenase K00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]
D SPH_0551 ilvB; acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
D SPH_0552 ilvN; acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6]
D SPH_0553 ilvC; ketol-acid reductoisomerase K00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]
D SPH_2318 ilvD; dihydroxy-acid dehydratase K01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]
D SPH_0955 ilvE; branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D SPH_2136 aminotransferase, class I and II K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D SPH_1374 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase) K01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13]
C 00300 Lysine biosynthesis [PATH:spv00300]
D SPH_1493 homoserine dehydrogenase (HDH) K00003 hom; homoserine dehydrogenase [EC:1.1.1.3]
D SPH_0521 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4]
D SPH_1117 asd; aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D SPH_1118 dapA; dihydrodipicolinate synthase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]
D SPH_1671 dapB; dihydrodipicolinate reductase K00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
D SPH_2285 galactoside O-acetyltransferase K00674 dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]
D SPH_0262 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
D SPH_2119 diaminopimelate decarboxylase K01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]
D SPH_0135 putative aminotransferase A K00841 patA; aminotransferase [EC:2.6.1.-]
D SPH_2284 peptidase, M20/M25/M40 family K05823 dapL; N-acetyldiaminopimelate deacetylase [EC:3.5.1.47]
D SPH_1778 UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
C 00310 Lysine degradation
C 00220 Arginine biosynthesis [PATH:spv00220]
D SPH_2341 argF; ornithine carbamoyltransferase K00611 OTC; ornithine carbamoyltransferase [EC:2.1.3.3]
D SPH_0215 argG; argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5]
D SPH_0216 argH; argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1]
D SPH_2340 arcA; arginine deiminase K01478 arcA; arginine deiminase [EC:3.5.3.6]
D SPH_0611 glnA; glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D SPH_1391 carB; carbamoyl-phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D SPH_1392 carA; carbamoyl-phosphate synthase, small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D SPH_2342 arcC; carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2]
D SPH_1446 NAD(p)-specific glutamate dehydrogenase K00262 E1.4.1.4; glutamate dehydrogenase (NADP+) [EC:1.4.1.4]
D SPH_2136 aminotransferase, class I and II K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
C 00330 Arginine and proline metabolism [PATH:spv00330]
D SPH_1026 arginine decarboxylase K01585 speA; arginine decarboxylase [EC:4.1.1.19]
D SPH_1030 aguA; agmatine deiminase K10536 aguA; agmatine deiminase [EC:3.5.3.12]
D SPH_1031 aguB; N-carbamoylputrescine amidase K12251 aguB; N-carbamoylputrescine amidase [EC:3.5.1.53]
D SPH_1028 lys; saccharopine dehydrogenase K27502 capadh; carboxyaminopropylagmatine dehydrogenase [EC:1.5.1.55]
D SPH_1029 nspC; carboxynorspermidine decarboxylase K27684 capadc; carboxyaminopropylagmatine decarboxylase [EC:4.1.1.127]
D SPH_1027 speE; spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
D SPH_1122 acetyltransferase, gnat family K00657 speG; diamine N-acetyltransferase [EC:2.3.1.57]
D SPH_1042 proC; pyrroline-5-carboxylate reductase K00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]
D SPH_1040 proB; glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11]
D SPH_1041 proA; glutamate-5-semialdehyde dehydrogenase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]
C 00340 Histidine metabolism
C 00350 Tyrosine metabolism
D SPH_2179 aldehyde-alcohol dehydrogenase 2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D SPH_0401 alcohol dehydrogenase, propanol-preferring K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
C 00360 Phenylalanine metabolism
C 00380 Tryptophan metabolism
C 00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:spv00400]
D SPH_1804 3-deoxy-7-phosphoheptulonate synthase K01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
D SPH_1805 3-deoxy-7-phosphoheptulonate synthase K01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
D SPH_1507 aroB; 3-dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4]
D SPH_1509 aroD; 3-dehydroquinate dehydratase, type I K03785 aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10]
D SPH_1502 aroK; shikimate kinase K00891 aroK; shikimate kinase [EC:2.7.1.71]
D SPH_1503 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase K00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]
D SPH_1506 aroC; chorismate synthase K01736 aroC; chorismate synthase [EC:4.2.3.5]
D SPH_1939 trpE; anthranilate synthase component I K01657 trpE; anthranilate synthase component I [EC:4.1.3.27]
D SPH_1938 para-aminobenzoate/anthranilate synthase glutamine amidotransferasecomponent II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
D SPH_1937 trpD; anthranilate phosphoribosyltransferase K00766 trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18]
D SPH_1935 trpF; N-(5'phosphoribosyl)anthranilate isomerase K01817 trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24]
D SPH_1936 trpC; indole-3-glycerol phosphate synthase K01609 trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48]
D SPH_1932 trpA; tryptophan synthase, alpha subunit K01695 trpA; tryptophan synthase alpha chain [EC:4.2.1.20]
D SPH_1934 trpB; tryptophan synthase, beta subunit K01696 trpB; tryptophan synthase beta chain [EC:4.2.1.20]
D SPH_1438 chorismate mutase K04516 AROA1; chorismate mutase [EC:5.4.99.5]
D SPH_1505 prephenate dehydrogenase K04517 tyrA2; prephenate dehydrogenase [EC:1.3.1.12]
D SPH_1501 prephenate dehydratase (PDT) K04518 pheA2; prephenate dehydratase [EC:4.2.1.51]
B
B 09106 Metabolism of other amino acids
C 00410 beta-Alanine metabolism
C 00430 Taurine and hypotaurine metabolism [PATH:spv00430]
D SPH_1191 pta; phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D SPH_2197 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
C 00440 Phosphonate and phosphinate metabolism
C 00450 Selenocompound metabolism [PATH:spv00450]
D SPH_1637 cystathionine gamma-synthase (CGS) (O-succinylhomoserine(thiol)-lyase) K01739 metB; cystathionine gamma-synthase [EC:2.5.1.48]
D SPH_1636 putative aminotransferase B K14155 patB; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
D SPH_0684 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase K00549 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14]
D SPH_0972 cysteine desulfurase K11717 sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]
D SPH_1574 trxB; thioredoxin-disulfide reductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9]
D SPH_0887 metG; methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
C 00460 Cyanoamino acid metabolism [PATH:spv00460]
D SPH_2141 L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1]
D SPH_2113 asnA; aspartate--ammonia ligase K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1]
D SPH_1127 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
C 00470 D-Amino acid metabolism [PATH:spv00470]
D SPH_1802 alr; alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D SPH_1779 D-alanine--D-alanine ligase (D-alanylalanine synthetase)(D-Ala-D-Ala ligase) K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D SPH_2372 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D SPH_2370 dltC; D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D SPH_1997 murI; glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3]
D SPH_0782 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D SPH_2119 diaminopimelate decarboxylase K01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]
C 00480 Glutathione metabolism [PATH:spv00480]
D SPH_0899 aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
D SPH_0883 gor; glutathione-disulfide reductase K00383 GSR; glutathione reductase (NADPH) [EC:1.8.1.7]
D SPH_0482 gnd; 6-phosphogluconate dehydrogenase, decarboxylating K00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]
D SPH_1358 zwf; glucose-6-phosphate dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
D SPH_0425 peroxiredoxin Hyr1 K00432 gpx; glutathione peroxidase [EC:1.11.1.9]
D SPH_1027 speE; spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
B
B 09107 Glycan biosynthesis and metabolism
C 00520 Amino sugar and nucleotide sugar metabolism [PATH:spv00520]
D SPH_0824 NanE/NanK bifunctional enzyme K01788 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]
D SPH_1472 putative N-acetylmannosamine-6-phosphate 2-epimerase (ManNAc-6-P epimerase) K01788 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]
D SPH_1791 putative N-acetylmannosamine-6-P epimerase K01788 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]
D SPH_1089 glmU; UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]
D SPH_0465 UDP-N-acetylglucosamine 2-epimerase K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]
D SPH_1173 murA1; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D SPH_2108 murA2; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D SPH_1520 murB; UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D SPH_0164 beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_2334 N-acetyl-beta-D-glucosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_2211 nagA; N-acetylglucosamine-6-phosphate deacetylase K01443 nagA; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]
D SPH_1674 glmM; phosphoglucosamine mutase K03431 glmM; phosphoglucosamine mutase [EC:5.4.2.10]
D SPH_0432 phosphotransferase system sugar-specific EII component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-]
D SPH_0434 N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
D SPH_0435 phosphotransferase system sugar-specific EII component K02746 agaW; N-acetylgalactosamine PTS system EIIC component
D SPH_0436 phosphotransferase system sugar-specific EII component K02747 agaE; N-acetylgalactosamine PTS system EIID component
D SPH_1546 glucosamine-6-phosphate deaminase K02564 nagB; glucosamine-6-phosphate deaminase [EC:3.5.99.6]
D SPH_0383 glmS; glutamine-fructose-6-phosphate transaminase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D SPH_1829 fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4]
D SPH_2257 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D SPH_0837 manA; mannose-6-phosphate isomerase, class I K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]
D SPH_0763 glucokinase (Glucose kinase) K25026 glk; glucokinase [EC:2.7.1.2]
D SPH_1610 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D SPH_2279 galU; UTP-glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D SPH_0252 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D SPH_1969 galK; galactokinase K00849 galK; galactokinase [EC:2.7.1.6]
D SPH_1968 galT; galactose-1-phosphate uridylyltransferase K00965 galT; UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]
D SPH_1720 galE; UDP-glucose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D SPH_0170 phosphotransferase system sugar-specific EII component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D SPH_2358 PTS system, IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D SPH_0400 mannose-specific phosphotransferase system component iiab K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D SPH_0168 phosphotransferase system sugar-specific eiic component K02795 manY; mannose PTS system EIIC component
D SPH_0399 PTS system sorbose-specific EIIC component K02795 manY; mannose PTS system EIIC component
D SPH_2356 phosphotransferase system sugar-specific EII component K02795 manY; mannose PTS system EIIC component
D SPH_0169 PTS system, IID component K02796 manZ; mannose PTS system EIID component
D SPH_0398 PTS system, mannose/fructose/sorbose family, EIID component K02796 manZ; mannose PTS system EIID component
D SPH_2355 mannose permease iid component K02796 manZ; mannose PTS system EIID component
D SPH_1215 glgC; glucose-1-phosphate adenylyltransferase K00975 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]
D SPH_1216 glgD; glucose-1-phosphate adenylyltransferase, GlgD subunit K00975 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]
D SPH_0466 rfbA; glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
C 00541 Biosynthesis of various nucleotide sugars [PATH:spv00541]
D SPH_1089 glmU; UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]
D SPH_0202 CapD protein, required for the biosynthesis of type 1 capsular polysaccharide K24300 wbpM; UDP-N-acetylglucosamine 4,6-dehydratase [EC:4.2.1.135]
D SPH_1952 Cps7G K25626 aatB; UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine / UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose transaminase [EC:2.6.1.92 2.6.1.-]
D SPH_1471 N-acetylneuraminate lyase K01639 E4.1.3.3; N-acetylneuraminate lyase [EC:4.1.3.3]
D SPH_1784 N-acetylneuraminate lyase K01639 E4.1.3.3; N-acetylneuraminate lyase [EC:4.1.3.3]
D SPH_0465 UDP-N-acetylglucosamine 2-epimerase K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]
D SPH_2279 galU; UTP-glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D SPH_0252 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D SPH_0466 rfbA; glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D SPH_0468 rfbB; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D SPH_0467 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D SPH_0469 rfbD; dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
C 00510 N-Glycan biosynthesis
C 00513 Various types of N-glycan biosynthesis
C 00512 Mucin type O-glycan biosynthesis
C 00515 Mannose type O-glycan biosynthesis
C 00514 Other types of O-glycan biosynthesis
C 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
C 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
C 00533 Glycosaminoglycan biosynthesis - keratan sulfate
C 00531 Glycosaminoglycan degradation
C 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
C 00601 Glycosphingolipid biosynthesis - lacto and neolacto series
C 00603 Glycosphingolipid biosynthesis - globo and isoglobo series
C 00604 Glycosphingolipid biosynthesis - ganglio series
C 00511 Other glycan degradation [PATH:spv00511]
D SPH_1468 sialidase B (Neuraminidase B) K01186 NEU1; sialidase-1 [EC:3.2.1.18]
D SPH_1797 neuraminidase K01186 NEU1; sialidase-1 [EC:3.2.1.18]
D SPH_0741 beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23]
D SPH_0164 beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_2334 N-acetyl-beta-D-glucosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_2336 sugar hydrolase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D SPH_1067 endo-beta-N-acetylglucosaminidase K23989 lytD; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [EC:3.2.1.96]
D SPH_2339 FucA K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51]
D SPH_2354 large secreted protein K15923 AXY8; alpha-L-fucosidase 2 [EC:3.2.1.51]
C 00540 Lipopolysaccharide biosynthesis
C 00542 O-Antigen repeat unit biosynthesis
C 00550 Peptidoglycan biosynthesis [PATH:spv00550]
D SPH_1173 murA1; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D SPH_2108 murA2; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D SPH_1520 murB; UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D SPH_1633 murC; UDP-N-acetylmuramate--alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
D SPH_0782 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D SPH_1779 D-alanine--D-alanine ligase (D-alanylalanine synthetase)(D-Ala-D-Ala ligase) K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D SPH_1778 UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
D SPH_1069 diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) K00887 dgkA; undecaprenol kinase [EC:2.7.1.66]
D SPH_0378 uppS; di-trans,poly-cis-decaprenylcistransferase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D SPH_0565 undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
D SPH_0447 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D SPH_0783 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D SPH_0476 penicillin-binding protein 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D SPH_2166 penicillin-binding protein 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]
D SPH_1154 cell division protein FtsW K03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_0905 RodA K05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_0976 penicillin-binding protein 3 K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D SPH_0722 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D SPH_1643 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7]
D SPH_1701 Mur ligase family protein K23393 murT; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13]
D SPH_1702 cobyric acid synthase K07009 gatD; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13]
D SPH_0708 MurM K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10]
D SPH_0709 MurN K12554 murN; alanine adding enzyme [EC:2.3.2.-]
D SPH_2287 penicillin-binding protein 1B K03693 pbp1b; penicillin-binding protein 1B
D SPH_1781 penicillin-binding protein 2B K00687 pbp2B; penicillin-binding protein 2B
D SPH_0446 penicillin-binding protein 2X K12556 pbp2X; penicillin-binding protein 2X
C 00552 Teichoic acid biosynthesis [PATH:spv00552]
D SPH_0565 undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
D SPH_0460 UDP-N-acetyl-D-mannosamine transferase K05946 tagA; N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase [EC:2.4.1.187]
D SPH_2372 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D SPH_2370 dltC; D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D SPH_2371 protein DltB K03739 dltB; membrane protein involved in D-alanine export
D SPH_2369 D-alanine transfer from undecaprenol-phosphate to the poly K03740 dltD; D-alanine transfer protein
D SPH_1500 transcriptional regulator, LytR family K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-]
D SPH_2091 regulator of lytrabc operon K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-]
D SPH_1164 glycosyl transferase, group 1 K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]
D SPH_1163 glycosyl transferase CpoA K13678 cpoA; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-galactosyltransferase [EC:2.4.1.-]
D SPH_0202 CapD protein, required for the biosynthesis of type 1 capsular polysaccharide K24300 wbpM; UDP-N-acetylglucosamine 4,6-dehydratase [EC:4.2.1.135]
D SPH_1952 Cps7G K25626 aatB; UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine / UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose transaminase [EC:2.6.1.92 2.6.1.-]
D SPH_1953 bacterial sugar transferase family protein K25627 K25627; AATGal transferase [EC:2.7.8.-]
D SPH_0201 glycosyl transferase K25650 K25650; teichoic acid beta-1,3-glucosyltransferase [EC:2.4.1.-]
D SPH_1499 licD3 protein K25651 licD3; teichoic acid ribitol-phosphate transferase
D SPH_1497 galactosyl transferase paralog K25652 K25652; teichoic acid N-acetylgalactosaminyltransferase [EC:2.4.1.-]
D SPH_1498 glycosyl transferase, group 1 family protein K25653 K25653; teichoic acid N-acetylgalactosaminyltransferase [EC:2.4.1.-]
D SPH_1385 choline kinase K25657 licA; choline kinase [EC:2.7.1.32]
D SPH_1383 LicC homolog K25658 licC; choline-phosphate cytidylyltransferase [EC:2.7.7.15]
D SPH_0461 Cps19aG K07271 licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]
D SPH_1389 required for phosphorylcholine incorporation in teichoic and lipoteichoic acids K07271 licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]
D SPH_1496 membrane protein, putative K25659 K25659; teichoic acid polymerase [EC:2.4.1.-]
D SPH_2010 O-antigen polymerase family K25660 tacL; lipoteichoic acid ligase
C 00571 Lipoarabinomannan (LAM) biosynthesis
C 00572 Arabinogalactan biosynthesis - Mycobacterium
C 00543 Exopolysaccharide biosynthesis [PATH:spv00543]
D SPH_0687 cysE; serine O-acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]
B
B 09108 Metabolism of cofactors and vitamins
C 00730 Thiamine metabolism [PATH:spv00730]
D SPH_0813 thiD; phosphomethylpyrimidine kinase K00941 thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]
D SPH_0985 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_1185 putative Probable cysteine desulfurase (NifS protein homolog) K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_0986 thiI; thiamine biosynthesis/tRNA modification protein ThiI K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D SPH_0804 thiM; hydroxyethylthiazole kinase K00878 thiM; hydroxyethylthiazole kinase [EC:2.7.1.50]
D SPH_0811 hydroxyethylthiazole kinase K00878 thiM; hydroxyethylthiazole kinase [EC:2.7.1.50]
D SPH_0805 thiE1; thiamine-phosphate pyrophosphorylase K00788 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]
D SPH_0812 thiE2; thiamine-phosphate pyrophosphorylase K00788 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]
D SPH_2125 rsgA; ribosome small subunit-dependent GTPase A K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]
D SPH_2123 thiamine pyrophosphokinase K00949 thiN; thiamine pyrophosphokinase [EC:2.7.6.2]
D SPH_0344 adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D SPH_0802 tena/thi-4 family K03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]
D SPH_0809 tena/thi-4 family K03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]
C 00740 Riboflavin metabolism [PATH:spv00740]
D SPH_0279 riboflavin biosynthesis protein ribAB K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]
D SPH_0281 ribD; riboflavin biosynthesis protein RibD K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]
D SPH_0402 Cof family protein K21064 ycsE; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
D SPH_0278 ribH; 6,7-dimethyl-8-ribityllumazine synthase K00794 ribH; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
D SPH_0280 ribE; riboflavin synthase, alpha subunit K00793 ribE; riboflavin synthase [EC:2.5.1.9]
D SPH_1202 ribF; riboflavin biosynthesis protein RibF K11753 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]
D SPH_0804 thiM; hydroxyethylthiazole kinase K00878 thiM; hydroxyethylthiazole kinase [EC:2.7.1.50]
D SPH_0811 hydroxyethylthiazole kinase K00878 thiM; hydroxyethylthiazole kinase [EC:2.7.1.50]
D SPH_1090 ADP-ribose pyrophosphatase K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-]
C 00750 Vitamin B6 metabolism [PATH:spv00750]
D SPH_1710 phosphomethylpyrimidine kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35]
D SPH_2222 thrC; threonine synthase K01733 thrC; threonine synthase [EC:4.2.3.1]
D SPH_1584 pyridoxine biosynthesis protein K06215 pdxS; pyridoxal 5'-phosphate synthase pdxS subunit [EC:4.3.3.6]
D SPH_1583 SNO glutamine amidotransferase family superfamily K08681 pdxT; pyridoxal 5'-phosphate synthase pdxT subunit [EC:4.3.3.6]
C 00760 Nicotinate and nicotinamide metabolism [PATH:spv00760]
D SPH_2171 nadC; nicotinate-nucleotide diphosphorylase (carboxylating) K00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]
D SPH_1551 pncB; putative nicotinate phosphoribosyltransferase K00763 pncB; nicotinate phosphoribosyltransferase [EC:6.3.4.21]
D SPH_0929 purine nucleoside phosphorylase I, inosine and guanosine-specific K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]
D SPH_0934 deoD; purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]
D SPH_1856 nadD; nicotinate (nicotinamide) nucleotide adenylyltransferase K00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]
D SPH_1550 nadE; NAD+ synthetase K01916 nadE; NAD+ synthase [EC:6.3.1.5]
D SPH_1189 probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase) K00858 ppnK; NAD+ kinase [EC:2.7.1.23]
C 00770 Pantothenate and CoA biosynthesis [PATH:spv00770]
D SPH_0551 ilvB; acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
D SPH_0552 ilvN; acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6]
D SPH_0553 ilvC; ketol-acid reductoisomerase K00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]
D SPH_2318 ilvD; dihydroxy-acid dehydratase K01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]
D SPH_0937 coaA; pantothenate kinase K00867 coaA; type I pantothenate kinase [EC:2.7.1.33]
D SPH_1345 coaB; phosphopantothenate--cysteine ligase K21977 coaB; phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5]
D SPH_1346 coaC; phosphopantothenoylcysteine decarboxylase K01598 PPCDC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36]
D SPH_2111 coaD; pantetheine-phosphate adenylyltransferase K00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]
D SPH_1072 coaE; dephospho-CoA kinase K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24]
D SPH_1803 acpS; holo-(acyl-carrier-protein) synthase K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]
D SPH_0955 ilvE; branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
C 00780 Biotin metabolism [PATH:spv00780]
D SPH_0531 3-oxoacyl-[acyl-carrier-protein] synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D SPH_0529 fabG; 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D SPH_0895 3-ketoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D SPH_0533 fabZ; beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D SPH_2017 biotin-[acetyl-CoA-carboxylase] ligase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
C 00785 Lipoic acid metabolism
C 00790 Folate biosynthesis [PATH:spv00790]
D SPH_0408 folE; GTP cyclohydrolase I K01495 GCH1; GTP cyclohydrolase IA [EC:3.5.4.16]
D SPH_0409 bifunctional folate synthesis protein K13940 sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3]
D SPH_0406 folP; dihydropteroate synthase K00796 folP; dihydropteroate synthase [EC:2.5.1.15]
D SPH_1685 folA; dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]
D SPH_0313 dihydrofolate:folylpolyglutamate synthetase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
D SPH_0407 dihydrofolate synthetase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
D SPH_0279 riboflavin biosynthesis protein ribAB K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]
D SPH_0760 chorismate binding enzyme K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38]
D SPH_1892 NADPH-dependent 7-cyano-7-deazaguanine reductase K09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
C 00670 One carbon pool by folate [PATH:spv00670]
D SPH_1685 folA; dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]
D SPH_1344 fhs; formate--tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3]
D SPH_0924 bifunctional protein FolD K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
D SPH_1127 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D SPH_0155 purN; phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
D SPH_0157 purH; bifunctional purine biosynthesis protein PurH K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D SPH_0764 thyA; thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45]
D SPH_0685 metF; 5,10-methylenetetrahydrofolate reductase K00297 metF; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]
D SPH_2283 5-formyltetrahydrofolate cyclo-ligase K01934 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]
D SPH_0862 metK; methionine adenosyltransferase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
C 00830 Retinol metabolism
C 00860 Porphyrin metabolism [PATH:spv00860]
D SPH_1111 hemH; ferrochelatase K01772 hemH; protoporphyrin/coproporphyrin ferrochelatase [EC:4.98.1.1 4.99.1.9]
C 00130 Ubiquinone and other terpenoid-quinone biosynthesis
B
B 09109 Metabolism of terpenoids and polyketides
C 00900 Terpenoid backbone biosynthesis [PATH:spv00900]
D SPH_1836 hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
D SPH_1835 hydroxymethylglutaryl-CoA reductase, degradative K00054 mvaA; hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88]
D SPH_0488 mvk; mevalonate kinase K00869 MVK; mevalonate kinase [EC:2.7.1.36]
D SPH_0490 phosphomevalonate kinase K00938 E2.7.4.2; phosphomevalonate kinase [EC:2.7.4.2]
D SPH_0489 mvaD; diphosphomevalonate decarboxylase K01597 MVD; diphosphomevalonate decarboxylase [EC:4.1.1.33]
D SPH_0491 fni; isopentenyl-diphosphate delta-isomerase, type 2 K01823 idi; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]
D SPH_1323 geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]
D SPH_0378 uppS; di-trans,poly-cis-decaprenylcistransferase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
C 00902 Monoterpenoid biosynthesis
C 00909 Sesquiterpenoid and triterpenoid biosynthesis
C 00904 Diterpenoid biosynthesis
C 00906 Carotenoid biosynthesis
C 00905 Brassinosteroid biosynthesis
C 00981 Insect hormone biosynthesis
C 00908 Zeatin biosynthesis
C 00903 Limonene degradation
C 00907 Pinene, camphor and geraniol degradation
C 01052 Type I polyketide structures
C 00522 Biosynthesis of 12-, 14- and 16-membered macrolides
C 01051 Biosynthesis of ansamycins
D SPH_1729 tkt1; transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2183 tkt2; transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2319 transketolase, C-subunit K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D SPH_2320 transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
C 01059 Biosynthesis of enediyne antibiotics
C 01056 Biosynthesis of type II polyketide backbone
C 01057 Biosynthesis of type II polyketide products
C 00253 Tetracycline biosynthesis
C 00523 Polyketide sugar unit biosynthesis [PATH:spv00523]
D SPH_0466 rfbA; glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D SPH_0468 rfbB; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D SPH_0467 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D SPH_0469 rfbD; dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
C 01054 Nonribosomal peptide structures
C 01053 Biosynthesis of siderophore group nonribosomal peptides
C 01055 Biosynthesis of vancomycin group antibiotics
D SPH_0468 rfbB; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
B
B 09110 Biosynthesis of other secondary metabolites
C 00940 Phenylpropanoid biosynthesis
C 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
C 00941 Flavonoid biosynthesis
C 00944 Flavone and flavonol biosynthesis
C 00942 Anthocyanin biosynthesis
C 00943 Isoflavonoid biosynthesis
C 00946 Degradation of flavonoids
C 00901 Indole alkaloid biosynthesis
C 00403 Indole diterpene alkaloid biosynthesis
C 00950 Isoquinoline alkaloid biosynthesis
C 00960 Tropane, piperidine and pyridine alkaloid biosynthesis
C 00996 Biosynthesis of various alkaloids
C 00232 Caffeine metabolism
C 00965 Betalain biosynthesis
C 00966 Glucosinolate biosynthesis
C 00402 Benzoxazinoid biosynthesis
C 00311 Penicillin and cephalosporin biosynthesis
D SPH_1800 xylan esterase 1 K01060 cah; cephalosporin-C deacetylase [EC:3.1.1.41]
C 00332 Carbapenem biosynthesis [PATH:spv00332]
D SPH_1040 proB; glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11]
D SPH_1041 proA; glutamate-5-semialdehyde dehydrogenase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]
C 00261 Monobactam biosynthesis [PATH:spv00261]
D SPH_0521 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4]
D SPH_1117 asd; aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D SPH_1118 dapA; dihydrodipicolinate synthase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]
D SPH_1671 dapB; dihydrodipicolinate reductase K00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
C 00331 Clavulanic acid biosynthesis
C 00521 Streptomycin biosynthesis [PATH:spv00521]
D SPH_0763 glucokinase (Glucose kinase) K25026 glk; glucokinase [EC:2.7.1.2]
D SPH_1610 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D SPH_1534 inositol monophosphatase family protein K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D SPH_0466 rfbA; glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D SPH_0468 rfbB; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D SPH_0467 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D SPH_0469 rfbD; dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
C 00524 Neomycin, kanamycin and gentamicin biosynthesis
D SPH_0763 glucokinase (Glucose kinase) K25026 glk; glucokinase [EC:2.7.1.2]
C 00525 Acarbose and validamycin biosynthesis [PATH:spv00525]
D SPH_0466 rfbA; glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D SPH_0468 rfbB; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
C 00401 Novobiocin biosynthesis
D SPH_1505 prephenate dehydrogenase K04517 tyrA2; prephenate dehydrogenase [EC:1.3.1.12]
C 00404 Staurosporine biosynthesis
C 00405 Phenazine biosynthesis
D SPH_1939 trpE; anthranilate synthase component I K01657 trpE; anthranilate synthase component I [EC:4.1.3.27]
D SPH_1938 para-aminobenzoate/anthranilate synthase glutamine amidotransferasecomponent II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
C 00333 Prodigiosin biosynthesis
D SPH_0528 fabD; malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D SPH_0529 fabG; 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D SPH_0895 3-ketoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
C 00254 Aflatoxin biosynthesis
C 00998 Biosynthesis of various antibiotics
D SPH_0138 conserved domain protein K02078 acpP; acyl carrier protein
D SPH_0526 conserved domain protein K02078 acpP; acyl carrier protein
C 00999 Biosynthesis of various plant secondary metabolites
D SPH_0862 metK; methionine adenosyltransferase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
C 00997 Biosynthesis of various other secondary metabolites
B
B 09111 Xenobiotics biodegradation and metabolism
C 00362 Benzoate degradation [PATH:spv00362]
D SPH_0173 glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2]
D SPH_1120 conserved domain protein K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6]
C 00627 Aminobenzoate degradation
D SPH_2116 acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7]
C 00364 Fluorobenzoate degradation
C 00625 Chloroalkane and chloroalkene degradation [PATH:spv00625]
D SPH_0401 alcohol dehydrogenase, propanol-preferring K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D SPH_2179 aldehyde-alcohol dehydrogenase 2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
C 00361 Chlorocyclohexane and chlorobenzene degradation
D SPH_0173 glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2]
C 00623 Toluene degradation
C 00622 Xylene degradation [PATH:spv00622]
D SPH_0173 glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2]
D SPH_1120 conserved domain protein K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6]
C 00633 Nitrotoluene degradation
C 00642 Ethylbenzene degradation
C 00643 Styrene degradation
D SPH_0173 glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2]
C 00791 Atrazine degradation
C 00930 Caprolactam degradation
C 00363 Bisphenol degradation
C 00621 Dioxin degradation
D SPH_1120 conserved domain protein K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6]
C 00626 Naphthalene degradation [PATH:spv00626]
D SPH_0401 alcohol dehydrogenase, propanol-preferring K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D SPH_2179 aldehyde-alcohol dehydrogenase 2 K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
C 00624 Polycyclic aromatic hydrocarbon degradation
C 00365 Furfural degradation
C 00984 Steroid degradation
C 00980 Metabolism of xenobiotics by cytochrome P450
C 00982 Drug metabolism - cytochrome P450
C 00983 Drug metabolism - other enzymes
B
B 09112 Not included in regular maps
C 09113 Global maps only
#
A09120 Genetic Information Processing
B
B 09121 Transcription
C 03020 RNA polymerase [PATH:spv03020]
D SPH_2102 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D SPH_2101 rpoC; DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D SPH_0349 rpoA; DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D SPH_1846 rpoZ; DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D SPH_0603 rpoE; DNA-directed RNA polymerase, delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta
C 03022 Basal transcription factors
C 03040 Spliceosome
B
B 09122 Translation
C 03010 Ribosome [PATH:spv03010]
D SPH_0963 putative 30S ribosomal protein S1 homolog K02945 RP-S1; small subunit ribosomal protein S1
D SPH_2410 rpsB; ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2
D SPH_0329 rpsC; ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3
D SPH_0187 rpsD; ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4
D SPH_0340 rpsE; ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5
D SPH_1655 rpsF; ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6
D SPH_0388 rpsG; ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7
D SPH_0337 rpsH; ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8
D SPH_0412 rpsI; ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9
D SPH_0322 rpsJ; ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10
D SPH_0348 rpsK; ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11
D SPH_0387 rpsL; ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12
D SPH_0347 rpsM; ribosomal protein S13p/S18e K02952 RP-S13; small subunit ribosomal protein S13
D SPH_0336 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14
D SPH_1739 rpsO; ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15
D SPH_0873 rpsP; ribosomal protein S16 K02959 RP-S16; small subunit ribosomal protein S16
D SPH_0332 rpsQ; ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17
D SPH_1653 rpsR; ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18
D SPH_0327 rpsS; ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19
D SPH_0936 rpsT; ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20
D SPH_1545 rpsU; ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21
D SPH_0724 rplA; ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1
D SPH_0326 rplB; ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2
D SPH_0323 rplC; ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3
D SPH_0324 rplD; ribosomal protein L4/L1 family K02926 RP-L4; large subunit ribosomal protein L4
D SPH_0335 50S ribosomal protein L5 (BL6) K02931 RP-L5; large subunit ribosomal protein L5
D SPH_0338 50S ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6
D SPH_1485 rplL; ribosomal protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12
D SPH_2402 rplI; ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9
D SPH_1486 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10
D SPH_0723 rplK; ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11
D SPH_0411 rplM; ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13
D SPH_0333 rplN; ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14
D SPH_0342 rplO; ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15
D SPH_0330 rplP; ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16
D SPH_0350 rplQ; ribosomal protein L17 K02879 RP-L17; large subunit ribosomal protein L17
D SPH_0339 rplR; ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18
D SPH_1435 rplS; ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19
D SPH_1062 rplT; ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20
D SPH_1197 rplU; ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21
D SPH_0328 rplV; ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22
D SPH_0325 rplW; ribosomal protein L23 K02892 RP-L23; large subunit ribosomal protein L23
D SPH_0334 rplX; ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24
D SPH_1199 rpmA; ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27
D SPH_0548 rpmB; ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28
D SPH_0331 rpmC; ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29
D SPH_0341 rpmD; ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30
D SPH_1441 rpmE; ribosomal protein L31 K02909 RP-L31; large subunit ribosomal protein L31
D SPH_2326 rpmF; ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32
D SPH_1074 rpmG1; ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33
D SPH_2327 rpmG2; ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33
D SPH_2135 rpmH; ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34
D SPH_1061 rpmI; ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35
D SPH_0346 rpmJ; ribosomal protein L36 K02919 RP-L36; large subunit ribosomal protein L36
D SPH_0016 rrs1; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2040 rrs2; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2161 rrs3; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2253 rrs4; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_0019 rrl1; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2037 rrl2; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2158 rrl3; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2250 rrl4; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_0020 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2036 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2157 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2249 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
C 00970 Aminoacyl-tRNA biosynthesis [PATH:spv00970]
D SPH_0017 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D SPH_2039 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D SPH_2160 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D SPH_2252 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D SPH_1364 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_1434 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_2029 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_2150 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_2435 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_0021 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D SPH_2430 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D SPH_2103 tRNA-Cys K14222 tRNA-Cys; tRNA Cys
D SPH_0962 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D SPH_2240 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D SPH_0015 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2041 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2162 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2254 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2431 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2022 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D SPH_2031 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D SPH_2152 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D SPH_2247 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D SPH_2241 tRNA-His K14226 tRNA-His; tRNA His
D SPH_2021 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D SPH_2246 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D SPH_1695 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2030 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2033 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2151 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2154 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2239 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_1908 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D SPH_2034 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D SPH_2155 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D SPH_2024 tRNA-Met K14230 tRNA-Met; tRNA Met
D SPH_2026 tRNA-Met K14230 tRNA-Met; tRNA Met
D SPH_2027 tRNA-Met K14230 tRNA-Met; tRNA Met
D SPH_2244 tRNA-Met K14230 tRNA-Met; tRNA Met
D SPH_2023 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D SPH_2243 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D SPH_2028 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D SPH_2149 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D SPH_0978 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D SPH_2020 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D SPH_2025 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D SPH_2245 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D SPH_1115 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D SPH_2032 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D SPH_2153 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D SPH_0961 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D SPH_2242 tRNA-Trp K14236 tRNA-Tyr; tRNA Tyr
D SPH_2035 tRNA-Asp K14237 tRNA-Val; tRNA Val
D SPH_2156 tRNA-Asp K14237 tRNA-Val; tRNA Val
D SPH_2248 tRNA-Val K14237 tRNA-Val; tRNA Val
D SPH_2256 gltX; glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
D SPH_0543 glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADTsubunit A) K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
D SPH_0542 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
D SPH_0544 gatC; glutamyl-tRNA(Gln) amidotransferase, C subunit K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]
D SPH_1514 alaS; alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D SPH_2303 aspS; aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D SPH_1656 asnS; asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D SPH_1591 glyQ; glycyl-tRNA synthetase, alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D SPH_1590 glyS; glycyl-tRNA synthetase, beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D SPH_1742 thrS; threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D SPH_0519 serS; seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D SPH_0689 cysS; cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D SPH_0887 metG; methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D SPH_1844 fmt; methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]
D SPH_0666 valS; valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D SPH_0372 leuS; leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D SPH_1767 ileS; isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D SPH_0799 lysS; lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D SPH_2266 argS; arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D SPH_0381 proS; prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D SPH_2312 hisS; histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D SPH_0678 pheS; phenylalanyl-tRNA synthetase, alpha subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D SPH_0680 pheT; phenylalanyl-tRNA synthetase, beta subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D SPH_2288 tyrS; tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D SPH_2424 trpS; tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C 03013 Nucleocytoplasmic transport
C 03015 mRNA surveillance pathway
C 03008 Ribosome biogenesis in eukaryotes
D SPH_1363 rnc; ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3]
B
B 09123 Folding, sorting and degradation
C 03060 Protein export [PATH:spv03060]
D SPH_0343 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY
D SPH_1874 translocase, putative K03076 secY; preprotein translocase subunit SecY
D SPH_2165 secE; preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE
D SPH_1075 secG; preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG
D SPH_0437 yajC1; preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D SPH_2182 yajC2; preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D SPH_2117 membrane protein OxaA 2 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_2194 membrane protein OxaA 1 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_1806 secA; preprotein translocase, SecA subunit K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D SPH_1870 preprotein translocase subunit SecA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D SPH_1428 ffh; signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D SPH_2440 srpB; bacterial signal recognition particle RNA K01983 ffs; SRP RNA
D SPH_1359 cell division protein FtsY K03110 ftsY; fused signal recognition particle receptor
D SPH_0511 lepB; signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
D SPH_1037 lspA; signal peptidase II K03101 lspA; signal peptidase II [EC:3.4.23.36]
C 04141 Protein processing in endoplasmic reticulum
C 04130 SNARE interactions in vesicular transport
C 04120 Ubiquitin mediated proteolysis
C 04122 Sulfur relay system [PATH:spv04122]
D SPH_0985 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_1185 putative Probable cysteine desulfurase (NifS protein homolog) K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_0234 trmU; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D SPH_0986 thiI; thiamine biosynthesis/tRNA modification protein ThiI K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
C 03050 Proteasome
C 03018 RNA degradation [PATH:spv03018]
D SPH_1222 eno; phosphopyruvate hydratase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D SPH_0686 pnp; polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D SPH_1076 rnr; ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1]
D SPH_1698 DEAD/DEAH box helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D SPH_1848 conserved hypothetical protein K18682 rny; ribonucrease Y [EC:3.1.-.-]
D SPH_0237 metallo-beta-lactamase superfamily protein K12574 rnj; ribonuclease J [EC:3.1.-.-]
D SPH_0706 metallo-beta-lactamase superfamily protein K12574 rnj; ribonuclease J [EC:3.1.-.-]
D SPH_1003 pfkA; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D SPH_0624 dnaK; chaperone protein DnaK K04043 dnaK; molecular chaperone DnaK
D SPH_2050 groL; chaperonin GroL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
B
B 09124 Replication and repair
C 03030 DNA replication [PATH:spv03030]
D SPH_1094 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D SPH_1002 DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D SPH_0390 polC; DNA polymerase III, alpha subunit, Gram-positive type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D SPH_0968 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D SPH_1044 DNA polymerase III subunit delta K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D SPH_0864 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D SPH_0002 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D SPH_2401 dnaB; replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D SPH_1160 dnaG; DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D SPH_0082 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_1654 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_2052 single-strand binding protein family K03111 ssb; single-strand DNA-binding protein
D SPH_1274 ribonuclease HII (RNase HII) K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D SPH_0512 rnhC; ribonuclease hiii K03471 rnhC; ribonuclease HIII [EC:3.1.26.4]
D SPH_0131 DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D SPH_1210 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03410 Base excision repair [PATH:spv03410]
D SPH_1395 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D SPH_1283 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
D SPH_1342 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D SPH_1071 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
D SPH_0283 DNA-3-methyladenine glycosylase 1 K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
D SPH_1959 xth; exodeoxyribonuclease III K01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]
D SPH_2227 endonuclease/exonuclease/phosphatase family K01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]
D SPH_0131 DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D SPH_0705 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D SPH_1210 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03420 Nucleotide excision repair [PATH:spv03420]
D SPH_0006 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
D SPH_0305 uvrA; excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
D SPH_1353 uvrB; excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
D SPH_0711 uvrC; excinuclease ABC, C subunit K03703 uvrC; excinuclease ABC subunit C
D SPH_1179 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D SPH_0131 DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D SPH_1210 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03430 Mismatch repair [PATH:spv03430]
D SPH_2264 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D SPH_0515 MutS2 family protein K07456 mutS2; DNA mismatch repair protein MutS2
D SPH_0277 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D SPH_1179 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D SPH_1325 xseA; exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D SPH_1324 xseB; exodeoxyribonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D SPH_0705 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D SPH_0082 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_1654 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_2052 single-strand binding protein family K03111 ssb; single-strand DNA-binding protein
D SPH_1002 DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D SPH_0390 polC; DNA polymerase III, alpha subunit, Gram-positive type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D SPH_0002 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D SPH_0968 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D SPH_0864 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D SPH_1044 DNA polymerase III subunit delta K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D SPH_1094 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D SPH_1210 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D SPH_1966 modification methylase DpnIIA K06223 dam; DNA adenine methylase [EC:2.1.1.72]
C 03440 Homologous recombination [PATH:spv03440]
D SPH_0705 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D SPH_0082 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_1654 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_2052 single-strand binding protein family K03111 ssb; single-strand DNA-binding protein
D SPH_2422 DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
D SPH_0136 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
D SPH_1780 recR; recombination protein RecR K06187 recR; recombination protein RecR
D SPH_2089 recA; protein RecA K03553 recA; recombination protein RecA
D SPH_0131 DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D SPH_0282 ruvA; holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
D SPH_0376 ruvB; holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D SPH_0290 divergent AAA domain family K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D SPH_1801 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D SPH_0510 helicase, RecD/TraA family K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
D SPH_1002 DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D SPH_0390 polC; DNA polymerase III, alpha subunit, Gram-positive type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D SPH_0002 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D SPH_0968 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D SPH_0864 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D SPH_1044 DNA polymerase III subunit delta K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D SPH_1094 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D SPH_1845 primosomal protein N' (ATP-dependent helicase PriA)(Replication factor Y) K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
C 03450 Non-homologous end-joining
C 03460 Fanconi anemia pathway
B
B 09126 Chromosome
C 03082 ATP-dependent chromatin remodeling
C 03083 Polycomb repressive complex
B
B 09125 Information processing in viruses
C 03230 Viral genome structure
C 03240 Viral replication
C 03250 Viral life cycle - HIV-1 [PATH:spv03250]
D SPH_0870 peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
C 03260 Virion - Human immunodeficiency virus
C 03271 Virion - Rotavirus
C 03262 Virion - Coronavirus
C 03261 Virion - Influenza virus
C 03263 Virion - Enterovirus
C 03264 Virion - Flavivirus and Alphavirus
C 03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
C 03273 Virion - Lassa virus and SFTS virus
C 03272 Virion - Hepatitis viruses
C 03266 Virion - Herpesvirus
C 03268 Virion - Orthopoxvirus
C 03267 Virion - Adenovirus
C 03259 Virion - Bacteriophages T4 and T7
C 03258 Virion - Bacteriophage lambda
#
A09130 Environmental Information Processing
B
B 09131 Membrane transport
C 02010 ABC transporters [PATH:spv02010]
D SPH_1946 ABC transporter, substrate-binding protein K02012 afuA; iron(III) transport system substrate-binding protein
D SPH_2072 ABC transporter, substrate-binding protein K02012 afuA; iron(III) transport system substrate-binding protein
D SPH_1944 binding-protein-dependent transport systems inner membrane component K02011 afuB; iron(III) transport system permease protein
D SPH_2074 binding-protein-dependent transport systems inner membrane component K02011 afuB; iron(III) transport system permease protein
D SPH_0356 lactose transport ATP-binding protein LacK K02010 afuC; iron(III) transport system ATP-binding protein [EC:7.2.2.7]
D SPH_1945 spermidine/putrescine import ATP-binding protein PotA K02010 afuC; iron(III) transport system ATP-binding protein [EC:7.2.2.7]
D SPH_2073 spermidine/putrescine ABC transporter ATP-binding subunit K02010 afuC; iron(III) transport system ATP-binding protein [EC:7.2.2.7]
D SPH_1516 ABC transporter substrate-binding protein - spermidine/putrescine transport K11069 potD; spermidine/putrescine transport system substrate-binding protein
D SPH_1517 spermidine/putrescine ABC transporter, permease protein K11070 potC; spermidine/putrescine transport system permease protein
D SPH_1518 ABC transporter membrane-spanning permease - spermidine/putrescine transport K11071 potB; spermidine/putrescine transport system permease protein
D SPH_1519 spermidine/putrescine import ATP-binding protein PotA K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11]
D SPH_1977 choline transporter K05845 opuC; osmoprotectant transport system substrate-binding protein
D SPH_1978 choline transport ATP-binding protein opuBA K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9]
D SPH_1694 multiple sugar-binding transport ATP-binding protein MsmK K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-]
D SPH_2297 maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein
D SPH_2298 maltodextrin transport system permease protein MalC K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D SPH_2299 ABC transporter membrane-spanning permease - maltose/maltodextrin K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D SPH_2014 sugar ABC transporter, sugar-binding protein K10117 msmE; raffinose/stachyose/melibiose transport system substrate-binding protein
D SPH_2013 sugar ABC transporter, permease protein K10118 msmF; raffinose/stachyose/melibiose transport system permease protein
D SPH_2012 sugar ABC transporter, permease protein K10119 msmG; raffinose/stachyose/melibiose transport system permease protein
D SPH_0193 ABC transporter, substrate-binding protein K17318 lplA; putative aldouronate transport system substrate-binding protein
D SPH_0828 bacterial extracellular solute-binding protein K17318 lplA; putative aldouronate transport system substrate-binding protein
D SPH_0191 ABC transporter membrane-spanning permease - sugar transport K17319 lplB; putative aldouronate transport system permease protein
D SPH_0825 protein LplB K17319 lplB; putative aldouronate transport system permease protein
D SPH_0192 protein LplC K17320 lplC; putative aldouronate transport system permease protein
D SPH_0826 protein LplC K17320 lplC; putative aldouronate transport system permease protein
D SPH_0944 lipoprotein K07335 bmpA; basic membrane protein A and related proteins
D SPH_0946 ABC transporter membrane-spanning permease - ribose/galactose transport K23535 nupB; general nucleoside transport system permease protein
D SPH_0947 ABC transporter membrane-spanning permease - ribose/galactose transport K23536 nupC; general nucleoside transport system permease protein
D SPH_0945 ribose import ATP-binding protein RbsA K23537 nupA; general nucleoside transport system ATP-binding protein
D SPH_1531 phosphate-binding protein PstS 1 (PBP 1) K02040 pstS; phosphate transport system substrate-binding protein
D SPH_2271 ABC transporter substrate-binding protein - phosphate transport K02040 pstS; phosphate transport system substrate-binding protein
D SPH_1530 pstC1; phosphate ABC transporter, permease protein PstC K02037 pstC; phosphate transport system permease protein
D SPH_2272 pstC2; phosphate ABC transporter, permease protein PstC K02037 pstC; phosphate transport system permease protein
D SPH_1529 pstA1; phosphate ABC transporter, permease protein PstA K02038 pstA; phosphate transport system permease protein
D SPH_2273 pstA2; phosphate ABC transporter, permease protein PstA K02038 pstA; phosphate transport system permease protein
D SPH_1527 pstB1; phosphate ABC transporter, ATP-binding protein K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D SPH_1528 pstB2; phosphate ABC transporter, ATP-binding protein K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D SPH_2274 pstB3; phosphate ABC transporter, ATP-binding protein K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D SPH_1356 amino acid ABC transporter, amino acid-binding protein/permease protein K10036 glnH; glutamine transport system substrate-binding protein
D SPH_1357 glutamine transport ATP-binding protein GlnQ K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1]
D SPH_0703 ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor K10039 peb1A; aspartate/glutamate/glutamine transport system substrate-binding protein
D SPH_0701 ABC transporter membrane-spanning permease - glutamine transport K10040 peb1B; aspartate/glutamate/glutamine transport system permease protein
D SPH_0702 ABC transporter membrane-spanning permease - glutamine transport K10040 peb1B; aspartate/glutamate/glutamine transport system permease protein
D SPH_0704 glutamine transport ATP-binding protein GlnQ K10041 peb1C; aspartate/glutamate/glutamine transport system ATP-binding protein [EC:7.4.2.1]
D SPH_0260 ABC transporter substrate-binding protein - amino acid transport K02424 tcyA; L-cystine transport system substrate-binding protein
D SPH_1577 ABC transporter membrane-spanning permease - aspartate/glutamate transport K10009 tcyB; L-cystine transport system permease protein
D SPH_1576 L-cystine import ATP-binding protein TcyN K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1]
D SPH_1525 amino acid ABC transporter, amino acid-binding protein K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein
D SPH_0922 amino acid ABC transporter, permease protein K17077 artQ; arginine/lysine/histidine transport system permease protein
D SPH_0923 glutamine transport ATP-binding protein GlnQ K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1]
D SPH_0560 amino acid ABC transporter, amino acid-binding protein/permease protein K17073 lysX1; putative lysine transport system substrate-binding protein
D SPH_0559 L-cystine import ATP-binding protein TcyN K17076 lysY; putative lysine transport system ATP-binding protein
D SPH_0850 ABC transporter substrate-binding protein - branched chain amino acid transport K01999 livK; branched-chain amino acid transport system substrate-binding protein
D SPH_0851 high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) K01997 livH; branched-chain amino acid transport system permease protein
D SPH_0852 ABC transporter membrane-spanning permease - branched chain amino acid transport K01998 livM; branched-chain amino acid transport system permease protein
D SPH_0853 high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) K01995 livG; branched-chain amino acid transport system ATP-binding protein
D SPH_0854 high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) K01996 livF; branched-chain amino acid transport system ATP-binding protein
D SPH_0261 lipoprotein K02073 metQ; D-methionine transport system substrate-binding protein
D SPH_0264 ABC transporter permease protein K02072 metI; D-methionine transport system permease protein
D SPH_0263 methionine import ATP-binding protein MetN K02071 metN; D-methionine transport system ATP-binding protein
D SPH_0474 oligopeptide binding protein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_1641 oligopeptide binding lipoprotein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_2009 AmiA protein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_2008 oligopeptide transport system permease protein AmiC K15581 oppB; oligopeptide transport system permease protein
D SPH_2007 oligopeptide transport system permease protein AmiD K15582 oppC; oligopeptide transport system permease protein
D SPH_2006 oligopeptide transport ATP-binding protein OppD K15583 oppD; oligopeptide transport system ATP-binding protein
D SPH_2005 oligopeptide transport ATP-binding protein AmiF K10823 oppF; oligopeptide transport system ATP-binding protein
D SPH_1134 ABC transporter substrate-binding protein - iron transport K25286 fagD; iron-siderophore transport system substrate-binding protein
D SPH_1135 iron-compound ABC transporter, permease protein K23186 fepD; iron-siderophore transport system permease protein
D SPH_1136 ABC transporter membrane-spanning permease - iron transport K23187 fepG; iron-siderophore transport system permease protein
D SPH_1137 ferric enterobactin transport ATP-binding protein FepC K23188 fepC; iron-siderophore transport system ATP-binding protein [EC:7.2.2.17 7.2.2.-]
D SPH_1103 zinc-binding lipoprotein AdcA K09815 znuA; zinc transport system substrate-binding protein
D SPH_2364 zinc-binding lipoprotein AdcA K09815 znuA; zinc transport system substrate-binding protein
D SPH_2365 ABC transporter membrane-spanning permease - Zinc K09816 znuB; zinc transport system permease protein
D SPH_2366 zinc transport system ATP-binding protein AdcC K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20]
D SPH_1759 manganese ABC transporter substrate-binding lipoprotein (Adhesin B) (Saliva-binding protein) K19971 psaA; manganese/zinc transport system substrate-binding protein
D SPH_1758 manganese transport system membrane protein MntB K19972 psaC; manganese/zinc transport system permease protein
D SPH_1757 manganese transport system ATP-binding protein MntA K10830 psaB; manganese/zinc transport system ATP-binding protein [EC:7.2.2.5]
D SPH_0882 biotin synthase K03523 bioY; biotin transport system substrate-specific component
D SPH_0597 cobalt transport family protein K16785 ecfT; energy-coupling factor transport system permease protein
D SPH_0808 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein
D SPH_2414 ABC transporter permease protein K16785 ecfT; energy-coupling factor transport system permease protein
D SPH_2416 cobalt import ATP-binding protein CbiO 2 K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D SPH_1020 ABC-type antimicrobial peptide transport system, permease component K19084 braE; bacitracin transport system permease protein
D SPH_1019 bacitracin export ATP-binding protein BceA K19083 braD; bacitracin transport system ATP-binding protein
D SPH_0858 cell division ABC transporter, permease protein FtsX K09811 ftsX; cell division transport system permease protein
D SPH_0857 ftsE; cell division ATP-binding protein FtsE K09812 ftsE; cell division transport system ATP-binding protein
D SPH_1955 ABC transporter, ATP-binding protein K18889 mdlA; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_1954 ABC transporter, ATP-binding protein K18890 mdlB; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_2263 ABC transporter, ATP-binding/permease protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_2260 ABC transporter, ATP-binding/permease protein K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_1489 ABC transporter, ATP-binding/permease protein K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_1488 ABC transporter, ATP-binding/permease protein K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_0148 transport/processing ATP-binding protein ComA K12292 comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
D SPH_0636 transport/processing ATP-binding protein ComA K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
C 02060 Phosphotransferase system (PTS) [PATH:spv02060]
D SPH_1297 ptsP; phosphoenolpyruvate-protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9]
D SPH_1298 phosphocarrier protein HPr (Histidine-containing protein) K02784 ptsH; phosphocarrier protein HPr
D SPH_0859 pts system, iibc component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208]
D SPH_1830 pts system, sucrose-specific iibc component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211]
D SPH_0675 phosphotransferase system sugar-specific EII component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-]
D SPH_2000 treP; pts system, trehalose-specific iibc component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201]
D SPH_0506 mannitol-specific phosphotransferase enzyme iia component K02798 cmtB; mannitol PTS system EIIA component [EC:2.7.1.197]
D SPH_0504 pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) K02800 mtlA; mannitol PTS system EIICBA or EIICB component [EC:2.7.1.197]
D SPH_0588 lactose-specific phosphotransferase enzyme iia component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D SPH_1306 lactose-specific phosphotransferase enzyme iia component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D SPH_0590 pts system lactose-specific eiicb component (eiicb-lac) (eii-lac) K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D SPH_1305 PTS system, lactose-specific IIC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D SPH_0366 phosphotransferase system sugar-specific eiia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_1926 lichenan-specific phosphotransferase enzyme iia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_2178 lichenan-specific phosphotransferase enzyme iia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_0367 phosphotransferase system sugar-specific eiib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_1927 lichenan-specific phosphotransferase enzyme iib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_2177 lichenan-specific phosphotransferase enzyme iib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_0368 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_0586 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_1925 phosphotransferase system K02761 celB; cellobiose PTS system EIIC component
D SPH_1929 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_2176 phosphotransferase system system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D SPH_0170 phosphotransferase system sugar-specific EII component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D SPH_2358 PTS system, IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D SPH_0400 mannose-specific phosphotransferase system component iiab K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D SPH_0168 phosphotransferase system sugar-specific eiic component K02795 manY; mannose PTS system EIIC component
D SPH_0399 PTS system sorbose-specific EIIC component K02795 manY; mannose PTS system EIIC component
D SPH_2356 phosphotransferase system sugar-specific EII component K02795 manY; mannose PTS system EIIC component
D SPH_0169 PTS system, IID component K02796 manZ; mannose PTS system EIID component
D SPH_0398 PTS system, mannose/fructose/sorbose family, EIID component K02796 manZ; mannose PTS system EIID component
D SPH_2355 mannose permease iid component K02796 manZ; mannose PTS system EIID component
D SPH_0432 phosphotransferase system sugar-specific EII component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-]
D SPH_0434 N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
D SPH_0435 phosphotransferase system sugar-specific EII component K02746 agaW; N-acetylgalactosamine PTS system EIIC component
D SPH_0436 phosphotransferase system sugar-specific EII component K02747 agaE; N-acetylgalactosamine PTS system EIID component
D SPH_0738 phosphotransferase system sugar-specific EII component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204]
D SPH_0739 PTS system, galactose-specific IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204]
D SPH_1315 PTS system, galactose-specific IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204]
D SPH_0740 phosphotransferase system sugar-specific EII component K20114 gatC; galactose PTS system EIIC component
D SPH_2189 ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D SPH_2190 ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D SPH_2322 phosphotransferase system, galactitol-specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D SPH_2191 ascorbate-specific PTS system enzyme IIC K03475 ulaA; ascorbate PTS system EIIC component
D SPH_2321 ascorbate-specific PTS system enzyme IIC K03475 ulaA; ascorbate PTS system EIIC component
D SPH_0981 PTS system, Fru family, IIC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D SPH_1731 PTS system, IIC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D SPH_1733 PTS system, IIA component K02768 fruB; fructose PTS system EIIA component [EC:2.7.1.202]
D SPH_0980 pfkB; 1-phosphofructokinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56]
C 03070 Bacterial secretion system [PATH:spv03070]
D SPH_2165 secE; preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE
D SPH_1075 secG; preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG
D SPH_0343 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY
D SPH_1874 translocase, putative K03076 secY; preprotein translocase subunit SecY
D SPH_0437 yajC1; preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D SPH_2182 yajC2; preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D SPH_2117 membrane protein OxaA 2 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_2194 membrane protein OxaA 1 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_1806 secA; preprotein translocase, SecA subunit K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D SPH_1870 preprotein translocase subunit SecA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D SPH_1359 cell division protein FtsY K03110 ftsY; fused signal recognition particle receptor
D SPH_1428 ffh; signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D SPH_1242 TraG/TraD family protein
B
B 09132 Signal transduction
C 02020 Two-component system [PATH:spv02020]
D SPH_2270 histidine kinase PnpS K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
D SPH_2269 alkaline phosphatase synthesis transcriptional regulatory proteinphoP K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
D SPH_1531 phosphate-binding protein PstS 1 (PBP 1) K02040 pstS; phosphate transport system substrate-binding protein
D SPH_2271 ABC transporter substrate-binding protein - phosphate transport K02040 pstS; phosphate transport system substrate-binding protein
D SPH_2438 trypsin domain protein K04771 degP; serine protease Do [EC:3.4.21.107]
D SPH_1340 sensor protein YycG K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
D SPH_1341 alkaline phosphatase synthesis transcriptional regulatory proteinphoP K07668 vicR; two-component system, OmpR family, response regulator VicR
D SPH_0001 dnaA; chromosomal replication initiator protein DnaA K02313 dnaA; chromosomal replication initiator protein
D SPH_0186 histidine kinase K10681 saeS; two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3]
D SPH_0185 response regulator SaeR K10682 saeR; two-component system, OmpR family, response regulator SaeR
D SPH_1020 ABC-type antimicrobial peptide transport system, permease component K19084 braE; bacitracin transport system permease protein
D SPH_1019 bacitracin export ATP-binding protein BceA K19083 braD; bacitracin transport system ATP-binding protein
D SPH_1743 histidine kinase K19081 braS; two-component system, OmpR family, sensor histidine kinase BraS/BceS [EC:2.7.13.3]
D SPH_1744 response regulator K19082 braR; two-component system, OmpR family, response regulator protein BraR/BceR
D SPH_2372 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D SPH_2371 protein DltB K03739 dltB; membrane protein involved in D-alanine export
D SPH_2370 dltC; D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D SPH_2369 D-alanine transfer from undecaprenol-phosphate to the poly K03740 dltD; D-alanine transfer protein
D SPH_0901 sensor protein CiaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
D SPH_0900 transcriptional regulatory protein CiaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR
D SPH_0722 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D SPH_0633 histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D SPH_0632 response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA
D SPH_0148 transport/processing ATP-binding protein ComA K12292 comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
D SPH_0149 transport protein ComB K12293 comB; competence factor transport accessory protein ComB
D SPH_2434 conserved domain protein K12415 comC; competence-stimulating peptide
D SPH_2433 ComD K12294 comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3]
D SPH_2432 response regulator K12295 comE; two-component system, LytTR family, response regulator ComE
D SPH_0014 competence-specific global transcription modulator K12296 comX1_2; competence protein ComX
D SPH_2163 competence-specific global transcription modulator K12296 comX1_2; competence protein ComX
D SPH_1699 major facilitator:Oxalate:Formate Antiporter K08177 oxlT; MFS transporter, OFA family, oxalate/formate antiporter
D SPH_0010 beta-lactamase class A K01467 ampC; beta-lactamase class C [EC:3.5.2.6]
D SPH_2144 histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
D SPH_2143 response regulator K07693 desR; two-component system, NarL family, response regulator DesR
D SPH_0493 histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
D SPH_0494 response regulator K11618 liaR; two-component system, NarL family, response regulator LiaR
D SPH_0611 glnA; glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D SPH_0267 sensor histidine kinase, putative K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D SPH_0757 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D SPH_0268 response regulator K07720 yesN; two-component system, response regulator YesN
D SPH_2181 phosphotyrosine protein phosphatase K25307 wzb; low molecular weight protein-tyrosine phosphatase [EC:3.1.3.48]
D SPH_0465 UDP-N-acetylglucosamine 2-epimerase K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]
C 04010 MAPK signaling pathway
C 04013 MAPK signaling pathway - fly
C 04016 MAPK signaling pathway - plant
C 04011 MAPK signaling pathway - yeast
C 04012 ErbB signaling pathway
C 04014 Ras signaling pathway
C 04015 Rap1 signaling pathway
C 04310 Wnt signaling pathway
C 04330 Notch signaling pathway
C 04340 Hedgehog signaling pathway
C 04341 Hedgehog signaling pathway - fly
C 04350 TGF-beta signaling pathway
C 04390 Hippo signaling pathway
C 04391 Hippo signaling pathway - fly
C 04392 Hippo signaling pathway - multiple species
C 04370 VEGF signaling pathway
C 04371 Apelin signaling pathway
C 04630 JAK-STAT signaling pathway
C 04064 NF-kappa B signaling pathway
C 04668 TNF signaling pathway
C 04066 HIF-1 signaling pathway
C 04068 FoxO signaling pathway
C 04020 Calcium signaling pathway
C 04070 Phosphatidylinositol signaling system
C 04072 Phospholipase D signaling pathway
C 04071 Sphingolipid signaling pathway
C 04024 cAMP signaling pathway
C 04022 cGMP-PKG signaling pathway
C 04151 PI3K-Akt signaling pathway
C 04152 AMPK signaling pathway
C 04150 mTOR signaling pathway
C 04075 Plant hormone signal transduction
B
B 09133 Signaling molecules and interaction
C 04080 Neuroactive ligand-receptor interaction
C 04082 Neuroactive ligand signaling
C 04081 Hormone signaling
C 04060 Cytokine-cytokine receptor interaction
C 04061 Viral protein interaction with cytokine and cytokine receptor
C 04512 ECM-receptor interaction
C 04514 Cell adhesion molecules
#
A09140 Cellular Processes
B
B 09141 Transport and catabolism
C 04144 Endocytosis
C 04145 Phagosome
C 04142 Lysosome [PATH:spv04142]
D SPH_2339 FucA K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51]
D SPH_0164 beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_2334 N-acetyl-beta-D-glucosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_1468 sialidase B (Neuraminidase B) K01186 NEU1; sialidase-1 [EC:3.2.1.18]
D SPH_1797 neuraminidase K01186 NEU1; sialidase-1 [EC:3.2.1.18]
D SPH_1923 sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1) K13444 SUMF1; formylglycine-generating enzyme [EC:1.8.3.7]
C 04146 Peroxisome [PATH:spv04146]
D SPH_0488 mvk; mevalonate kinase K00869 MVK; mevalonate kinase [EC:2.7.1.36]
D SPH_0865 superoxide dismutase [Mn] (General stress protein 24)(GSP24) K04564 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]
C 04140 Autophagy - animal
C 04138 Autophagy - yeast
C 04136 Autophagy - other
C 04137 Mitophagy - animal
C 04139 Mitophagy - yeast
C 04148 Efferocytosis
B
B 09143 Cell growth and death
C 04110 Cell cycle
C 04111 Cell cycle - yeast
C 04112 Cell cycle - Caulobacter
C 04113 Meiosis - yeast
C 04114 Oocyte meiosis
C 04210 Apoptosis
C 04214 Apoptosis - fly
C 04215 Apoptosis - multiple species
C 04216 Ferroptosis
C 04217 Necroptosis
C 04115 p53 signaling pathway
C 04218 Cellular senescence
B
B 09144 Cellular community - eukaryotes
C 04510 Focal adhesion
C 04520 Adherens junction
C 04530 Tight junction
C 04540 Gap junction
C 04550 Signaling pathways regulating pluripotency of stem cells
B
B 09145 Cellular community - prokaryotes
C 02024 Quorum sensing [PATH:spv02024]
D SPH_0450 luxS; S-ribosylhomocysteinase LuxS K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]
D SPH_1939 trpE; anthranilate synthase component I K01657 trpE; anthranilate synthase component I [EC:4.1.3.27]
D SPH_1938 para-aminobenzoate/anthranilate synthase glutamine amidotransferasecomponent II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
D SPH_1804 3-deoxy-7-phosphoheptulonate synthase K01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
D SPH_1805 3-deoxy-7-phosphoheptulonate synthase K01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
D SPH_0850 ABC transporter substrate-binding protein - branched chain amino acid transport K01999 livK; branched-chain amino acid transport system substrate-binding protein
D SPH_0851 high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) K01997 livH; branched-chain amino acid transport system permease protein
D SPH_0852 ABC transporter membrane-spanning permease - branched chain amino acid transport K01998 livM; branched-chain amino acid transport system permease protein
D SPH_0853 high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) K01995 livG; branched-chain amino acid transport system ATP-binding protein
D SPH_0854 high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) K01996 livF; branched-chain amino acid transport system ATP-binding protein
D SPH_0281 ribD; riboflavin biosynthesis protein RibD K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]
D SPH_0633 histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D SPH_0632 response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA
D SPH_2065 pneumolysin (Thiol-activated cytolysin) K11031 slo; thiol-activated cytolysin
D SPH_2434 conserved domain protein K12415 comC; competence-stimulating peptide
D SPH_0148 transport/processing ATP-binding protein ComA K12292 comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
D SPH_0149 transport protein ComB K12293 comB; competence factor transport accessory protein ComB
D SPH_2433 ComD K12294 comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3]
D SPH_2432 response regulator K12295 comE; two-component system, LytTR family, response regulator ComE
D SPH_0642 hypothetical protein K20341 blpL; immunity protein
D SPH_0901 sensor protein CiaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
D SPH_0900 transcriptional regulatory protein CiaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR
D SPH_0474 oligopeptide binding protein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_1641 oligopeptide binding lipoprotein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_2009 AmiA protein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_2008 oligopeptide transport system permease protein AmiC K15581 oppB; oligopeptide transport system permease protein
D SPH_2007 oligopeptide transport system permease protein AmiD K15582 oppC; oligopeptide transport system permease protein
D SPH_2006 oligopeptide transport ATP-binding protein OppD K15583 oppD; oligopeptide transport system ATP-binding protein
D SPH_2005 oligopeptide transport ATP-binding protein AmiF K10823 oppF; oligopeptide transport system ATP-binding protein
D SPH_0142 transcriptional regulator, XRE-family K20342 comR; HTH-type transcriptional regulator, regulator for ComX
D SPH_2131 transcriptional activator K20342 comR; HTH-type transcriptional regulator, regulator for ComX
D SPH_0014 competence-specific global transcription modulator K12296 comX1_2; competence protein ComX
D SPH_2163 competence-specific global transcription modulator K12296 comX1_2; competence protein ComX
D SPH_0634 double glycine cleavage site bacteriolysin superfamily K20343 blpC; peptide pheromone BlpC
D SPH_0636 transport/processing ATP-binding protein ComA K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D SPH_0635 BlpC ABC transporter K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter
D SPH_1308 lacD; tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]
D SPH_2117 membrane protein OxaA 2 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_2194 membrane protein OxaA 1 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_2165 secE; preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE
D SPH_1075 secG; preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG
D SPH_0343 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY
D SPH_1874 translocase, putative K03076 secY; preprotein translocase subunit SecY
D SPH_0437 yajC1; preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D SPH_2182 yajC2; preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D SPH_1806 secA; preprotein translocase, SecA subunit K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D SPH_1870 preprotein translocase subunit SecA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D SPH_1359 cell division protein FtsY K03110 ftsY; fused signal recognition particle receptor
D SPH_1428 ffh; signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D SPH_1208 transcriptional regulator
C 05111 Biofilm formation - Vibrio cholerae
C 02025 Biofilm formation - Pseudomonas aeruginosa
C 02026 Biofilm formation - Escherichia coli
B
B 09142 Cell motility
C 02030 Bacterial chemotaxis
C 02040 Flagellar assembly [PATH:spv02040]
D SPH_0260 ABC transporter substrate-binding protein - amino acid transport K02424 tcyA; L-cystine transport system substrate-binding protein
D SPH_1161 RNA polymerase sigma factor RpoD (Sigma-A) (Sigma-43) K03086 rpoD; RNA polymerase primary sigma factor
C 04814 Motor proteins
C 04820 Cytoskeleton in muscle cells
D SPH_1222 eno; phosphopyruvate hydratase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
C 04810 Regulation of actin cytoskeleton
#
A09150 Organismal Systems
B
B 09151 Immune system
C 04640 Hematopoietic cell lineage
C 04610 Complement and coagulation cascades
C 04611 Platelet activation
C 04613 Neutrophil extracellular trap formation
C 04620 Toll-like receptor signaling pathway
C 04624 Toll and Imd signaling pathway
C 04621 NOD-like receptor signaling pathway
C 04622 RIG-I-like receptor signaling pathway
C 04623 Cytosolic DNA-sensing pathway
C 04625 C-type lectin receptor signaling pathway
C 04650 Natural killer cell mediated cytotoxicity
C 04612 Antigen processing and presentation
C 04660 T cell receptor signaling pathway
C 04658 Th1 and Th2 cell differentiation
C 04659 Th17 cell differentiation
C 04657 IL-17 signaling pathway
C 04662 B cell receptor signaling pathway
C 04664 Fc epsilon RI signaling pathway
C 04666 Fc gamma R-mediated phagocytosis
C 04670 Leukocyte transendothelial migration
C 04672 Intestinal immune network for IgA production
C 04062 Chemokine signaling pathway
B
B 09152 Endocrine system
C 04911 Insulin secretion
C 04910 Insulin signaling pathway
C 04922 Glucagon signaling pathway
C 04923 Regulation of lipolysis in adipocytes
C 04920 Adipocytokine signaling pathway
C 03320 PPAR signaling pathway
C 04929 GnRH secretion
C 04912 GnRH signaling pathway
C 04913 Ovarian steroidogenesis
C 04915 Estrogen signaling pathway
C 04914 Progesterone-mediated oocyte maturation
C 04917 Prolactin signaling pathway
C 04921 Oxytocin signaling pathway
C 04926 Relaxin signaling pathway
C 04935 Growth hormone synthesis, secretion and action
C 04918 Thyroid hormone synthesis
C 04919 Thyroid hormone signaling pathway
C 04928 Parathyroid hormone synthesis, secretion and action
C 04916 Melanogenesis
C 04924 Renin secretion
C 04614 Renin-angiotensin system
C 04925 Aldosterone synthesis and secretion
C 04927 Cortisol synthesis and secretion
B
B 09153 Circulatory system
C 04260 Cardiac muscle contraction
C 04261 Adrenergic signaling in cardiomyocytes
C 04270 Vascular smooth muscle contraction
B
B 09154 Digestive system
C 04970 Salivary secretion
C 04971 Gastric acid secretion
C 04972 Pancreatic secretion
C 04976 Bile secretion
C 04973 Carbohydrate digestion and absorption
C 04974 Protein digestion and absorption
C 04975 Fat digestion and absorption
C 04979 Cholesterol metabolism
C 04977 Vitamin digestion and absorption
C 04981 Folate transport and metabolism [PATH:spv04981]
D SPH_2283 5-formyltetrahydrofolate cyclo-ligase K01934 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]
D SPH_1685 folA; dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]
D SPH_1127 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D SPH_0764 thyA; thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45]
C 04980 Cobalamin transport and metabolism
C 04978 Mineral absorption
B
B 09155 Excretory system
C 04962 Vasopressin-regulated water reabsorption
C 04960 Aldosterone-regulated sodium reabsorption
C 04961 Endocrine and other factor-regulated calcium reabsorption
C 04964 Proximal tubule bicarbonate reclamation
C 04966 Collecting duct acid secretion
B
B 09156 Nervous system
C 04724 Glutamatergic synapse
C 04727 GABAergic synapse
C 04725 Cholinergic synapse
C 04728 Dopaminergic synapse
C 04726 Serotonergic synapse
C 04720 Long-term potentiation
C 04730 Long-term depression
C 04723 Retrograde endocannabinoid signaling
C 04721 Synaptic vesicle cycle
C 04722 Neurotrophin signaling pathway
B
B 09157 Sensory system
C 04744 Phototransduction
C 04745 Phototransduction - fly
C 04740 Olfactory transduction
C 04742 Taste transduction
C 04750 Inflammatory mediator regulation of TRP channels
B
B 09158 Development and regeneration
C 04320 Dorso-ventral axis formation
C 04360 Axon guidance
C 04361 Axon regeneration
C 04380 Osteoclast differentiation
C 04382 Cornified envelope formation
D SPH_0397 aminopeptidase C (Bleomycin hydrolase) K01372 BLMH; bleomycin hydrolase [EC:3.4.22.40]
B
B 09149 Aging
C 04211 Longevity regulating pathway
C 04212 Longevity regulating pathway - worm
C 04213 Longevity regulating pathway - multiple species
B
B 09159 Environmental adaptation
C 04710 Circadian rhythm
C 04713 Circadian entrainment
C 04711 Circadian rhythm - fly
C 04712 Circadian rhythm - plant
C 04714 Thermogenesis
C 04626 Plant-pathogen interaction
#
A09160 Human Diseases
B
B 09161 Cancer: overview
C 05200 Pathways in cancer
C 05202 Transcriptional misregulation in cancer
C 05206 MicroRNAs in cancer
C 05205 Proteoglycans in cancer
C 05204 Chemical carcinogenesis - DNA adducts
C 05207 Chemical carcinogenesis - receptor activation
C 05208 Chemical carcinogenesis - reactive oxygen species
C 05203 Viral carcinogenesis
C 05230 Central carbon metabolism in cancer
C 05231 Choline metabolism in cancer
C 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
B
B 09162 Cancer: specific types
C 05210 Colorectal cancer
C 05212 Pancreatic cancer
C 05225 Hepatocellular carcinoma
C 05226 Gastric cancer
C 05214 Glioma
C 05216 Thyroid cancer
C 05221 Acute myeloid leukemia
C 05220 Chronic myeloid leukemia
C 05217 Basal cell carcinoma
C 05218 Melanoma
C 05211 Renal cell carcinoma
C 05219 Bladder cancer
C 05215 Prostate cancer
C 05213 Endometrial cancer
C 05224 Breast cancer
C 05222 Small cell lung cancer
C 05223 Non-small cell lung cancer
B
B 09172 Infectious disease: viral
C 05166 Human T-cell leukemia virus 1 infection
C 05170 Human immunodeficiency virus 1 infection
C 05161 Hepatitis B
C 05160 Hepatitis C
C 05171 Coronavirus disease - COVID-19
C 05164 Influenza A
C 05162 Measles
C 05168 Herpes simplex virus 1 infection
C 05163 Human cytomegalovirus infection
C 05167 Kaposi sarcoma-associated herpesvirus infection
C 05169 Epstein-Barr virus infection
C 05165 Human papillomavirus infection
B
B 09171 Infectious disease: bacterial
C 05110 Vibrio cholerae infection
C 05120 Epithelial cell signaling in Helicobacter pylori infection
C 05130 Pathogenic Escherichia coli infection
C 05132 Salmonella infection
C 05131 Shigellosis
C 05135 Yersinia infection
C 05133 Pertussis
C 05134 Legionellosis
C 05150 Staphylococcus aureus infection
C 05152 Tuberculosis
C 05100 Bacterial invasion of epithelial cells
D SPH_1950 cell wall surface anchor family protein K13925 pfbA; plasmin and fibronectin-binding protein A
B
B 09174 Infectious disease: parasitic
C 05146 Amoebiasis
C 05144 Malaria
C 05145 Toxoplasmosis
C 05140 Leishmaniasis
C 05142 Chagas disease
C 05143 African trypanosomiasis
B
B 09163 Immune disease
C 05310 Asthma
C 05322 Systemic lupus erythematosus
C 05323 Rheumatoid arthritis
C 05320 Autoimmune thyroid disease
C 05321 Inflammatory bowel disease
C 05330 Allograft rejection
C 05332 Graft-versus-host disease
C 05340 Primary immunodeficiency
B
B 09164 Neurodegenerative disease
C 05010 Alzheimer disease
C 05012 Parkinson disease
C 05014 Amyotrophic lateral sclerosis
C 05016 Huntington disease
C 05017 Spinocerebellar ataxia
C 05020 Prion disease
C 05022 Pathways of neurodegeneration - multiple diseases
B
B 09165 Substance dependence
C 05030 Cocaine addiction
C 05031 Amphetamine addiction
C 05032 Morphine addiction
C 05033 Nicotine addiction
C 05034 Alcoholism
B
B 09166 Cardiovascular disease
C 05417 Lipid and atherosclerosis
C 05418 Fluid shear stress and atherosclerosis
C 05410 Hypertrophic cardiomyopathy
C 05412 Arrhythmogenic right ventricular cardiomyopathy
C 05414 Dilated cardiomyopathy
C 05415 Diabetic cardiomyopathy
C 05416 Viral myocarditis
B
B 09167 Endocrine and metabolic disease
C 04930 Type II diabetes mellitus
C 04940 Type I diabetes mellitus
C 04950 Maturity onset diabetes of the young
C 04936 Alcoholic liver disease
C 04932 Non-alcoholic fatty liver disease
C 04931 Insulin resistance
C 04933 AGE-RAGE signaling pathway in diabetic complications
C 04934 Cushing syndrome
B
B 09175 Drug resistance: antimicrobial
C 01501 beta-Lactam resistance [PATH:spv01501]
D SPH_0010 beta-lactamase class A K01467 ampC; beta-lactamase class C [EC:3.5.2.6]
D SPH_0474 oligopeptide binding protein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_1641 oligopeptide binding lipoprotein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_2009 AmiA protein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_2008 oligopeptide transport system permease protein AmiC K15581 oppB; oligopeptide transport system permease protein
D SPH_2007 oligopeptide transport system permease protein AmiD K15582 oppC; oligopeptide transport system permease protein
D SPH_2006 oligopeptide transport ATP-binding protein OppD K15583 oppD; oligopeptide transport system ATP-binding protein
D SPH_2005 oligopeptide transport ATP-binding protein AmiF K10823 oppF; oligopeptide transport system ATP-binding protein
D SPH_0476 penicillin-binding protein 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D SPH_2287 penicillin-binding protein 1B K03693 pbp1b; penicillin-binding protein 1B
D SPH_2166 penicillin-binding protein 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]
D SPH_1781 penicillin-binding protein 2B K00687 pbp2B; penicillin-binding protein 2B
D SPH_0446 penicillin-binding protein 2X K12556 pbp2X; penicillin-binding protein 2X
C 01502 Vancomycin resistance [PATH:spv01502]
D SPH_1779 D-alanine--D-alanine ligase (D-alanylalanine synthetase)(D-Ala-D-Ala ligase) K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D SPH_1802 alr; alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D SPH_1778 UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
D SPH_0447 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D SPH_0783 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D SPH_0722 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
C 01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:spv01503]
D SPH_2438 trypsin domain protein K04771 degP; serine protease Do [EC:3.4.21.107]
D SPH_0870 peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
D SPH_2372 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D SPH_2371 protein DltB K03739 dltB; membrane protein involved in D-alanine export
D SPH_2370 dltC; D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D SPH_2369 D-alanine transfer from undecaprenol-phosphate to the poly K03740 dltD; D-alanine transfer protein
B
B 09176 Drug resistance: antineoplastic
C 01521 EGFR tyrosine kinase inhibitor resistance
C 01524 Platinum drug resistance
C 01523 Antifolate resistance
C 01522 Endocrine resistance
#
A09180 Brite Hierarchies
B
B 09181 Protein families: metabolism
C 01000 Enzymes [BR:spv01000]
C 01001 Protein kinases [BR:spv01001]
D SPH_1841 Stk1 K12132 prkC; eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1]
D SPH_0458 tyrosine-protein kinase CpsD K00903 epsB; protein-tyrosine kinase [EC:2.7.10.3]
D SPH_2270 histidine kinase PnpS K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
D SPH_1340 sensor protein YycG K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
D SPH_0186 histidine kinase K10681 saeS; two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3]
D SPH_1743 histidine kinase K19081 braS; two-component system, OmpR family, sensor histidine kinase BraS/BceS [EC:2.7.13.3]
D SPH_0901 sensor protein CiaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
D SPH_2144 histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
D SPH_0493 histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
D SPH_0633 histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D SPH_2433 ComD K12294 comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3]
D SPH_0267 sensor histidine kinase, putative K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D SPH_0757 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C 01009 Protein phosphatases and associated proteins [BR:spv01009]
D SPH_1003 pfkA; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D SPH_1842 protein phosphatase PrpC K20074 prpC; PPM family protein phosphatase [EC:3.1.3.16]
C 01002 Peptidases and inhibitors [BR:spv01002]
D SPH_1037 lspA; signal peptidase II K03101 lspA; signal peptidase II [EC:3.4.23.36]
D SPH_0397 aminopeptidase C (Bleomycin hydrolase) K01372 BLMH; bleomycin hydrolase [EC:3.4.22.40]
D SPH_0959 pcp; pyroglutamyl-peptidase I K01304 pcp; pyroglutamyl-peptidase [EC:3.4.19.3]
D SPH_1562 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
D SPH_1180 glutamine amidotransferase, class I K07010 K07010; putative glutamine amidotransferase
D SPH_2259 glutamine amidotransferase K07010 K07010; putative glutamine amidotransferase
D SPH_0148 transport/processing ATP-binding protein ComA K12292 comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
D SPH_0636 transport/processing ATP-binding protein ComA K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D SPH_2411 general stress protein GSP-781 K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
D SPH_0153 purF; amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
D SPH_0383 glmS; glutamine-fructose-6-phosphate transaminase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D SPH_0906 4-methyl-5 K03152 thiJ; protein deglycase [EC:3.5.1.124]
D SPH_1333 sortase K07284 srtA; sortase A [EC:3.4.22.70]
D SPH_0255 caax amino protease family K07052 K07052; CAAX protease family protein
D SPH_0284 caax amino protease family K07052 K07052; CAAX protease family protein
D SPH_0404 caax amino protease family protein K07052 K07052; CAAX protease family protein
D SPH_0644 immunity protein BlpY K07052 K07052; CAAX protease family protein
D SPH_0646 caax amino protease family K07052 K07052; CAAX protease family protein
D SPH_1034 caax amino protease family K07052 K07052; CAAX protease family protein
D SPH_1237 caax amino protease family K07052 K07052; CAAX protease family protein
D SPH_1474 caax amino protease family K07052 K07052; CAAX protease family protein
D SPH_1482 caax amino protease family K07052 K07052; CAAX protease family protein
D SPH_2306 caax amino protease family K07052 K07052; CAAX protease family protein
D SPH_0899 aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
D SPH_1080 pepF1; oligoendopeptidase F K08602 pepF; oligoendopeptidase F [EC:3.4.24.-]
D SPH_1756 endopeptidase O K07386 pepO; putative endopeptidase [EC:3.4.24.-]
D SPH_0722 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D SPH_0715 pepV; dipeptidase PepV K01274 pepV; beta-Ala-Xaa dipeptidase [EC:3.4.13.-]
D SPH_0262 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
D SPH_1110 pepT; peptidase T K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4]
D SPH_2284 peptidase, M20/M25/M40 family K05823 dapL; N-acetyldiaminopimelate deacetylase [EC:3.5.1.47]
D SPH_1176 map; methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
D SPH_0306 Xaa-Pro dipeptidase K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]
D SPH_1229 immunoglobulin A1 protease K01390 iga; IgA-specific metalloendopeptidase [EC:3.4.24.13]
D SPH_0759 zmpB; zinc metalloprotease ZmpB K08643 zmpB; zinc metalloprotease ZmpB [EC:3.4.24.-]
D SPH_0394 aminopeptidase PepS K19689 ampS; aminopeptidase [EC:3.4.11.-]
D SPH_0013 hflB; ATP-dependent metallopeptidase HflB K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D SPH_1982 pepA; glutamyl aminopeptidase K01261 pepA; glutamyl aminopeptidase [EC:3.4.11.7]
D SPH_0720 peptidase, M42 K01269 yhfE; aminopeptidase [EC:3.4.11.-]
D SPH_1399 putative Probable protease HtpX homolog K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
D SPH_0380 rseP; RIP metalloprotease RseP K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
D SPH_2438 trypsin domain protein K04771 degP; serine protease Do [EC:3.4.21.107]
D SPH_0976 penicillin-binding protein 3 K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D SPH_0848 clpP; Clp protease K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
D SPH_1001 Xaa-pro dipeptidyl-peptidase K01281 pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11]
D SPH_2110 ATP-dependent protease La K07177 K07177; Lon-like protease
D SPH_0511 lepB; signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
D SPH_0051 phage prohead protease, HK97 family K06904 GP4; Escherichia/Staphylococcus phage prohead protease
D SPH_1556 peptidase, U32 family K08303 prtC; U32 family peptidase [EC:3.4.-.-]
D SPH_1558 peptidase, U32 family protein K08303 prtC; U32 family peptidase [EC:3.4.-.-]
C 01003 Glycosyltransferases [BR:spv01003]
D SPH_1164 glycosyl transferase, group 1 K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]
D SPH_1163 glycosyl transferase CpoA K13678 cpoA; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-galactosyltransferase [EC:2.4.1.-]
D SPH_1217 glycogen synthase (Starch [bacterial glycogen]synthase) K00703 glgA; starch synthase [EC:2.4.1.21]
D SPH_0476 penicillin-binding protein 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D SPH_2287 penicillin-binding protein 1B K03693 pbp1b; penicillin-binding protein 1B
D SPH_2166 penicillin-binding protein 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]
D SPH_1154 cell division protein FtsW K03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_0905 RodA K05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_0460 UDP-N-acetyl-D-mannosamine transferase K05946 tagA; N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase [EC:2.4.1.187]
D SPH_1953 bacterial sugar transferase family protein K25627 K25627; AATGal transferase [EC:2.7.8.-]
D SPH_0201 glycosyl transferase K25650 K25650; teichoic acid beta-1,3-glucosyltransferase [EC:2.4.1.-]
D SPH_1497 galactosyl transferase paralog K25652 K25652; teichoic acid N-acetylgalactosaminyltransferase [EC:2.4.1.-]
D SPH_1498 glycosyl transferase, group 1 family protein K25653 K25653; teichoic acid N-acetylgalactosaminyltransferase [EC:2.4.1.-]
C 01005 Lipopolysaccharide biosynthesis proteins [BR:spv01005]
D SPH_1719 bactoprenol glucosyl transferase K12999 rgpI; glucosyltransferase [EC:2.4.1.-]
C 01011 Peptidoglycan biosynthesis and degradation proteins [BR:spv01011]
D SPH_1173 murA1; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D SPH_2108 murA2; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D SPH_1520 murB; UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D SPH_1633 murC; UDP-N-acetylmuramate--alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
D SPH_0782 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D SPH_1643 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7]
D SPH_1779 D-alanine--D-alanine ligase (D-alanylalanine synthetase)(D-Ala-D-Ala ligase) K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D SPH_0708 MurM K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10]
D SPH_0709 MurN K12554 murN; alanine adding enzyme [EC:2.3.2.-]
D SPH_1802 alr; alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D SPH_1997 murI; glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3]
D SPH_0447 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D SPH_0783 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D SPH_0565 undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
D SPH_0476 penicillin-binding protein 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D SPH_2287 penicillin-binding protein 1B K03693 pbp1b; penicillin-binding protein 1B
D SPH_2166 penicillin-binding protein 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]
D SPH_1781 penicillin-binding protein 2B K00687 pbp2B; penicillin-binding protein 2B
D SPH_0446 penicillin-binding protein 2X K12556 pbp2X; penicillin-binding protein 2X
D SPH_0976 penicillin-binding protein 3 K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D SPH_1154 cell division protein FtsW K03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_0905 RodA K05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_0722 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D SPH_2411 general stress protein GSP-781 K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
D SPH_1333 sortase K07284 srtA; sortase A [EC:3.4.22.70]
D SPH_1630 aminodeoxychorismate lyase K07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29]
C 01004 Lipid biosynthesis proteins [BR:spv01004]
D SPH_0528 fabD; malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D SPH_0525 beta-ketoacyl-acyl carrier protein synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]
D SPH_0531 3-oxoacyl-[acyl-carrier-protein] synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D SPH_0529 fabG; 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D SPH_0895 3-ketoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D SPH_0533 fabZ; beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D SPH_0527 putative enoyl-(acyl-carrier-protein) reductase II K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]
D SPH_0523 enoyl-CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14]
D SPH_0137 plsX; fatty acid/phospholipid synthesis protein PlsX K03621 plsX; phosphate acyltransferase [EC:2.3.1.274]
D SPH_0951 membrane protein, putative K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D SPH_1737 acyltransferase family protein K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
C 01008 Polyketide biosynthesis proteins
C 01006 Prenyltransferases [BR:spv01006]
D SPH_1323 geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]
D SPH_0378 uppS; di-trans,poly-cis-decaprenylcistransferase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D SPH_0766 miaA; tRNA delta(2)-isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
C 01007 Amino acid related enzymes [BR:spv01007]
D SPH_2256 gltX; glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
D SPH_2288 tyrS; tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D SPH_2424 trpS; tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D SPH_0689 cysS; cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D SPH_2266 argS; arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D SPH_0887 metG; methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D SPH_1767 ileS; isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D SPH_0666 valS; valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D SPH_0372 leuS; leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D SPH_0799 lysS; lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D SPH_2303 aspS; aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D SPH_1656 asnS; asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D SPH_2312 hisS; histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D SPH_1591 glyQ; glycyl-tRNA synthetase, alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D SPH_1590 glyS; glycyl-tRNA synthetase, beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D SPH_0519 serS; seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D SPH_0381 proS; prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D SPH_1742 thrS; threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D SPH_1514 alaS; alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D SPH_0678 pheS; phenylalanyl-tRNA synthetase, alpha subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D SPH_0680 pheT; phenylalanyl-tRNA synthetase, beta subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D SPH_2136 aminotransferase, class I and II K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D SPH_0135 putative aminotransferase A K00841 patA; aminotransferase [EC:2.6.1.-]
D SPH_1636 putative aminotransferase B K14155 patB; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
D SPH_0955 ilvE; branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D SPH_0760 chorismate binding enzyme K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38]
C 00199 Cytochrome P450
C 00194 Photosynthesis proteins [BR:spv00194]
D SPH_1618 atpC; ATP synthase F1, epsilon subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon
D SPH_1619 atpD; ATP synthase F1, beta subunit K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
D SPH_1620 atpG; ATP synthase F1, gamma subunit K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma
D SPH_1621 atpA; ATP synthase F1, alpha subunit K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
D SPH_1622 atpH; ATP synthase F1, delta subunit K02113 ATPF1D; F-type H+-transporting ATPase subunit delta
D SPH_1623 atpF; ATP synthase F0, B subunit K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D SPH_1625 conserved domain protein K02110 ATPF0C; F-type H+-transporting ATPase subunit c
D SPH_1624 atpB; ATP synthase F0, A subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a
B
B 09182 Protein families: genetic information processing
C 03000 Transcription factors [BR:spv03000]
D SPH_0083 hypothetical protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_1233 methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_1302 lactose phosphotransferase system repressor K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor
D SPH_0979 transcriptional repressor of the fructose operon K03436 fruR2; DeoR family transcriptional regulator, fructose operon transcriptional repressor
D SPH_1913 sugar-binding transcriptional regulator, LacI family protein K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D SPH_1970 GalR K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D SPH_2142 ccpA; catabolite control protein A K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D SPH_2301 HTH-type transcriptional regulator MalR (Maltose operontranscriptional repressor) K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D SPH_2001 treR; trehalose operon repressor K03486 treR2; GntR family transcriptional regulator, trehalose operon transcriptional repressor
D SPH_2174 transcriptional regulator, GntR family K03492 gmuR; GntR family transcriptional regulator, regulator of glucomannan utilization
D SPH_1563 transcriptional regulator, GntR family protein K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator
D SPH_0610 HTH-type transcriptional regulator GlnR K03713 glnR; MerR family transcriptional regulator, glutamine synthetase repressor
D SPH_1972 transcriptional regulator, MerR family K21745 adhR; MerR family transcriptional regulator, aldehyde-responsive regulator
D SPH_0199 transcription regulator K10947 K10947; PadR family transcriptional regulator
D SPH_0890 transcriptional regulator, PadR family K10947 K10947; PadR family transcriptional regulator
D SPH_1749 iron-dependent transcriptional regulator K03709 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator
D SPH_2017 biotin-[acetyl-CoA-carboxylase] ligase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
D SPH_1262 conserved hypothetical protein K18830 pezA; HTH-type transcriptional regulator / antitoxin PezA
D SPH_0142 transcriptional regulator, XRE-family K20342 comR; HTH-type transcriptional regulator, regulator for ComX
D SPH_2131 transcriptional activator K20342 comR; HTH-type transcriptional regulator, regulator for ComX
D SPH_2120 purR; pur operon repressor K09685 purR; HTH-type transcriptional regulator, purine operon repressor
D SPH_1182 redox-sensing transcriptional repressor rex K01926 rex; redox-sensing transcriptional repressor
D SPH_1697 codY; GTP-sensing transcriptional pleiotropic repressor CodY K03706 codY; transcriptional pleiotropic repressor
D SPH_1132 conserved hypothetical protein K07727 K07727; putative transcriptional regulator
D SPH_0030 conserved domain protein K07729 K07729; putative transcriptional regulator
D SPH_0443 conserved domain protein K07729 K07729; putative transcriptional regulator
D SPH_1553 conserved domain protein K07729 K07729; putative transcriptional regulator
D SPH_2309 conserved domain protein K07729 K07729; putative transcriptional regulator
D SPH_0674 transcription antiterminator LicT K03488 licT; beta-glucoside operon transcriptional antiterminator
D SPH_2185 transcriptional regulator, BglG family K03493 bglG1; transcriptional antiterminator
D SPH_0505 putative transcriptional regulator MtlR K03483 mtlR; mannitol operon transcriptional activator
D SPH_2439 stage 0 sporulation protein J K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D SPH_1307 transcription antiterminator LacT K02531 lacT; transcriptional antiterminator
D SPH_1000 arginine repressor K03402 argR; transcriptional regulator of arginine metabolism
D SPH_1321 transcriptional regulator of arginine metabolism expression K03402 argR; transcriptional regulator of arginine metabolism
D SPH_2265 argR; arginine repressor K03402 argR; transcriptional regulator of arginine metabolism
D SPH_1930 ROK family protein, putative K02565 nagC; N-acetylglucosamine repressor
D SPH_0622 hrcA; heat-inducible transcription repressor HrcA K03705 hrcA; heat-inducible transcriptional repressor
D SPH_0802 tena/thi-4 family K03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]
D SPH_0809 tena/thi-4 family K03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]
D SPH_2394 transcriptional regulator CtsR K03708 ctsR; transcriptional regulator of stress and heat shock response
D SPH_1394 PyrR bifunctional protein K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]
D SPH_1821 nrdR; transcriptional regulator NrdR K07738 nrdR; transcriptional repressor NrdR
D SPH_0014 competence-specific global transcription modulator K12296 comX1_2; competence protein ComX
D SPH_2163 competence-specific global transcription modulator K12296 comX1_2; competence protein ComX
C 03021 Transcription machinery [BR:spv03021]
D SPH_0349 rpoA; DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D SPH_2102 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D SPH_2101 rpoC; DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D SPH_0603 rpoE; DNA-directed RNA polymerase, delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta
D SPH_1846 rpoZ; DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D SPH_1161 RNA polymerase sigma factor RpoD (Sigma-A) (Sigma-43) K03086 rpoD; RNA polymerase primary sigma factor
D SPH_0650 nusA; transcription termination factor NusA K02600 nusA; transcription termination/antitermination protein NusA
D SPH_0539 nusB; transcription antitermination factor NusB K03625 nusB; transcription antitermination protein NusB
D SPH_2164 nusG; transcription termination/antitermination factor NusG K02601 nusG; transcription termination/antitermination protein NusG
D SPH_1629 transcription elongation factor GreA K03624 greA; transcription elongation factor GreA
C 03019 Messenger RNA biogenesis [BR:spv03019]
D SPH_1363 rnc; ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3]
D SPH_0237 metallo-beta-lactamase superfamily protein K12574 rnj; ribonuclease J [EC:3.1.-.-]
D SPH_0706 metallo-beta-lactamase superfamily protein K12574 rnj; ribonuclease J [EC:3.1.-.-]
D SPH_1848 conserved hypothetical protein K18682 rny; ribonucrease Y [EC:3.1.-.-]
D SPH_1076 rnr; ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1]
D SPH_2121 3'-5' exoribonuclease YhaM K03698 cbf; 3'-5' exoribonuclease [EC:3.1.-.-]
D SPH_1698 DEAD/DEAH box helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D SPH_0861 ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7]
D SPH_1222 eno; phosphopyruvate hydratase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D SPH_0686 pnp; polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D SPH_1003 pfkA; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D SPH_0624 dnaK; chaperone protein DnaK K04043 dnaK; molecular chaperone DnaK
D SPH_2050 groL; chaperonin GroL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D SPH_1680 putative P-loop ATPase protein K06958 rapZ; RNase adapter protein RapZ
C 03041 Spliceosome
C 03011 Ribosome [BR:spv03011]
D SPH_0963 putative 30S ribosomal protein S1 homolog K02945 RP-S1; small subunit ribosomal protein S1
D SPH_2410 rpsB; ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2
D SPH_0329 rpsC; ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3
D SPH_0187 rpsD; ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4
D SPH_0340 rpsE; ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5
D SPH_1655 rpsF; ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6
D SPH_0388 rpsG; ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7
D SPH_0337 rpsH; ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8
D SPH_0412 rpsI; ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9
D SPH_0322 rpsJ; ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10
D SPH_0348 rpsK; ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11
D SPH_0387 rpsL; ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12
D SPH_0347 rpsM; ribosomal protein S13p/S18e K02952 RP-S13; small subunit ribosomal protein S13
D SPH_0336 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14
D SPH_1739 rpsO; ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15
D SPH_0873 rpsP; ribosomal protein S16 K02959 RP-S16; small subunit ribosomal protein S16
D SPH_0332 rpsQ; ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17
D SPH_1653 rpsR; ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18
D SPH_0327 rpsS; ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19
D SPH_0936 rpsT; ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20
D SPH_1545 rpsU; ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21
D SPH_0724 rplA; ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1
D SPH_0326 rplB; ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2
D SPH_0323 rplC; ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3
D SPH_0324 rplD; ribosomal protein L4/L1 family K02926 RP-L4; large subunit ribosomal protein L4
D SPH_0335 50S ribosomal protein L5 (BL6) K02931 RP-L5; large subunit ribosomal protein L5
D SPH_0338 50S ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6
D SPH_2402 rplI; ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9
D SPH_1486 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10
D SPH_0723 rplK; ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11
D SPH_1485 rplL; ribosomal protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12
D SPH_0411 rplM; ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13
D SPH_0333 rplN; ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14
D SPH_0342 rplO; ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15
D SPH_0330 rplP; ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16
D SPH_0350 rplQ; ribosomal protein L17 K02879 RP-L17; large subunit ribosomal protein L17
D SPH_0339 rplR; ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18
D SPH_1435 rplS; ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19
D SPH_1062 rplT; ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20
D SPH_1197 rplU; ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21
D SPH_0328 rplV; ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22
D SPH_0325 rplW; ribosomal protein L23 K02892 RP-L23; large subunit ribosomal protein L23
D SPH_0334 rplX; ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24
D SPH_1199 rpmA; ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27
D SPH_0548 rpmB; ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28
D SPH_0331 rpmC; ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29
D SPH_0341 rpmD; ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30
D SPH_1441 rpmE; ribosomal protein L31 K02909 RP-L31; large subunit ribosomal protein L31
D SPH_2326 rpmF; ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32
D SPH_1074 rpmG1; ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33
D SPH_2327 rpmG2; ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33
D SPH_2135 rpmH; ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34
D SPH_1061 rpmI; ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35
D SPH_0346 rpmJ; ribosomal protein L36 K02919 RP-L36; large subunit ribosomal protein L36
D SPH_0020 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2036 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2157 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2249 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_0016 rrs1; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2040 rrs2; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2161 rrs3; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2253 rrs4; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_0019 rrl1; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2037 rrl2; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2158 rrl3; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2250 rrl4; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
C 03009 Ribosome biogenesis [BR:spv03009]
D SPH_1363 rnc; ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3]
D SPH_1070 era; GTP-binding protein Era K03595 era; GTPase
D SPH_1167 Spo0B-associated GTP-binding protein K03979 obgE; GTPase [EC:3.6.5.-]
D SPH_0650 nusA; transcription termination factor NusA K02600 nusA; transcription termination/antitermination protein NusA
D SPH_0539 nusB; transcription antitermination factor NusB K03625 nusB; transcription antitermination protein NusB
D SPH_2164 nusG; transcription termination/antitermination factor NusG K02601 nusG; transcription termination/antitermination protein NusG
D SPH_0396 RNA pseudouridine synthase family protein K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]
D SPH_0775 ribosomal small subunit pseudouridine synthase A, putative K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]
D SPH_2126 ksgA; dimethyladenosine transferase K02528 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]
D SPH_1843 sun; ribosomal RNA small subunit methyltransferase B K03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]
D SPH_0940 methyltransferase small domain superfamily K00564 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]
D SPH_2112 N6-adenine-specific methylase K08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]
D SPH_1898 conserved hypothetical protein K09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]
D SPH_1401 gidB; methyltransferase GidB K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]
D SPH_0444 mraW; S-adenosyl-methyltransferase MraW K03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]
D SPH_1046 conserved hypothetical protein K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]
D SPH_1322 tylA; hemolysin A K06442 tlyA; 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]
D SPH_2291 rRNA K00563 rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187]
D SPH_1573 RNA methyltransferase, TrmH family, group 3 K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]
D SPH_1510 methyltransferase K06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]
D SPH_0867 radical SAM enzyme, Cfr family K06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]
D SPH_1131 rumA; 23S rRNA (uracil-5-)-methyltransferase RumA K03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]
D SPH_1990 rluB; ribosomal large subunit pseudouridine synthase B K06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]
D SPH_1038 rluD; ribosomal large subunit pseudouridine synthase D K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D SPH_1190 ribosomal large subunit pseudouridine synthase, RluD subfamily K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D SPH_2167 ribosomal large subunit pseudouridine synthase, RluD subfamily K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D SPH_1420 rRNA adenine N-6-methyltransferase (Macrolide-lincosamide-streptogramin B resistance protein) K00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]
D SPH_0243 rimI; ribosomal-protein-alanine acetyltransferase K03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]
D SPH_0876 rimM; 16S rRNA processing protein RimM K02860 rimM; 16S rRNA processing protein RimM
D SPH_1899 prmA; ribosomal protein L11 methyltransferase K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]
D SPH_0310 conserved hypothetical protein K07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-]
D SPH_0690 ribonuclease III family protein K11145 mrnC; mini-ribonuclease III [EC:3.1.26.-]
D SPH_1698 DEAD/DEAH box helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D SPH_0861 ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7]
D SPH_2125 rsgA; ribosome small subunit-dependent GTPase A K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]
D SPH_1817 GTP-binding protein EngA K03977 engA; GTPase
D SPH_1273 GTP-binding protein K14540 rbgA; ribosome biogenesis GTPase A
D SPH_0767 hflX; GTP-binding proten HflX K03665 hflX; GTPase
D SPH_1858 GTP-binding protein K06948 yqeH; 30S ribosome assembly GTPase
D SPH_1125 Sua5/YciO/YrdC/YwlC family protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D SPH_1753 spoT; guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]
D SPH_0654 rbfA; ribosome-binding factor A K02834 rbfA; ribosome-binding factor A
D SPH_0649 conserved hypothetical protein K09748 rimP; ribosome maturation factor RimP
D SPH_2421 S4 domain protein YaaA, putative K14761 rlbA; ribosome-associated protein
D SPH_1853 putative iojap homolog K09710 ybeB; ribosome-associated protein
D SPH_1068 conserved hypothetical protein K07042 ybeY; probable rRNA maturation factor
D SPH_1857 conserved hypothetical protein K07574 yhbY; RNA-binding protein
D SPH_2404 ribosome-associated protein Y K05808 hpf; ribosome hibernation promoting factor
D SPH_0004 ychF; GTP-binding protein YchF K06942 ychF; ribosome-binding ATPase
D SPH_1396 conserved hypothetical protein K07040 yceD; DUF177 domain-containing protein
C 03016 Transfer RNA biogenesis [BR:spv03016]
D SPH_0769 rnz; ribonuclease Z K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D SPH_1670 tRNA nucleotidyltransferase/poly(A) polymerase family protein K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
D SPH_0381 proS; prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D SPH_1767 ileS; isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D SPH_0372 leuS; leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D SPH_0887 metG; methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D SPH_2266 argS; arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D SPH_0799 lysS; lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D SPH_2303 aspS; aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D SPH_1514 alaS; alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D SPH_1656 asnS; asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D SPH_1742 thrS; threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D SPH_0519 serS; seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D SPH_0689 cysS; cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D SPH_0666 valS; valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D SPH_2312 hisS; histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D SPH_0678 pheS; phenylalanyl-tRNA synthetase, alpha subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D SPH_0680 pheT; phenylalanyl-tRNA synthetase, beta subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D SPH_2288 tyrS; tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D SPH_2424 trpS; tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D SPH_1752 dtd; D-tyrosyl-tRNA(Tyr) deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D SPH_0627 histidine triad domain protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D SPH_0648 trmB; tRNA (guanine-N(7)-)-methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D SPH_1711 truA; tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D SPH_1328 truB; tRNA pseudouridine synthase B K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D SPH_0985 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_1185 putative Probable cysteine desulfurase (NifS protein homolog) K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_1125 Sua5/YciO/YrdC/YwlC family protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D SPH_0766 miaA; tRNA delta(2)-isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D SPH_1119 trmE; tRNA modification GTPase TrmE K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D SPH_0236 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D SPH_2195 rnpA; ribonuclease P protein component K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]
D SPH_2442 bacterial RNase P, class B K01978 rnpB; M1 RNA
D SPH_1591 glyQ; glycyl-tRNA synthetase, alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D SPH_1590 glyS; glycyl-tRNA synthetase, beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D SPH_2256 gltX; glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
D SPH_1086 regulatory protein K03976 ybaK; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]
D SPH_0069 tRNA-specific adenosine deaminase K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]
D SPH_2384 tRNA-dihydrouridine synthase B K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]
D SPH_1047 trmFO; tRNA:M(5)U-54 methyltransferase K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]
D SPH_0877 trmD; tRNA (guanine-N1)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D SPH_1724 Bcl-2 family protein K06967 trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217]
D SPH_0598 RNA methyltransferase, TrmH family, group 2 K03216 trmL; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]
D SPH_2115 possible rRNA/tRNA methylase K03437 spoU; RNA methyltransferase, TrmH family
D SPH_0234 trmU; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D SPH_1547 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
D SPH_1892 NADPH-dependent 7-cyano-7-deazaguanine reductase K09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D SPH_2213 tgt; queuine tRNA-ribosyltransferase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
D SPH_0986 thiI; thiamine biosynthesis/tRNA modification protein ThiI K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D SPH_0011 tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]
D SPH_0242 glycoprotein endopeptidase K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
D SPH_0244 O-sialoglycoprotein endopeptidase (Glycoprotease) K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]
D SPH_2093 conserved hypothetical protein K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
D SPH_1851 conserved hypothetical protein K27343 tmcAL; tRNAmet cytidine acetate ligase [EC:6.3.1.22]
D SPH_1076 rnr; ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1]
D SPH_0686 pnp; polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
C 03012 Translation factors [BR:spv03012]
D SPH_0653 translation initiation factor IF-2 K02519 infB; translation initiation factor IF-2
D SPH_1060 infC; translation initiation factor IF-3 K02520 infC; translation initiation factor IF-3
D SPH_1207 ATPase component of ABC transporter with duplicated ATPase domains K06158 ABCF3; ATP-binding cassette, subfamily F, member 3
D SPH_2409 tsf; translation elongation factor Ts K02357 tsf; elongation factor Ts
D SPH_1601 tuf; translation elongation factor Tu K02358 tuf; elongation factor Tu
D SPH_0389 fusA; translation elongation factor G K02355 fusA; elongation factor G
D SPH_1123 prfA; peptide chain release factor 1 K02835 prfA; peptide chain release factor 1
D SPH_1049 frr; ribosome recycling factor K02838 frr; ribosome recycling factor
D SPH_1124 hemK; protein-(glutamine-N5) methyltransferase, release factor-specific K02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297]
D SPH_0005 pth; peptidyl-tRNA hydrolase K01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]
D SPH_0345 infA; translation initiation factor IF-1 K02518 infA; translation initiation factor IF-1
D SPH_0541 efp; translation elongation factor P K02356 efp; elongation factor P
D SPH_0856 prfB; peptide chain release factor 2 K02836 prfB; peptide chain release factor 2
D SPH_0545 prfC; peptide chain release factor 3 K02837 prfC; peptide chain release factor 3
C 03110 Chaperones and folding catalysts [BR:spv03110]
D SPH_2393 chaperone ClpB 1 K03696 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC
D SPH_0920 negative regulator of genetic competence ClpC/mecB K03697 clpE; ATP-dependent Clp protease ATP-binding subunit ClpE
D SPH_0449 ATP-dependent Clp protease ATP-binding subunit ClpL K04086 clpL; ATP-dependent Clp protease ATP-binding subunit ClpL
D SPH_1683 clpX; ATP-dependent Clp protease, ATP-binding subunit ClpX K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
D SPH_0624 dnaK; chaperone protein DnaK K04043 dnaK; molecular chaperone DnaK
D SPH_2050 groL; chaperonin GroL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D SPH_0625 dnaJ; chaperone protein DnaJ K03686 dnaJ; molecular chaperone DnaJ
D SPH_2383 hslO; chaperonin HslO K04083 hslO; molecular chaperone Hsp33
D SPH_0623 grpE; co-chaperone GrpE K03687 GRPE; molecular chaperone GrpE
D SPH_2051 groS; chaperonin GroS K04078 groES; chaperonin GroES
D SPH_2438 trypsin domain protein K04771 degP; serine protease Do [EC:3.4.21.107]
D SPH_0013 hflB; ATP-dependent metallopeptidase HflB K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D SPH_1624 atpB; ATP synthase F0, A subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D SPH_0164 beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_2334 N-acetyl-beta-D-glucosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
D SPH_0870 peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
D SPH_1652 Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D SPH_1082 foldase protein PrsA K07533 prsA; foldase protein PrsA [EC:5.2.1.8]
D SPH_1891 trx; thioredoxin K03671 TXN; thioredoxin
C 04131 Membrane trafficking [BR:spv04131]
D SPH_2100 nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D SPH_2336 sugar hydrolase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D SPH_2168 gap; glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D SPH_1765 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D SPH_1004 pyk; pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
C 04121 Ubiquitin system
C 03051 Proteasome
C 03032 DNA replication proteins [BR:spv03032]
D SPH_0083 hypothetical protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_1233 methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_1205 DNA-binding protein HU 1 (DNA-binding protein II) (HB) K03530 hupB; DNA-binding protein HU-beta
D SPH_0001 dnaA; chromosomal replication initiator protein DnaA K02313 dnaA; chromosomal replication initiator protein
D SPH_2401 dnaB; replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D SPH_0040 gp21 K02315 dnaC; DNA replication protein DnaC
D SPH_1160 dnaG; DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D SPH_1820 replication initiation and membrane attachment protein K03346 dnaB; replication initiation and membrane attachment protein
D SPH_1819 primosomal protein DnaI K11144 dnaI; primosomal protein DnaI
D SPH_0082 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_1654 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_2052 single-strand binding protein family K03111 ssb; single-strand DNA-binding protein
D SPH_1002 DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D SPH_0390 polC; DNA polymerase III, alpha subunit, Gram-positive type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D SPH_0002 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D SPH_0864 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D SPH_1044 DNA polymerase III subunit delta K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D SPH_1094 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D SPH_0968 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D SPH_1274 ribonuclease HII (RNase HII) K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D SPH_0512 rnhC; ribonuclease hiii K03471 rnhC; ribonuclease HIII [EC:3.1.26.4]
D SPH_0131 DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D SPH_1210 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D SPH_1966 modification methylase DpnIIA K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D SPH_1334 gyrA; DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
D SPH_0908 gyrB; DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
D SPH_0954 parC; DNA topoisomerase IV, A subunit K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D SPH_0952 parE; DNA topoisomerase IV, B subunit K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D SPH_1378 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
C 03036 Chromosome and associated proteins [BR:spv03036]
D SPH_0083 hypothetical protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_1233 methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_1363 rnc; ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3]
D SPH_1205 DNA-binding protein HU 1 (DNA-binding protein II) (HB) K03530 hupB; DNA-binding protein HU-beta
D SPH_0001 dnaA; chromosomal replication initiator protein DnaA K02313 dnaA; chromosomal replication initiator protein
D SPH_1686 DNA protection during starvation protein K04047 dps; starvation-inducible DNA-binding protein
D SPH_1362 smc; chromosome segregation protein SMC K03529 smc; chromosome segregation protein
D SPH_1992 ScpA/B protein K05896 scpA; segregation and condensation protein A
D SPH_1991 scpB; segregation and condensation protein B K06024 scpB; segregation and condensation protein B
D SPH_1775 ftsA; cell division protein FtsA K03590 ftsA; cell division protein FtsA
D SPH_0008 septum formation initiator K13052 divIC; cell division protein DivIC
D SPH_0857 ftsE; cell division ATP-binding protein FtsE K09812 ftsE; cell division transport system ATP-binding protein
D SPH_0983 DNA translocase FtsK K03466 ftsK; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family
D SPH_2228 putative otitis media-associated H10 K03466 ftsK; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family
D SPH_0445 ftsL; cell division protein FtsL K03586 ftsL; cell division protein FtsL
D SPH_0784 cell division protein DivIB K03589 ftsQ; cell division protein FtsQ
D SPH_1154 cell division protein FtsW K03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_0858 cell division ABC transporter, permease protein FtsX K09811 ftsX; cell division transport system permease protein
D SPH_1774 ftsZ; cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ
D SPH_0909 ezrA; septation ring formation regulator EzrA K06286 ezrA; septation ring formation regulator
D SPH_1769 cell-division initiation protein K04074 divIVA; cell division initiation protein
D SPH_1772 YlmF protein K09772 sepF; cell division inhibitor SepF
D SPH_2413 mreC; rod shape-determining protein MreC K03570 mreC; rod shape-determining protein MreC
D SPH_2412 mreD; rod shape-determining protein MreD K03571 mreD; rod shape-determining protein MreD
D SPH_0905 RodA K05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_2439 stage 0 sporulation protein J K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D SPH_0954 parC; DNA topoisomerase IV, A subunit K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D SPH_0952 parE; DNA topoisomerase IV, B subunit K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D SPH_0236 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D SPH_1401 gidB; methyltransferase GidB K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]
D SPH_1047 trmFO; tRNA:M(5)U-54 methyltransferase K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]
D SPH_0670 Fic protein family K04095 fic; cell filamentation protein, protein adenylyltransferase [EC:2.7.7.108]
D SPH_1682 GTP-binding protein K03978 engB; GTP-binding protein
D SPH_1678 conserved hypothetical protein K09762 whiA; cell division protein WhiA
C 03400 DNA repair and recombination proteins [BR:spv03400]
D SPH_1579 O6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SPH_1283 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
D SPH_1342 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D SPH_1395 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D SPH_0918 MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SPH_1282 mutator MutT protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SPH_1349 NTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SPH_1900 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SPH_0122 deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SPH_0283 DNA-3-methyladenine glycosylase 1 K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
D SPH_1071 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
D SPH_1959 xth; exodeoxyribonuclease III K01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]
D SPH_2227 endonuclease/exonuclease/phosphatase family K01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]
D SPH_0705 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D SPH_1210 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D SPH_0131 DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D SPH_0305 uvrA; excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
D SPH_1353 uvrB; excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
D SPH_0711 uvrC; excinuclease ABC, C subunit K03703 uvrC; excinuclease ABC subunit C
D SPH_1179 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D SPH_2102 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D SPH_2101 rpoC; DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D SPH_0349 rpoA; DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D SPH_0603 rpoE; DNA-directed RNA polymerase, delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta
D SPH_1846 rpoZ; DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D SPH_0006 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
D SPH_2264 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D SPH_0515 MutS2 family protein K07456 mutS2; DNA mismatch repair protein MutS2
D SPH_0277 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D SPH_1325 xseA; exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D SPH_1324 xseB; exodeoxyribonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D SPH_1002 DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D SPH_0390 polC; DNA polymerase III, alpha subunit, Gram-positive type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D SPH_0002 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D SPH_0864 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D SPH_1044 DNA polymerase III subunit delta K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D SPH_1094 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D SPH_0968 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D SPH_0082 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_1654 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_2052 single-strand binding protein family K03111 ssb; single-strand DNA-binding protein
D SPH_1966 modification methylase DpnIIA K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D SPH_0510 helicase, RecD/TraA family K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
D SPH_2089 recA; protein RecA K03553 recA; recombination protein RecA
D SPH_0282 ruvA; holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
D SPH_0376 ruvB; holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D SPH_1845 primosomal protein N' (ATP-dependent helicase PriA)(Replication factor Y) K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D SPH_0124 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
D SPH_2422 DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
D SPH_0290 divergent AAA domain family K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D SPH_1801 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D SPH_0136 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
D SPH_1780 recR; recombination protein RecR K06187 recR; recombination protein RecR
D SPH_1320 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D SPH_0477 recU; recombination protein U K03700 recU; recombination protein U
D SPH_1226 addA; recombination helicase AddA K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
D SPH_1225 rexB; ATP-dependent nuclease subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D SPH_1334 gyrA; DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
D SPH_0908 gyrB; DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
D SPH_1378 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
D SPH_1205 DNA-binding protein HU 1 (DNA-binding protein II) (HB) K03530 hupB; DNA-binding protein HU-beta
D SPH_0567 DNA polymerase IV (Pol IV) K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D SPH_2044 RecA regulator RecX K03565 recX; regulatory protein
D SPH_0904 DnaQ family exonuclease/DinG family helicase, putative K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D SPH_1300 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SPH_1301 ribonucleoside-diphosphate reductase, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D SPH_1440 DHH subfamily 1 protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
C 03029 Mitochondrial biogenesis [BR:spv03029]
D SPH_0653 translation initiation factor IF-2 K02519 infB; translation initiation factor IF-2
D SPH_1060 infC; translation initiation factor IF-3 K02520 infC; translation initiation factor IF-3
D SPH_2409 tsf; translation elongation factor Ts K02357 tsf; elongation factor Ts
D SPH_1601 tuf; translation elongation factor Tu K02358 tuf; elongation factor Tu
D SPH_0389 fusA; translation elongation factor G K02355 fusA; elongation factor G
D SPH_1070 era; GTP-binding protein Era K03595 era; GTPase
D SPH_2288 tyrS; tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D SPH_0372 leuS; leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D SPH_2303 aspS; aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D SPH_2266 argS; arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D SPH_0543 glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADTsubunit A) K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
D SPH_0542 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
D SPH_0544 gatC; glutamyl-tRNA(Gln) amidotransferase, C subunit K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]
D SPH_0082 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_1654 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) K03111 ssb; single-strand DNA-binding protein
D SPH_2052 single-strand binding protein family K03111 ssb; single-strand DNA-binding protein
D SPH_0624 dnaK; chaperone protein DnaK K04043 dnaK; molecular chaperone DnaK
D SPH_0623 grpE; co-chaperone GrpE K03687 GRPE; molecular chaperone GrpE
D SPH_2050 groL; chaperonin GroL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D SPH_2051 groS; chaperonin GroS K04078 groES; chaperonin GroES
D SPH_0625 dnaJ; chaperone protein DnaJ K03686 dnaJ; molecular chaperone DnaJ
D SPH_0985 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_1185 putative Probable cysteine desulfurase (NifS protein homolog) K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_2117 membrane protein OxaA 2 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_2194 membrane protein OxaA 1 K03217 yidC; YidC/Oxa1 family membrane protein insertase
B
B 09183 Protein families: signaling and cellular processes
C 02000 Transporters [BR:spv02000]
D SPH_1955 ABC transporter, ATP-binding protein K18889 mdlA; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_1954 ABC transporter, ATP-binding protein K18890 mdlB; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_2263 ABC transporter, ATP-binding/permease protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_2260 ABC transporter, ATP-binding/permease protein K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_1489 ABC transporter, ATP-binding/permease protein K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_1488 ABC transporter, ATP-binding/permease protein K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump
D SPH_0148 transport/processing ATP-binding protein ComA K12292 comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
D SPH_0636 transport/processing ATP-binding protein ComA K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D SPH_1669 ABC transporter, ATP-binding protein K15738 uup; ABC transport system ATP-binding/permease protein
D SPH_1946 ABC transporter, substrate-binding protein K02012 afuA; iron(III) transport system substrate-binding protein
D SPH_2072 ABC transporter, substrate-binding protein K02012 afuA; iron(III) transport system substrate-binding protein
D SPH_1944 binding-protein-dependent transport systems inner membrane component K02011 afuB; iron(III) transport system permease protein
D SPH_2074 binding-protein-dependent transport systems inner membrane component K02011 afuB; iron(III) transport system permease protein
D SPH_0356 lactose transport ATP-binding protein LacK K02010 afuC; iron(III) transport system ATP-binding protein [EC:7.2.2.7]
D SPH_1945 spermidine/putrescine import ATP-binding protein PotA K02010 afuC; iron(III) transport system ATP-binding protein [EC:7.2.2.7]
D SPH_2073 spermidine/putrescine ABC transporter ATP-binding subunit K02010 afuC; iron(III) transport system ATP-binding protein [EC:7.2.2.7]
D SPH_1516 ABC transporter substrate-binding protein - spermidine/putrescine transport K11069 potD; spermidine/putrescine transport system substrate-binding protein
D SPH_1517 spermidine/putrescine ABC transporter, permease protein K11070 potC; spermidine/putrescine transport system permease protein
D SPH_1518 ABC transporter membrane-spanning permease - spermidine/putrescine transport K11071 potB; spermidine/putrescine transport system permease protein
D SPH_1519 spermidine/putrescine import ATP-binding protein PotA K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11]
D SPH_1977 choline transporter K05845 opuC; osmoprotectant transport system substrate-binding protein
D SPH_1978 choline transport ATP-binding protein opuBA K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9]
D SPH_1694 multiple sugar-binding transport ATP-binding protein MsmK K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-]
D SPH_2297 maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein
D SPH_2298 maltodextrin transport system permease protein MalC K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D SPH_2299 ABC transporter membrane-spanning permease - maltose/maltodextrin K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D SPH_2014 sugar ABC transporter, sugar-binding protein K10117 msmE; raffinose/stachyose/melibiose transport system substrate-binding protein
D SPH_2013 sugar ABC transporter, permease protein K10118 msmF; raffinose/stachyose/melibiose transport system permease protein
D SPH_2012 sugar ABC transporter, permease protein K10119 msmG; raffinose/stachyose/melibiose transport system permease protein
D SPH_0193 ABC transporter, substrate-binding protein K17318 lplA; putative aldouronate transport system substrate-binding protein
D SPH_0828 bacterial extracellular solute-binding protein K17318 lplA; putative aldouronate transport system substrate-binding protein
D SPH_0191 ABC transporter membrane-spanning permease - sugar transport K17319 lplB; putative aldouronate transport system permease protein
D SPH_0825 protein LplB K17319 lplB; putative aldouronate transport system permease protein
D SPH_0192 protein LplC K17320 lplC; putative aldouronate transport system permease protein
D SPH_0826 protein LplC K17320 lplC; putative aldouronate transport system permease protein
D SPH_1912 ABC transporter substrate-binding protein - sugar transport K10120 msmE; fructooligosaccharide transport system substrate-binding protein
D SPH_1911 ABC transporter, permease protein K10121 msmF; fructooligosaccharide transport system permease protein
D SPH_1910 ABC transporter membrane-spanning permease - sugar transport K10122 msmG; fructooligosaccharide transport system permease protein
D SPH_0944 lipoprotein K07335 bmpA; basic membrane protein A and related proteins
D SPH_0946 ABC transporter membrane-spanning permease - ribose/galactose transport K23535 nupB; general nucleoside transport system permease protein
D SPH_0947 ABC transporter membrane-spanning permease - ribose/galactose transport K23536 nupC; general nucleoside transport system permease protein
D SPH_0945 ribose import ATP-binding protein RbsA K23537 nupA; general nucleoside transport system ATP-binding protein
D SPH_1790 ABC transporter substrate-binding protein - sugar transport K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein
D SPH_1795 ABC transporter substrate-binding protein - sugar transport K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein
D SPH_1789 sugar ABC transporter, permease protein K02025 ABC.MS.P; multiple sugar transport system permease protein
D SPH_1794 ABC transporter, permease protein K02025 ABC.MS.P; multiple sugar transport system permease protein
D SPH_1788 ABC transporter membrane-spanning permease - sugar transport K02026 ABC.MS.P1; multiple sugar transport system permease protein
D SPH_1793 ABC transporter membrane-spanning permease - sugar transport K02026 ABC.MS.P1; multiple sugar transport system permease protein
D SPH_1531 phosphate-binding protein PstS 1 (PBP 1) K02040 pstS; phosphate transport system substrate-binding protein
D SPH_2271 ABC transporter substrate-binding protein - phosphate transport K02040 pstS; phosphate transport system substrate-binding protein
D SPH_1530 pstC1; phosphate ABC transporter, permease protein PstC K02037 pstC; phosphate transport system permease protein
D SPH_2272 pstC2; phosphate ABC transporter, permease protein PstC K02037 pstC; phosphate transport system permease protein
D SPH_1529 pstA1; phosphate ABC transporter, permease protein PstA K02038 pstA; phosphate transport system permease protein
D SPH_2273 pstA2; phosphate ABC transporter, permease protein PstA K02038 pstA; phosphate transport system permease protein
D SPH_1527 pstB1; phosphate ABC transporter, ATP-binding protein K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D SPH_1528 pstB2; phosphate ABC transporter, ATP-binding protein K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D SPH_2274 pstB3; phosphate ABC transporter, ATP-binding protein K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D SPH_1356 amino acid ABC transporter, amino acid-binding protein/permease protein K10036 glnH; glutamine transport system substrate-binding protein
D SPH_1357 glutamine transport ATP-binding protein GlnQ K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1]
D SPH_0703 ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor K10039 peb1A; aspartate/glutamate/glutamine transport system substrate-binding protein
D SPH_0701 ABC transporter membrane-spanning permease - glutamine transport K10040 peb1B; aspartate/glutamate/glutamine transport system permease protein
D SPH_0702 ABC transporter membrane-spanning permease - glutamine transport K10040 peb1B; aspartate/glutamate/glutamine transport system permease protein
D SPH_0704 glutamine transport ATP-binding protein GlnQ K10041 peb1C; aspartate/glutamate/glutamine transport system ATP-binding protein [EC:7.4.2.1]
D SPH_0260 ABC transporter substrate-binding protein - amino acid transport K02424 tcyA; L-cystine transport system substrate-binding protein
D SPH_1577 ABC transporter membrane-spanning permease - aspartate/glutamate transport K10009 tcyB; L-cystine transport system permease protein
D SPH_1576 L-cystine import ATP-binding protein TcyN K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1]
D SPH_1525 amino acid ABC transporter, amino acid-binding protein K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein
D SPH_0922 amino acid ABC transporter, permease protein K17077 artQ; arginine/lysine/histidine transport system permease protein
D SPH_0923 glutamine transport ATP-binding protein GlnQ K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1]
D SPH_0850 ABC transporter substrate-binding protein - branched chain amino acid transport K01999 livK; branched-chain amino acid transport system substrate-binding protein
D SPH_0851 high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) K01997 livH; branched-chain amino acid transport system permease protein
D SPH_0852 ABC transporter membrane-spanning permease - branched chain amino acid transport K01998 livM; branched-chain amino acid transport system permease protein
D SPH_0853 high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) K01995 livG; branched-chain amino acid transport system ATP-binding protein
D SPH_0854 high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) K01996 livF; branched-chain amino acid transport system ATP-binding protein
D SPH_0261 lipoprotein K02073 metQ; D-methionine transport system substrate-binding protein
D SPH_0264 ABC transporter permease protein K02072 metI; D-methionine transport system permease protein
D SPH_0263 methionine import ATP-binding protein MetN K02071 metN; D-methionine transport system ATP-binding protein
D SPH_1157 ABC transporter substrate binding protein K01989 K01989; putative tryptophan/tyrosine transport system substrate-binding protein
D SPH_1159 ABC transporter, ATP-binding protein K05832 K05832; putative tryptophan/tyrosine transport system permease protein
D SPH_0560 amino acid ABC transporter, amino acid-binding protein/permease protein K17073 lysX1; putative lysine transport system substrate-binding protein
D SPH_0559 L-cystine import ATP-binding protein TcyN K17076 lysY; putative lysine transport system ATP-binding protein
D SPH_0214 ABC transporter solute-binding protein - amino acid transport K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein
D SPH_0713 ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein
D SPH_0792 ABC-type amino acid transport/signal transduction system, periplasmic component/domain K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein
D SPH_1612 ABC transporter substrate-binding protein - glutamine transport K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein
D SPH_0797 ABC transporter membrane-spanning permease - glutamine transport K02029 ABC.PA.P; polar amino acid transport system permease protein
D SPH_1614 amino acid ABC transporter, permease protein K02029 ABC.PA.P; polar amino acid transport system permease protein
D SPH_1613 glutamine transport ATP-binding protein GlnQ K02028 ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:7.4.2.1]
D SPH_0474 oligopeptide binding protein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_1641 oligopeptide binding lipoprotein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_2009 AmiA protein K15580 oppA; oligopeptide transport system substrate-binding protein
D SPH_2008 oligopeptide transport system permease protein AmiC K15581 oppB; oligopeptide transport system permease protein
D SPH_2007 oligopeptide transport system permease protein AmiD K15582 oppC; oligopeptide transport system permease protein
D SPH_2006 oligopeptide transport ATP-binding protein OppD K15583 oppD; oligopeptide transport system ATP-binding protein
D SPH_2005 oligopeptide transport ATP-binding protein AmiF K10823 oppF; oligopeptide transport system ATP-binding protein
D SPH_1134 ABC transporter substrate-binding protein - iron transport K25286 fagD; iron-siderophore transport system substrate-binding protein
D SPH_1135 iron-compound ABC transporter, permease protein K23186 fepD; iron-siderophore transport system permease protein
D SPH_1136 ABC transporter membrane-spanning permease - iron transport K23187 fepG; iron-siderophore transport system permease protein
D SPH_1137 ferric enterobactin transport ATP-binding protein FepC K23188 fepC; iron-siderophore transport system ATP-binding protein [EC:7.2.2.17 7.2.2.-]
D SPH_1988 iron-compound ABC transporter, iron-compound-binding protein K25282 yclQ; iron-siderophore transport system substrate-binding protein
D SPH_1986 ABC transporter membrane-spanning permease - ferric iron transport K25283 yclO; iron-siderophore transport system permease protein
D SPH_1985 ABC transporter membrane-spanning permease - ferric iron transport K25284 yclN; iron-siderophore transport system permease protein
D SPH_1987 ferrichrome transport ATP-binding protein FhuC K25285 yclP; iron-siderophore transport system ATP-binding protein [EC:7.2.2.-]
D SPH_1103 zinc-binding lipoprotein AdcA K09815 znuA; zinc transport system substrate-binding protein
D SPH_2364 zinc-binding lipoprotein AdcA K09815 znuA; zinc transport system substrate-binding protein
D SPH_2365 ABC transporter membrane-spanning permease - Zinc K09816 znuB; zinc transport system permease protein
D SPH_2366 zinc transport system ATP-binding protein AdcC K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20]
D SPH_1759 manganese ABC transporter substrate-binding lipoprotein (Adhesin B) (Saliva-binding protein) K19971 psaA; manganese/zinc transport system substrate-binding protein
D SPH_1758 manganese transport system membrane protein MntB K19972 psaC; manganese/zinc transport system permease protein
D SPH_1757 manganese transport system ATP-binding protein MntA K10830 psaB; manganese/zinc transport system ATP-binding protein [EC:7.2.2.5]
D SPH_0882 biotin synthase K03523 bioY; biotin transport system substrate-specific component
D SPH_0594 protein YdcD K16924 mtsT; energy-coupling factor transport system substrate-specific component
D SPH_0265 membrane-bound protein K16926 htsT; energy-coupling factor transport system substrate-specific component
D SPH_0597 cobalt transport family protein K16785 ecfT; energy-coupling factor transport system permease protein
D SPH_0808 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein
D SPH_2414 ABC transporter permease protein K16785 ecfT; energy-coupling factor transport system permease protein
D SPH_2416 cobalt import ATP-binding protein CbiO 2 K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D SPH_0596 putative ABC transporter ATP-binding protein// K01552 ecfA; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D SPH_0807 ABC transporter ATP-binding protein - cobalt or other cation transport K01552 ecfA; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D SPH_0806 ABC-type cobalt transport system, permease component K16925 ykoE; energy-coupling factor transport system permease protein
D SPH_1020 ABC-type antimicrobial peptide transport system, permease component K19084 braE; bacitracin transport system permease protein
D SPH_1019 bacitracin export ATP-binding protein BceA K19083 braD; bacitracin transport system ATP-binding protein
D SPH_0886 ABC-type antimicrobial peptide transport system, permease component K24948 yknZ; antimicrobial peptide resistance transport system permease protein
D SPH_0885 macrolide export ATP-binding/permease protein MacB K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-]
D SPH_0858 cell division ABC transporter, permease protein FtsX K09811 ftsX; cell division transport system permease protein
D SPH_0857 ftsE; cell division ATP-binding protein FtsE K09812 ftsE; cell division transport system ATP-binding protein
D SPH_0729 ABC transporter permease protein K25154 evrC; viologen exporter family transport system permease protein
D SPH_0728 membrane protein K25155 evrB; viologen exporter family transport system permease protein
D SPH_0727 ABC transporter ATP-binding protein - role in polysaccharide efflux K25156 evrA; viologen exporter family transport system ATP-binding protein
D SPH_0629 ABC transporter, permease protein K25157 ecsB; ABC-2 type transport system permease protein
D SPH_0628 ABC-type transporter ATP-binding protein EcsA K25158 ecsA; ABC-2 type transport system ATP-binding protein
D SPH_1058 membrane protein, putative K01992 ABC-2.P; ABC-2 type transport system permease protein
D SPH_1511 membrane protein, putative K01992 ABC-2.P; ABC-2 type transport system permease protein
D SPH_1554 membrane protein, putative K01992 ABC-2.P; ABC-2 type transport system permease protein
D SPH_1825 ABC transporter membrane-spanning permease - Na+ export K01992 ABC-2.P; ABC-2 type transport system permease protein
D SPH_2145 ABC-type multidrug transport system, permease component K01992 ABC-2.P; ABC-2 type transport system permease protein
D SPH_0146 hypothetical protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_0791 ABC transporter, ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_1057 ABC transporter, ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_1287 bacitracin transport ATP-binding protein BcrA K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_1512 ABC transporter, ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_1555 ABC transporter ATP-binding protein - multidrug efflux K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_1808 ABC transporter, ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_1823 ABC transporter, ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_1824 ABC transporter, ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_1826 ABC transporter ATP-binding protein - Na+ export K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_2146 ABC transporter, ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D SPH_0694 ABC transporter membrane-spanning permease - Pep export K02004 ABC.CD.P; putative ABC transport system permease protein
D SPH_0696 ABC transporter membrane-spanning permease - Pep export K02004 ABC.CD.P; putative ABC transport system permease protein
D SPH_1761 efflux ABC transporter, permease protein K02004 ABC.CD.P; putative ABC transport system permease protein
D SPH_2097 bacteriocin-associated integral membrane protein K02004 ABC.CD.P; putative ABC transport system permease protein
D SPH_2129 immunity protein, putative K02004 ABC.CD.P; putative ABC transport system permease protein
D SPH_2169 efflux ABC transporter, permease protein K02004 ABC.CD.P; putative ABC transport system permease protein
D SPH_0213 macrolide export ATP-binding/permease protein MacB K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D SPH_0695 ABC transporter ATP-binding protein - Pep export K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D SPH_0781 ABC transporter, ATP-binding protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D SPH_1478 ABC transporter, ATP-binding protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D SPH_1762 macrolide export ATP-binding/permease protein MacB K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D SPH_2098 ABC-type antimicrobial peptide transport system, ATPase component K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D SPH_2128 ABC-type antimicrobial peptide transport system, ATPase component K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D SPH_0970 sufC; FeS assembly ATPase SufC K09013 sufC; Fe-S cluster assembly ATP-binding protein
D SPH_1280 mate efflux family protein K26939 norM; MATE family, multidrug efflux pump
D SPH_2088 DNA-damage-inducible protein K26937 dinF; MATE family, multidrug efflux pump
D SPH_2221 multi antimicrobial extrusion K26937 dinF; MATE family, multidrug efflux pump
D SPH_1699 major facilitator:Oxalate:Formate Antiporter K08177 oxlT; MFS transporter, OFA family, oxalate/formate antiporter
D SPH_0200 cyanate permease K03449 MFS.CP; MFS transporter, CP family, cyanate transporter
D SPH_1073 multidrug resistance protein MdtG K08161 mdtG; MFS transporter, DHA1 family, multidrug resistance protein
D SPH_1297 ptsP; phosphoenolpyruvate-protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9]
D SPH_1298 phosphocarrier protein HPr (Histidine-containing protein) K02784 ptsH; phosphocarrier protein HPr
D SPH_0859 pts system, iibc component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208]
D SPH_1830 pts system, sucrose-specific iibc component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211]
D SPH_0675 phosphotransferase system sugar-specific EII component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-]
D SPH_2000 treP; pts system, trehalose-specific iibc component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201]
D SPH_1733 PTS system, IIA component K02768 fruB; fructose PTS system EIIA component [EC:2.7.1.202]
D SPH_0981 PTS system, Fru family, IIC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D SPH_1731 PTS system, IIC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D SPH_0506 mannitol-specific phosphotransferase enzyme iia component K02798 cmtB; mannitol PTS system EIIA component [EC:2.7.1.197]
D SPH_0504 pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) K02800 mtlA; mannitol PTS system EIICBA or EIICB component [EC:2.7.1.197]
D SPH_0588 lactose-specific phosphotransferase enzyme iia component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D SPH_1306 lactose-specific phosphotransferase enzyme iia component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D SPH_0590 pts system lactose-specific eiicb component (eiicb-lac) (eii-lac) K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D SPH_1305 PTS system, lactose-specific IIC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D SPH_0366 phosphotransferase system sugar-specific eiia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_1926 lichenan-specific phosphotransferase enzyme iia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_2178 lichenan-specific phosphotransferase enzyme iia component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D SPH_0367 phosphotransferase system sugar-specific eiib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_1927 lichenan-specific phosphotransferase enzyme iib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_2177 lichenan-specific phosphotransferase enzyme iib component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D SPH_0368 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_0586 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_1925 phosphotransferase system K02761 celB; cellobiose PTS system EIIC component
D SPH_1929 lichenan permease iic component K02761 celB; cellobiose PTS system EIIC component
D SPH_2176 phosphotransferase system system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D SPH_0738 phosphotransferase system sugar-specific EII component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204]
D SPH_0739 PTS system, galactose-specific IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204]
D SPH_1315 PTS system, galactose-specific IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204]
D SPH_0740 phosphotransferase system sugar-specific EII component K20114 gatC; galactose PTS system EIIC component
D SPH_0400 mannose-specific phosphotransferase system component iiab K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D SPH_0170 phosphotransferase system sugar-specific EII component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D SPH_2358 PTS system, IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D SPH_0168 phosphotransferase system sugar-specific eiic component K02795 manY; mannose PTS system EIIC component
D SPH_0399 PTS system sorbose-specific EIIC component K02795 manY; mannose PTS system EIIC component
D SPH_2356 phosphotransferase system sugar-specific EII component K02795 manY; mannose PTS system EIIC component
D SPH_0169 PTS system, IID component K02796 manZ; mannose PTS system EIID component
D SPH_0398 PTS system, mannose/fructose/sorbose family, EIID component K02796 manZ; mannose PTS system EIID component
D SPH_2355 mannose permease iid component K02796 manZ; mannose PTS system EIID component
D SPH_0432 phosphotransferase system sugar-specific EII component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-]
D SPH_0434 N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
D SPH_0435 phosphotransferase system sugar-specific EII component K02746 agaW; N-acetylgalactosamine PTS system EIIC component
D SPH_0436 phosphotransferase system sugar-specific EII component K02747 agaE; N-acetylgalactosamine PTS system EIID component
D SPH_2189 ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D SPH_2190 ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D SPH_2322 phosphotransferase system, galactitol-specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D SPH_2191 ascorbate-specific PTS system enzyme IIC K03475 ulaA; ascorbate PTS system EIIC component
D SPH_2321 ascorbate-specific PTS system enzyme IIC K03475 ulaA; ascorbate PTS system EIIC component
D SPH_1290 dihydroxyacetone kinase, phosphotransfer subunit K05881 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121]
D SPH_1894 aquaporin Z - water channel protein K06188 aqpZ; aquaporin Z
D SPH_1603 glycerol facilitator-aquaporin gla (Aquaglyceroporin)(Glyceroaquaporin) K02440 glpF; glycerol uptake facilitator
D SPH_2379 glycerol uptake facilitator protein K02440 glpF; glycerol uptake facilitator
D SPH_1336 potassium/ion channel protein K10716 kch; voltage-gated potassium channel
D SPH_1112 mscL; large conductance mechanosensitive channel protein K03282 mscL; large conductance mechanosensitive channel
D SPH_1861 small conductance mechanosensitive ion channel K22044 ybiO; moderate conductance mechanosensitive channel
D SPH_0288 magnesium and cobalt transporter K03284 corA; magnesium transporter
D SPH_1436 putative Protein CrcB homolog 1 K06199 crcB; fluoride exporter
D SPH_1437 putative Protein CrcB homolog 2 K06199 crcB; fluoride exporter
D SPH_2105 CBS domain protein K03699 tlyC; magnesium and cobalt exporter, CNNM family
D SPH_1973 cation diffusion facilitator transporter - heavy metal transport K16264 czcD; cobalt-zinc-cadmium efflux system protein
D SPH_0179 Trk transporter membrane-spanning protein - K+ transport K03498 trkH; trk/ktr system potassium uptake protein
D SPH_0591 Trk transporter membrane-spanning protein - K+ transport K03498 trkH; trk/ktr system potassium uptake protein
D SPH_0180 potassium uptake protein, Trk family K03499 trkA; trk/ktr system potassium uptake protein
D SPH_0592 potassium uptake protein, Trk family K03499 trkA; trk/ktr system potassium uptake protein
D SPH_1427 uraA; uracil permease K02824 uraA; uracil permease
D SPH_1963 xanthine permease K16169 pbuX; xanthine permease
D SPH_0403 xanthine/uracil permease family protein K06901 pbuG; adenine/guanine/hypoxanthine permease
D SPH_1275 voltage-gated chloride channel family protein K03281 clcA; chloride channel protein, CIC family
D SPH_0606 sodium-dependent phosphate transporter K03324 yjbB; phosphate:Na+ symporter
D SPH_0258 branched-chain amino acid permease K26605 azlC; branched chain amino acid efflux pump
D SPH_0259 branched-chain amino acid transport protein AzlD K26606 azlD; branched chain amino acid efflux pump
D SPH_0599 conserved hypothetical protein K23675 fmnP; riboflavin transporter
D SPH_1348 conserved hypothetical protein K16788 niaX; niacin transporter
D SPH_1021 integral membrane protein K22736 VIT; vacuolar iron transporter family protein
D SPH_1154 cell division protein FtsW K03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]
D SPH_1442 hypothetical protein K07243 FTR; high-affinity iron transporter
D SPH_1443 hypothetical protein K16301 efeB; deferrochelatase/peroxidase EfeB [EC:1.11.1.-]
D SPH_0753 cytoChrome c-type biogenesis protein K06196 ccdA; cytochrome c-type biogenesis protein
D SPH_1100 cytoChrome c-type biogenesis protein K06196 ccdA; cytochrome c-type biogenesis protein
D SPH_0635 BlpC ABC transporter K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter
D SPH_0884 membrane-fusion protein K24950 yknX; membrane fusion protein, antimicrobial resistance system
D SPH_0458 tyrosine-protein kinase CpsD K00903 epsB; protein-tyrosine kinase [EC:2.7.10.3]
D SPH_0457 Cps19aC K19420 epsA; protein tyrosine kinase modulator
D SPH_1975 nicotinamide mononucleotide transporter K03811 pnuC; nicotinamide mononucleotide transporter
D SPH_1943 putative Mg2+ transporter-C (MgtC) family protein K07507 mgtC; putative Mg2+ transporter-C (MgtC) family protein
D SPH_2075 MgtC/SapB transporter K07507 mgtC; putative Mg2+ transporter-C (MgtC) family protein
C 02044 Secretion system [BR:spv02044]
D SPH_1771 yggt family, putative K02221 yggT; YggT family protein
D SPH_1054 competence protein K02237 comEA; competence protein ComEA
D SPH_0846 ComE operon protein 2 K01493 comEB; dCMP deaminase [EC:3.5.4.12]
D SPH_1055 DNA internalization-related competence protein ComEC/Rec2 K02238 comEC; competence protein ComEC
D SPH_2406 superfamily II ATP-dependent DNA/RNA helicase required for DNA uptake K02240 comFA; competence protein ComFA
D SPH_2405 involved in transformation K02242 comFC; competence protein ComFC
D SPH_2207 putative ABC transporter subunit ComYA K02243 comGA; competence protein ComGA
D SPH_2206 competence protein CglB K02244 comGB; competence protein ComGB
D SPH_2205 competence protein K02245 comGC; competence protein ComGC
D SPH_2204 competence protein CglD K02246 comGD; competence protein ComGD
D SPH_2202 competence protein ComGF K02248 comGF; competence protein ComGF
D SPH_1933 type 4 prepilin peptidase K02236 comC; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
D SPH_1806 secA; preprotein translocase, SecA subunit K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D SPH_1870 preprotein translocase subunit SecA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D SPH_2165 secE; preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE
D SPH_1075 secG; preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG
D SPH_0343 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY
D SPH_1874 translocase, putative K03076 secY; preprotein translocase subunit SecY
D SPH_1428 ffh; signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D SPH_1359 cell division protein FtsY K03110 ftsY; fused signal recognition particle receptor
D SPH_0437 yajC1; preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D SPH_2182 yajC2; preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D SPH_2117 membrane protein OxaA 2 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_2194 membrane protein OxaA 1 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D SPH_1873 accessory secretory protein Asp1 K12268 asp1; accessory secretory protein Asp1
D SPH_1872 accessory secretory protein Asp2 K12269 asp2; accessory secretory protein Asp2
D SPH_1871 accessory secretory protein Asp3 K12270 asp3; accessory secretory protein Asp3
C 02042 Bacterial toxins [BR:spv02042]
D SPH_0518 exfoliative toxin A K11041 eta; exfoliative toxin A/B
D SPH_2065 pneumolysin (Thiol-activated cytolysin) K11031 slo; thiol-activated cytolysin
D SPH_2105 CBS domain protein K03699 tlyC; magnesium and cobalt exporter, CNNM family
D SPH_1582 hemolysin-3 (Hemolysin III) (Hly-III) K11068 hlyIII; hemolysin III
C 02022 Two-component system [BR:spv02022]
D SPH_2270 histidine kinase PnpS K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
D SPH_2269 alkaline phosphatase synthesis transcriptional regulatory proteinphoP K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
D SPH_1340 sensor protein YycG K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
D SPH_1341 alkaline phosphatase synthesis transcriptional regulatory proteinphoP K07668 vicR; two-component system, OmpR family, response regulator VicR
D SPH_0186 histidine kinase K10681 saeS; two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3]
D SPH_0185 response regulator SaeR K10682 saeR; two-component system, OmpR family, response regulator SaeR
D SPH_1743 histidine kinase K19081 braS; two-component system, OmpR family, sensor histidine kinase BraS/BceS [EC:2.7.13.3]
D SPH_1744 response regulator K19082 braR; two-component system, OmpR family, response regulator protein BraR/BceR
D SPH_0901 sensor protein CiaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
D SPH_0900 transcriptional regulatory protein CiaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR
D SPH_2144 histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
D SPH_2143 response regulator K07693 desR; two-component system, NarL family, response regulator DesR
D SPH_0493 histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
D SPH_0494 response regulator K11618 liaR; two-component system, NarL family, response regulator LiaR
D SPH_0633 histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D SPH_0632 response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA
D SPH_2433 ComD K12294 comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3]
D SPH_2432 response regulator K12295 comE; two-component system, LytTR family, response regulator ComE
D SPH_0267 sensor histidine kinase, putative K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D SPH_0757 histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D SPH_0268 response regulator K07720 yesN; two-component system, response regulator YesN
C 02035 Bacterial motility proteins [BR:spv02035]
D SPH_0260 ABC transporter substrate-binding protein - amino acid transport K02424 tcyA; L-cystine transport system substrate-binding protein
C 03037 Cilium and associated proteins
C 04812 Cytoskeleton proteins [BR:spv04812]
D SPH_1774 ftsZ; cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ
D SPH_1775 ftsA; cell division protein FtsA K03590 ftsA; cell division protein FtsA
D SPH_2439 stage 0 sporulation protein J K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
C 04147 Exosome [BR:spv04147]
D SPH_1222 eno; phosphopyruvate hydratase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D SPH_2168 gap; glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D SPH_0608 pgk; phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D SPH_1004 pyk; pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D SPH_0870 peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
D SPH_2050 groL; chaperonin GroL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D SPH_0624 dnaK; chaperone protein DnaK K04043 dnaK; molecular chaperone DnaK
D SPH_2257 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D SPH_2423 guaB; inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
D SPH_1601 tuf; translation elongation factor Tu K02358 tuf; elongation factor Tu
D SPH_0627 histidine triad domain protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D SPH_1335 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D SPH_0344 adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D SPH_1691 apt; adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]
D SPH_0216 argH; argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1]
D SPH_0215 argG; argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5]
D SPH_2339 FucA K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51]
D SPH_1969 galK; galactokinase K00849 galK; galactokinase [EC:2.7.1.6]
D SPH_1214 glgB; 1,4-alpha-glucan branching enzyme K00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]
D SPH_2381 glpK; glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30]
D SPH_0611 glnA; glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D SPH_0157 purH; bifunctional purine biosynthesis protein PurH K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D SPH_1358 zwf; glucose-6-phosphate dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
D SPH_1688 tpiA; triose-phosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D SPH_1765 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
C 02048 Prokaryotic defense system [BR:spv02048]
D SPH_0619 type I restriction-modification system, R subunit K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
D SPH_0998 type I restriction-modification system R subunit K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
D SPH_0614 type I site-specific deoxyribonuclease chain S K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
D SPH_0616 type I restriction-modification system, S subunit K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
D SPH_0617 Type I restriction modification DNA specificity domain protein K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
D SPH_0993 type I restriction enzyme EcoBI specificity protein (S protein)(S.EcoBI) K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
D SPH_0997 restriction modification system DNA specificity domain K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
D SPH_0618 type I restriction enzyme EcoEI M protein (M.EcoEI) K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
D SPH_0992 type I restriction modification enzyme methylase subunit K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
D SPH_1964 type II restriction enzyme DpnII K01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]
D SPH_1966 modification methylase DpnIIA K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D SPH_1561 DNA modification methyltransferase M.XbaI K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]
D SPH_1965 DNA methylase K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]
D SPH_2198 adenine-specific DNA methylase K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]
D SPH_0083 hypothetical protein K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_1233 methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D SPH_0047 HNH endonuclease domain protein K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D SPH_1337 cytotoxic translational repressor of toxin-antitoxin stability system K06218 relE; mRNA interferase RelE/StbE
D SPH_0392 DNA damage inducible protein K19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]
D SPH_0391 addiction module antitoxin, RelB/DinJ family K07473 dinJ; DNA-damage-inducible protein J
D SPH_1849 addiction module toxin, Txe/YoeB family K19158 yoeB; toxin YoeB [EC:3.1.-.-]
D SPH_1850 prevent-host-death family protein K19159 yefM; antitoxin YefM
D SPH_0995 prophage maintenance system killer protein K07341 doc; death on curing protein
D SPH_1263 signal recognition particle GTPase K16214 pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]
D SPH_1262 conserved hypothetical protein K18830 pezA; HTH-type transcriptional regulator / antitoxin PezA
D SPH_1774 ftsZ; cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ
D SPH_0954 parC; DNA topoisomerase IV, A subunit K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D SPH_0952 parE; DNA topoisomerase IV, B subunit K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D SPH_0985 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D SPH_1185 putative Probable cysteine desulfurase (NifS protein homolog) K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C 04030 G protein-coupled receptors
C 04050 Cytokine receptors
C 04054 Pattern recognition receptors
C 03310 Nuclear receptors
C 04040 Ion channels [BR:spv04040]
C 04031 GTP-binding proteins
C 04052 Cytokines and neuropeptides
C 04515 Cell adhesion molecules
C 04090 CD molecules [BR:spv04090]
C 01504 Antimicrobial resistance genes [BR:spv01504]
D SPH_1149 aminoglycoside 6'-N-acetyltransferase K18816 aac6-I; aminoglycoside 6'-N-acetyltransferase I [EC:2.3.1.82]
D SPH_1409 tetracycline resistance protein K18220 tetM; ribosomal protection tetracycline resistance protein
D SPH_1420 rRNA adenine N-6-methyltransferase (Macrolide-lincosamide-streptogramin B resistance protein) K00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]
D SPH_1266 chloramphenicol O-acetyltransferase K19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]
D SPH_0722 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D SPH_2372 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D SPH_2371 protein DltB K03739 dltB; membrane protein involved in D-alanine export
D SPH_2370 dltC; D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D SPH_2369 D-alanine transfer from undecaprenol-phosphate to the poly K03740 dltD; D-alanine transfer protein
C 00535 Proteoglycans
C 00536 Glycosaminoglycan binding proteins
C 00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
C 04091 Lectins
C 04990 Domain-containing proteins not elsewhere classified
B
B 09185 Viral protein families
C 03200 Viral proteins
C 03210 Viral fusion proteins
B
B 09184 RNA family
C 03100 Non-coding RNAs [BR:spv03100]
D SPH_0017 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D SPH_2039 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D SPH_2160 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D SPH_2252 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D SPH_1364 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_1434 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_2029 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_2150 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_2435 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D SPH_0021 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D SPH_2430 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D SPH_2103 tRNA-Cys K14222 tRNA-Cys; tRNA Cys
D SPH_0962 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D SPH_2240 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D SPH_0015 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2041 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2162 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2254 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2431 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D SPH_2022 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D SPH_2031 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D SPH_2152 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D SPH_2247 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D SPH_2241 tRNA-His K14226 tRNA-His; tRNA His
D SPH_2021 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D SPH_2246 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D SPH_1695 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2030 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2033 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2151 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2154 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_2239 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D SPH_1908 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D SPH_2034 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D SPH_2155 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D SPH_2024 tRNA-Met K14230 tRNA-Met; tRNA Met
D SPH_2026 tRNA-Met K14230 tRNA-Met; tRNA Met
D SPH_2027 tRNA-Met K14230 tRNA-Met; tRNA Met
D SPH_2244 tRNA-Met K14230 tRNA-Met; tRNA Met
D SPH_2023 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D SPH_2243 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D SPH_2028 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D SPH_2149 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D SPH_0978 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D SPH_2020 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D SPH_2025 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D SPH_2245 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D SPH_1115 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D SPH_2032 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D SPH_2153 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D SPH_0961 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D SPH_2242 tRNA-Trp K14236 tRNA-Tyr; tRNA Tyr
D SPH_2035 tRNA-Asp K14237 tRNA-Val; tRNA Val
D SPH_2156 tRNA-Asp K14237 tRNA-Val; tRNA Val
D SPH_2248 tRNA-Val K14237 tRNA-Val; tRNA Val
D SPH_0016 rrs1; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2040 rrs2; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2161 rrs3; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_2253 rrs4; 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D SPH_0019 rrl1; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2037 rrl2; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2158 rrl3; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_2250 rrl4; 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D SPH_0020 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2036 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2157 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2249 rrf; 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D SPH_2441 putative tmRNA K15035 ssrA; transfer-messenger RNA
D SPH_2442 bacterial RNase P, class B K01978 rnpB; M1 RNA
D SPH_2440 srpB; bacterial signal recognition particle RNA K01983 ffs; SRP RNA
#
A09190 Not Included in Pathway or Brite
B
B 09191 Unclassified: metabolism
C 99980 Enzymes with EC numbers
D SPH_0431 gluconate 5-dehydrogenase (5-keto-D-gluconate 5-reductase) K00046 idnO; gluconate 5-dehydrogenase [EC:1.1.1.69]
D SPH_0755 peptide methionine sulfoxide reductase MsrA/msrB K12267 msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]
D SPH_1490 peptide methionine sulfoxide reductase MsrA/msrB K12267 msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]
D SPH_1666 glutathione S-transferase family protein K11209 yghU; GSH-dependent disulfide-bond oxidoreductase [EC:1.8.4.-]
D SPH_1760 thiol peroxidase (Scavengase P20) K11065 tpx; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24]
D SPH_1677 thioredoxin reductase K21567 fnr; ferredoxin/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1]
D SPH_0320 nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein K04068 nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]
D SPH_0363 pyruvate formate-lyase 3 K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4]
D SPH_2118 pflA; pyruvate formate-lyase 1-activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4]
D SPH_1078 tehB; tellurite resistance protein TehB K16868 tehB; tellurite methyltransferase [EC:2.1.1.265]
D SPH_0480 methyltransferase K07444 ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]
D SPH_0679 acetyltransferase, gnat family K22441 paiA; diamine N-acetyltransferase [EC:2.3.1.57]
D SPH_1537 integral membrane protein K27959 lit; lyso-form N-acyl lipoprotein transferase [EC:2.3.1.-]
D SPH_1543 lgt; prolipoprotein diacylglyceryl transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145]
D SPH_1586 thiamine biosynthesis lipoprotein K03734 apbE; FAD:protein FMN transferase [EC:2.7.1.180]
D SPH_0550 dihydroxyacetone kinase family protein K07030 fakA; fatty acid kinase [EC:2.7.2.18]
D SPH_2375 GBSi1, group II intron, maturase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D SPH_1676 conserved hypothetical protein K18672 dacA; diadenylate cyclase [EC:2.7.7.85]
D SPH_1544 hprK; HPr(Ser) kinase/phosphatase K06023 hprK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]
D SPH_0707 tributyrin esterase K03930 estA; putative tributyrin esterase [EC:3.1.1.-]
D SPH_0456 tyrosine-protein phosphatase CpsB K01104 E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48]
D SPH_1859 yqeG; had superfamily (subfamily iiia) phosphatase K07015 yqeG; putative phosphatase [EC:3.1.3.-]
D SPH_2133 deoxyribonuclease, TatD family K03424 tatD; TatD DNase family protein [EC:3.1.21.-]
D SPH_2132 putative primase homolog K05985 rnmV; ribonuclease M5 [EC:3.1.26.8]
D SPH_0452 trehalose-6-phosphate hydrolase (Alpha,alpha-phosphotrehalase) K01215 dexB; glucan 1,6-alpha-glucosidase [EC:3.2.1.70]
D SPH_0475 endo-alpha-N-acetylgalactosaminidase K17624 engCP; endo-alpha-N-acetylgalactosaminidase [EC:3.2.1.97]
D SPH_0433 unsaturated glucuronyl hydrolase K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180]
D SPH_1572 def1; peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88]
D SPH_1665 def2; polypeptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88]
D SPH_1594 peptidoglycan GlcNAc deacetylase K22278 pgdA; peptidoglycan-N-acetylglucosamine deacetylase [EC:3.5.1.104]
D SPH_1681 endoribonuclease L-PSP, putative K09022 ridA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]
D SPH_0925 putative YjeF homolog, C-terminus K17758 nnrD; ADP-dependent NAD(P)H-hydrate dehydratase [EC:4.2.1.136]
D SPH_0426 hyaluronate lyase K01727 hysA; hyaluronate lyase [EC:4.2.2.1]
D SPH_2359 fucose operon FucU protein K02431 fucU; L-fucose mutarotase [EC:5.1.3.29]
D SPH_1667 calcium-transporting ATPase 1 (Golgi Ca(2+)-ATPase) K01537 ATP2C; P-type Ca2+ transporter type 2C [EC:7.2.2.10]
D SPH_1736 cation transport ATPase K12952 ctpE; cation-transporting P-type ATPase E [EC:7.2.2.-]
C 99981 Carbohydrate metabolism
D SPH_0855 AcuB family protein K04767 acuB; acetoin utilization protein AcuB
C 99982 Energy metabolism
D SPH_0973 SUF system FeS assembly protein, NifU family K04488 iscU; nitrogen fixation protein NifU and related proteins
D SPH_1700 probable pyridine nucleotide-disulfide oxidoreductase YkgC K21739 rclA; probable pyridine nucleotide-disulfide oxidoreductase
C 99983 Lipid metabolism
D SPH_1204 conserved hypothetical protein K25232 fakB; fatty acid kinase fatty acid binding subunit
D SPH_1672 conserved hypothetical protein K25232 fakB; fatty acid kinase fatty acid binding subunit
C 99984 Nucleotide metabolism
D SPH_0271 ribonucleotide reductase K03647 nrdI; protein involved in ribonucleotide reduction
D SPH_2106 DNA-entry nuclease (Competence-specific nuclease) K15051 endA; DNA-entry nuclease
C 99985 Amino acid metabolism
D SPH_1773 pyridoxal phosphate enzyme, YggS family K06997 yggS; PLP dependent protein
C 99986 Glycan metabolism
C 99987 Cofactor metabolism
C 99988 Secondary metabolism
C 99999 Others
B
B 09192 Unclassified: genetic information processing
C 99973 Transcription
D SPH_0075 phage antirepressor protein K07741 antB; anti-repressor protein
D SPH_0307 regulatory protein spx K16509 spxA; regulatory protein spx
D SPH_1235 conserved hypothetical protein K16509 spxA; regulatory protein spx
D SPH_1536 regulatory protein spx K16509 spxA; regulatory protein spx
D SPH_1014 S1 RNA binding domain protein K06959 tex; protein Tex
C 99974 Translation
D SPH_1651 S1-type RNA-binding domain K07570 GSP13; general stress protein 13
C 99975 Protein processing
D SPH_0509 tig; trigger factor K03545 tig; trigger factor
D SPH_1077 smpB; SsrA-binding protein K03664 smpB; SsrA-binding protein
D SPH_1299 glutaredoxin K06191 nrdH; glutaredoxin-like protein NrdH
D SPH_1494 adapter protein MecA K16511 mecA1_2; adapter protein MecA 1/2
C 99976 Replication and repair
D SPH_1181 DNA repair protein RadC K03630 radC; DNA repair protein RadC
D SPH_2122 competence-induced protein Ccs50 K09760 rmuC; DNA recombination protein RmuC
D SPH_1649 conserved hypothetical protein K07461 K07461; putative endonuclease
D SPH_1382 dprA; DNA protecting protein DprA K04096 smf; DNA processing protein
D SPH_1689 DNA replication protein DnaD K02086 dnaD; DNA replication protein
D SPH_1422 transcriptional regulator, Cro/CI family K07467 nicK; putative DNA relaxase
D SPH_0099 phage terminase, large subunit, pbsx family K06909 xtmB; phage terminase large subunit
D SPH_1907 chromosome segregation helicase K07478 ycaJ; putative ATPase
D SPH_0300 prophage Sa05, DNA primase, P4 family K06919 K06919; putative DNA primase/helicase
D SPH_0682 transposase K07482 K07482; transposase, IS30 family
D SPH_1626 transposase K07482 K07482; transposase, IS30 family
D SPH_0916 transposase K07483 K07483; transposase
D SPH_1278 transposase K07483 K07483; transposase
D SPH_1454 transposase subfamily, putative K07483 K07483; transposase
D SPH_0913 transposase K07484 K07484; transposase
D SPH_0570 transposase K07485 K07485; transposase
D SPH_0888 transposase K07485 K07485; transposase
D SPH_1230 transposase K07485 K07485; transposase
D SPH_1418 transposase K07485 K07485; transposase
D SPH_1484 transposase K07485 K07485; transposase
D SPH_2238 transposase K07485 K07485; transposase
D SPH_2387 transposase K07485 K07485; transposase
D SPH_1920 conserved hypothetical protein K07487 K07487; transposase
D SPH_1598 transposase K07494 K07494; putative transposase
D SPH_0502 integrase core domain protein K07497 K07497; putative transposase
D SPH_0950 integrase core domain protein K07497 K07497; putative transposase
D SPH_1083 integrase core domain, putative K07497 K07497; putative transposase
D SPH_1279 integrase core domain, putative K07497 K07497; putative transposase
D SPH_1455 integrase core domain protein K07497 K07497; putative transposase
D SPH_1726 integrase core domain protein K07497 K07497; putative transposase
C 99979 Viral proteins
C 99998 Others
D SPH_1195 conserved hypothetical protein K09747 ebfC; nucleoid-associated protein EbfC
B
B 09193 Unclassified: signaling and cellular processes
C 99977 Transport
D SPH_1102 amino acid permease family protein K03294 TC.APA; basic amino acid/polyamine antiporter, APA family
D SPH_1470 sodium:solute symporter family protein K03307 TC.SSS; solute:Na+ symporter, SSS family
D SPH_0838 sodium-dependent transporter K03308 TC.NSS; neurotransmitter:Na+ symporter, NSS family
D SPH_0516 D-alanine glycine permease K03310 TC.AGCS; alanine or glycine:cation symporter, AGCS family
D SPH_0719 brnQ; branched-chain amino acid transport system II carrier protein K03311 TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family
C 99978 Cell growth
D SPH_0481 conserved hypothetical protein K20073 mapZ; mid-cell-anchored protein Z
D SPH_2193 jag protein K06346 jag; spoIIIJ-associated protein
D SPH_1141 Low similarity to site-specific recombinase K06400 spoIVCA; site-specific DNA recombinase
C 99993 Cell motility
C 99995 Signaling proteins
D SPH_0776 typA; GTP-binding protein TypA/BipA K06207 typA; GTP-binding protein
D SPH_0351 ACT domain protein K07166 K07166; ACT domain-containing protein
D SPH_1052 PhoH family protein K06217 phoH; phosphate starvation-inducible protein PhoH and related proteins
C 99992 Structural proteins
D SPH_1088 lyzozyme M1 K07273 acm; lysozyme
C 99994 Others
D SPH_1526 phoU1; phosphate transport system regulatory protein PhoU K02039 phoU; phosphate transport system protein
D SPH_2275 phoU2; phosphate transport system regulatory protein PhoU K02039 phoU; phosphate transport system protein
D SPH_1376 copper homeostasis protein CutC K06201 cutC; copper homeostasis protein
B
B 09194 Poorly characterized
C 99996 General function prediction only
D SPH_1079 competence protein K06198 coiA; competence protein CoiA
D SPH_2054 conserved hypothetical protein K06878 K06878; tRNA-binding protein
D SPH_0974 sufB; FeS assembly protein SufB K09014 sufB; Fe-S cluster assembly protein SufB
D SPH_0971 sufD; FeS assembly protein SufD K09015 sufD; Fe-S cluster assembly protein SufD
D SPH_0752 ribonuclease BN K07058 K07058; membrane protein
D SPH_0194 rhodanese domain protein K07146 K07146; UPF0176 protein
D SPH_1400 cytoplasmic membrane protein K03744 lemA; LemA protein
D SPH_1015 zinc-dependent metalloprotease K03095 sprL; SprT-like protein
D SPH_1087 integral membrane protein K08974 K08974; putative membrane protein
D SPH_1011 ABC transporter, substrate-binding protein K08986 ycgQ; putative membrane protein
D SPH_1715 phnA; alkylphosphonate utilization operon protein PhnA K06193 phnA; protein PhnA
C 99997 Function unknown
D SPH_1431 HD superfamily phosphohydrolase K06885 K06885; uncharacterized protein
D SPH_2114 membrane protein K06890 K06890; uncharacterized protein
D SPH_0132 CoA binding protein K06929 K06929; uncharacterized protein
D SPH_1296 conserved hypothetical protein K06940 K06940; uncharacterized protein
D SPH_0874 conserved domain protein K06960 K06960; uncharacterized protein
D SPH_1012 putative permease K07089 K07089; uncharacterized protein
D SPH_1922 domain of unknown function, putative K07090 K07090; uncharacterized protein
D SPH_1995 phosphodiesterase, family K07095 K07095; uncharacterized protein
D SPH_1350 transcriptional regulator, biotin repressor family K07105 K07105; uncharacterized protein
D SPH_1740 YwnB K07118 K07118; uncharacterized protein
D SPH_0770 oxidoreductase K07124 K07124; uncharacterized protein
D SPH_0421 ATPase K07133 K07133; uncharacterized protein
D SPH_1989 conserved hypothetical protein K08998 K08998; uncharacterized protein
D SPH_0660 hemerythrin HHE cation binding domain subfamily, putative K09155 K09155; uncharacterized protein
D SPH_0352 conserved hypothetical protein K09157 K09157; uncharacterized protein
D SPH_2337 twin-arginine translocation pathway signal K09704 K09704; uncharacterized protein
D SPH_2268 conserved hypothetical protein K09705 K09705; uncharacterized protein
D SPH_1429 putative helix-turn-helix protein K09787 K09787; uncharacterized protein
D SPH_1377 conserved hypothetical protein K09790 K09790; uncharacterized protein
D SPH_1050 s1 RNA binding domain K00243 K00243; uncharacterized protein
D SPH_1662 conserved hypothetical protein K09861 K09861; uncharacterized protein
D SPH_0377 conserved hypothetical protein K09962 K09962; uncharacterized protein
D SPH_1998 conserved hypothetical protein K09976 K09976; uncharacterized protein
D SPH_1198 conserved hypothetical protein K07584 ysxB; uncharacterized protein
D SPH_2045 conserved hypothetical protein K07586 ygaC; uncharacterized protein
D SPH_0651 ylxr homolog K07742 ylxR; uncharacterized protein
!
#
#[ KO | BRITE | KEGG2 | KEGG ]
#Last updated: June 22, 2025