+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces rapamycinicus

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS E M271_40735 hypothetical protein K16420 rapA_B_C; rapamycin polyketide synthase A/B/C D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E M271_12960 beta-ACP synthase K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E M271_12965 polyketide beta-ketoacyl synthase K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E M271_12970 Curamycin polyketide synthase acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E M271_12975 polyketide cyclase K14670 whiEVI; aromatase E M271_12980 polyketide synthase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E M271_05000 metallo-beta-lactamase K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS D Decaketide PKS B Type III PKS C Plant type C Fungal type C Bacterial type D M271_00240 hypothetical protein K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] D M271_09145 stilbene synthase K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D M271_00400 protein mbtH K05375 mbtH; MbtH protein D M271_09105 antibiotic synthesis protein MbtH K05375 mbtH; MbtH protein D M271_09665 hypothetical protein K05375 mbtH; MbtH protein D M271_27660 protein mbtH K05375 mbtH; MbtH protein D M271_31740 protein mbtH K05375 mbtH; MbtH protein D M271_40600 hypothetical protein K05375 mbtH; MbtH protein D M271_46675 hypothetical protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D M271_09920 hypothetical protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D M271_30130 enterobactin synthase K02364 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72] C Bacillibactin synthetase D M271_09920 hypothetical protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase D M271_09930 hypothetical protein K12239 pchE; L-cysteine---[L-cysteinyl-carrier protein] ligase PchE [EC:6.2.1.69] D M271_09960 hypothetical protein K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69] C Mycobactin synthetase C Vibriobactin synthetase D M271_09920 hypothetical protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Myxochelin synthetase D M271_09920 hypothetical protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase D M271_09920 hypothetical protein K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Isonitrile lipopeptide synthase # APolyketide tailoring proteins B Hydrolase B Ketoreductase B Oxygenase C M271_45445 3-(3-hydroxyphenyl)propionate hydroxylase K16022 rif19; flavoprotein hydroxylase C M271_50030 hypothetical protein K16022 rif19; flavoprotein hydroxylase C M271_40650 hypothetical protein K16379 fkbD; cytochrome P450 C-9 hydroxylase C M271_40670 hypothetical protein K16380 rapN; cytochrome P450 RapN C M271_14635 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C M271_32985 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C M271_00830 epoxide hydrolase K21159 sgcF; epoxide hydrolase C M271_01315 epoxide hydrolase K21159 sgcF; epoxide hydrolase C M271_18355 epoxide hydrolase K21159 sgcF; epoxide hydrolase C M271_42485 epoxide hydrolase K21159 sgcF; epoxide hydrolase C M271_30845 FAD-binding monooxygenase K14253 oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232] C M271_00275 hypothetical protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C M271_09135 hypothetical protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C M271_12955 hypothetical protein K14673 whiEII; putative monooxygenase C M271_12945 monooxygenase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C M271_40645 31-O-demethyl-FK506 methyltransferase K16381 fkbM; 31-O-methyltransferase C M271_37845 SAM-dependent methyltransferase K16028 asm17; O-methyltransferase C M271_50120 hypothetical protein K16028 asm17; O-methyltransferase C M271_12995 O-methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-] B Glycosyltransferase B Halogenase C M271_00350 hypothetical protein K16431 cepH; FAD-dependent halogenase [EC:1.14.19.-] C M271_09130 hypothetical protein K16431 cepH; FAD-dependent halogenase [EC:1.14.19.-] C M271_09845 FAD-dependent oxidoreductase K14257 ctcP; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-] B beta-Branched incorporating proteins B Others C M271_37830 3-hydroxyacyl-CoA dehydrogenase K16024 asm13; methoxymalonate biosynthesis protein C M271_50125 hypothetical protein K16024 asm13; methoxymalonate biosynthesis protein C M271_37835 methoxymalonate biosynthesis protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein C M271_41245 hypothetical protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein C M271_50130 hypothetical protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein C M271_37840 hypothetical protein K16026 asm15; methoxymalonate biosynthesis protein C M271_50135 hypothetical protein K16026 asm15; methoxymalonate biosynthesis protein C M271_50140 hypothetical protein K16027 asm16; methoxymalonate biosynthesis protein C M271_45480 hypothetical protein K15466 rifF; amide synthase C M271_11995 hypothetical protein K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C M271_12030 hypothetical protein K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C M271_12130 hypothetical protein K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C M271_12185 hypothetical protein K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C M271_27745 flavin reductase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C M271_40705 hypothetical protein K16378 rapP; pipecolate-incorporating enzyme C M271_09870 hypothetical protein K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase C M271_06890 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] B Aminotransferase C M271_00255 hypothetical protein K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] C M271_09150 hypothetical protein K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] C M271_27675 aminotransferase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] B Others C M271_39675 aminotransferase class V K04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17] C M271_09160 hypothetical protein K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46] C M271_27680 hypothetical protein K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46] C M271_09165 hypothetical protein K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] C M271_27675 aminotransferase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] C M271_46055 2-hydroxy-acid oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] C M271_00280 hypothetical protein K16425 dpgB; isomerase DpgB C M271_09140 hypothetical protein K16425 dpgB; isomerase DpgB C M271_00275 hypothetical protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C M271_09135 hypothetical protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2025