+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptosporangium roseum
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
E Sros_8815 Polyketide synthase modules and related protein-like protein K12443 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
D Sros_6999 Polyketide synthase modules and related protein-like protein K15314 sgcE; enediyne polyketide synthase
D Sros_8249 Polyketide synthase modules and related protein-like protein K15314 sgcE; enediyne polyketide synthase
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E Sros_4153 hypothetical protein K14670 whiEVI; aromatase
E Sros_4148 hypothetical protein K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E Sros_4150 3-oxoacyl-(acyl-carrier-protein) synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E Sros_4151 3-oxoacyl-(acyl-carrier-protein) synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E Sros_4152 conserved hypothetical protein K05553 actI3; minimal PKS acyl carrier protein
E Sros_6284 beta-lactamase domain-containing protein K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E Sros_4150 3-oxoacyl-(acyl-carrier-protein) synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E Sros_4151 3-oxoacyl-(acyl-carrier-protein) synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E Sros_4152 conserved hypothetical protein K05553 actI3; minimal PKS acyl carrier protein
D Decaketide PKS
E Sros_4150 3-oxoacyl-(acyl-carrier-protein) synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E Sros_4151 3-oxoacyl-(acyl-carrier-protein) synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E Sros_4152 conserved hypothetical protein K05553 actI3; minimal PKS acyl carrier protein
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D Sros_5949 3-oxoacyl-(ACP) synthase III K16167 bpsA; alkylresorcinol/alkylpyrone synthase
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D Sros_6555 conserved hypothetical protein K05375 mbtH; MbtH protein
D Sros_6841 MbtH domain-containing protein K05375 mbtH; MbtH protein
D Sros_6969 conserved hypothetical protein K05375 mbtH; MbtH protein
D Sros_5581 conserved hypothetical protein K05375 mbtH; MbtH protein
D Sros_2422 conserved hypothetical protein K05375 mbtH; MbtH protein
D Sros_3469 conserved hypothetical protein K05375 mbtH; MbtH protein
D Sros_2200 conserved hypothetical protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Bacillibactin synthetase
D Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
D Sros_3767 pyochelin synthetase F K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69]
C Mycobactin synthetase
C Vibriobactin synthetase
D Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D Sros_3774 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
C Sros_6998 hypothetical protein K15315 sgcE10; enediyne core biosynthesis thioesterase
B Ketoreductase
B Oxygenase
C Sros_4752 hypothetical protein K14632 actVA6; C-6 monooxygenase
C Sros_8715 cytochrome P450-family protein K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C Sros_6983 cytochrome P450-family protein K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C Sros_6973 4-hydroxyphenylacetate 3-monooxygenase oxygenase component K21184 sgcC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]
C Sros_5100 putative hydrolase K21159 sgcF; epoxide hydrolase
C Sros_5218 putative hydrolase K21159 sgcF; epoxide hydrolase
C Sros_2973 Microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase
C Sros_0451 Microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase
C Sros_1214 putative hydrolase K21159 sgcF; epoxide hydrolase
C Sros_9243 putative hydrolase K21159 sgcF; epoxide hydrolase
C Sros_4599 putative hydrolase K21159 sgcF; epoxide hydrolase
C Sros_4618 putative epoxide hydrolase K21159 sgcF; epoxide hydrolase
C Sros_4149 hypothetical protein K14673 whiEII; putative monooxygenase
C Sros_4181 PheA/TfdB family FAD-binding monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
C Sros_4156 PheA/TfdB family FAD-binding monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C Sros_6986 hydroxyneurosporene-O-methyltransferase K21178 sgcD4; O-methyltransferase [EC:2.1.1.-]
C Sros_6962 hydroxyneurosporene-O-methyltransferase K21178 sgcD4; O-methyltransferase [EC:2.1.1.-]
C Sros_5950 conserved hypothetical protein K16168 bpsB; methyltransferase
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
C Sros_7003 hypothetical protein K21160 sgcE2; enediyne biosynthesis protein E2
C Sros_7002 hypothetical protein K21161 sgcE3; enediyne biosynthesis protein E3
C Sros_8246 hypothetical protein K21161 sgcE3; enediyne biosynthesis protein E3
C Sros_7001 hypothetical protein K21162 sgcE4; enediyne biosynthesis protein E4
C Sros_8247 hypothetical protein K21162 sgcE4; enediyne biosynthesis protein E4
C Sros_7000 hypothetical protein K21163 sgcE5; enediyne biosynthesis protein E5
C Sros_8248 hypothetical protein K21163 sgcE5; enediyne biosynthesis protein E5
C Sros_6996 cytochrome P450 family protein K21164 sgcE7; enediyne biosynthesis protein E7
C Sros_6993 hypothetical protein K21165 sgcE8; enediyne biosynthesis protein E8
C Sros_6992 Choline dehydrogenase and related flavoprotein-like protein K21166 sgcE9; enediyne biosynthesis protein E9
C Sros_6990 wyosine base formation K21167 sgcE11; enediyne biosynthesis protein E11
C Sros_6976 Non-ribosomal peptide synthetase modules and related protein-like protein K21186 sgcC5; condensation enzyme
C Sros_6997 flavin reductase-like, FMN-binding protein K21185 sgcE6; flavin reductase
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ANonribosomal peptide tailoring proteins
B Reductase
C Sros_3769 conserved hypothetical protein K12241 pchG; pyochelin biosynthesis protein PchG
B Thioesterase
C Sros_6554 Oleoyl-(acyl-carrier-protein) hydrolase K12242 pchC; pyochelin biosynthesis protein PchC
B Oxygenase
B Glycosyltransferase
C Sros_5179 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
B Aminotransferase
B Others
C Sros_3487 selenocysteine lyase / isopenicillin N epimerase K04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17]
C Sros_6970 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]
C Sros_4590 aspartate racemase K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024