+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces reticuli

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS E TUE45_00070 eryA_1; Erythronolide synthase, modules 1 and 2 K15670 rifA; rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74] E TUE45_00071 eryA_2; Erythronolide synthase, modules 3 and 4 K15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6 E TUE45_00072 eryA_3; Erythronolide synthase, modules 3 and 4 K15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6 E TUE45_pSRc_0203 eryA_1; Erythronolide synthase, modules 3 and 4 K15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6 E TUE45_00074 eryA_4; Erythronolide synthase, modules 3 and 4 K15673 rifE; rifamycin polyketide synthase modules 9 and 10 D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E TUE45_02738 Actinorhodin polyketide putative beta-ketoacyl synthase 1 K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E TUE45_02737 Actinorhodin polyketide putative beta-ketoacyl synthase 2 K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E TUE45_02736 Oxytetracycline polyketide synthase acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E TUE45_02735 Putative polyketide cyclase K14670 whiEVI; aromatase E TUE45_02734 tcmI; Tetracenomycin polyketide synthesis protein TcmI K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E TUE45_01297 Actinorhodin polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01570 Actinorhodin polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01296 Actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01569 Actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01110 Oxytetracycline polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01317 Oxytetracycline polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01568 Actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01316 actIII_1; Putative ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E TUE45_01559 actIII_2; Putative ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E TUE45_01286 Putative polyketide cyclase K05554 actVII; aromatase [EC:4.2.1.-] E TUE45_01574 Putative polyketide cyclase K05554 actVII; aromatase [EC:4.2.1.-] E TUE45_01293 ccrA; Beta-lactamase type II precursor K05555 actIV; cyclase [EC:4.-.-.-] E TUE45_01564 cphA; Beta-lactamase precursor K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E TUE45_01297 Actinorhodin polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01570 Actinorhodin polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01296 Actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01569 Actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01110 Oxytetracycline polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01317 Oxytetracycline polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01568 Actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01316 actIII_1; Putative ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E TUE45_01559 actIII_2; Putative ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] D Decaketide PKS E TUE45_01297 Actinorhodin polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01570 Actinorhodin polyketide putative beta-ketoacyl synthase 1 K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01296 Actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01569 Actinorhodin polyketide putative beta-ketoacyl synthase 2 K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E TUE45_01110 Oxytetracycline polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01317 Oxytetracycline polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01568 Actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E TUE45_01316 actIII_1; Putative ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E TUE45_01559 actIII_2; Putative ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D TUE45_01597 Polyketide synthase-like Pks10 K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D TUE45_00364 MbtH-like protein K05375 mbtH; MbtH protein D TUE45_06410 MbtH-like protein K05375 mbtH; MbtH protein D TUE45_pSRc_0206 TUE45_pSRTUE45c_0206; MbtH-like protein K05375 mbtH; MbtH protein D TUE45_pSRc_0455 TUE45_pSRTUE45c_0455; MbtH-like protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D TUE45_07225 npt; 4'-phosphopantetheinyl transferase Npt K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7] C Bacillibactin synthetase C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase C Myxochelin synthetase C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase C Isonitrile lipopeptide synthase # APolyketide tailoring proteins B Hydrolase B Ketoreductase B Oxygenase C TUE45_00084 mhpA_1; 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase K16022 rif19; flavoprotein hydroxylase C TUE45_pSRc_0218 mhpA; 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase K16022 rif19; flavoprotein hydroxylase C TUE45_00479 Cytochrome P450 107B1 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C TUE45_00829 eryF; 6-deoxyerythronolide B hydroxylase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C TUE45_01059 vdh_1; Vitamin D(3) 25-hydroxylase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C TUE45_01321 Antibiotic biosynthesis monooxygenase K15941 snoaB; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-] C TUE45_02739 qdoI_2; Quercetin 2,3-dioxygenase K14673 whiEII; putative monooxygenase C TUE45_02741 tfdB; 2,4-dichlorophenol 6-monooxygenase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C TUE45_01299 tcmN_1; Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN K14251 oxyF; C-methyltransferase [EC:2.1.1.-] C TUE45_02733 tcmN_2; Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN K14251 oxyF; C-methyltransferase [EC:2.1.1.-] B Glycosyltransferase B Halogenase C TUE45_00076 lodB; Putative FAD-dependent oxidoreductase LodB K16033 asm12; FADH2-dependent halogenase C TUE45_pSRc_0457 TUE45_pSRTUE45c_0457; Phytanoyl-CoA dioxygenase (PhyH) K15650 cmaB; non-haem Fe2+, alpha-ketoglutarate-dependent halogenase B beta-Branched incorporating proteins B Others C TUE45_00075 rifF; Proansamycin X synthase K15466 rifF; amide synthase C TUE45_pSRc_0202 rifF; Proansamycin X synthase K15466 rifF; amide synthase C TUE45_01579 hypothetical protein K14626 actVIA; actinorhodin biosynthesis protein ActVIA C TUE45_01562 snaC; NADH:riboflavin 5'-phosphate oxidoreductase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C TUE45_00621 rbmH_1; Flavin reductase (NADPH) K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] C TUE45_06418 rbmH_2; Flavin reductase (NADPH) K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase C TUE45_06932 hypothetical protein K04793 mbtG; mycobactin lysine-N-oxygenase B Glycosyltransferase C TUE45_pSRc_0432 TUE45_pSRTUE45c_0432; hypothetical protein K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] B Aminotransferase B Others C TUE45_06938 4-hydroxymandelate synthase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46] C TUE45_pSRc_0230 TUE45_pSRTUE45c_0230; Lactate 2-monooxygenase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2025