+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Serratia rubidaea</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
C    CDK (cyclin dependent kinase)
C    DDK (Dbf-4 dependent kinase)
C    GINS complex
C    Other initiation factors
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
C    DNA polymerase epsilon complex
C    DNA polymerase delta complex
C    DNA polymerase gamma complex (mitochondrial)
C    RPA (replication protein A)
C    RFC (replication factor C)
C    RNase H
D      AXX16_4225 Ribonuclease HI	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
C    Other elongation factors
B  DNA Replication Termination Factors
C    DNA methylation enzymes
D      AXX16_0047 DNA-cytosine methyltransferase	K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 
C    Prevention of re-replication factors
C    Telomere proteins
D      Shelterin complex
D      TERB1-TERB2-MAJIN complex
D      CST complex (animals)
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      Dyskerin complex
C    Telomerase complex (fungi)
D      Sm core complex
C    ELG1-RFC complex
C    MRN complex
C    Other termination factors
B  DNA Topoisomerases
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      AXX16_4088 DNA-binding protein HU-beta	K03530 hupB; DNA-binding protein HU-beta 
D      AXX16_3152 Integration host factor alpha subunit	K04764 ihfA; integration host factor subunit alpha 
D      AXX16_3481 Integration host factor beta subunit	K05788 ihfB; integration host factor subunit beta 
D      AXX16_0523 Chromosomal replication initiator protein DnaA	K02313 dnaA; chromosomal replication initiator protein 
D      AXX16_0952 Replicative DNA helicase	K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] 
D      AXX16_1122 DNA primase	K02316 dnaG; DNA primase [EC:2.7.7.101] 
D      AXX16_0970 Single-stranded DNA-binding protein	K03111 ssb; single-strand DNA-binding protein 
C    Initiation factors (archaeal)
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
E        AXX16_1561 DNA polymerase III alpha subunit	K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] 
E        AXX16_0522 DNA polymerase III beta subunit	K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] 
E        AXX16_0079 DNA polymerase III chi subunit	K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7] 
E        AXX16_3981 DNA polymerase III delta subunit	K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] 
E        AXX16_3309 DNA polymerase III delta prime subunit	K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] 
E        AXX16_2043 DNA polymerase III epsilon subunit	K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] 
E        AXX16_4224 DNA polymerase III epsilon subunit	K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] 
E        AXX16_4043 DNA polymerase III subunits gamma and tau	K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] 
E        AXX16_4510 DNA polymerase III psi subunit	K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7] 
E        AXX16_2437 DNA polymerase III theta subunit	K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7] 
E        AXX16_4003 DNA polymerase III theta subunit	K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7] 
D      RNase H
E        AXX16_4225 Ribonuclease HI	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
E        AXX16_1560 Ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      Other elongation factors
E        AXX16_0585 DNA polymerase I	K02335 polA; DNA polymerase I [EC:2.7.7.7] 
E        AXX16_0606 DNA ligase, LigB	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
E        AXX16_1845 DNA ligase	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
C    Elongation factors (archaeal)
D      B-family DNA polymerases
D      D-family DNA polymerases
D      RNase H
E        AXX16_4225 Ribonuclease HI	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
E        AXX16_1560 Ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      RFC (replication factor C)
D      Other elongation factors
B  DNA Replication Termination Factors
C    Terminus site-binding protein
D      AXX16_2759 DNA replication terminus site-binding protein	K10748 tus; DNA replication terminus site-binding protein 
C    DNA methylation enzymes
D      AXX16_0811 Methyl-directed repair DNA adenine methylase	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
D      AXX16_2510 Methyl-directed repair DNA adenine methylase	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
C    Prevention of re-replication factors
D      AXX16_3940 SeqA protein, negative modulator of initiation of replication	K03645 seqA; negative modulator of initiation of replication 
D      AXX16_1778 Chromosomal replication initiator protein DnaA	K10763 hda; DnaA-homolog protein 
B  DNA Topoisomerases
C    AXX16_2012 DNA gyrase subunit A	K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 
C    AXX16_0520 DNA gyrase subunit B	K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 
C    AXX16_1153 Topoisomerase IV subunit A	K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] 
C    AXX16_1149 Topoisomerase IV subunit B	K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] 
C    AXX16_2718 DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
C    AXX16_2661 DNA topoisomerase III	K03169 topB; DNA topoisomerase III [EC:5.6.2.1] 
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#Last updated: August 27, 2025