+F Repair protein KO
#
DNA Repair and Recombination Proteins - Sporothrix schenckii
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SPSK_04600 methylated-DNA-protein-cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SPSK_06116 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E SPSK_05302 uracil-DNA glucosyllase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SPSK_00047 TDG/mug DNA glucosyllase family protein K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E SPSK_08707 A/G-specific adenine glucosyllase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SPSK_00804 N-glucosyllase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E SPSK_05083 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E SPSK_03279 AP endonuclease 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E SPSK_05918 AP endonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F SPSK_05870 DNA polymerase delta subunit 1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F SPSK_05144 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F SPSK_01261 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F SPSK_03840 DNA polymerase epsilon subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F SPSK_10334 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
E SPSK_09621 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E SPSK_04302 flap endonuclease-1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E SPSK_01443 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
E SPSK_01080 tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E SPSK_09595 histidine triad nucleotide-binding protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E SPSK_04209 bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E SPSK_07148 poly [ADP-ribose] polymerase K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F SPSK_04902 xeroderma pigmentosum group C-complementing protein K10838 XPC; xeroderma pigmentosum group C-complementing protein
F SPSK_08436 xeroderma pigmentosum group C-complementing protein K10838 XPC; xeroderma pigmentosum group C-complementing protein
F SPSK_05132 UV excision repair protein RAD23 K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F SPSK_02774 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F SPSK_04945 cullin 4 K10609 CUL4; cullin 4
F SPSK_08361 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
F SPSK_05034 DNA repair protein RAD7 K15082 RAD7; DNA repair protein RAD7
F SPSK_04885 DNA repair protein RAD16 K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F SPSK_04798 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F SPSK_10960 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F SPSK_01794 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F SPSK_08051 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F SPSK_01895 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F SPSK_02760 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F SPSK_02509 hypothetical protein K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F SPSK_08032 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F SPSK_07979 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F SPSK_10002 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F SPSK_05588 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F SPSK_10938 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F SPSK_02774 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F SPSK_04945 cullin 4 K10609 CUL4; cullin 4
F SPSK_08361 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F SPSK_00744 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F SPSK_02168 DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F SPSK_05575 transcription elongation factor K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E SPSK_08566 DNA excision repair protein ERCC-3 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E SPSK_00280 DNA excision repair protein ERCC-2 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E SPSK_00301 hypothetical protein K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E SPSK_01543 transcription initiation factor TFIIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E SPSK_01566 transcription initiation factor TFIIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E SPSK_01146 transcription initiation factor TFIIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E SPSK_02439 transcription initiation factor TFIIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E SPSK_05738 TFIIH basal transcription factor complex TTD-A subunit K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E SPSK_09298 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E SPSK_09275 cyclin H K06634 CCNH; cyclin H
E SPSK_05383 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E SPSK_07207 replication factor A1 K07466 RFA1; replication factor A1
E SPSK_03513 replication factor A2 K10739 RFA2; replication factor A2
E SPSK_04623 replication factor A3 K10740 RPA3; replication factor A3
D Other NER factors
E SPSK_02531 DNA-repair protein complementing XP-A cell K10847 XPA; DNA-repair protein complementing XP-A cells
E SPSK_06311 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E SPSK_08455 DNA excision repair protein ERCC-4 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E SPSK_08333 DNA excision repair protein ERCC-5 K10846 ERCC5; DNA excision repair protein ERCC-5
E SPSK_01443 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E SPSK_08341 DNA repair/transcription protein MET18/MMS19 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E SPSK_03967 cullin 3 K03869 CUL3; cullin 3
E SPSK_00326 transcription elongation factor B, polypeptide 1 K03872 ELOC; elongin-C
E SPSK_09164 hypothetical protein K15077 ELA1; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E SPSK_00411 DNA mismatch repair protein MSH2 K08735 MSH2; DNA mismatch repair protein MSH2
E SPSK_00073 DNA mismatch repair protein MSH3 K08736 MSH3; DNA mismatch repair protein MSH3
E SPSK_02949 DNA mismatch repair protein MSH6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E SPSK_03079 DNA mismatch repair protein MLH1 K08734 MLH1; DNA mismatch repair protein MLH1
E SPSK_08387 DNA mismatch repair protein PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E SPSK_10291 DNA mismatch repair protein MLH3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E SPSK_05870 DNA polymerase delta subunit 1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E SPSK_05144 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E SPSK_01261 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E SPSK_07207 replication factor A1 K07466 RFA1; replication factor A1
E SPSK_03513 replication factor A2 K10739 RFA2; replication factor A2
E SPSK_04623 replication factor A3 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E SPSK_01394 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E SPSK_06294 replication factor C subunit 2/4 K10755 RFC2_4; replication factor C subunit 2/4
E SPSK_04381 replication factor C subunit 2/4 K10755 RFC2_4; replication factor C subunit 2/4
E SPSK_01787 replication factor C subunit 3/5 K10756 RFC3_5; replication factor C subunit 3/5
E SPSK_09352 replication factor C subunit 3/5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E SPSK_09621 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E SPSK_01479 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E SPSK_01443 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E SPSK_01829 WD domain protein K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E SPSK_03072 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E SPSK_00983 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
E SPSK_03072 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E SPSK_00983 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E SPSK_00830 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E SPSK_00830 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
E SPSK_01570 DNA repair protein RAD57 K10958 RAD57; DNA repair protein RAD57
D Rad52 family proteins
E SPSK_08796 DNA repair and recombination protein RAD52 K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E SPSK_00436 DNA repair and recombination protein RAD54 and RAD54-like protein K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
D RecQ family DNA helicases
E SPSK_02920 bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E SPSK_02920 bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E SPSK_07113 DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E SPSK_00587 RecQ-mediated genome instability protein 1 K15364 NCE4; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E SPSK_07207 replication factor A1 K07466 RFA1; replication factor A1
E SPSK_03513 replication factor A2 K10739 RFA2; replication factor A2
E SPSK_04623 replication factor A3 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E SPSK_03083 hypothetical protein K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E SPSK_08376 SMC5 protein K22803 SMC5; structural maintenance of chromosomes protein 5
E SPSK_00385 SMC6 protein K22804 SMC6; structural maintenance of chromosomes protein 6
E SPSK_00518 DNA repair protein Nse1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E SPSK_05250 hypothetical protein K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E SPSK_06141 hypothetical protein K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E SPSK_02241 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E SPSK_06137 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E SPSK_06751 26 proteasome complex subunit DSS1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E SPSK_09188 structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E SPSK_08490 holliday junction resolvase YEN1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E SPSK_04173 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E SPSK_00410 hypothetical protein K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E SPSK_01076 hypothetical protein K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
E SPSK_08289 ATP-dependent DNA helicase MPH1 K14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E SPSK_08665 ATP-dependent DNA helicase 2 subunit 1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E SPSK_07043 ATP-dependent DNA helicase 2 subunit 2 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E SPSK_03072 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E SPSK_00983 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E SPSK_05890 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E SPSK_08421 hypothetical protein K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
E SPSK_04106 DNA polymerase lambda subunit K10981 POL4; DNA polymerase IV [EC:2.7.7.7]
D Other NHEJ factors
E SPSK_09595 histidine triad nucleotide-binding protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E SPSK_07126 DNA repair protein K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E SPSK_10452 Endonuclease/Exonuclease/phosphatase family protein K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
E SPSK_05663 apoptosis-inducing TAF9-like domain 1 family protein K11511 APITD1; centromere protein S
D Bloom's syndrome complex (BTR)
E SPSK_02920 bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E SPSK_07113 DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E SPSK_00587 RecQ-mediated genome instability protein 1 K15364 NCE4; RecQ-mediated genome instability protein 1
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E SPSK_00696 fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E SPSK_00830 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
E SPSK_04884 telomere length regulation protein K11137 TELO2; telomere length regulation protein
E SPSK_08375 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
E SPSK_05197 WD repeat-containing protein K23314 WRAP53; telomerase Cajal body protein 1
E SPSK_08948 hypothetical protein K24752 WDR70; WD repeat-containing protein 70
E SPSK_01829 WD domain protein K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D SPSK_05931 DNA polymerase eta subunit K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D SPSK_00239 DNA polymerase iota subunit K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D SPSK_03129 DNA polymerase kappa subunit K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D SPSK_02160 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D SPSK_05815 DNA polymerase zeta subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D SPSK_00906 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D SPSK_07447 E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D SPSK_10447 DNA repair protein RAD5 K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D SPSK_01946 ubiquitin-conjugating enzyme E2 variant K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D SPSK_06576 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D SPSK_09621 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D SPSK_01498 hypothetical protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D SPSK_07314 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D SPSK_02527 HUS1 checkpoint protein K10903 HUS1; HUS1 checkpoint protein
D SPSK_03407 cell cycle checkpoint protein K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D SPSK_00674 cell cycle checkpoint protein K06662 HRAD17; cell cycle checkpoint protein
D SPSK_06294 replication factor C subunit 2/4 K10755 RFC2_4; replication factor C subunit 2/4
D SPSK_04381 replication factor C subunit 2/4 K10755 RFC2_4; replication factor C subunit 2/4
D SPSK_01787 replication factor C subunit 3/5 K10756 RFC3_5; replication factor C subunit 3/5
D SPSK_09352 replication factor C subunit 3/5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D SPSK_03407 cell cycle checkpoint protein K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D SPSK_03890 replication fork protection complex subunit Tof1/Swi1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D SPSK_04441 replication fork protection complex subunit Csm3/Swi3 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D SPSK_00656 mediator of replication checkpoint protein 1 K11272 MRC1; mediator of replication checkpoint protein 1
C Triple T complex
D SPSK_04884 telomere length regulation protein K11137 TELO2; telomere length regulation protein
D SPSK_03889 heat repeat protein K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D SPSK_01936 hypothetical protein K23388 UBL4; ubiquitin-like protein 4
D SPSK_06426 hypothetical protein K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D SPSK_02913 serine/threonineeeee-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D SPSK_04788 ataxia telangectasia mutated family protein K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D SPSK_04135 serine/threonineeeee-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D SPSK_05999 serine/threonineeeee-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D SPSK_04062 M-phase inducer tyrosine phosphatase K02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]
D SPSK_06387 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein K06630 YWHAE; 14-3-3 protein epsilon
D SPSK_05465 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein K06630 YWHAE; 14-3-3 protein epsilon
D SPSK_00667 mitosis inhibitor protein kinase SWE1 K03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]
D SPSK_08564 hypothetical protein K24664 FKH; forkhead protein FKH
D SPSK_04312 vacuolar protein-sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D SPSK_00312 hypothetical protein K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D SPSK_05856 DNA polymerase phi subunit K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D SPSK_00692 DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D SPSK_08871 hypothetical protein K17815 EXO5; exonuclease V [EC:3.1.-.-]
D SPSK_03497 nuclease S1 K05986 NUCS; nuclease S1 [EC:3.1.30.1]
D SPSK_03447 hypothetical protein K05986 NUCS; nuclease S1 [EC:3.1.30.1]
C Helicases
D SPSK_05829 hypothetical protein K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D SPSK_03335 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D SPSK_00435 pre-mRNA-splicing factor CDC5/CEF1 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D SPSK_05541 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D SPSK_03309 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D SPSK_08033 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SPSK_09806 dUTP pyrophosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SPSK_03956 ribonucleoside-diphosphate reductase subunit M1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D SPSK_02467 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SPSK_04600 methylated-DNA-protein-cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SPSK_06116 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E SPSK_05302 uracil-DNA glucosyllase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SPSK_05349 DNA-3-methyladenine glucosyllase II K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E SPSK_08707 A/G-specific adenine glucosyllase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SPSK_05286 formamidopyrimidine-DNA glucosyllase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SPSK_05083 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E SPSK_08337 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E SPSK_08337 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D SPSK_08033 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SPSK_09806 dUTP pyrophosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024