+F Repair protein KO
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DNA Repair and Recombination Proteins - Syngnathus scovelli (Gulf pipefish)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 125978900 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 125994679 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 125970945 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 125975867 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 125984598 CPD photolyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 125993711 uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 125993817 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 125970926 thymine DNA glycosylase, tandem duplicate 1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 125970931 G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 125983895 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 125977552 single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 125967709 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 125988083 methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 125988455 N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 125970986 endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 125991131 endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 125969584 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 125992258 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 125987994 DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 125984096 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 125993768 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 125984636 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 125994249 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 125980455 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 125966768 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 125968160 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 125993508 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 125985477 zgc:110269; probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 125985750 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 125985130 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 125994146 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 125975308 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 125981708 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 125966696 tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 125968431 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 125968509 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 125971874 bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 125982411 high mobility group protein B1a K10802 HMGB1; high mobility group protein B1
E 125971958 high mobility group-T protein-like K10802 HMGB1; high mobility group protein B1
E 125968896 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 125989817 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 125977830 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 125985150 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 125973600 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 125987898 DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 125983064 RAD23 homolog A, nucleotide excision repair protein a K10839 RAD23; UV excision repair protein RAD23
F 125976178 UV excision repair protein RAD23 homolog B-like isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 125980215 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 125979381 uncharacterized protein LOC125979381 isoform X1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 125984196 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 125966633 cullin-4A K10609 CUL4; cullin 4
F 125987951 cullin-4B K10609 CUL4; cullin 4
F 125966849 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 125970244 DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 125988233 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 125990127 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 125971347 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 125972391 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 125972906 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 125984192 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 125977326 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 125976099 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 125972634 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 125967213 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 125976901 DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 125986758 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 125984196 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 125966633 cullin-4A K10609 CUL4; cullin 4
F 125987951 cullin-4B K10609 CUL4; cullin 4
F 125966849 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 125994577 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 125978555 DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 125980778 UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 125983209 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 125968846 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 125986109 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 125972170 general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 125970115 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 125993646 general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 125994344 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 125986682 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 125990221 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 125994509 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 125993876 cyclin-H K06634 CCNH; cyclin H
E 125981386 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 125982297 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 125972162 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 125974690 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 125986664 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 125969201 DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 125973991 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 125991343 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 125967181 DNA excision repair protein ERCC-5 homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 125985130 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 125991508 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 125984668 cullin-3-B-like isoform X1 K03869 CUL3; cullin 3
E 125972833 cullin-3b isoform X1 K03869 CUL3; cullin 3
E 125982506 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 125985991 elongin-C K03872 ELOC; elongin-C
E 125983762 elongin-B-like K03873 ELOB; elongin-B
E 125991042 elongin-B-like K03873 ELOB; elongin-B
E 125979011 elongin A, like isoform X1 K15076 ELOA; elongin-A
E 125986533 elongin-A K15076 ELOA; elongin-A
E 125994300 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 125977668 ubiquitin-associated protein 2a isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 125993855 DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 125978407 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 125973511 PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 125978711 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 125991564 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 125981391 DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 125984096 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 125993768 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 125984636 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 125982297 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 125972162 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 125974690 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 125986664 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 125968551 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 125976162 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 125987832 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 125982524 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 125993735 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 125993508 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 125978489 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 125982411 high mobility group protein B1a K10802 HMGB1; high mobility group protein B1
E 125971958 high mobility group-T protein-like K10802 HMGB1; high mobility group protein B1
E 125985130 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 125967200 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 125972798 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 125982743 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 125975362 nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 125990982 uncharacterized protein LOC125990982 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125973659 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 125990982 uncharacterized protein LOC125990982 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125979500 BRCA1-A complex subunit Abraxas 1-like isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 125966932 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 125981422 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 125979354 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 125980179 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 125990982 uncharacterized protein LOC125990982 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125972195 Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 125969441 DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 125990982 uncharacterized protein LOC125990982 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125986087 DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 125972798 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 125982743 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 125975362 nibrin K10867 NBN; nibrin
D BRCA complex
E 125990982 uncharacterized protein LOC125990982 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125989756 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 125989756 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 125989768 DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 125988059 DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 125981711 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 125985803 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 125990502 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 125971018 DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
E 125983356 RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 125976276 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 125989404 helicase ARIP4-like isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 125977087 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 125975353 DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 125992032 ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 125970637 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 125986719 ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 125983385 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 125970637 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 125983119 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125994535 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125994743 DNA topoisomerase 3-beta-1-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125965883 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 125984027 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 125982297 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 125972162 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 125974690 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 125986664 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 125983997 serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 125977379 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 125977356 serine/threonine-protein phosphatase 4 regulatory subunit 2-B K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 125988487 serine/threonine-protein phosphatase 4 regulatory subunit 2-A-like K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 125990562 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 125978789 serine/threonine-protein phosphatase 4 regulatory subunit 3-A-like isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
E 125976991 AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 125980707 AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 125980655 AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 125983124 AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 125987816 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 125983005 si:dkey-119f1.1; structural maintenance of chromosomes protein 6-like isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 125990450 protein LRATD1 K22805 FAM84A; protein FAM84A
E 125968585 non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 125975198 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 125968638 necdin-like 2 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 125989032 non-structural maintenance of chromosomes element 4 homolog A isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 125993560 SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 125978505 SMC5-SMC6 complex localization factor protein 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 125980995 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 125985084 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 125986966 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 125980140 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 125979036 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 125983935 structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 125990204 flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 125970466 spatacsin K19026 SPG11; spatacsin
E 125981131 zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 125992506 RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 125971157 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 125988778 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 125978548 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 125985378 DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 125975197 protein LRATD2-like K22810 FAM84B; protein FAM84B
E 125986918 protein LRATD2a K22810 FAM84B; protein FAM84B
E 125968367 BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 125984848 cilia and flagella associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 125966148 hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 125982730 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 125983205 ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 125982198 BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 125989316 heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 125975331 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 125980377 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 125978621 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 125992312 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 125991510 X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 125973322 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 125985671 DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 125972798 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 125982743 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 125988348 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 125979405 DNA repair protein XRCC4-like isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 125988478 non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 125968896 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 125978672 DNA nucleotidylexotransferase isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 125994146 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 125968431 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 125968509 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 125991948 protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 125987037 tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 125967711 si:dkey-127k13.1; PWWP domain-containing DNA repair factor 3A K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 125971051 si:ch211-127m7.2; uncharacterized protein si:ch211-127m7.2 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 125983373 jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 125994195 zgc:101664; shieldin complex subunit 3 isoform X1 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 125973625 Fanconi anemia group B protein isoform X1 K10889 FANCB; fanconi anemia group B protein
E 125965837 Fanconi anemia group C protein isoform X1 K10890 FANCC; fanconi anemia group C protein
E 125988916 Fanconi anemia group E protein isoform X1 K10892 FANCE; fanconi anemia group E protein
E 125970139 Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 125978564 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 125980469 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 125970997 Fanconi anemia core complex-associated protein 24 isoform X1 K10898 FAAP24; fanconi anemia-associated protein
E 125991150 Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 125984428 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 125972059 hairy-related 6 isoform X1 K06054 HES1; hairy and enhancer of split 1
E 125988822 hairy-related 9 K06054 HES1; hairy and enhancer of split 1
E 125977175 centromere protein S K11511 APITD1; centromere protein S
E 125984014 centromere protein X K15360 STRA13; centromere protein X
E 125988029 ubiquitin-conjugating enzyme E2 T isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 125970637 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 125983119 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125994535 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125994743 DNA topoisomerase 3-beta-1-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 125965883 recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 125984027 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 125977828 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 125971205 Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 125990982 uncharacterized protein LOC125990982 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 125972195 Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 125970091 fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 125989756 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 125988059 DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 125991734 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 125973177 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 125984822 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 125965732 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 125971090 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 125992264 serine/threonine-protein phosphatase 6 regulatory subunit 2a isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 125970391 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 125987124 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 125974853 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 125974098 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 125976774 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
E 125988803 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 125990018 E3 ubiquitin-protein ligase rnf8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 125972900 E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 125972365 E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 125967597 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 125976718 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 125979198 taperin K24164 TPRN; taperin
E 125979626 WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 125967200 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 125978862 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 125994027 DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 125993575 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 125974127 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 125989788 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 125989458 ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 125974026 ubiquitin conjugating enzyme E2 A, like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 125982425 ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 125977831 E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 125981370 helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 125976986 ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 125985386 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 125988034 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 125970531 ubiquitin-conjugating enzyme E2Na K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 125992358 ubiquitin-conjugating enzyme E2Nb K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 125993508 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 125992312 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 125990391 DNA-dependent metalloprotease SPRTN isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 125979350 germ cell nuclear acidic protein isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 125986115 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 125965876 cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 125986339 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 125979454 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 125993630 cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 125976162 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 125987832 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 125982524 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 125993735 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 125979454 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 125977150 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 125967224 TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 125986708 claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 125991734 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 125989048 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 125993800 TELO2-interacting protein 2 isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 125975253 large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 125986672 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 125993852 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 125991515 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 125980935 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 125971837 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 125990249 cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 125982679 serine/threonine-protein kinase Chk1 isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 125993791 serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 125980641 M-phase inducer phosphatase 2 isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 125989401 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 125977667 14-3-3 protein beta/alpha-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 125987279 14-3-3-like protein 1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 125981406 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 125974928 14-3-3 protein beta/alpha-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 125982484 14-3-3 protein gamma-1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 125972669 14-3-3 protein gamma-1 isoform X1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 125982245 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 125971953 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 K06630 YWHAE; 14-3-3 protein epsilon
D 125966660 neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 125990738 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 125970923 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 125971198 wee1-like protein kinase 2 isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 125990034 period circadian protein homolog 1b K21944 PER1; period circadian protein 1
D 125984518 period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 125972529 period circadian protein homolog 2-like isoform X1 K02633 PER2; period circadian protein 2
D 125976890 period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 125982756 plastin-3 isoform X1 K17336 PLS3; plastin-3
D 125990867 plastin-3-like isoform X1 K17336 PLS3; plastin-3
D 125970069 interferon-stimulated gene 20 kDa protein K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 125984756 serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 125977926 serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 125974223 serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 125974688 serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 125974808 serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 125988150 protein downstream neighbor of son homolog isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 125976193 KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 125983809 KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 125984936 KN motif and ankyrin repeat domain-containing protein 4-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 125979996 KN motif and ankyrin repeat domain-containing protein 1-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 125973092 KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 125993965 KN motif and ankyrin repeat domain-containing protein 1a K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 125986250 charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 125984490 vacuolar protein sorting-associated protein 4B isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 125980672 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 125968511 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 125968544 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 125982146 myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 125969286 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 125990979 DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 125988213 5' exonuclease Apollo isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 125968764 endonuclease V-like isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 125987999 DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 125967560 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 125993877 DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 125986674 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 125978100 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 125989244 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 125979706 pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 125983923 oxidized purine nucleoside triphosphate hydrolase isoform X1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 125993819 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 125967576 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 125972683 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 125990495 ribonucleoside-diphosphate reductase subunit M2 isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125990658 ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 125987060 ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 125978900 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 125984598 CPD photolyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 125993711 uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 125977552 single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 125983895 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 125967709 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 125969584 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 125992308 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 125992308 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 125967576 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024